Photo of Brian Johnstone, Ph.D., FORS

Brian Johnstone Ph.D., FORS

    • Adjunct Professor of Orthopaedics and Rehabilitation School of Medicine
    • Cell and Developmental Biology Graduate Program School of Medicine
    • Molecular and Medical Genetics Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Education

  • B.S., Brunel University, Middlesex 1983
  • Ph.D., University of London; Kennedy Institute 1987

Honors and awards

  • Dr. Johnstone received the Marshall R. Urist MD Award in 2017. This prestigious award, sponsored by the Journal of Orthopaedic Research (JOR), honors an investigator who has established him/herself as a cutting-edge researcher in tissue regeneration research and has done so with a sustained ongoing body of focused research in the area of tissue regeneration as it relates to the musculoskeletal system.
  • In March 2018, Dr. Johnstone was inducted into the inaugural class of ORS Fellows. The ORS Fellows Program recognizes individuals who have demonstrated service and leadership, substantial achievement, expert knowledge, and significant contributions to the field of musculoskeletal research and the Orthopaedic Research Society (ORS). Fellows represent the ORS as the thought leaders and topic experts in their respective disciplines. Fellows will also serve as role models in the ORS membership community and in the field of musculoskeletal research.

Publications

  • "α10 Integrin expression is up-regulated on fibroblast growth factor-2-treated mesenchymal stem cells with improved chondrogenic differentiation potential" Stem Cells and Development December 1 2007
  • "Experimental osteoarthritis in dogs" Osteoarthritis and Cartilage  1996
  • "Differential roles for small leucine-rich proteoglycans in bone formation" European Cells and Materials  2003
  • "Osteoarthritis in cynomolgus macaques II. Detection of modulated proteoglycan epitopes in cartilage and synovial fluid" Journal of Orthopaedic Research  1995
  • "Stem cells for cartilage regeneration" European Cells and Materials August 2009
  • "Cell Sources for Cartilage Tissue Engineering"  February 9 2006
  • "Tissue engineering for articular cartilage repair - The state of the art" European Cells and Materials  2012
  • "In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells" Experimental Cell Research January 10 1998
  • "Immunohistochemical study of a chondroitin-6-sulfate in growth plates of broiler chickens with high and low genetic predispositions to tibial dyschondroplasia" Avian Diseases  1996
  • "Involvement of caspase-3 in epigallocatechin-3-gallate-mediated apoptosis of human chondrosarcoma cells" Biochemical and Biophysical Research Communications April 21 2000
  • "Stem cell based tissue engineering for meniscus repair" Journal of Biomedical Materials Research - Part B Applied Biomaterials May 2008
  • "Augmentation of Rabbit Posterolateral Spondylodesis Using a Novel Demineralized Bone Matrix-Hyaluronan Putty" Spine November 1 2003
  • "The fluid content of the human intervertebral disc" Spine  1992
  • "Cyclic hydrostatic pressure enhances the chondrogenic phenotype of human mesenchymal progenitor cells differentiated in vitro" Journal of Orthopaedic Research  2003
  • "Evaluation of a Novel Spine and Surface Topography System for Dynamic Spinal Curvature Analysis during Gait" PLoS One July 23 2013
  • "Hypoxia-inducible factor 3-alpha expression is associated with the stable chondrocyte phenotype" Journal of Orthopaedic Research November 1 2015
  • "Ascorbate-enhanced chondrogenesis of ATDC5 cells" European Cells and Materials July 2006
  • "A quadripotential mesenchymal progenitor cell isolated from the marrow of an adult mouse" Journal of Bone and Mineral Research  1999
  • "Genetic enhancement of matrix synthesis by articular chondrocytes" Arthritis and Rheumatology May 2000
  • "Temporal exposure to chondrogenic factors modulates human mesenchymal stem cell chondrogenesis in hydrogels" Tissue Engineering - Part A. February 1 2011
  • "Immunohistochemical analysis of an equine model of synovitis-induced arthritis" American Journal of Veterinary Research July 1996
  • "Evaluation criteria for musculoskeletal and craniofacial tissue engineering constructs" Tissue Engineering - Part A. November 1 2008
  • "Gene-induced chondrogenesis of primary mesenchymal stem cells in vitro" Molecular Therapy August 2005
  • "Augmentation of spinal arthrodesis with autologous bone marrow in a rabbit posterolateral spine fusion model" Spine March 1 1999
  • "Hypoxia promotes redifferentiation and suppresses markers of hypertrophy and degeneration in both healthy and osteoarthritic chondrocytes" Arthritis Research and Therapy August 21 2013
  • "Mesenchymal stem cells and chondrogenesis" European Cells and Materials September 2002
  • "Characterization and chondrocyte differentiation stage-specific expression of KRAB zinc-finger protein gene ZNF470" Experimental Cell Research September 10 2004
  • "Effect of age and sampling site on the chondro-osteogenic potential of rabbit marrow-derived mesenchymal progenitor cells" Journal of Orthopaedic Research  2000
  • "Visible light photoinitiation of mesenchymal stem cell-laden bioresponsive hydrogels" European Cells and Materials December 2011
  • "The dynamic structure of the pericellular matrix on living cells" Journal of Cell Biology December 1993

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