Photo of Christina A. Harrington, Ph.D.

Christina A. Harrington Ph.D.

  • (503) 418-2737
    • Research Associate Professor of Molecular and Medical Genetics School of Medicine
    • Director, Integrated Genomics Laboratory IG.Integrated Genomics
    • OHSU Knight Cancer Institute School of Medicine

Dr. Harrington is Director of the Integrated Genomics Laboratory at OHSU and Research Associate Professor in the Department of Molecular and Medical Genetics.  Within the Integrated Genomics Lab she directs the Gene Profiling Shared Resource and the DNA Services Core. She has worked with RNA technology and DNA variation analysis technologies throughout her research career.  Her experience includes DNA microarrays, real-time PCR, and sequencing. At OHSU she initially set up and managed the Affymetrix microarray core in 2000 and has continued to expand resources and expertise for core users seeking services and support for high-throughput, genome-wide analyses of RNA and DNA. In addition to ongoing management of the Gene Profiling Shared Resource (GPSR), she oversees the OHSU Integrated Genomics Laboratory (IGL), a centralized laboratory home for next-generation sequencing, DNA microarray, high-throughput real-time PCR technologies and for RNA and DNA isolation support. The IGL coordinates services and infrastructure for the Gene Profiling Shared Resource, the Massively Parallel Sequencing Shared Resource, and the DNA Services Core. Prior to joining OHSU, Dr. Harrington was employed at Affymetrix from 1997 through 2000, as a Senior Staff Scientist and Manager of the Scientific Liaison Group. In this capacity she was involved in the development of the GeneChip array expression profiling application and was responsible for the Affymetrix Academic User Center, a program of research collaborations with academic investigators. Prior to her position at Affymetrix, Dr. Harrington worked in the field of molecular neurobiology, from 1995-1997 as a Research Officer at the Garvan Institute for Medical Research, Sydney, Australia, and earlier as a Principal Research Fellow in the Laboratory for Molecular Pharmacology, University College, London, United Kingdom. Dr. Harrington has a PhD in Molecular, Cellular and Developmental Biology from the University of Colorado, Boulder, and a BS in Biology from California Institute of Technology. In addition to overseeing the operation of the IGL and the GPSR, Dr. Harrington collaborates with many research groups on campus in the application of RNA and DNA analysis techniques to important questions in biomedical research. Recent publications include work examining cerebral spinal fluid for small RNA biomarkers of Alzheimer's disease (Lusardi et al., J Alzheimer's Disease, in 2016) and identification of gene expression changes that may provide diagnostic information for patients with inflammatory disease (Rosenbaum et al., JAMA Ophthalmology, 2015). 

Areas of interest

  • genomics technology, gene expression regulation, biomarkers

Education

  • Ph.D., Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Boulder Colorado United States 1982

Publications

  • "Gene expression profiling of whole blood" BMC Genomics January 5 2009
  • "Randomization in laboratory procedure is key to obtaining reproducible microarray results" PLoS One November 14 2008
  • "Expression profiling of B cell chronic lymphocytic leukemia suggests deficient CD1-mediated immunity, polarized cytokine response, altered adhesion and increased intracellular protein transport and processing of leukemic cells" Leukemia December 1 2002
  • "Gene expression profiling in ischemic brain injury and ischemic tolerance"   2007
  • "Molecular diagnosis of orbital inflammatory disease" Experimental and Molecular Pathology April 1 2015
  • "Translational gene mapping of cognitive decline" Neurobiology of Aging April 2008
  • "Analysis of mucosal gene expression in inflammatory bowel disease by parallel oligonucleotide arrays" Physiological Genomics February 2001
  • "High throughput sequencing in mice" BMC Genomics August 17 2009
  • "Analysis of high density expression microarrays with signed-rank call algorithms" Bioinformatics December 1 2002
  • "Parallel gene expression changes in sarcoidosis involving the lacrimal gland, orbital tissue, or blood" JAMA Ophthalmology July 1 2015
  • "Computational detection of alternative exon usage" Frontiers in Neuroscience  2011
  • "Steroid hormone regulation of ribosomal RNA in rat hypothalamus" Journal of Neuroscience  1990
  • "Effect of ischaemic preconditioning on genomic response to cerebral ischaemia" The Lancet September 27 2003
  • "A gene expression signature of CD34+ cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib" Blood January 14 2010
  • "Application of biostatistics and bioinformatics tools to identify putative transcription factor-gene regulatory network of ankylosing spondylitis and sarcoidosis" Communications in Statistics - Theory and Methods  2009
  • "Dual-Trait Selection for Ethanol Consumption and Withdrawal" Alcoholism: Clinical and Experimental Research December 1 2014
  • "Tyrosine hydroxylase mRNA in the neurons of the tuberoinfundibular region and zona incerta examined after gonadal steroid hormone treatment" Molecular Endocrinology  1989
  • "Orbital pseudotumor can be a localized form of granulomatosis with polyangiitis as revealed by gene expression profiling" Experimental and Molecular Pathology October 1 2015
  • "Systemic lipopolysaccharide protects the brain from ischemic injury by reprogramming the response of the brain to stroke" Journal of Neuroscience August 5 2009
  • "In situ hybridization analysis of osmotic stimulus-induced changes in ribosomal RNA in rat supraoptic nucleus" Journal of Comparative Neurology  1988
  • "Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP" Proceedings of the National Academy of Sciences of the United States of America  1987
  • "In chronic myeloid leukemia white cells from cytogenetic responders and non-responders to imatinib have very similar gene expression signatures" Haematologica April 2005
  • "The role of the immune response in the pathogenesis of thyroid eye disease" PLoS One September 15 2015
  • "Identification and cell type specificity of the tyrosine hydroxylase gene promoter" Nucleic Acids Research March 15 1987
  • "Hypothesis" Clinical Immunology August 2009
  • "Expression profiling of the ovarian surface kinome reveals candidate genes for early neoplastic changes" Translational Oncology  2009
  • "Insights in to the pathogenesis of axial spondyloarthropathy based on gene expression profiles" Arthritis Research and Therapy November 9 2009
  • "Use of bioanalyzer electropherograms for quality control and target evaluation in microarray expression profiling studies of ocular tissues" Journal of Ocular Biology, Diseases, and Informatics December 2009
  • "Fibrosis, gene expression and orbital inflammatory disease" British Journal of Ophthalmology October 1 2015
  • "Lgg4 immunostaining and its implications in orbital inflammatory disease" PLoS One October 10 2014

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