Photo of Alexander Guimaraes, M.D., Ph.D.

Alexander Guimaraes M.D., Ph.D.

  • (503) 418-0990
    • Professor of Diagnostic Radiology School of Medicine
    • Vice-chair, Diagnostic Radiology Research
    • Cancer Biology Graduate Program School of Medicine

I am section head of abdominal imaging within the Department of Radiology. I am very excited about the opportunities available at OHSU, the focused direction that OHSU is taking towards precision medicine, molecular imaging, and cancer in specific. These initiatives dovetail very much with my interests and background, and I am eager to become a part of the OHSU efforts. Furthermore, these interests are in concert with the philosophy of the Department of Radiology as we increase our translational efforts and research footprint within the institution.

I graduated from University of Michigan in 1988 with a degree in nuclear engineering and began gravitating to imaging sciences and interactions of radiation and matter. I attended the Massachusetts Institute of Technology and continued to refine my interests in imaging sciences by completing a Ph.D. in radiological sciences and nuclear engineering using MRI to better understand and study quantitative assessments of neuronal degeneration.  This both enhanced my appreciation of scientific research, but also fomented my desire to treat patients. I graduated from Harvard Medical School with a desire to pursue radiology and become a physician scientist. I completed my training in radiology at the Massachusetts General Hospital where I was chief resident, and also was asked to stay on staff in the Division of Abdominal Imaging and Interventional Radiology. While on staff, I received grants to allow me to pursue post-doctoral training in molecular imaging at the Center for Molecular Imaging research, and further refined my goals into developing MRI for imaging the tumor microenvironment. I was on staff for 10 years, and my career as a physician scientist at the Massachusetts General Hospital culminated as the medical director of the Martinos Center for Biomedical Imaging, where I combined my interests in cancer imaging, for awards in imaging pancreatic cancer with magnetic nanoparticles and also became a leader in PET-MRI research over the past few years.

My long-term professional goal is to develop and lead research initiatives in the development of quantitative tools to evaluate with MRI the early diagnosis and efficacy of therapeutic strategies against cancer. Quantitative imaging and molecular imaging are challenging new fields that are constantly evolving and growing. Furthermore, the field of cancer therapeutics has demonstrated a near exponential growth in the development of novel small molecule targeted agents. Although imaging plays a significant role in the evaluation of these therapeutic agents, there is a need for physician radiologic scientists who both engage and treat these patients, and also are interested in leading the effort for the development of quantitative, diagnostic tools aimed at accurately assessing the efficacy of these therapies in the preclinical and clinical setting. Furthermore, there is a need for biologists, molecular oncologists, and other basic scientists to have an increased understanding of the role of imaging in their science. This will allow the proper education and training at the undergraduate, graduate and post-doctoral level to occur in order to have a clear translational path from pre-clinical to clinical trial design.

During the last 10 years, in addition to NIH funding, and clinical work, I have been involved in graduate education at MIT and Harvard Medical school at the undergraduate and graduate levels in courses including anatomy, and magnetic resonance imaging. Furthermore, I have had the pleasure of spending the last four years on the Harvard/MIT Division of Health Sciences and Technology (HST) medical school admissions committee. I am excited about mentoring the clinical faculty in my section towards enhancing their research opportunities at OHSU, and also at the opportunity to continue such efforts including mentoring students with an emphasis on molecular and cellular biology and cancer biology while at OHSU as it pertains to imaging within their scientific questions. I am honored to hopefully serve as a bridge between our two departments and engage others within the imaging community to do the same.

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Education

  • B.S., University of Michigan, Ann Arbor Michigan 1988
  • Ph.D., Massachusetts Institute of Technology, Cambridge Massachusetts 1994
  • M.D., Harvard Medical School, Boston Massachusetts 1999
  • Residency:

    • Diagnostic radiology, Massachusetts General Hospital, Boston, MA 2004
  • Fellowship:

    • Abdominal imaging, Massachusetts General Hospital, Boston, MA 2005

Publications

  • "Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer" Clinical Cancer Research January 15 2015
  • "The hippocampal formation participates in novel picture encoding" Proceedings of the National Academy of Sciences of the United States of America August 6 1996
  • "Comparison of CE-FDG-PET/CT with CE-FDG-PET/MR in the evaluation of osseous metastases in breast cancer patients" British Journal of Cancer April 28 2015
  • "BRAF activation initiates but does not maintain invasive prostate adenocarcinoma" PLoS One December 16 2008
  • "Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft model" Pancreas November 2008
  • "Case 20-2012" New England Journal of Medicine June 28 2012
  • "Meta-analysis of the technical performance of an imaging procedure" Statistical Methods in Medical Research February 27 2015
  • "Brain choline-containing compounds are elevated in HIV-positive patients before the onset of AIDS dementia complex" Neurology March 1996
  • "Imaging of the pancreas" Applied Radiology  2013
  • "Erratum" American Journal of Neuroradiology  1993
  • "In response to Dr. Garbow and colleagues" International Journal of Radiation Oncology Biology Physics March 1 2011
  • "Mucinous cystadenoma of the lung" AJR. American journal of roentgenology August 2004
  • "Stellenwert neuer MR-Techniken in der MR-PET" Der Radiologe December 2013
  • "State-of-the-art PET/CT of the pancreas" Radiographics July 2012
  • "Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients" Journal of Clinical Investigation January 4 2011
  • "Image-guided treatment in the hepatobiliary system" Radiographics September 1 2015
  • "Variability of brain lithium levels during maintenance treatment" Biological Psychiatry October 1 1995
  • "Treatment of deep intramuscular and musculoskeletal abscess" AJR. American journal of roentgenology May 2011
  • "Imaging of the pancreas" Applied Radiology  2013
  • "Re" Radiographics July 2012
  • "American College of Radiology and Society of Nuclear Medicine and Molecular Imaging joint credentialing statement for PET/MR imaging" Journal of Nuclear Medicine April 1 2015
  • "The phosphoinositide 3-kinase regulatory subunit p85α can exert tumor suppressor properties through negative regulation of growth factor signaling" Journal of Cancer Research July 1 2010
  • "Case 31-2009" New England Journal of Medicine October 8 2009
  • "Feasibility study of in vivo MRI based dosimetric verification of proton end-of-range for liver cancer patients" Radiotherapy and Oncology March 2013
  • "MR-PET of the body" European Journal of Radiology Open  2014
  • "Echoplanar chemical shift imaging" Magnetic Resonance in Medicine  1999
  • "Body MR imaging" Radiographics September 1 2015
  • "Increased cerebral blood volume in HIV-positive patients detected by functional MRI" Neurology June 1998
  • "Case 3-2013" New England Journal of Medicine January 24 2013
  • "The emerging science of quantitative imaging biomarkers terminology and definitions for scientific studies and regulatory submissions" Statistical Methods in Medical Research February 27 2015

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