Alina Maloyan, Ph.D, FAHA
- Associate Professor of Medicine, Division of Cardiovascular Medicine, School of Medicine
- Joint Faculty, Biomedical Engineering, School of Medicine
- Joint Faculty, Chemical Physiology and Biochemistry, School of Medicine
- Faculty, Graduate Program in Biomedical Sciences, School of Medicine
- Center for Developmental Health, School of Medicine
- Physiology and Pharmacology Graduate Program, School of Medicine
Biography
Dr. Alina Maloyan, Ph.D. holds an Associate Professor position in the Knight Cardiovascular Institute at the Oregon Health and Science University where she and her research group investigate how maternal obesity affects placental function and predisposes the offspring to metabolic and cardiovascular diseases in adult life, so-called. developmental programming. Dr. Maloyan earned her Ph.D. in Physiology from Hebrew University in Jerusalem.
Dr. Maloyan's research focuses on understanding the effect of maternal obesity on placental and fetal cardiac metabolism. More than 65% of women entering pregnancy in the US are overweight or obese. Maternal obesity increases the risk of adverse pregnancy outcomes including malformations, preeclampsia, gestational diabetes, and stillbirth. Most importantly, in utero exposure to maternal obesity causes changes in the offspring's body composition, cardiovascular and metabolic function thereby predisposing the offspring to obesity, cardiovascular and metabolic diseases in later life.
Dr. Maloyan’s research interests include metabolic, physiological, and epigenetic changes occurring as a result of maternal obesity. She focuses on three major areas: the role of the placenta in the developmental programming of maternal obesity; metabolic and epigenetic changes in the fetal heart as result of exposure to adverse intrauterine environments; the role of autophagy in developmental programming.
Education and training
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Degrees
- Ph.D., 2004, Hebrew University
Memberships and associations:
- 2003- American Heart Association
- 2013- Society for Reproductive Investigation
- 2016- Society for Study of Reproduction
Areas of interest
- Developmental Origins of Health and Disease (DOHaD)
- maternal obesity
- placental function
- metabolic disease
- immunometabolism
Honors and awards
- 1996 Golda Meir Graduate Student Award
- 1998 Golda Meir Graduate Student Award
- 1999 Maria Rossi Escoli Graduate Student Research Award
- 2011 NIH/NICHD Young Investigator Award
- 2017 Fellow of American Heart Association
Publications
Selected publications
- Maloyan A. Placental Autophagy: Causes and Consequences. Current Opinion in Physiology. 2026:100902
- Alharithi YJ, Smith G, Maloyan A. Developmental origins of immunometabolic health. Immunometabolism (Cobham). 2026;8(1):e00075
- Philips EA, Alharithi Y, Wilson TD, Broberg C, Davis BA, Koch S, et al. Maternal obesity programs cardiac remodeling in offspring via epigenetic, metabolic, and immune dysregulations. bioRxiv. 2025.
- Alharithi YJ, Phillips EA, Wilson TD, Couvillion SP, Nicora CD, Darakjian P, et al. Metabolomic and transcriptomic remodeling of bone marrow myeloid cells in response to maternal obesity. Am J Physiol Endocrinol Metab. 2025;328(2):E254–e71
- Phillips EA, Alharithi YJ, Kadam L, Coussens LM, Kumar S, Maloyan A. Metabolic abnormalities in the bone marrow cells of young offspring born to mothers with obesity. Int J Obes (Lond). 2024;48(11):1542–51
- Calco GN, Alharithi YJ, Williams KR, Jacoby DB, Fryer AD, Maloyan A, et al. Maternal high-fat diet increases airway sensory innervation and reflex bronchoconstriction in adult offspring. Am J Physiol Lung Cell Mol Physiol. 2023;325(1):L66–l73.
- Phillips EA, Hendricks N, Bucher M, Maloyan A. Vitamin D Supplementation Improves Mitochondrial Function and Reduces Inflammation in Placentae of Obese Women. Front Endocrinol (Lausanne). 2022;13:893848
- Montaniel KRC, Bucher M, Phillips EA, Li C, Sullivan EL, Kievit P, et al. Dipeptidyl peptidase IV inhibition delays developmental programming of obesity and metabolic disease in male offspring of obese mothers. J Dev Orig Health Dis. 2022;13(6):727–40
- Bucher M, Montaniel KRC, Myatt L, Weintraub S, Tavori H, Maloyan A. Dyslipidemia, insulin resistance, and impairment of placental metabolism in the offspring of obese mothers. J Dev Orig Health Dis. 2021;12(5):738–47
- Muralimanoharan S, Li C, Nakayasu ES, Casey CP, Metz TO, Nathanielsz PW, et al. Sexual dimorphism in the fetal cardiac response to maternal nutrient restriction. J Mol Cell Cardiol. 2017;108:181–93