Photo of James McCormick, Ph.D.

James McCormick Ph.D.

    • Associate Professor of Medicine, Division of Nephrology and Hypertension School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Dr. McCormick completed his PhD in the laboratory of Dr. Jonathan Seckl in Edinburgh, UK.  During his graduate work, he focused on transcriptional regulation of the  glucocorticoid receptor, a key mediator of perinatal “programming” of adult  diseases such as hypertension and dementia. He completed an American Heart  Association-funded postdoctoral fellowship with Dr. David Pearce in the  Division of Nephrology at UCSF, studying the physiological roles of serum and  glucocorticoid-induced kinase (SGK)  isoforms, and how they differentially regulate renal sodium transport. He  joined the Division of Nephrology & Hypertension at OHSU in 2005. His  current work uses mouse models to examine mechanisms of blood pressure regulation.

Education

  • B.S., University of Edinburgh, Edinburgh United Kingdom 1996
  • Ph.D., University of Edinburgh, Edinburgh United Kingdom 2000
  • Fellowship:

    • Nephrology - University of California, San Francisco, 2000-2004

Memberships and associations

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Publications

  • "WNK kinases and renal sodium transport in health and disease" Hypertension March 2008
  • "Decreased intestinal glucose transport in the sgk3-knockout mouse" Pflugers Archiv European Journal of Physiology December 2005
  • "SPAK differentially mediates vasopressin effects on sodium cotransporters" Journal of the American Society of Nephrology : JASN February 28 2013
  • "Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride" Cell Metabolism January 6 2015
  • "Renal function of gene-targeted mice lacking both SGK1 and SGK3" American Journal of Physiology - Renal Fluid and Electrolyte Physiology April 2006
  • "Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development" Molecular Biology of the Cell September 2004
  • "Overexpression of the sodium chloride cotransporter is not sufficient to cause familial hyperkalemic hypertension" Hypertension November 2011
  • "Sympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension" Hypertension  2014
  • "Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice" Molecular Endocrinology December 2011
  • "Glucocorticoids prolong CA2+ transients in hippocampal-derived h19-7 neurons by repressing the plasma membrane CA2+-atpase-1" Molecular Endocrinology  2002
  • "WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron" Kidney International August 28 2006
  • "High tail-cuff blood pressure in mice 1 week after shipping" American Journal of Hypertension May 2011
  • "A SPAK isoform switch modulates renal salt transport and blood pressure" Cell Metabolism September 7 2011
  • "Akt2 and SGK3 are both determinants of postnatal hair follicle development" FASEB Journal September 2009
  • "The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension" Nature Medicine October 2011
  • "Tissue-specific differences in rat glucocorticoid receptor gene transcriptional regulation" Biochemical Society Transactions  1998
  • "Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3" Journal of Clinical Investigation November 3 2014
  • "Regulation of NKCC2 activity by inhibitory SPAK isoforms" American Journal of Physiology - Renal Fluid and Electrolyte Physiology December 15 2013
  • "5′-heterogeneity of glucocorticoid receptor messenger RNA is tissue specific" Molecular Endocrinology  2000
  • "Distal convoluted tubule" Comprehensive Physiology January 1 2015
  • "NH2 terminus of serum and glucocorticoid-regulated kinase 1 binds to phosphoinositides and is essential for isoform-specific physiological functions" American Journal of Physiology - Renal Fluid and Electrolyte Physiology June 2007
  • "SGK1" Physiology April 2005
  • "The WNK kinase network regulating sodium, potassium, and blood pressure" Journal of the American Society of Nephrology : JASN April 2011
  • "Pathogenesis of calcineurin inhibitor-induced hypertension" Journal of Nephrology June 2012
  • "Enhanced phosphorylation of Na+ -Cl- co-transporter in experimental metabolic syndrome" Clinical Science December 2012
  • "Altered renal FGF23-mediated activity involving MAPK and Wnt" Journal of Endocrinology  2010
  • "Sgk1 Mediates Osmotic Induction of NPR-A Gene in Rat Inner Medullary Collecting Duct Cells" Hypertension April 2004
  • "The WNKs" Physiological Reviews January 2011
  • "Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3" Journal of Physiology June 1 2005
  • "Differential regulation of corticosteroid receptors by monoamine neurotransmitters and antidepressant drugs in primary hippocampal culture" Neuroscience June 6 2003

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