Disease-related peripheral neuropathy

If you have peripheral neuropathy, you might have:

  • Burning or tingling
  • Numbness
  • Unusual sensations
  • Weakness or pain

Causes of peripheral neuropathy include:

  • Genetic diseases, such as Friedreich's ataxia or Charcot-Marie-Tooth disorder
  • Metabolic or endocrine system conditions, such as diabetes, chronic renal failure, porphyria, amyloidosis, liver failure or hypothyroidism (low thyroid)
  • Toxic causes, such as chemotherapy drugs, drinking too much alcohol, exposure to toxic metals, excess intake of vitamin B6 or radiation exposure
  • Autoimmune diseases such as Guillain-Barré syndrome, lupus or rheumatoid arthritis
  • Vitamin deficiency (not enough of certain vitamins)
  • Physical trauma, such as nerve compression, a cut injury, or a projectile injury such as a gunshot wound
  • Other conditions, such as shingles, malignant (cancerous) disease or HIV infection


Your doctor determines the best treatment for your peripheral neuropathy based on:

  • Your age, general health and medical history
  • Extent of your condition
  • How well certain medications, procedures or treatments work for you
  • How your doctor expects your condition to progress (get worse or better)
  • Your opinion or preference


OHSU's Nerve Center offers a wide range of neurodiagnostic (nerve diagnosis) services to evaluate your anatomy (structure of your body) and see if your brain, spinal cord, muscles, nerves and blood flow are functioning properly.

Our goal is to offer reliable and complete testing to help diagnose, manage and track your health condition. 

Learn more about diagnostic procedures

Many peripheral nervous system diseases may cause similar symptoms as muscle problems (myopathies). That's why it's important for a doctor to make an accurate diagnosis using diagnostic testing.

Learn about neuromuscular (nerve and muscle) disorders and myopathies