Jodi L. McBride, Ph.D.

  • Associate Professor, Oregon National Primate Research Center
  • Associate Professor of Behavioral Neuroscience, School of Medicine
  • Behavioral Neuroscience Graduate Program, School of Medicine
  • Neuroscience Graduate Program, School of Medicine

Biography

Jodi McBride, PhD, is an Associate Professor of Neuroscience at Oregon Health & Science University in Portland, Oregon. Her laboratory is situated at the Oregon National Primate Research Center (ONPRC) and her research program is aimed at both modeling and treating neurodegenerative diseases with a current focus on Huntington’s and Batten diseases. Her expertise in viral gene delivery has allowed for the creation of a rhesus macaque model of Huntington’s disease that closely replicates the neuropathology, transcript dysregulation and behavioral manifestations of the disease. Additionally, as part of a large collaborative effort, her group discovered and characterized the first non-human primate model of Batten disease. A cohort of CLN7 mutant Japanese macaques at the ONPRC show lysosomal storage accumulation, progressive blindness, tremor and ataxia, with a severe atrophy of the cerebellum and cerebrum. With these primate models in hand, she is working collaboratively to develop novel biomarkers of disease expression (imaging and biofluids) as well as assess gene therapy strategies, with a keen interest in using novel viral vector serotypes to optimize delivery of the appropriate gene to the brain regions most effected in each disease.   

 

Education

  • B.S., 1998, University of Illinois
  • Ph.D., 2005, Rush University Medical Center
  • Fellowship:

    • Post-doctoral fellowship, Gene Therapy, University of Iowa, 2005-2008
    • Post-doctoral fellowship, Neuroscience, Oregon National Primate Research Center, 2008-2010

Honors and awards

  • 2008 Keynote Address, Huntington’s disease Society of America conference, Chicago, IL
  • 2015 OHSU Technology Transfer and Business Development Award: Top Industry Collaboration
  • 2016 OHSU Technology Transfer and Business Development Award: Recognized Industry Collaboration
  • 2017 OHSU Technology Transfer and Business Development Award: Recognized Industry Collaboration
  • 2019 OHSU Brain Institute Festival of Lights Award for innovative and important neuroscience research within the OHSU community that has the potential to significantly change the way medical problems are addressed
  • 2021 Nomination for the National Institute of Neurological Disorders and Stroke (NINDS) Landis Award for Outstanding Mentorship

Memberships and associations

  • American Society of Gene and Cell Therapy, member
  • Society for Neuroscience, member
  • Society for Neuroscience, Oregon Chapter, member
  • Molecular Therapy, Associate Editor

Areas of interest

  • Developing therapies for neurodegenerative diseases, including Huntington's and Batten diseases
  • Creating non-human primate models of neurodegenerative diseases
  • Developing and testing novel gene therapy strategies to deliver genes to the brain
  • Assessing brain connectivity in neurodegenerative diseases using novel imaging techniques
  • Translational therapeutics
  • Viral vectors
  • Neurosurgery

Publications

Selected publications

  • Kordower JH, Emborg ME, Bloch J, Shuang M, Chu Y, Leventhal L, McBride JL, Chen E, Palfi S, Roitberg BZ, Brown D, Holden J, Pyzalski R, Taylor MD, Carvey P, Ling ZD, Trono D, Hantraye P, Deglon N, Aebischer P.  Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson’s disease.  Science 290(27):767-773, 2000. PubMed PMID: 11052933. 
  • McBride JL, Ramaswamy S, Bartus R, Gasmi M, Herzog C, Brandon E, Zhou L, Pitzer MR, Barry-Kravis E, Kordower JH.  Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's disease.  Proceedings of the National Academy of Sciences 103(24):9345-50, 2006. PubMed PMID: 16751280; PubMed Central PMCID: PMC1482612.
  • Kumar P, Wu H, McBride JL, Jung KE, Kim MH, Davidson BL, Lee SK, Shankar P, Manjunath N. Transvascular delivery of small interfering RNA to the central nervous system. Nature 5;448 (7149):39-43, 2007. PubMed PMID: 17572664.
  • McBride JL, Boudreau R, Harper SQ, Staber PD, Mas Monteys A, Martins I, Burstein H, Peluso RW, Polisky B, Carter B and Davidson BL. Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi.  Proceedings of the National Academy of Sciences, 105(15) 5868-5873, 2008. doi: 10.1073/pnas.0801775105. Epub 2008 Apr 8.
  • Boudreau RL, McBride JL, Martins I, Shen S, Xing Y, Carter BJ and Davidson BL.  Non-allele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington’s disease mice. Molecular Therapy, 17(6):1053-63, 2009. doi: 10.1038/mt.2009.17. Epub 2009 Feb 24. PubMed PMID: 19240687; PubMed Central PMCID: PMC2835182.
  • McBride JL, Pitzer, MR, Boudreau RL, Dufour B, Ojeda SR and Davidson BL. Preclinical Safety of RNAi-Mediated HTT Suppression in the Rhesus Macaque as a Potential Therapy for Huntington's Disease. Molecular Therapy, 19(12): 2152-2162, 2011. doi: 10.1038/mt.2011.219. Epub 2011 Oct 25. PubMed PMID: 22031240; PubMed Central PMCID: PMC3242667.
  • McBride JL, Neuringer M, Ferguson B, Renner L, McGill T, Stoddard J, Peterson S, Zweig R, Kohama S, Tagge I, Su W, Sherman L, Domire J, Ducore R, Colgin L and Lewis A. Discovery of  a CLN7 model of Batten Disease in non-human primates, Neurobiology of Disease, 119: 65-78, 2018. doi: 10.1016/j.nbd.2018.07.013. Epub 2018 Jul 23. PubMed PMID: 30048804; PubMed Central PMCID: PMC6200145.
  • Liguore WA, Domire JS, Button D, Wang Y, Dufour BD, Srinivasan S, McBride JL. AAV-PHP.B Administration Results in a Differential Pattern of CNS Biodistribution in Non-human Primates Compared with Mice. Molecular Therapy. 2019 Nov 6;27(11):2018-2037. doi: 10.1016/j.ymthe.2019.07.017. Epub 2019 Aug 5. PMID: 31420242; PMCID: PMC6838922.
  • Weiss AR, Liguore WA, Domire JS, Button D, and McBride, JL. Intra-striatal AAV2.retro administration leads to extensive retrograde transport in the rhesus macaque brain: implications for disease modeling and therapeutic development. Scientific Reports.  Apr 24;10(1):6970, 2020. doi: 10.1038/s41598-020-63559-7. PubMed PMID: 32332773; PubMed Central PMCID: PMC7181773.
  • Weiss AR, Liu Z, Wang X, Liguore WA, Kroenke C and McBride, JL. The macaque brain ONPRC18 template with combined gray and white matter labelmap for multimodal neuroimaging studies of nonhuman primates, NeuroImage, Oct 30;117517. doi: 10.1016/j.neuroimage.2020.117517. Online ahead of print. January 2021. PMID: 33137475.

Publications

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