Headshot photo of Baotong Xie, Ph.D.

Baotong Xie, Ph.D.

  • Research Assistant Professor of Integrative Biosciences, School of Dentistry


Dr. Xie received his Ph.D. in biochemistry and cellular biology from Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences. He then, as a postdoctoral researcher, started to use Drosophila as a model organism to investigate neuronal cell fate determination at Cincinnati Children’s Hospital Medical Center. As a research assistant professor, Dr. Xie’s current research interests focus on: 1) using Drosophila to understand the host-microbiome interactions and the role of human oral bacteria in health; 2) understanding the molecular mechanisms of the Hippo signaling pathway in neuronal cell fate determination and in tissue growth control.

Areas of interest

  • The formation of a functional nerve system requires the generation of a great diversity of neuronal subtypes. Our research interests focus on the elucidation of the molecular mechanisms underlying neuronal diversification.


Selected publications

  • Baotong Xie*, David Morton and Tiffany Cook*. Opposing transcriptional and post-transcriptional roles for Scalloped in binary Hippo-dependent neural fate decisions. Developmental Biology, In Press, available online at: https://doi.org/10.1016/j.ydbio.2019.06.022. * Corresponding author.
  • Jukam D**, Xie B**, Rister J**, Terrell D, Charlton-Perkins M, Pistillo D, Gebelein B, Desplan C, & Cook T. Opposite network-level feedback in the Hippo pathway for growth regulation and post-mitotic neural fate. Science, 2013 Oct 11, 342 (6155): 1238016. (**equal contribution).
  • Terrell DA, Xie B, Workman M, Mahato S, Zelhof A, Gebelein B and Cook T. OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye. Developmental Dynamics, 2012 Jan, 241(1): 215-228.
  • Johnston R, Otake Y, Sood P, Vogt N, Behnia R, Vasiliauskas D, McDonald E, Xie B, Koenig S, Cook T, Gebelein B, Kussell E, Nagakoshi H, Desplan C. Interlocked feedforward loops ensure robust Rhodopsin expression in the Drosophila eye. Cell, 2011 Jun, 145(6): 956-68.
  • Charlton-Perkins M, Whitaker L, Fei Y, Xie B, Li-Kroeger D, Gebelein B, Cook T. Prospero and Pax2 combinatorially control neural cell fate decisions by modulating Ras- and Notch-dependent signaling. Neural Development, 2011 May; 6:20.
  • McDonald EC**, Xie B**, Workman M, Charlton-Perkins M, Terrell DA, Reischl J, Wimmer EA, Gebelein BA, Cook TA. Seperable transcriptional regulatory domains with Otd control photoreceptor terminal differentiation events. Developmental Biology. 2010 Nov; 347(1): 122-32. (**equal contribution).
  • Xie B, Charlton-Perkins M, McDonald E, Gebelein B, Cook T. Senseless functions as a molecular switch for color photoreceptor differentiation in Drosophila. Development. 2007 Dec; 134(23): 4243-53.
  • Fu ZY, Xie BT, Ma YT, Gong ZX. Preparation of monoclonal antibodies against human ventricular myosin light chain 1 (HVMLC1) for functional studies. Acta Biochim Biophys Sin (Shanghai). 2006 Sep; 38(9):625-32.
  • Xie B, Huang R, Huang L, Zhou G, Gong Z. The functional domains of human ventricular myosin light chain 1. Biophys Chem. 2003 Oct 1; 106(1):57-66.
  • Xie BT, Ye YJ, Gong ZX. The phosphorylation of NS protein of wheat rosette stunt virus. Acta Biochim Biophys Sin (Shanghai). 2003 Jun;35(6):518-21.


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