Headshot photo of Cristiane Miranda Franca

Cristiane Miranda Franca

  • Research Assistant Professor of Restorative Dentistry, School of Dentistry


Dr. Cristiane Franca is a dentist-scientist with a Ph.D. in Oral Pathology and postdoctoral training in Biomaterials and Tissue Engineering. Currently, Dr. Franca is a Research Assistant Professor in the Department of Restorative Dentistry, Division of Biomaterials and Biomechanics at OHSU School of Dentistry. Her research focuses on understanding the interactions of biomaterials and the immune system to harness the integration of engineered tissues with the host. To that end, her research platform encompasses four major areas: (a) tissue engineering strategies for dental and craniofacial regeneration, (b) design, fabrication, and application of organs-on-a-chip and microfluidic microdevices to model dental and craniofacial diseases, (c) development and clinical translation of immunomodulatory materials, and (d) advanced microscopy. She has published over 70 papers in scientific journals and book chapters.


Education and training

    • D.D.S., 1994, Federal University of Goias
    • Ph.D., 1999, University of Sao Paulo
  • Fellowship

    • Postdoctoral fellowship – Biomaterials and Tissue Engineering – Oregon Health & Science University – 2017-2021

Memberships and associations:

  • International Association for Dental Research (IADR) & American Association for Dental Research (AADR)
  • American Association for the Advancement of Science (AAAS)


Selected publications

  • Rodrigues NS*, França CM*, Tahayeri A, Ren Z, Saboia VPA, Smith AJ, Ferracane JL, Koo H, Bertassoni LE. Biomaterial and Biofilm Interactions with the Pulp-Dentin Complex-on-a-Chip. J Dent Res. 2021 May 26:220345211016429.
  • Twohig C, Helsinga M, Mansoorifar A, Athirasala A, Tahayeri A, França CM, Pajares SA, Abdelmoniem R, Scherrer S, Durual S, Ferracane J, Bertassoni LE. A dual-ink 3D printing strategy to engineer pre-vascularized bone scaffolds in-vitro. Mater Sci Eng C Mater Biol Appl. 2021 Apr;123:111976.
  • Fernandes KPS, Ferrari RM, Bussadori SK, Franca CM. Vascular Photobiomodulation. Photobiomodul Photomed Laser Surg. 2021 Mar;39(3):143-144
  • Parthiban SP, He W, Monteiro N, Athirasala A, França CM, Bertassoni LE. Engineering pericyte-supported microvascular capillaries in cell-laden hydrogels using stem cells from the bone marrow, dental pulp and dental apical papilla. Sci Rep. 2020;10(1):21579.
  • Horsophonphong S, Sercia A, França CM, Tahayeri A, Reddy AP, Wilmarth PA, Surarit R, Smith AJ, Ferracane JL, Bertassoni LE. Equivalence of human and bovine dentin matrix molecules for dental pulp regeneration: proteomic analysis and biological function. Arch Oral Biol. 2020;119:104888.
  • Subbiah R, Hipfinger C, Tahayeri A, Athirasala A, Horsophongphong S, Thrivikraman G, Franca CM, Cunha DA, Manssorifar A, Zahariev A, Jones JM, Coelho PG, Witek L, Xie H, Guldberg RE, Bertassoni LE. 3D printing of microgel-loaded modular mirocages as instructive scaffolds for tissue engineering. Adv Materials. 2020 32(36):e2001736.
  • Franca CM*, Tahayeri A*, Rodrigues NS, Ferdosian S, Puppin-Rontani R, Ferracane JL, Bertassoni LE. The tooth on-a-chip: a microphysiologic model system mimicking the biologic interface of the tooth with biomaterials. Lab Chip 2020;20(2):405-413.
  • Franca CM*, Sercia A, Prakash Parthiban S, Bertassoni LE. Current and future applications of 3D bioprinting in endodontic regeneration – a short review. CDA Journal. 2019;47(10): 645-52. 
  • Franca CM*, Riggers R*, Muschler JL, Widbiller M, Lococo PM, Diogenes A, Bertassoni LE. 3D-Imaging of Whole Neuronal and Vascular Networks of the Human Dental Pulp via CLARITY and light sheet microscopy. Sci Rep 2019;9(1):10860
  • Franca CM, Thrivikraman G, Athirasala A, Tahayeri A, Gower L, Bertassoni L. The influence of collagen biomineralization on pericyte differentiation and vascularization of engineered bone scaffolds. J Biom Mat B. 2018;107(5):1522-1532


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