Photo of James E. Korkola, Ph.D.

James E. Korkola Ph.D.

  • (503) 494-4943
    • Assistant Professor of Biomedical Engineering School of Medicine
    • Biomedical Informatics Graduate Program School of Medicine

Dr. Korkola's research work is primarily on breast cancer, with a focus on how interactions with microenvironment impact the phenotype of cancer cells, emphasizing those that alter the way cells respond to therapy. The Korkola Lab also is interested in understanding the mechanisms of resistance induced by extrinsic and intrinsic factors and developing multidrug combinations to overcome resistance and improve patient outcomes.

Education

  • Ph.D., University of Toronto 1999

Publications

  • "Bladder cancer outcome and subtype classification by gene expression" Clinical Cancer Research June 1 2005
  • "Resistance to mammary tumorigenesis in Copenhagen rats is associated with the loss of preneoplastic lesions" Carcinogenesis  1999
  • "Array-based comparative genomic hybridization for genome-wide screening of DNA copy number in bladder tumors" Journal of Cancer Research June 1 2003
  • "Constitutive gene expression predisposes morphogen-mediated cell fate responses of NT2/D1 and 27X-1 human embryonal carcinoma cells" Stem Cells March 2007
  • "In vivo differentiation and genomic evolution in adult male germ cell tumors" Genes Chromosomes and Cancer January 2008
  • "Joint estimation of multiple related biological networks" Annals of Applied Statistics September 1 2014
  • "Biology and genetics of adult male germ cell tumors" Journal of Clinical Oncology December 10 2006
  • "Interferon-α Resistance Associated Genes in Renal Cell Carcinoma Identified by Expression Profiling" Journal of Urology April 2007
  • "Identification and validation of a gene expression signature that predicts outcome in adult men with germ cell tumors" Journal of Clinical Oncology November 1 2009
  • "The transcription factor ZNF217 Is a prognostic biomarker and therapeutic target during breast cancer progression" Cancer Discovery July 2012
  • "Identification and quantification of AKT isoforms and phosphoforms in breast cancer using a novel nanofluidic immunoassay" Molecular and Cellular Proteomics November 2013
  • "Resistance of Copenhagen rats to chemical induction of glutathione S-transferase 7-7-positive liver foci" Carcinogenesis September 1997
  • "Resistance of Copenhagen rats to hepatocarcinogenesis does not involve T-cell immunity" Carcinogenesis  2001
  • "Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib" Breast Cancer Research and Treatment September 2012
  • "Modeling precision treatment of breast cancer." Genome Biology  2013
  • "Cyclin D1 expression during rat mammary tumor development and its potential role in the resistance of the Copenhagen rat" Breast Cancer Research  1999
  • "A genetic strategy for single and combinatorial analysis of miRNA function in mammalian hematopoietic stem cells" Stem Cells February 2010
  • "Molecular events in germ cell tumours" BJU International November 2009
  • "Resistance to chemically-induced mammary tumors in Copenhagen x nude-derived F2 athymic rats" Carcinogenesis  1997
  • "Differentiation of Lobular versus Ductal Breast Carcinomas by Expression Microarray Analysis" Journal of Cancer Research November 1 2003
  • "Tissue-specific resistance to cancer development in the rat" Carcinogenesis  2002
  • "Subtype and pathway specific responses to anticancer compounds in breast cancer" Proceedings of the National Academy of Sciences of the United States of America February 21 2012
  • "Heterogeneity in cancer dynamics"  July 28 2015
  • "Identification of a robust gene signature that predicts breast cancer outcome in independent data sets" BMC Cancer April 11 2007
  • "A Central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma" Cancer Discovery August 2012
  • "Gene expression-based classification of nonseminomatous male germ cell tumors" Oncogene July 28 2005
  • "Integrated genomic analyses of ovarian carcinoma" Nature June 30 2011
  • "Testicular mixed germ cell tumors" Modern Pathology August 2009
  • "Array-based comparative genomic hybridization from formalin-fixed, paraffin-embedded breast tumors" Journal of Molecular Diagnostics February 2005
  • "Transcriptional program associated with IFN-α response of renal cell carcinoma" Journal of Interferon and Cytokine Research March 2006

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