The Development, Differentiation and Disease (D3) Hub offers research and training in the mechanisms of cell signaling and development, and how the misregulation of these normal mechanisms leads to a wide variety of diseases. Using a range of model systems, hub-affiliated faculty explore processes that are crucial for the formation and function of tissues, organs, and organisms. Areas of interest include the mechanisms that control cell proliferation and migration; the temporal and spatial regulation of gene expression in cells and organisms; biosynthesis, assembly and function of cellular components; intracellular trafficking and signal transduction; and neurogenesis and neuronal development. Faculty also seek to understand how the misregulation of these normal mechanisms can lead to the onset, progression, and dissemination of a range of important diseases that affect human health, with the long-term goal of identifying new opportunities for therapeutic treatments. Current areas of expertise among the faculty include the molecular mechanisms of homeostasis and metabolic disorders; mechanisms of cellular differentiation and oncogenesis; basic and applied research on musculoskeletal development and repair; and developmental neuroscience, coupled with cellular and molecular mechanisms neurological disorders.
- Cell Signaling in Development and Disease (CSDD)
- Developmental Neuroscience and Neurological Disease (DNND)
Hub Director: Philip Copenhaver, Ph.D.
- Michael Heinrich, M.D.
- Peter Hurlin, Ph.D.
- Brian Johnstone, Ph.D.
- Doris Kretzschmar, Ph.D.
- Evan Lind, Ph.D.
- Owen McCarty, Ph.D.
- Charles Meshul, Ph.D.
- Anusha Mishra, Ph.D.
- Kelly Monk, Ph.D.
- Swetha Murthy, Ph.D.
- Linda Musil, Ph.D.
- Alex Nechiporuk, Ph.D.
- Jeffrey Nolz, Ph.D.
- Naoki Oshimori, Ph.D.
- Bret Pearson. Ph.D.
- Ferdinando Pucci, Ph.D.
In addition to the PBMS core curriculum, students who join the Development, Differentiation and Disease (D3) hub will be encouraged to take the following core course(s) and 3 credits of electives based on the student's individual training plan/research interests. Additionally, students will participate in their hubs seminar series, journal club(s) / grand rounds, and annual retreat / symposia.
- Development, Differentiation and Disease
- Tissue Biology
- Advanced Topics in Developmental Neuroscience
- Mechanisms of Development
- Topical Nano courses (0.5 cr) featuring targeted deep dives into current topics.
- Previous offerings include:
- Novel 3D Cell Culture Platforms for Studying Cellular Biology and Disease Mechanisms
- CRISPR-Cas9 System
- Biology and Pathology of Extracellular Vesicles
- A Hands-On Introduction to RNAseq
- Secret Life of Noncoding RNAs
- Introduction to Single-Cells ‘Omics’ Data Analysis
- New Methods for Live-Cell Imaging in Embryos and Organs
- Metabolomic Strategies to Investigate Normal and Abnormal Development
- Previous offerings include:
- Combined Basic Sciences
- Basic and Translational (CSDD)
- Vollum Neuroscience (DNND)
- Cell and Developmental Biology
Annual Meeting(s) and Symposia(s)
- Annual Combined Graduate Retreat