Photo of Eric Barklis, Ph.D.

Eric Barklis Ph.D.

  • (503) 494-2429
    • Professor of Molecular Microbiology and Immunology School of Medicine
    • Molecular Microbiology and Immunology Graduate Program School of Medicine
    • Cancer Biology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Experience

2001-present - Professor, Vollum Institute and MMI, OHSU
1999-present - Director, Electron Microscope Core Facility, OHSU
1994-01 - Associate Professor, Vollum Institute and MMI, OHSU
1987-94 - Assistant Professor, Vollum Institute and MMI, OHSU
1984-87 - Postdoctoral Fellow, Massachusetts Institute of Technology

Education

  • B.S., Massachusetts Institute of Technology, Cambridge Massachusetts 1973
  • Ph.D., Massachusetts Institute of Technology, Cambridge Massachusetts 1984

Publications

  • "Structure of the Dictyostelium discoideum prestalk D11 gene and protein" Molecular and Cellular Biology  1985
  • "Two distinct sequence elements mediate retroviral gene expression in embryonal carcinoma cells" Journal of Virology  1987
  • "Conditional infectivity of a human immunodeficiency virus matrix domain deletion mutant" Journal of Virology December 1993
  • "Retrovirus capsid protein assembly arrangements" Journal of Molecular Biology  2003
  • "HIV-1 matrix organizes as a hexamer of trimers on membranes containing phosphatidylinositol-(4,5)-bisphosphate" Virology May 10 2009
  • "Structural interactions between retroviral Gag proteins examined by cysteine cross-linking" Journal of Virology  1995
  • "Solution structures of human immunodeficiency virus type 1 (HIV-1) and moloney murine leukemia virus (MoMLV) capsid protein major-homology-region peptide analogs by NMR spectroscopy" FEBS Journal October 1 1998
  • "Retrovirus-mediated insertion of expressed and non-expressed genes at identical chromosomal locations" Nucleic Acids Research May 25 1993
  • "Stem cell factor binding to retrovirus primer binding site silencers" Journal of Virology  1995
  • "Assembly of retrovirus capsid-nucleocapsid proteins in the presence of membranes or RNA" Journal of Virology  2000
  • "Analysis of the assembly function of the human immunodeficiency virus type 1 gag protein nucleocapsid domain" Journal of Virology March 1998
  • "EMXtalOrg" Ultramicroscopy October 2002
  • "Second site reversion of a mutation near the amino terminus of the HIV-1 capsid protein" Virology December 2013
  • "Virus assembly as a target for antiretroviral therapy"  April 1 2013
  • "Assembly of gag-β-galactosidase proteins into retrovirus particles" Journal of Virology  1990
  • "Second-site compensatory mutations of HIV-1 capsid mutations" Journal of Virology May 2011
  • "S-180 cells secrete nerve growth factor protein similar to 7S-nerve growth factor" Journal of Neuroscience Research  1981
  • "Organization of HIV-1 capsid proteins on a lipid monolayer" Journal of Biological Chemistry March 27 1998
  • "Retroviral envelope protein fusions to secreted and membrane markers" Virology  1992
  • "Hexagonal organization of Moloney murine leukemia virus capsid proteins" Virology  2002
  • "Structural analysis of membrane-bound retrovirus capsid proteins" EMBO Journal March 17 1997
  • "Atomic force microscopy and electron microscopy analysis of retrovirus Gag proteins assembled in vitro on lipid bilayers" Biophysical Journal  2000
  • "Human immunodeficiency virus type 1 matrix protein assembles on membranes as a hexamer" Journal of Virology February 2007
  • "In situ localization of actin mRNA in Dictyostelium discoideum aggregates" Experimental Cell Research  1985
  • "HIV-1 Nef Assembles a Src Family Kinase-ZAP-70/Syk-PI3K Cascade to Downregulate Cell-Surface MHC-I" Cell Host and Microbe April 19 2007
  • "A stem cell-specific silencer in the primer-binding site of a retrovirus" Molecular and Cellular Biology March 1991
  • "Analysis of human immunodeficiency virus type 1 matrix binding to membranes and nucleic acids" Journal of Virology December 2009
  • "Analysis of the N-terminal region of the murine leukemia virus nucleocapsid protein" Virus Research January 2011
  • "Structure-specific recognition protein 1 facilitates microtubule growth and bundling required for mitosis" Molecular and Cellular Biology February 2010
  • "Crosslink analysis of N-terminal, C-terminal, and N/B determining regions of the Moloney murine leukemia virus capsid protein" Virology March 30 2000

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