Carol Hanna, Ph.D.

  • Research Assistant Professor, Oregon National Primate Research Center
  • Director, Assisted Reproductive Technology (ART) Core, Oregon National Primate Research Center

Biography

Carol Hanna, Ph.D. is a Research Assistant Professor in the Division of Reproductive and Developmental Sciences at the Oregon National Primate Research Center (ONPRC).  She is an investigator with the Oregon Permanent Contraception Research Center (OPERM) and Director of the Assisted Reproductive Technology (ART) Core.

 

Dr. Hanna’s research is focused on development of novel, nonhormonal contraceptives for women using multiple platforms.  By leveraging mechanisms of meiosis regulation, on-demand or reversible contraception strategies are being investigated by targeting specific proteins expressed in the oocyte for inhibition or selective degradation to disrupt the ability of the ovulated egg to undergo fertilization.  Additionally, collaborative multidisciplinary studies within the Bill and Melinda Gates Foundation-funded OPERM Center explore nonsurgical alternatives to permanent contraception.  Dr. Hanna and her colleagues have demonstrated the feasibility to deliver sclerosing agents with a thermal responsive, nontoxic gel to fallopian tubes for the induction of tubal occlusion, creating a blockade of sperm and egg interaction.

 

As director of the ART Core, Dr. Hanna and her team are continually optimizing conventional nonhuman primate ART such as semen collection and cryopreservation, artificial insemination, in vitro oocyte maturation and fertilization, embryo culture and cryopreservation, and advanced micromanipulation techniques including embryo injection, intracytoplasmic sperm injection, polar body biopsy, assisted hatching, and blastocyst biopsy.  Since 2016 she was been working with gene editing approaches in to develop specific models of disease and is part of the NIH Somatic Cell Genome Editing Resource focused on creating a reporter system to test next generation gene editing technology.  

 

Education and training

    • B.S., 1997, Colorado State University
    • M.S., 2001, Texas A&M University
    • Ph.D., 2008, Texas A&M University,
  • Fellowship

    • Postdoctoral Fellow, Oregon National Primate Research Center, Beaverton, OR., United States, 2012

Memberships and associations:

  • Member, International Embryo Transfer Society
  • Member, Society for the Study of Reproduction
  • Member, The American Society for Reproductive Medicine

Publications

Selected publications

  • Shetty G, Mitchell JM, Meyer JM, Wu Z, Lam TNA, Phan TT, Zhang J, Hill L, Tailor RC, Peters KA, Penedo MC, Hanna C, Orwig KE, Meistrich ML. Restoration of functional sperm production in irradiated pubertal rhesus monkeys by spermatogonial stem cell transplantation. Andrology. 2020 Sep;8(5):1428-1441. doi: 10.1111/andr.12807. Epub 2020 May 18. PubMed PMID: 32351003; PubMed Central PMCID: PMC7521830
  • Hanna CB, Mudaliar D, John K, Allen CL, Sun L, Hawkinson JE, Schönbrunn E, Georg GI, Jensen JT. Development of WEE2 kinase inhibitors as novel non-hormonal female contraceptives that target meiosis†. Biol Reprod. 2020 Aug 4;103(2):368-377. doi: 10.1093/biolre/ioaa097. PubMed PMID: 32667031; PubMed Central PMCID: PMC7401407
  • Hanna CB, Yao S, Martin M, Schonbrunn E, Georg GI, Jensen JT, Cuellar RA. Identification and Screening of Selective WEE2 Inhibitors to Develop Non-Hormonal Contraceptives that Specifically Target Meiosis. ChemistrySelect. 2019 December; 4:13363-13369. doi: 10.1002.
  • Fayomi AP, Peters K, Sukhwani M, Valli-Pulaski H, Shetty G, Meistrich ML, Houser L, Robertson N, Roberts V, Ramsey C, Hanna C, Hennebold JD, Dobrinski I, Orwig KE. Autologous grafting of cryopreserved prepubertal rhesus testis produces sperm and offspring. Science. 2019 Mar 22;363(6433):1314-1319. doi: 10.1126/science.aav2914. PubMed PMID: 30898927; PubMed Central PMCID: PMC6598202
  • Ramsey C, Hanna C. In Vitro Culture of Rhesus Macaque (Macaca mulatta) Embryos. Methods Mol Biol. 2019;2006:341-353. doi: 10.1007/978-1-4939-9566-0_23. PubMed PMID: 31230291
  • Jensen JT, Hanna C, Mishler E, Lim JY, Slayden OD. Effect of menstrual cycle phase and hormonal treatments on evaluation of tubal patency in baboons. J Med Primatol. 2018 Feb;47(1):40-45. doi: 10.1111/jmp.12317. Epub 2017 Oct 24. PubMed PMID: 29063622; PubMed Central PMCID: PMC5771854
  • Jensen JT, Hanna C, Yao S, Thompson E, Bauer C, Slayden OD. Transcervical administration of polidocanol foam prevents pregnancy in female baboons. Contraception. 2016 Nov;94(5):527-533. doi: 10.1016/j.contraception.2016.07.008. Epub 2016 Jul 13. PubMed PMID: 27421766; PubMed Central PMCID: PMC5083254
  • Jensen JT, Hanna C, Yao S, Bauer C, Morgan TK, Slayden OD. Characterization of tubal occlusion after transcervical polidocanol foam (PF) infusion in baboons. Contraception. 2015 Aug;92(2):96-102. doi: 10.1016/j.contraception.2015.06.002. Epub 2015 Jun 9. PubMed PMID: 26070857; PubMed Central PMCID: PMC4521910
  • Hanna CB, Yao S, Ramsey CM, Hennebold JD, Zelinski MB, Jensen JT. Phosphodiesterase 3 (PDE3) inhibition with cilostazol does not block in vivo oocyte maturation in rhesus macaques (Macaca mulatta). Contraception. 2015 May;91(5):418-22. doi: 10.1016/j.contraception.2015.01.017. Epub 2015 Jan 30. PubMed PMID: 25645461; PubMed Central PMCID: PMC4417033
  • Hanna CB, Hennebold JD. Ovarian germline stem cells: an unlimited source of oocytes?. Fertil Steril. 2014 Jan;101(1):20-30. doi: 10.1016/j.fertnstert.2013.11.009. Review. PubMed PMID: 24382341; PubMed Central PMCID: PMC3926438.

Publications

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