Photo of Ann Hill, Ph.D.

Ann Hill Ph.D.

  • (503) 494-0763
    • Professor of Molecular Microbiology and Immunology School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine
    • Cancer Biology Graduate Program School of Medicine

Education
1990 - Ph.D., Australian National University
1979 - M.B., B.S., University of NSW, Sydney, Australia

Experience
2004-present - Associate Professor, MMI, OHSU
1996-04 - Assistant Professor, MMI, OHSU
1995 - Postdoctoral Fellowship, The Arthritis Foundation, MIT, Boston
1993 - The Royal Society Travelling Fellowship to Japan
1990-94 - Oxford Nuffield Dominions Medical Fellowship
1983-84 - Immunology Registrar, St. Vincents Hospital, Sydney
1979-82 - Resident Medical Officer, Sydney Hospital, Sydney, Australia

Biography

My laboratory investigates T cell immunity to viral infections. Our main interest is in herpesvirus immune evasion genes- how they function, and what effect this has on the immune response to the virus and the virus infective process. We use murine cytomegalovirus (MCMV) as our main model. Cytomegalovirus (CMV) is a ubiquitous infection, infecting approximately 70% of adults in the US. CMV infects in childhood and establishes lifelong infection, usually without symptoms. Immunity to CMV occupies a surprisingly high proportion of the immune system throughout life: around 4% of CD4+ and 10% of CD8+ T cells in chronically infected people are specific for CMV, probably more than for any other virus. This high number of T cells is thought to be maintained by recurrent virus activity, which nevertheless normally remains below the threshold of detection. However, if immunity is compromised, CMV rapidly reactivates and is a main cause of morbidity in most clinically immunocompromized states. It thus appears that the chronic equilibrium between CMV and host involves a lot of activity on both virus and host sides. The long term goal of my lab is to understand this equilibrium and its consequences for the host.

Publications

  • "The multiple immune-evasion genes of murine cytomegalovirus are not redundant" Journal of Experimental Medicine October 1 2001
  • "Cytokine-mediated activation of NK cells during viral infection" Journal of Virology  2015
  • "HLA class I molecules are not transported to the cell surface in cells infected with herpes simplex virus types 1 and 2" Journal of Immunology March 15 1994
  • "Bovine herpesvirus-1 infection affects the peptide transport activity in bovine cells" Virus Research January 1998
  • "Inhibition of major histocompatibility complex class I antigen presentation in pig and primate cells by herpes simplex virus type 1 and 2 ICP47" Journal of Virology June 1998
  • "Cross-presentation of a spread-defective MCMV is sufficient to prime the majority of virus-specific CD8+ T cells" PLoS One March 12 2010
  • "Ly49P recognition of cytomegalovirus-infected cells expressing H2-D k and CMV-encoded m04 correlates with the NK cell antiviral response" Journal of Experimental Medicine March 16 2009
  • "Preliminary analysis of murine cytotoxic T cell responses to the proteins of the flavivirus Kunjin using vaccinia virus expression" Journal of General Virology  1991
  • "Quantitative considerations of T-cell activation and self tolerance." Immunological Reviews August 1987
  • "Herpes Simplex Virus Blocks Intracellular Transport of HLA-G in Placentally Derived Human Cells" Journal of Immunology October 15 1996
  • "The role of NKG2D signaling in inhibition of cytotoxic T-lymphocyte lysis by the murine cytomegalovirus immunoevasin m152/gp40" Journal of Virology November 2007
  • "Ir1 genes, peripheral cross-tolerance and immunodominance in MHC Class I-restricted T-cell responses" Immunological Reviews June 1993
  • "When the Going Gets Tough, Memory T Cells Check Out" Immunity August 26 2011
  • "Coordinated function of murine cytomegalovirus genes completely inhibits CTL lysis" Journal of Immunology September 1 2006
  • "Avoiding immunity and apoptosis" Advances in Virus Research April 1998
  • "MHC class I immune evasion in MCMV infection" Medical Microbiology and Immunology June 2008
  • "Alloreactive cytotoxic T cells recognize MHC class I antigen without peptide specificity" Journal of Immunology September 15 1991
  • "Competition for antigen at the level of the APC is a major determinant of immunodominance during memory inflation in murine cytomegalovirus infection" Journal of Immunology April 1 2013
  • "Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors" Science May 17 2002
  • "Different rates of HLA class I molecule assembly which are determined by amino acid sequence in the α2 domain" Immunogenetics January 1993
  • "CD4+ T cell help has an epitope-dependent impact on CD8 + T cell memory inflation during murine cytomegalovirus infection" Journal of Immunology September 15 2009
  • "Loss of HLA class-I alleles, heavy chains and β2-microglobulin in colorectal cancer" International Journal of Cancer  1992
  • "Viral interference with antigen presentation" Nature Immunology November 1 2002
  • "Sustained CD8+ T cell memory inflation after infection with a single-cycle Cytomegalovirus" PLoS Pathogens October 2011
  • "Cytomegalovirus" Trends in Microbiology  1998
  • "Viral interference with antigen presentation does not alter acute or chronic CD8 T cell immunodominance in murine cytomegalovirus infection" Journal of Immunology June 1 2007
  • "Cytomegalovirus-based cancer vaccines expressing TRP2 induce rejection of melanoma in mice" Biochemical and Biophysical Research Communications July 26 2013
  • "Murine cytomegalovirus interference with antigen presentation has little effect on the size or the effector memory phenotype of the CD8 T cell response" Journal of Immunology June 1 2004
  • "Herpesvirus evasion of the immune system" Current Topics in Microbiology and Immunology  1998
  • "The murine cytomegalovirus immune evasion protein m4/gp34 forms biochemically distinct complexes with class I MHC at the cell surface and in a pre-golgi compartment" Journal of Immunology October 1 2001

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