David C. Parker, Ph.D.

  • Molecular Microbiology and Immunology Graduate Program, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine

Biography

Dr. Parker’s laboratory is interested in the cell-surface molecules and intracellular signaling pathways which determine whether an encounter between helper T cells and B cells or other antigen presenting cells results in immunity or tolerance. In a simplified model of peripheral tolerance to self, we found that a signal through OX40 (CD134) blocks functional anergy in transferred T cells responding to transgenic or allogeneic antigens, drives the T cells to differentiate into cytokine-secreting effector cells and results in fatal acute graft versus host disease in unirradiated recipient animals. Current work is focused on the role of the alternative pathway of NFkB activation in that model.

In a second project, the lab is exploring the possibility that certain subsets of weakly autoreactive B cells play an essential role as antigen-presenting cells in inducing tolerance to self antigens in T cells. In a third project, we are exploring the "immunological synapse," the structure that forms in the contact zone between a T cell and an antigen presenting cell. We are examining the role of the synapse in the specific delivery of effector cytokines from T cells to antigen presenting cells, with an emphasis on the membrane-bound TNF family members, CD40L (CD154) and FasL. We are also exploring differences among T cell subsets in the structure of the synapse and the functional consequences of those differences.

Education

  • Ph.D., 1971, University of California

Memberships and associations

  • American Association of ImmunologistsFederation of American ScientistsUnion of Concerned Scientists

Publications

Publications

  • {{ pub.journalAssociation.journal.names[0].value }}