Headshot photo of Cecily Vauna Bishop, Ph.D.

Cecily Vauna Bishop, Ph.D.

  • Adjunct Research Assistant Professor, Oregon National Primate Research Center


Cecily Bishop, Ph.D., is an Adjunct Research Assistant Professor in the Division of Reproductive & Developmental Sciences at ONPRC.  Her research at ONPRC aims to investigate the incompletely understood molecular pathways associated with normal and pathologic ovarian and uterine angiogenesis in primates. 

The mid-cycle surge of luteinizing hormone (LH) is responsible for reorganizing the ovulatory follicle into a corpus luteum (CL), which produces the progesterone necessary for embryo implantation. As part of the structural and cellular changes that happen after ovulation, a wave of neovascularization occurs, forming a CL with a network of highly permeable capillaries. In turn, this newly formed vasculature allows for the significant levels of progesterone produced by the CL to enter the circulation and support implantation/ pregnancy. Abnormal angiogenesis is associated with several reproductive disorders, including Ovarian Hyperstimulation Syndrome (OHSS), which occurs during assisted reproductive therapies and endometriosis.   

Techniques used to interrogate mediators of ovarian and uterine angiogenesis range from molecular (i.e. gene product expression and shRNA-knockdown of select gene targets) to contrast-enhanced ultrasound (CEUS) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of reproductive tissue blood flow, volume, and permeability. Notably, she reported on the effects of intraovarian shRNA-knockdown of classical progesterone receptors during luteal formation in macaques. 

Dr. Bishop also leverages CEUS and similar, noninvasive 3D/4D ultrasound technology to assist studies of other novel genes involved in folliculogenesis, evaluate ovarian tissue engraftment following cryopreservation, and the role of the steroid hormone progesterone in normal ovarian function. Finally, she was also part of studies into the role of androgens and diet in a nonhuman primate model of polycystic ovarian syndrome (PCOS) funded by a NICHD National Center for Translational Research in Reproduction and Infertility (NCTRI) grant. Dr. Bishop performs additional research into other animal models relevant to human health as part of her research program at Oregon State University.

Education and training

  • Degrees

    • B.S., 2001, Washington State University
    • Ph.D., 2006, Oregon State University

Memberships and associations:

  • 2011 - 2013 Board of Reviewing Editors, Biology of Reproduction
  • 2012 - Active Member, Doctoral, American Society for Reproductive Medicine
  • 2013 - Member, Society for the Study of Reproduction
  • 2020 - Member, Society for Reproductive Investigation
  • 2019 - Member, American Society of Animal Science
  • 2023 - Associate Editor, Molecular Human Reproduction

Areas of interest

  • Ovarian Function
  • Angiogenesis
  • Reproductive Biology
  • Ultrasound
  • Magnetic Resonance Imaging
  • Ovarian/Uterine Blood Flow
  • Steroid Hormone Action

Honors and awards

  • 1999 President’s Honor Role for Term, Washington State University
  • 2003 Oregon Sports Lottery Scholarship, Oregon State University
  • 2003-2005 Fred F. McKenzie Memorial Scholarship (Awarded to Graduate Student in the Field of Reproduction), Oregon State University
  • 2006 Savory Outstanding Doctoral Student, College of Agriculture, Oregon State University
  • 2006 Appointment on OHSU’s Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants for Reproductive Sciences (T32-HD07133), Oregon Health & Science University
  • 2007 Extramural Loan Repayment Program for Contraception and Infertility Researchers (LRP-CIR) Award (NIH notice: NOT-OD-08-087), NICHD
  • 2009 Appointment on OHSU’s Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants for Reproductive Sciences (T32-HD07133), Oregon Health & Science University
  • 2010 Lalor Foundation Merit Award for Abstract Presented at Annual Meeting, Society for the Study of Reproduction
  • 2012 Third place Prize Poster, American Society for Reproductive Medicine


Selected publications

  • Bishop CV, Reiter TE, Erikson DW, Hanna CB, Daughtry BL, Chavez SL, Hennebold JD, Stoufer RL. Chronically elevated androgen and/or consumption of a Western-style diet impairs oocyte quality and granulosa cell function in the nonhuman primate periovulatory follicle. J Assist Reprod Genet. 2019;36(7):1497–1511. doi:10.1007/s10815-019-01497-8. PMID: 31187329; PMCID: PMC6657409.
  • Bishop CV, Mishler EC, Takahashi DL, Reiter TE, Bond KR, True CA, Slayden OD, Stouffer RL. Chronic hyperandrogenemia in the presence and absence of a western-style diet impairs ovarian and uterine structure/function in young adult rhesus monkeys. Hum Reprod. 2018 Jan 1;33(1):128-139. doi: 10.1093/humrep/dex338. PMID: 29190387; PMCID: PMC5850861.
  • Bishop CV, Stouffer RL, Takahashi DL, Mishler EC, Wilcox MC, Slayden OD, True CA. Chronic hyperandrogenemia and western-style diet beginning at puberty reduces fertility and increases metabolic dysfunction during pregnancy in young adult, female macaques. Hum Reprod. 2018 Apr 1;33(4):694-705. doi: 10.1093/humrep/dey013. PMID: 29401269; PMCID: PMC6454458.
  • Bishop CV, Lee DM, Slayden OD, Li X. Intravenous neutralization of vascular endothelial growth factor reduces vascular function/permeability of the ovary and prevents development of OHSS-like symptoms in rhesus monkeys. J Ovarian Res. 2017 Jul 6;10(1):41. doi: 10.1186/s13048-017-0340-5. PMID: 28683759; PMCID: PMC5501270.
  • Bishop CV, Molskness TA, Xu F, Belcik JT, Lindner JR, Slayden OD, Stouffer RL. Quantification of dynamic changes to blood volume and vascular flow in the primate corpus luteum during the menstrual cycle. J Med Primatol. 2014 Dec;43(6):445-54. doi: 10.1111/jmp.12132. Epub 2014 Jun 20. PMID: 24948037; PMCID: PMC4232987.PMID 29293939.
  • Xu J, Bishop CV, Lawson MS, Park BS, Xu F. Anti-Müllerian hormone promotes pre-antral follicle growth, but inhibits antral follicle maturation and dominant follicle selection in primates. Hum Reprod. 2016 Jul;31(7):1522-30. doi: 10.1093/humrep/dew100. Epub 2016 May 9. PMID: 27165618; PMCID: PMC4901882.
  • Bishop CV, Hennebold JD, Kahl CA, Stouffer RL. Knockdown of Progesterone Receptor (PGR) in Macaque Granulosa Cells Disrupts Ovulation and Progesterone Production. Biol Reprod. 2016 May;94(5):109. doi: 10.1095/biolreprod.115.134981. Epub 2016 Mar 16. PMID: 26985003; PMCID: PMC4939739.
  • Bishop CV. Progesterone inhibition of oxytocin signaling in endometrium. Front Neurosci. 2013 Aug 7;7:138. doi: 10.3389/fnins.2013.00138. PMID: 23966904; PMCID: PMC3735988.
  • Bishop CV, Bogan RL, Hennebold JD, Stouffer RL. Analysis of microarray data from the macaque corpus luteum; the search for common themes in primate luteal regression. Mol Hum Reprod. 2011 Mar;17(3):143-51. doi: 10.1093/molehr/gaq080. Epub 2010 Sep 20. PMID: 20855453; PMCID: PMC3143827.


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