Photo of James McCormick, Ph.D.

James McCormick Ph.D.

    • Associate Professor of Medicine, Division of Nephrology and Hypertension School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Dr. McCormick completed his PhD in the laboratory of Dr. Jonathan Seckl in Edinburgh, UK.  During his graduate work, he focused on transcriptional regulation of the  glucocorticoid receptor, a key mediator of perinatal “programming” of adult  diseases such as hypertension and dementia. He completed an American Heart  Association-funded postdoctoral fellowship with Dr. David Pearce in the  Division of Nephrology at UCSF, studying the physiological roles of serum and  glucocorticoid-induced kinase (SGK)  isoforms, and how they differentially regulate renal sodium transport. He  joined the Division of Nephrology & Hypertension at OHSU in 2005. His  current work uses mouse models to examine mechanisms of blood pressure regulation.

Education

  • B.S., University of Edinburgh, Edinburgh United Kingdom 1996
  • Ph.D., University of Edinburgh, Edinburgh United Kingdom 2000
  • Fellowship:

    • Nephrology - University of California, San Francisco, 2000-2004

Memberships and associations

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Publications

  • "Endothelial transcriptomics reveals activation of fibrosis-related pathways in hypertension." Physiological Genomics In: , Vol. 50, No. 2, 01.02.2018, p. 104-116.
  • "Potassium intake modulates the thiazide-sensitive sodium-chloride cotransporter (NCC) activity via the Kir4.1 potassium channel." Kidney International In: , 01.01.2018.
  • "Nephron remodeling underlies hyperkalemia in familial hyperkalemic hypertension." Journal of the American Society of Nephrology In: , Vol. 28, No. 9, 01.09.2017, p. 2555-2557.
  • "Potassium sensing by renal distal tubules requires Kir4.1." Journal of the American Society of Nephrology  In: , Vol. 28, No. 6, 01.06.2017, p. 1814-1825.
  • "Calcineurin inhibitor cyclosporine A activates renal NA-K-CL cotransporters via local and systemic mechanisms." American Journal of Physiology - Renal Physiology In: , Vol. 312, No. 3, 01.03.2017, p. F489-F501.
  • "SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule." Journal of Physiology In: , Vol. 594, No. 17, 01.09.2016, p. 4945-4966.
  • "The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapy." American Journal of Physiology - Renal Physiology In: , Vol. 310, No. 11, 01.06.2016, p. F1389-F1396.
  • "Calcineurin and Sorting-Related Receptor with A-Type Repeats Interact to Regulate the Renal Na-K-2Cl Cotransporter." Journal of the American Society of Nephrology  In: , Vol. 27, No. 1, 01.01.2016, p. 107-119.
  • "Direct and indirect mineralocorticoid effects determine distal salt transport." Journal of the American Society of Nephrology In: , Vol. 27, No. 8, 2016, p. 2436-2445.
  • "Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride." Cell Metabolism In: , Vol. 21, No. 1, 06.01.2015, p. 39-50.
  • "Distal convoluted tubule." Comprehensive Physiology In: , Vol. 5, No. 1, 01.01.2015, p. 45-98.
  • "Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3." Journal of Clinical Investigation In: , Vol. 124, No. 11, 03.11.2014, p. 4723-4736.
  • "Sympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension." Hypertension In: , Vol. 64, No. 1, 2014, p. 178-184.
  • "Regulation of NKCC2 activity by inhibitory SPAK isoforms : KS-SPAK is a more potent inhibitor than SPAK2." American Journal of Physiology - Renal Physiology In: , Vol. 305, No. 12, 15.12.2013.
  • "SPAK differentially mediates vasopressin effects on sodium cotransporters." Journal of the American Society of Nephrology  In: , Vol. 24, No. 3, 28.02.2013, p. 407-418.
  • "Enhanced phosphorylation of Na+ -Cl- co-transporter in experimental metabolic syndrome : Role of insulin." Clinical Science In: , Vol. 123, No. 11, 12.2012, p. 635-647.
  • "Pathogenesis of calcineurin inhibitor-induced hypertension." Journal of Nephrology In: , Vol. 25, No. 3, 06.2012, p. 269-275.
  • "Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice." Molecular Endocrinology  In: , Vol. 25, No. 12, 12.2011, p. 2106-2118.
  • "Overexpression of the sodium chloride cotransporter is not sufficient to cause familial hyperkalemic hypertension." Hypertension In: , Vol. 58, No. 5, 11.2011, p. 888-894.
  • "The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension." Nature Medicine In: , Vol. 17, No. 10, 10.2011, p. 1304-1309.
  • "A SPAK isoform switch modulates renal salt transport and blood pressure." Cell Metabolism In: , Vol. 14, No. 3, 07.09.2011, p. 352-364.
  • "High tail-cuff blood pressure in mice 1 week after shipping : The need for longer acclimation." American Journal of Hypertension In: , Vol. 24, No. 5, 05.2011, p. 534-536.
  • "The WNK kinase network regulating sodium, potassium, and blood pressure." Journal of the American Society of Nephrology In: , Vol. 22, No. 4, 04.2011, p. 605-614.
  • "The WNKs : Atypical protein kinases with pleiotropic actions." Physiological Reviews In: , Vol. 91, No. 1, 01.2011, p. 177-219.
  • "Altered renal FGF23-mediated activity involving MAPK and Wnt : Effects of the Hyp mutation." Journal of Endocrinology In: , Vol. 207, No. 1, 2010, p. 67-75.
  • "Akt2 and SGK3 are both determinants of postnatal hair follicle development." FASEB Journal  In: , Vol. 23, No. 9, 09.2009, p. 3193-3202.
  • "WNK kinases and renal sodium transport in health and disease : an integrated view." Hypertension In: , Vol. 51, No. 3, 03.2008, p. 588-596.
  • "NH2 terminus of serum and glucocorticoid-regulated kinase 1 binds to phosphoinositides and is essential for isoform-specific physiological functions." American Journal of Physiology - Renal Physiology  In: , Vol. 292, No. 6, 06.2007.
  • "WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron." Kidney International In: , Vol. 70, No. 4, 28.08.2006, p. 630-634.
  • "Renal function of gene-targeted mice lacking both SGK1 and SGK3." American Journal of Physiology - Regulatory Integrative and Comparative Physiology  In: , Vol. 290, No. 4, 04.2006.

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