Photo of Cecily Vauna Bishop, Ph.D.

Cecily Vauna Bishop Ph.D.

  •      (503) 346-5388
    • Adjunct Research Assistant Professor Oregon National Primate Research Center

Cecily Bishop, Ph.D. is an Adjunct Research Assistant Professor in the Division of Reproductive & Developmental Sciences at ONPRC.
Her research aims to investigate the incompletely understood molecular pathways associated with normal and pathologic ovarian angiogenesis.

The mid-cycle surge of luteinizing hormone (LH) is responsible for reorganizing the ovulatory follicle into a corpus luteum (CL), which produces the progesterone necessary for implantation of the embryo. As part of the structural and cellular changes that happen after ovulation, a wave of neovascularization occurs resulting in the formation of a CL with a network of highly permeable capillaries. In turn, this newly formed vasculature allows for the significant levels of progesterone produced by the CL to enter the circulation and support implantation/ pregnancy. Assisted reproduction protocols used to treat infertility in women often lead to the development of ovaries with many CL. In women and old world primates, development of multiple CL following ovarian stimulation result in abnormal ovarian/luteal vascularization and ovarian hyperpermeability that, in turn, may lead to abdominal ascites and systemic vascular dysfunction (known as ovarian hyperstimulation syndrome, or OHSS). Dr. Bishop’s research aims to identify novel targets for preventing OHSS from occurring in women undergoing infertility treatments.

Techniques used to interrogate mediators of ovarian angiogenesis range from molecular (i.e. gene expression and shRNA-knockdown of select gene targets), to contrast-enhanced ultrasound (CEUS) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) of ovarian blood flow, volume, and permeability.

Dr. Bishop is also involved in use of CEUS and 3D/4D ultrasound technology to assist studies of other novel genes involved in folliculogenesis, evaluate ovarian tissue engraftment following cryopreservation, and the role of the steroid hormone progesterone in normal ovarian function using shRNA-knockdown of specific progesterone receptors during luteal formation. Finally, she is also part of studies into the role of androgens and diet in a nonhuman primate model of polycystic ovarian syndrome (PCOS) funded by a NICHD National Center for Translational Research in Reproduction and Infertility (NCTRI) grant.


Areas of interest

  • Ovarian Function
  • Angiogenesis
  • Reproductive Biology
  • Ultrasound
  • Magnetic Resonance Imaging
  • Ovarian/Uterine Blood Flow
  • Steroid Hormone Action


  • B.S., Washington State University 2001
  • Ph.D., Oregon State University 2006

Honors and awards

  • 1999 President’s Honor Role for Term, Washington State University
  • 2003 Oregon Sports Lottery Scholarship, Oregon State University
  • 2003-2005 Fred F. McKenzie Memorial Scholarship (Awarded to Graduate Student in the Field of Reproduction), Oregon State University
  • 2006 Savory Outstanding Doctoral Student, College of Agriculture, Oregon State University
  • 2006 Appointment on OHSU’s Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants for Reproductive Sciences (T32-HD07133), Oregon Health & Science University
  • 2007 Extramural Loan Repayment Program for Contraception and Infertility Researchers (LRP-CIR) Award (NIH notice: NOT-OD-08-087), NICHD
  • 2009 Appointment on OHSU’s Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants for Reproductive Sciences (T32-HD07133), Oregon Health & Science University
  • 2010 Lalor Foundation Merit Award for Abstract Presented at Annual Meeting, Society for the Study of Reproduction
  • 2012 Third place Prize Poster, American Society for Reproductive Medicine

Memberships and associations

  • 2003 - 2006 Member, Gamma Sigma Delta, Oregon State University
  • 2003 - 2012 Trainee Member, Society for the Study of Reproduction
  • 2006 - 2011 Member (Trainee/ Fellow), The Endocrine Society
  • 2007 - 2011 Member (Trainee/ Fellow), American Society for Reproductive Medicine
  • 2011 - 2013 Board of Reviewing Editors, Biology of Reproduction
  • 2012 - Active Member, Doctoral, American Society for Reproductive Medicine
  • 2013 - Member, Society for the Study of Reproduction


  • "Exposure of female macaques to western-style diet with or without chronic T in vivo alters secondary follicle function during encapsulated 3-dimensional culture" Endocrinology March 1 2015
  • "Ovarian surface epitheliectomy in the non-human primate" Human Reproduction June 2011
  • "Progesterone suppresses an oxytocin-stimulated signal pathway in COS-7 cells transfected with the oxytocin receptor" Steroids December 22 2008
  • "Evaluation of antral follicle growth in the macaque ovary during the menstrual cycle and controlled ovarian stimulation by high-resolution ultrasonography" American Journal of Primatology May 2009
  • "Endocrine and local control of the primate corpus luteum" Reproductive biology December 2013
  • "Effects of hyperandrogenemia and increased adiposity on reproductive and metabolic parameters in young adult female monkeys" American Journal of Physiology - Renal Fluid and Electrolyte Physiology June 1 2014
  • "Elevated androgens during puberty in female rhesus monkeys lead to increased neuronal drive to the reproductive axis" Human Reproduction February 2012
  • "The ovine sexually dimorphic nucleus of the medial preoptic area is organized prenatally by testosterone" Endocrinology September 2007
  • "Progesterone inhibition of oxytocin signaling in endometrium" Frontiers in Neuroscience  2013
  • "Ovarian cycle-specific regulation of adipose tissue lipid storage by testosterone in female nonhuman primates" Endocrinology November 1 2013
  • "The effects of luteinizing hormone ablation/replacement versus steroid ablation/replacement on gene expression in the primate corpus luteum" Molecular Human Reproduction  2009
  • "Nongenomic action of progesterone inhibits oxytocin-induced phosphoinositide hydrolysis and prostaglandin F2α secretion in the ovine endometrium" Endocrinology February 2006
  • "Reproductive characteristics of endophyte-infected or novel tall fescue fed ewes" Livestock Science October 2006
  • "Quantification of dynamic changes to blood volume and vascular flow in the primate corpus luteum during the menstrual cycle" Journal of Medical Primatology December 1 2014
  • "Effects of steroid ablation and progestin replacement on the transcriptome of the primate corpus luteum during simulated early pregnancy" Molecular Human Reproduction March 2014
  • "Non-genomic actions of progesterone and estrogens in regulating reproductive events in domestic animals" Veterinary Journal June 2008
  • "Analysis of microarray data from the macaque corpus luteum; the search for common themes in primate luteal regression" Molecular Human Reproduction March 2011
  • "Board-invited review" Journal of Animal Science February 2008
  • "Microarray analysis of the primate luteal transcriptome during chorionic gonadotrophin administration simulating early pregnancy" Molecular Human Reproduction April 2012
  • "Contrast-enhanced ultrasound reveals real-time spatial changes in vascular perfusion during early implantation in the macaque uterus" Fertility and Sterility March 15 2011
  • "Dynamics of immune cell types within the macaque corpus luteum during the menstrual cycle" Biology of Reproduction November 1 2015
  • "Western-style diet, with and without chronic androgen treatment, alters the number, structure, and function of small antral follicles in ovaries of young adult monkeys" Fertility and Sterility August 28 2015
  • "Anti-Müllerian hormone promotes pre-antral follicle growth, but inhibits antral follicle maturation and dominant follicle selection in primates" Human Reproduction  2016
  • "Knockdown of progesterone receptor (PGR) in macaque granulosa cells disrupts ovulation and progesterone production" Biology of Reproduction May 1 2016
  • "Intravenous neutralization of vascular endothelial growth factor reduces vascular function/permeability of the ovary and prevents development of OHSS-like symptoms in rhesus monkeys" Journal of Ovarian Research July 6 2017
  • "Changes in immune cell distribution and their cytokine/chemokine production during regression of the rhesus macaque corpus luteum" Biology of Reproduction  2017
  • "Chronic hyperandrogenemia in the presence and absence of a western-style diet impairs ovarian and uterine structure/function in young adult rhesus monkeys" Human Reproduction January 1 2018
  • "Chronic hyperandrogenemia and western-style diet beginning at puberty reduces fertility and increases metabolic dysfunction during pregnancy in young adult, female macaques" Human Reproduction April 1 2018
  • "Combined androgen excess and Western-style diet accelerates adipose tissue dysfunction in young adult, female nonhuman primates" Human Reproduction September 1 2017
  • "Anti-Müllerian hormone is a survival factor and promotes the growth of rhesus macaque preantral follicles during matrix-free culture† " Biology of Reproduction January 1 2018

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