Photo of David M. Lewinsohn, M.D., Ph.D.

David M. Lewinsohn M.D., Ph.D.

    • Professor of Medicine, Division of Pulmonary and Critical Care Medicine School of Medicine
    • Molecular Microbiology and Immunology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

After receiving his B.S. in biology from Haverford College, David Lewinsohn attended Stanford University School of Medicine. In 1989 he received his Ph.D. in cancer biology and received his M.D. the same year. Dr. Lewinsohn was a Fellow of Pulmonary and Critical Care Medicine at the University of Washington, Seattle, WA, from 1993-1996, and a senior fellow and acting instructor from 1996-1998. During 1996-1998 he was also an investigator at the Infectious Disease Research Institute in Seattle, WA.

David Lewinsohn's original experience in immunology focused on defining the role of the homing receptor L-selectin on neutrophil adhesion. However, since his pulmonary fellowship, he has been interested in the immune system's ability to detect and respond to the intracellular infection with Mtb. While it is clear that CD4+ T cells play a central role in the control of mycobacterial infection, CD8+ T cells are uniquely poised to recognize those cells harboring intracellular bacteria, such that these responses can be used as a surrogate for bacterial burden and/or infection. As a result, he has focused his work on understanding the mechanisms by which human CD8+ T cells can recognize cells harboring intracellular Mtb.He has focused on human, Mtb-specific T cells, and have defined HLA alleles used to present Mtb-derived antigen, have allowed for the definition of those antigens and epitopes that are presented, and have allowed for the analysis of the mechanisms by which Mtb-derived antigens are processed and presented. 

His laboratory is run jointly with Dr. Deborah Lewinsohn, who is the Division Head of Pediatric Infectious Diseases, and whose interest has been in the immunology of pediatric TB, and the mechanisms underlying the susceptibility of young children to TB. As a result, the laboratory provides a rich environment spanning basic immune mechanisms underlying the cellular immunology and cellular biology of human infection with Mtb, to translation of these observations in TB endemic regions of the world.

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Education

  • M.D., Ph.D., Stanford University, Palo Alto California 1989
  • Residency:

    • Categorical Internal Medicine Residency, University of California, San Francisco 1992
  • Fellowship:

    • Categorical Internal Medicine Internship, University of California San Francisco 1990Pulmonary and Critical Care Medicine, University of Washington 1996
  • Certifications:

    • Pulmonary 1996Critical Care Medicine 1997

Publications

  • "Low levels of peripheral CD161++CD8+ Mucosal Associated Invariant T (MAIT) cells are found in HIV and HIV/TB co-infection" PLoS One December 31 2013
  • "Inhibition of HLA-DR assembly, transport, and loading by human cytomegalovirus glycoprotein US3" Journal of Virology November 2002
  • "CD8 + T cells provide an immunologic signature of tuberculosis in young children" American Journal of Respiratory and Critical Care Medicine January 15 2012
  • "The Mycobacterium tuberculosis Phagosome Is a HLA-I Processing Competent Organelle" PLoS Pathogens April 2009
  • "HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells" Journal of Experimental Medicine December 2 2002
  • "Identification of MHC class II restricted T-cell-mediated reactivity against MHC class I binding Mycobacterium tuberculosis peptides" Immunology April 2011
  • "Rudimentary TCR signaling triggers default IL-10 secretion by human TH1 cells" Journal of Immunology October 15 2001
  • "Profiling antibodies to Mycobacterium tuberculosis by multiplex microbead suspension arrays for serodiagnosis of tuberculosis" Clinical and Vaccine Immunology March 2008
  • "Enhanced binding of peripheral blood mononuclear leukocytes to γ-interferon-treated cultured keratinocytes" American Journal of Dermatopathology  1987
  • "A cell surface glycoprotein mediating neutrophil/endothelial interaction" Federation Proceedings  1985
  • "CD40 ligand inhibits Fas/CD95-mediated apoptosis of human blood-derived dendritic cells" European Journal of Immunology December 1997
  • "Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles" Journal of Immunology August 1 2004
  • "Individual RD1 -region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis" Molecular Microbiology January 2004
  • "New diagnostic methods for tuberculosis" Current Opinion in Infectious Diseases April 2009
  • "Mycobacterium tuberculosis-specific CD8+ T Cells Preferentially Recognize Heavily Infected Cells" American Journal of Respiratory and Critical Care Medicine December 1 2003
  • "Interactions between endothelial cells and leukocytes" Journal of Cellular Biochemistry  1986
  • "Interferon-γ release assays for diagnosing mycobacterium tuberculosis infection in renal dialysis patients" Clinical Journal of the American Society of Nephrology September 2008
  • "Vitamin D is required for IFN-γ-mediated antimicrobial activity of human macrophages" Science Translational Medicine October 12 2011
  • "TB Vaccines at the Turn of the Century" Seminars in Respiratory Infections December 2003
  • "Human Neonatal Dendritic Cells Are Competent in MHC Class I Antigen Processing and Presentation" PLoS One  2007
  • "Hematopoietic progenitor cell expression of the H-CAM (CD44) homing-associated adhesion molecule" Blood February 1 1990
  • "Interferon-γ assays for tuberculosis" American Journal of Respiratory and Critical Care Medicine September 1 2005
  • "Human purified protein derivative-specific CD4+ T cells use both CD95- dependent and CD95-independent cytolytic mechanisms" Journal of Immunology March 1 1998
  • "Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress" Mucosal Immunology January 2013
  • "Lymphocyte migration molecules." Advances in Experimental Medicine and Biology  1988
  • "Infection of APC by human cytomegalovirus controlled through recognition of endogenous nuclear immediate early protein 1 by specific CD4+ T lymphocytes" Journal of Immunology August 1 2002
  • "Secreted proteins from Mycobacterium tuberculosis gain access to the cytosolic MHC class-I antigen-processing pathway" Journal of Immunology July 1 2006
  • "Human mucosal associated invariant T cells detect bacterially infected cells" PLoS Biology June 2010
  • "An analysis of the epitope knowledge related to Mycobacteria" Immunome Research  2007
  • "Human Mycobacterium tuberculosis CD8 T Cell Antigens/Epitopes Identified by a Proteomic Peptide Library" PLoS One June 21 2013

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