Photo of Hiroyuki Nakai, M.D., Ph.D.

Hiroyuki Nakai M.D., Ph.D.

    • Professor of Molecular and Medical Genetics School of Medicine
    • Professor of Molecular Microbiology and Immunology School of Medicine
    • Molecular and Medical Genetics Graduate Program School of Medicine
    • Molecular Microbiology and Immunology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine
    • Neuroscience Graduate Program School of Medicine


  • "Clinical evaluation of ceftazidime monotherapy for infections complicated with hematological disorders" The Journal of antibiotics. Ser. B  1992
  • "Clinical effects of a combination treatment with fosfomycin and clavulanic acid/ticarcillin for infections in patients complicated with hematological disorders" The Journal of antibiotics. Ser. B  1994
  • "Chromosome 17 abnormalities and inactivation of the p53 gene in chronic myeloid leukemia and their prognostic significance" Leukemia and Lymphoma  1995
  • "Recruitment of single-stranded recombinant adeno-associated virus vector genomes and intermolecular recombination are responsible for stable transduction of liver in vivo" Journal of Virology  2000
  • "Frequency and spectrum of genomic integration of recombinant adeno-associated virus serotype 8 vector in neonatal mouse liver" Journal of Virology October 2008
  • "Robust systemic transduction with AAV9 vectors in mice" Molecular Therapy July 2006
  • "Inhibition of hepatitis B virus in mice by RNA interference" Biotechnology June 1 2003
  • "A combined consecutive therapy with fosfomycin and sulbactam/cefoperazone for bacterial infections associated with hematological diseases" The Journal of antibiotics. Ser. B  1995
  • "Is inactivation of the p53 gene a common event in leukemias and myelodysplastic syndrome with monosomy 17p? [2]" Leukemia  1994
  • "A new recombinant adeno-associated virus (AAV)-based random peptide display library system" Gene Therapy and Regulation October 2010
  • "p53 gene mutations and loss of a chromosome 17p in Philadelphia chromosome (Ph1)-positive acute leukemia" Leukemia October 1993
  • "Modified infusion procedures affect recombinant adeno-associated virus vector type 2 transduction in the liver" Human Gene Therapy March 2005
  • "A limited number of transducible hepatocytes restricts a wide-range linear vector dose response in recombinant adeno-associated virus-mediated liver transduction" Journal of Virology  2002
  • "Clinical evaluation of imipenem/cilastatin sodium as a second line regimen in severe infections associated with hematologic disorders" The Journal of antibiotics. Ser. B  1991
  • "Myelomonocytic crisis with t(5;17) and a p53 mutation in a patient with chronic myelogenous leukemia" American Journal of Hematology  1994
  • "Initial antibacterial therapy with imipenem/cilastatin sodium for infections in granulocytopenic patients with hematological diseases" Japanese Journal of Chemotherapy  1995
  • "Microsatellite instability is an early genetic event in myelodysplastic syndrome [2]" Blood  1995
  • "Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response" Nature Medicine March 2006
  • "i(17q) appearing in acute phase in Ph1-negative, BCR-negative CML" [Rinsho ketsueki] The Japanese journal of clinical hematology May 1992
  • "Direct injection into the dorsal root ganglion" Journal of Neuroscience Methods July 15 2011
  • "A combined sulbactam/cefoperazone and amikacin therapy for the treatment of infections complicated with hematological diseases" The Journal of antibiotics. Ser. B  1993
  • "Simulation analysis of intracellular Na+ and Cl- homeostasis during β1-adrenergic stimulation of cardiac myocyte" Progress in Biophysics and Molecular Biology January 2008
  • "Helper-independent and AAV-ITR-independent chromosomal integration of double-stranded linear DNA vectors in mice" Molecular Therapy January 1 2003
  • "Erratum" Nature Medicine May 2006
  • "Recombinant adeno-associated virus type 8-mediated extensive therapeutic gene delivery into skeletal muscle of α-sarcoglycan-deficient mice" Human Gene Therapy July 1 2008
  • "Identification and characterization of nuclear and nucleolar localization signals in the adeno-associated virus serotype 2 assembly-activating protein" Journal of Virology  2015
  • "Intraganglionic AAV6 Results in Efficient and Long-Term Gene Transfer to Peripheral Sensory Nervous System in Adult Rats" PLoS One April 16 2013
  • "An Experimental and Computational Evolution-Based Method to Study a Mode of Co-evolution of Overlapping Open Reading Frames in the AAV2 Viral Genome" PLoS One June 24 2013
  • "Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice" Journal of Virology January 2005
  • "Clinical evaluation of a combination treatment with cefminox and fosfomycin for infections complicated in patients with hematological disorders" The Journal of antibiotics. Ser. B  1991

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