Dr. Alina Maloyan, Ph.D. holds an Associate Professor position in the Knight Cardiovascular Institute at the Oregon Health and Science University where she and her research group investigate how maternal obesity affects placental function and predisposes the offspring to metabolic and cardiovascular diseases in adult life, so-called. developmental programming. Dr. Maloyan earned her Ph.D. in Physiology from Hebrew University in Jerusalem.
Dr. Maloyan's research focuses on understanding the effect of maternal obesity on placental and fetal cardiac metabolism. More than 65% of women entering pregnancy in the US are overweight or obese. Maternal obesity increases the risk of adverse pregnancy outcomes including malformations, preeclampsia, gestational diabetes, and stillbirth. Most importantly, in utero exposure to maternal obesity causes changes in the offspring's body composition, cardiovascular and metabolic function thereby predisposing the offspring to obesity, cardiovascular and metabolic diseases in later life.
Dr. Maloyan’s research interests include metabolic, physiological, and epigenetic changes occurring as a result of maternal obesity. She focuses on three major areas: the role of the placenta in the developmental programming of maternal obesity; metabolic and epigenetic changes in the fetal heart as result of exposure to adverse intrauterine environments; the role of autophagy in developmental programming.Read more
- Ph.D., Hebrew University, Jerusalem Israel 2004
Honors and awards
- 1996 Golda Meir Graduate Student Award
- 1998 Golda Meir Graduate Student Award
- 1999 Maria Rossi Escoli Graduate Student Research Award
- 2011 NIH/NICHD Young Investigator Award
Memberships and associations
- 2003- American Heart Association
- 2013- Society for Reproductive Investigation
- 2016- Society for Study of Reproduction
1. Muralimanoharan B, Li C, Nakayasu ES, Casey CP, Metz TO, Nathanielsz PW, and Maloyan A. Sexual Dimorphism in the Cardiac Response to Intrauterine Growth Restriction. Journal of Molecular and Cellular Cardiology. Jun 19;108:181-193, 2017
2. Muralimanoharan B, Guo C, Myatt L, and Maloyan A. Sexual Dimorphism in the NFκB1-Mediated Activation of miR-210 Expression and Mitochondrial Dysfunction in Placenta with Maternal Obesity. International Journal of Obesity, 2015,39(8):1274-81, PMID: 25833255, PMCID: PMC4526386.
3. Maloyan A, Muralimanoharan S, Huffman S, Cox LA, Nathanielsz PW, Myatt L, and Nijland MJ. Identification and Comparative Analyses of Myocardial miRNAs Involved in the Fetal Response to Maternal Obesity. Physiol Genomics, 2013, 45(19):889-900. PMID: 23922128, PMCID: PMC3798778
4. Muralimanoharan B, Gao X, Weintraub S, Myatt L, and Maloyan A. Sexual Dimorphism in Activation of Placental Autophagy with Evidence for Fetal Programming from a Placenta-specific Mouse Model. Autophagy. 12(5):752-69, 2016, PMID: 26986453, PMCID: PMC4854539.
5. Maloyan A, Sayegh J, Osinska H, Chua BH, Robbins J. Manipulation of death pathways in desmin-related cardiomyopathy. Circ Res,106:1524-1532, 2010, PMID: 20360253, PMCID: PMC2890082
6. Maloyan A, Osinska H, Lammerding J, Lee RT, Cingolani OH, Kass DA, Lorenz JN, Robbins J. Biochemical and mechanical dysfunction in a mouse model of desmin-related myopathy. Circ Res, 104(8):1021-1028, 2009, PMID: 19299643, PMCID: PMC4153728
7. Maloyan A, Gulick J, Glabe CG, Kayed R, Robbins J. Exercise reverses preamyloid oligomer and prolongs survival in alpha B-crystallin-based desmin-related cardiomyopathy. Proc Natl Acad Sci U S A, 104(14):5995-6000, 2007, PMID: 17389375, PMCID: PMC1851605
8. Maloyan A, Sanbe A, Osinska H, Westfall M, Robinson D, Imahashi K, Murphy E, Robbins J. Mitochondrial dysfunction, and apoptosis underlie the pathogenic process in alpha-B-crystallin desmin-related cardiomyopathy. Circulation, 112(22):3451-3461, 2005, PMID: 16316967, PMCID: PMC1398051
9. Sanbe A, Osinska H, Saffitz JE, Glabe CG, Kayed R, Maloyan A, Robbins J. Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis. Proc Natl Acad Sci U S A, 101(27):10132-10136, 2004, PMID: 15220483, PMCID: PMC454177
10. Weiss YG, Maloyan A, Tazelaar J, Raj N, Deutschman CS. Adenoviral transfer of HSP-70 into pulmonary epithelium ameliorates experimental acute respiratory distress syndrome. J Clin Invest, 110(6):801-806, 2002, PMID: 12235111, PMCID:PMC151132