Photo of David H. Farrell, Ph.D., F.A.H.A.

David H. Farrell Ph.D., F.A.H.A.

  • (503) 494-8602
    • Professor of Surgery, Division of Trauma, Critical Care and Acute Care Surgery School of Medicine
    • Founder and Chief Scientific Officer, Gamma Therapeutics Inc.
    • Program in Molecular and Cellular Biosciences School of Medicine

Areas of interest

  • Blood Coagulation
  • Fibrinogen Biology
  • Hemostasis and Thrombosis
  • Protein Biochemistry

Education

  • B.S., UCLA, Los Angeles California 1979
  • Ph.D., University of California, Irvine California 1986
  • Fellowship:

    • Oregon Health Sciences University, Portland, Oregon 1986
    • University of Washington, Seattle, Washington 1993

Honors and awards

  • Fellow, American Heart Association

Memberships and associations

  • American Heart Association
  • International Fibrinogen Research Society
  • International Society on Thrombosis and Haemostasis
  • Editorial Board, Journal of Hematology Research

Publications

  • "Binding of recombinant fibrinogen mutants to platelets" Journal of Biological Chemistry January 7 1994
  • "Localization of protease nexin-1 on the fibroblast extracellular matrix" Journal of Cellular Physiology  1988
  • "The contribution of the three hypothesized integrin-binding sites in fibrinogen to platelet-mediated clot retraction" Blood October 1 1998
  • "A regulatory gene, angR, of the iron uptake system of Vibrio anguillarum" Gene January 31 1990
  • "Further studies on the interaction of migrating keratinocytes with fibrinogen" Cell Communication and Adhesion  1994
  • "Fibrinogen Hershey IV" Thrombosis and Haemostasis June 2008
  • "Designing allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with Arg173 of exosite 2 to induce inhibition" Journal of Medicinal Chemistry August 9 2012
  • "γ′ Fibrinogen as a novel marker of thrombotic disease" Clinical Chemistry and Laboratory Medicine November 2012
  • "γ′ fibrinogen" Clinical Chemistry May 1 2010
  • "Assessment of genetic determinants of the association of γ′ fibrinogen in relation to cardiovascular disease" Arteriosclerosis, Thrombosis, and Vascular Biology October 2011
  • "Prognostic utility of biochemical markers of cardiovascular risk" Clinical Chemistry and Laboratory Medicine September 2013
  • "The fibrinogen Aα R16C mutation results in fibrinolytic resistance" British Journal of Haematology July 2006
  • "γA/γ′ fibrinogen inhibits thrombin-induced platelet aggregation" Thrombosis and Haemostasis November 2008
  • "Differential regulation of fibrinogen γ chain splice isoforms by interleukin-6" Thrombosis Research January 2013
  • "Antiplatelet effects of MK-852, a platellet fibrinogen receptor antagonist, in healthy volunteers" Journal of Clinical Pharmacology  2000
  • "Expression of antisense to integrin subunit β3 inhibits microvascular endothelial cell capillary tube formation in fibrin" Journal of Biological Chemistry October 13 2000
  • "The role of γA/γ' fibrinogen in plasma factor XIII activation" Journal of Biological Chemistry October 13 2000
  • "Recombinant human fibrinogen and sulfation of the γ′ chain" Biochemistry  1991
  • "Primetime for γ′" Blood August 28 2014
  • "New risk factor for venous thromboembolism?" Thrombosis and Haemostasis August 2008
  • "A simple two-step purification of protease nexin." Biochemical Journal August 1 1986
  • "Incorporation of vitronectin into fibrin clots. Evidence for a binding interaction between vitronectin and γA/γ′ fibrinogen" Journal of Biological Chemistry March 1 2002
  • "Erratum" Journal of Biological Chemistry November 10 2000
  • "Interaction of β3 integrin-derived peptides 214-218 and 217-231 with α(IIb)β3 complex and with fibrinogen Aα-chain" Thrombosis Research January 15 1997
  • "Complete sequence of virulence plasmid pJM1 from the marine fish pathogen Vibrio anguillarum strain 775" Journal of Bacteriology October 2003
  • "Human fibroblast adhesion to fibrinogen" Biochemistry February 4 1997
  • "Role of electrostatic interactions in binding of thrombin to the fibrinogen γ′ chain" Biochemistry April 24 2012
  • "Glycosaminoglycans on fibroblasts accelerate thrombin inhibition by protease nexin-1." Biochemical Journal July 15 1987
  • "Resistance of γA/γ' fibrin clots to fibrinolysis" Journal of Biological Chemistry May 30 1997
  • "Interactions of serine proteases with cultured fibroblasts." Journal of Cellular Biochemistry  1986

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