Photo of Bill Hoon Chang, M.D., Ph.D.

Bill Hoon Chang M.D., Ph.D.

Dr. Bill Chang is an associate professor in the Department of Pediatrics, Division of Hematology/Oncology /BMT.  Dr. Chang completed his fellowship in 2006 at Doernbecher, where he received the Robert C. Neerhout Fellow Award, the Ruth L.  Kirschstein National Research Service Award and the National Childhood Cancer Foundation Research Fellowship (2005). He completed his pediatric residency and  M.D./Ph.D. programs at OHSU. Dr. Chang received his Ph.D. in neuroscience, where he focused on signaling mechanisms within the cell. He currently is a researcher of hematologic malignancies in pediatric, adolescent and young adults. His teaching responsibilities include:  clinical education of residents and fellows; mentorship of students and post-doctoral fellows within the research lab; fellows basic lectures; physician assistant pediatric lecture series.

  • Residency:

    • Pediatrics, Oregon Health & Science University, 2003
  • Fellowship:

    • Fellowship in Pediatric Hematology/Oncology, Oregon Health & Science University, 2006
  • Certifications:

    • American Board of Pediatrics, 2003

Memberships and associations

  • American Academy of Pediatrics
  • American Association for Cancer Research
  • Children’s Oncology Group
  • American Society for Blood and Marrow Transplantation
  • American Society of Clinical Oncology
  • American Society of Hematology
  • American Society of Pediatric Hematology and Oncology

Publications

  • "TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia" Cancer Discovery May 2013
  • "The essential mitotic target of calmodulin is the 110-kilodalton component of the spindle pole body in Saccharomyces cerevisiae" Molecular and Cellular Biology December 1993
  • "Management of menstrual bleeding and cycle control after hematopoietic stem cell transplant" International Journal of Gynecology and Obstetrics January 2008
  • "Cellular Signaling through Multifunctional Ca 2+/Calmodulin-dependent Protein Kinase II" Journal of Biological Chemistry February 9 2001
  • "Chromosomes with delayed replication timing lead to checkpoint activation, delayed recruitment of Aurora B and chromosome instability" Oncogene March 22 2007
  • "Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML" New England Journal of Medicine  2013
  • "Comparison of methods to identify aberrant expression patterns in individual patients" Genome Medicine November 29 2013
  • "Self-Enforcing Feedback Activation between BCL6 and Pre-B Cell Receptor Signaling Defines a Distinct Subtype of Acute Lymphoblastic Leukemia" Cancer Cell March 9 2015
  • "Characterization of a calmodulin kinase II inhibitor protein in brain" Proceedings of the National Academy of Sciences of the United States of America September 1 1998
  • "Sorafenib treatment following hematopoietic stem cell transplant in pediatric FLT3/ITD acute myeloid leukemia" Pediatric Blood and Cancer June 1 2015
  • "Calcium/calmodulin-dependent protein kinase II inhibitor protein" Neuroscience February 14 2001
  • "Abnormal developmental control of replication-timing domains in pediatric acute lymphoblastic leukemia" PCR Methods and Applications October 2012
  • "In vitro sensitivity to dasatinib in lymphoblasts from a patient with t(17;19)(q22;p13) gene rearrangement pre-B acute lymphoblastic leukemia" Pediatric Blood and Cancer September 2012
  • "Serum Exosome MicroRNA as a minimally-invasive early biomarker of AML" Scientific Reports June 12 2015
  • "p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint" Journal of Biological Chemistry March 30 2007
  • "Targeting survivin and p53 in pediatric acute lymphoblastic leukemia" Leukemia April 2012
  • "RNAi screen for rapid therapeutic target identification in leukemia patients" Proceedings of the National Academy of Sciences of the United States of America May 26 2009
  • "Therapeutically targetable ALK mutations in leukemia" Journal of Cancer Research June 1 2015
  • "Identification in the calcineurin A subunit of the domain that binds the regulatory B subunit" Journal of Biological Chemistry  1995
  • "Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening" Journal of Cancer Research January 1 2013
  • "A unique case of adolescent CD56-negative extranodal NK/T-cell lymphoma, nasal type" Pediatric and Developmental Pathology January 2008
  • "Crosstalk between ROR1 and the Pre-B Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia" Cancer Cell November 13 2012
  • "Neuroblastoma Found in a 4-Year-Old After Rituximab Therapy for Opsoclonus-Myoclonus" Pediatric Neurology September 2006
  • "YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway" Journal of Hematology and Oncology April 22 2015
  • "Ca2+/calmodulin-dependent kinase II mediates simultaneous enhancement of gap-junctional conductance and glutamatergic transmission" Proceedings of the National Academy of Sciences of the United States of America October 27 1998
  • "Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes" Leukemia June 25 2015
  • "Preventive antibiotics in pediatric patients with acute myeloid leukemia (AML)" Pediatric Blood and Cancer July 1 2015
  • "Imatinib resistant BCR-ABL1 mutations at relapse in children with Ph +ALL" British Journal of Haematology May 2012
  • "A phase i study of quizartinib combined with chemotherapy in relapsed childhood leukemia" Clinical Cancer Research August 15 2016
  • "Targeting BCL-2 and ABL/LYN in Philadelphia chromosome-positive acute lymphoblastic leukemia" Science Translational Medicine August 31 2016

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