Photo of Daniel N. Streblow, Ph.D.

Daniel N. Streblow Ph.D.

    • Associate Professor VGTI-Vaccine and Gene Therapy Institute
    • Molecular Microbiology and Immunology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Dr. Daniel Streblow received his B.S. in Pharmacology/Toxicology from the University of Wisconsin-Madison in 1992. He graduated from University of Wisconsin-Madison with a Ph.D. in Viral Pathogenesis in 1997. Dr. Streblow received a NIH post-doctoral fellowship and worked with Dr. Jay A. Nelson in the Department of Molecular Microbiology and Immunology at Oregon Health & Science University. He is currently an Associate Scientist at the Vaccine and Gene Therapy Institute and Research Assistant Professor at the Department of Molecular Microbiology and Immunology.

The focus of the Streblow laboratory is on defining the role of human cytomegalovirus (HCMV) in the development of vascular disease and chronic rejection of organ allografts. The role of CMV in these diseases is still uncharacterized. Dr. Streblow's lab studies the following topics: 1) Determining the mechanisms of HCMV-accelerated vascular disease through identification of the viral genes expressed during these diseases using a HCMV microarray chip developed by Dr. Streblow's laboratory in combination with the Shared Microarray Core at VGTI. Once identified, the function of these viral genes will be examined using in vitro and in vivo models of CMV-accelerated vascular disease. 2) Determining the mechanisms of CMV-accelerated vascular disease in both mouse models of atherosclerosis and rat organ transplantation models using a DNA microarray approach. The Streblow lab in conjunction with Dr. Susan Orloff’s laboratory at OHSU has determined RCMV in vivo gene expression in infected rats and has begun functional studies of these genes. 3) Determine viral and host gene expression during the development of atherosclerosis and transplant vascular sclerosis, the vascular lesion associated with chronic allograft rejection 4) determining the mechanisms of viral acceleration of chronic allograft rejection from latently infected donor, which is the most common cause of HCMV-associated disease in transplant patients associated with expression during the different stages of viremia associated with CMV including 5) Determining the function of CMV-encoded chemokine receptors in the context of viral pathogenesis and acceleration of vascular disease. Dr. Streblow's lab has also generated a rhesus macaque (RM) chikungunya virus (CHIKV) infection animal model to identify correlates of CHIKV pathogenesis and to test novel antivirals and vaccines. They are working on developing a Zika virus RM model.

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Areas of interest

  • CMV pathogenesis and transplantation

Education

  • B.S., University of Wisconsin, Madison Wisconsin United States 1992
  • Ph.D., University of Wisconsin, Madison Wisconsin United States 1997

Publications

Selected publications

  • Hirsch AJ, Smith JL, Haese NN, Broeckel RM, Parkins CJ,Kreklywich C, DeFilippis VR, Denton M, Smith PP, Messer WB, Colgin LM, DucoreRM, Grigsby PL, Hennebold JD, Swanson T, Legasse AW, Axthelm MK, MacAllister R,Wiley CA, Nelson JA, Streblow DN. Zika Virus infection of rhesus macaques leadsto viral persistence in multiple tissues. PLoS Pathog. 2017 Mar9;13(3):e1006219. doi: 10.1371/journal.ppat.1006219. [PMID: 28278237]

  • Haese NN, Broeckel RM, Hawman DW, Heise MT, Morrison TE,Streblow DN. Animal Models of Chikungunya Virus Infection and Disease. J InfectDis. 2016 Dec 15;214(suppl 5):S482-S487. [PMID: 27920178]

  • Burwitz BJ, Malouli D, Bimber BN, Reed JS, Ventura AB,Hancock MH, Uebelhoer LS, Bhusari A, Hammond KB, Espinosa Trethewy RG, Klug A,Legasse AW, Axthelm MK, Nelson JA, Park BS, Streblow DN, Hansen SG, Picker LJ,Früh K, Sacha JB. Cross-Species Rhesus Cytomegalovirus Infection of CynomolgusMacaques. PLoS Pathog. 2016 Nov 9;12(11):e1006014. doi:10.1371/journal.ppat.1006014.[PMID: 27829026]

  • Caviness K, Bughio F, Crawford LB, Streblow DN, Nelson JA,Caposio P, Goodrum F. Complex Interplay of the UL136 Isoforms BalancesCytomegalovirus Replication and Latency. MBio. 2016 Mar 1;7(2):e01986. doi:10.1128/mBio.01986-15.[PMID: 26933055]

Publications

  • "Cytomegalovirus microRNA expression is tissue specific and is associated with persistence" Journal of Virology January 2011
  • "Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway" PLoS Pathogens May 1 2015
  • "Human cytomegalovirus UL97 kinase activity is required for the hyperphosphorylation of retinoblastoma protein and inhibits the formation of nuclear aggresomes" Journal of Virology May 2008
  • "Noncompetitive antagonism and inverse agonism as mechanism of action of nonpeptidergic antagonists at primate and rodent CXCR3 chemokine receptors" Journal of Pharmacology and Experimental Therapeutics May 2008
  • "Rat cytomegalovirus-accelerated transplant vascular sclerosis is reduced with mutation of the chemokine-receptor R33" American Journal of Transplantation March 2005
  • "FAK promotes organization of fibronectin matrix and fibrillar adhesions" Journal of Cell Science January 15 2004
  • "Gag protein from human immunodeficiency virus type 1 assembles in the absence of cyclophilin A" Virology December 5 1998
  • "Human cytomegalovirus secretome contains factors that induce angiogenesis and wound healing" Journal of Virology July 2008
  • "HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells" Journal of Experimental Medicine December 2 2002
  • "Therapeutic approaches to HIV infection based on virus structure and the host pathogen interaction" Current Topics in Microbiology and Immunology  1995
  • "Humanized mouse models of human cytomegalovirus infection" Current Opinion in Virology June 29 2015
  • "West Nile virus entry requires cholesterol-rich membrane microdomains and is independent of αvβ3 integrin" Journal of Virology June 2008
  • "Cytomegalovirus pp65 limits dissemination but is dispensable for persistence" Journal of Clinical Investigation  2014
  • "Chikungunya virus induces IPS-1-dependent innate immune activation and protein kinase R-independent translational shutoff" Journal of Virology January 2011
  • "Differential regulation of cell motility and invasion by FAK" Journal of Cell Biology March 3 2003
  • "The role of cytomegalovirus in angiogenesis" Virus Research May 2011
  • "Cytomegalovirus CC chemokine promotes immune cell migration" Journal of Virology November 2012
  • "Human Cytomegalovirus Chemokine Receptor US28-induced Smooth Muscle Cell Migration is Mediated by Focal Adhesion Kinase and Src" Journal of Biological Chemistry December 12 2003
  • "Kinetics and development of CMV-accelerated transplant vascular sclerosis in rat cardiac allografts is linked to early increase in chemokine expression and presence of virus" Transplantation Proceedings  2001
  • "Selective amplification of simian immunodeficiency virus genotypes after intrarectal inoculation of rhesus monkeys" Journal of Virology November 1994
  • "Rat cytomegalovirus vaccine prevents accelerated chronic rejection in CMV-Naïve recipients of infected donor allograft hearts" American Journal of Transplantation July 1 2015
  • "HCMV Infection of Humanized Mice after Transplantation of G-CSF-Mobilized Peripheral Blood Stem Cells from HCMV-Seropositive Donors" Biology of Blood and Marrow Transplantation January 2014
  • "Infection of APC by human cytomegalovirus controlled through recognition of endogenous nuclear immediate early protein 1 by specific CD4+ T lymphocytes" Journal of Immunology August 1 2002
  • "Erratum" Journal of Virology December 2004
  • "Elimination of donor-specific alloreactivity prevents cytomegalovirus-accelerated chronic rejection in rat small bowel and heart transplants" Transplantation March 15 2002
  • "Identification of proteins in human cytomegalovirus (HCMV) particles" Journal of Virology October 2004
  • "Retrieval of human cytomegalovirus glycoprotein B from cell surface is not required for virus envelopment in astrocytoma cells" Journal of Virology  2002
  • "Chikungunya viruses that escape monoclonal antibody therapy are clinically attenuated, stable, and not purified in mosquitoes" Journal of Virology  2014
  • "The human cytomegalovirus chemokine receptor US28 mediates vascular smooth muscle cell migration" Cell November 24 1999
  • "A novel human cytomegalovirus locus modulates cell type-specific outcomes of infection" PLoS Pathogens December 2011

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