Photo of David M. Cohen, M.D.

David M. Cohen M.D.

    • Professor of Medicine, Division of Nephrology and Hypertension School of Medicine
    • Professor of Cell, Developmental and Cancer Biology School of Medicine
    • Director, Genetics of Water Balance Consortium
    • Local Site Investigator, VA Million Veteran Program
    • Local Site Investigator, All of Us (Formerly the NIH Precision Medicine Initiative)
    • Cancer Biology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Dr. Cohen’s research interests center around the genetics and physiology of osmoregulation (water balance). His group conducts studies at the cellular level, in animal models, and in human cohorts. Dr. Cohen directs the Genetics of Water Balance Consortium, a global network of major cohorts investigating genetic associations in water balance-relevant phenotypes. He also serves as local site investigator for the Portland site of the VA’s Million Veteran Program – a national voluntary research program to study how genes affect veterans’ health. Local recruitment for this effort recently topped 11,000 enrolled veterans.

Areas of interest

  • Disorders of water balance
  • Genetics of water and electrolyte balance
  • Kidney stones
  • Genetics of racial disparity in the risk of chronic kidney disease
  • Evaluation of potential kidney donors

Education

  • B.S., Pennsylvania State University, State College Pennsylvania 1984
  • M.D., Jefferson Medical College of Thomas Jefferson University, Philadelphia Pennsylvania 1986
  • Internship:

    • Internal Medicine, University Hospital of Boston University Medical Center, 1986-1987
  • Residency:

    • Internal Medicine, University Hospital of Boston University Medical Center, 1987-1989
  • Fellowship:

    • Research Fellow, Howard Hughes Medical Institute, Laboratory of Molecular Genetics, Division of Genetics, Brigham and Women’s Hospital, 1993-1995
    • Clinical Fellow in Nephrology, Brigham and Women’s Hospital and Harvard Medical School, 1992-1993
    • Research Fellow in Medicine, Brigham and Women’s Hospital and Harvard Medical School, 1989-1992
  • Certifications:

    • American Board of Internal Medicine, Diplomate
    • American Board of Internal Medicine (Nephrology), Diplomate
    • Oregon License Registration

Publications

  • "WNK kinases influence TRPV4 channel function and localization" American Journal of Physiology - Renal Fluid and Electrolyte Physiology June 2006
  • "Human glucokinase gene" Proceedings of the National Academy of Sciences of the United States of America  1992
  • "Transcriptome-based analysis of kidney gene expression changes associated with diabetes in OVE26 mice, in the presence and absence of losartan treatment" PLoS One May 14 2014
  • "Mitogen-activated protein kinase cascades and the signaling of hyperosmotic stress to immediate early genes" Comparative Biochemistry and Physiology - A Physiology July 1997
  • "Urea protects from the proapoptotic effect of NaCl in renal medullary cells" American Journal of Physiology - Renal Fluid and Electrolyte Physiology  2000
  • "Individuality of the plasma sodium concentration" American Journal of Physiology - Renal Fluid and Electrolyte Physiology June 15 2014
  • "Evaluating hyponatremia" JAMA - Journal of the American Medical Association March 24 2015
  • "Regulation of TRPV1 by a novel renally expressed rat TRPV1 splice variant" American Journal of Physiology - Renal Fluid and Electrolyte Physiology January 2006
  • "Functional polymorphisms affecting the clinically important arginine-137 residue of AVPR2 do not influence serum sodium concentration at the population level" Physiological Genomics  2013
  • "Functional effects of nonsynonymous polymorphisms in the human TRPV1 gene" American Journal of Physiology - Renal Fluid and Electrolyte Physiology December 2007
  • "Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia" American Journal of Physiology - Renal Fluid and Electrolyte Physiology May 2008
  • "Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity" Proceedings of the National Academy of Sciences of the United States of America March 1 1993
  • "Urea signaling in cultured murine inner medullary collecting duct (mIMCD3) cells involves protein kinase C, inositol 1,4,5-trisphosphate (IP3), and a putative receptor tyrosine kinase" Journal of Clinical Investigation April 15 1996
  • "Urea and NaCl differentially regulate FAK and RAFTK/PYK2 in mIMCD3 renal medullary cells" American Journal of Physiology - Renal Fluid and Electrolyte Physiology September 1998
  • "Urea activates ribosomal s6 kinase (RSK) in a MEK-dependent fashion in renal mIMCD3 cells" American Journal of Physiology - Renal Fluid and Electrolyte Physiology January 1998
  • "A mutation creating an out-of-frame alternative translation initiation site in the GRHPR 5′UTR causing primary hyperoxaluria type II" Clinical Genetics November 1 2015
  • "Urea inducibility of egr-1 in murine inner medullary collecting duct cells is mediated by the serum response element and adjacent Ets motifs" Journal of Biological Chemistry  1996
  • "Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice" American Journal of Physiology - Renal Fluid and Electrolyte Physiology September 2010
  • "SRC family kinases in cell volume regulation" American Journal of Physiology - Renal Fluid and Electrolyte Physiology March 2005
  • "Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride" Cell Metabolism January 6 2015
  • "Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation" Journal of Biological Chemistry March 28 2003
  • "Urea and hypertonicity increase expression of heme oxygenase-1 in murine renal medullary cells" American Journal of Physiology - Renal Fluid and Electrolyte Physiology  2001
  • "Expression of GLUT-2 cDNA in human B lymphocytes" Biochimica et Biophysica Acta - Biomembranes November 9 1992
  • "Urea stress is more akin to EGF exposure than to hypertonic stress in renal medullary cells" American Journal of Physiology - Renal Fluid and Electrolyte Physiology September 2002
  • "Heritability of serum sodium concentration" Physiological Genomics February 2012
  • "Ras signaling in the inner medullary cell response to urea and NaCl" American Journal of Physiology - Renal Fluid and Electrolyte Physiology  2000
  • "A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia" Proceedings of the National Academy of Sciences of the United States of America August 18 2009
  • "Renal expression of osmotically responsive cation channel TRPV4 is restricted to water-impermeant nephron segments" American Journal of Physiology - Renal Fluid and Electrolyte Physiology July 2004
  • "ERK activation by urea in the renal inner medullary mIMCD3 cell line" American Journal of Physiology - Renal Fluid and Electrolyte Physiology August 1999
  • "TRPV4 and the mammalian kidney" Pflugers Archiv European Journal of Physiology October 2005

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