Photo of Bruce Jeffrey Schnapp, Ph.D.

Bruce Jeffrey Schnapp Ph.D.

  • (503) 494-8994
    • Professor of Cell, Developmental and Cancer Biology School of Medicine
    • Cell and Developmental Biology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Bruce Schnapp is a Professor in the Department of Cell, Developmental and Cancer Biology. He earned his B.S. (Biology) in 1972 and his Ph.D. (Neuroscience) in 1976 at the University of Connecticut. After postdoctoral work in the Department of Neurobiology at Harvard Medical School, Dr. Schnapp joined the intramural program at NIH in 1983, and maintained his lab off campus at the Marine Biological Laboratory in Woods Hole, MA until 1989. Dr. Schnapp was Associate Professor in the Department of Physiology at Boston University Medical School (1989-1990) before moving his lab to Department of Cell Biology at Harvard Medical School (1991-2001), and then to OHSU in 2001.

Areas of interest

  • cell biology; transport; kinesin; dynein; myosin; zebrafish; melanocytes

Publications

  • "Dynactin-dependent, dynein-driven vesicle transport in the absence of membrane proteins" Molecular Cell  2001
  • "A change in the selective translocation of the kinesin-1 motor domain marks the initial specification of the axon" Neuron March 16 2006
  • "Localization of Xenopus Vg1 mRNA by Vera protein and the endoplasmic reticulum" Science May 16 1997
  • "The kinesin motor KIF3A is a component of the presynaptic ribbon in vertebrate photoreceptors" Journal of Neuroscience February 1 1999
  • "Synaptic contacts between physiologically identified neurons in the visual system of the barnacle" Journal of Neuroscience  1983
  • "RNA localization" Current Biology March 6 2001
  • "A repeated IMP-binding motif controls oskar mRNA translation and anchoring independently of Drosophila melanogaster IMP" Journal of Cell Biology February 13 2006
  • "Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules" Journal of Cell Biology March 5 2001
  • "Optimized filter set and viewing conditions for the S65T mutant of GFP in living cells" BioTechniques August 1996
  • "Kinesin is bound with high affinity to squid axon organelles that move to the plus-end of microtubules" Journal of Cell Biology October 1992
  • "The primary structure and analysis of the squid kinesin heavy chain" Journal of Biological Chemistry February 25 1990
  • "The role of kinesin and other soluble factors in organelle movement along microtubules" Journal of Cell Biology  1988
  • "Zebrafish Melanophilin Facilitates Melanosome Dispersion by Regulating Dynein" Current Biology October 23 2007
  • "[53] Viewing single microtubules by video light microscopy" ImmunoMethods  1986
  • "Single microtubules from squid axoplasm support bidirectional movement of organelles" Cell  1985
  • "Different axoplasmic proteins generate movement in opposite directions along microtubules in vitro" Cell  1985
  • "RNA localization in Xenopus oocytes" Seminars in Cell and Developmental Biology December 1997
  • "Tracking kinesin-driven movements with nanometre-scale precision" Nature  1988
  • "Improved nm displacement detector for microscopic beads at frequencies below 10 Hz" Review of Scientific Instruments May 1997
  • "New developments in understanding rapid axonal transport" Trends in Neurosciences  1986
  • "Trafficking of signaling modules by kinesin motors" Journal of Cell Science June 1 2003
  • "Direct observation of kinesin stepping by optical trapping interferometry" Nature October 21 1993
  • "Projecting two-axis nanometer scale displacement of microscopic beads onto a quadrant photodetector with a laser beam" Review of Scientific Instruments October 1997
  • "Single kinesin molecules crossbridge microtubules in vitro" Proceedings of the National Academy of Sciences of the United States of America July 15 1993
  • "Movement of organelles along filaments dissociated from the axoplasm of the squid giant axon" Cell  1985
  • "A highly conserved RNA-binding protein for cytoplasmic mRNA localization in vertebrates" Current Biology April 23 1998
  • "Vesicle movements and microtubule-based motors." Journal of cell science. Supplement  1986
  • "Retroactive motors" Neuron  1997
  • "KIF3C and KIF3A form a novel neuronal heteromeric kinesin that associates with membrane vesicles" Molecular Biology of the Cell  1998
  • "Microtubules and the mechanism of directed organelle movement" Annals of the New York Academy of Sciences  1986

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