Systems/Computational

The nervous system is organized into a collection of neural subsystems that are interconnected in very precise ways in order to generate specific outputs based on information provided by a variety of inputs. For example, an outfielder in baseball may hear the crack of the bat striking a ball and at the same time see the ball arcing toward him. This auditory and visual information is passed to association subsystems where it is integrated with proprioceptive input in order to generate appropriate motor outputs, which enable the fielder to catch the ball. Systems neuroscientists seek to understand how sensory systems encode the sights, sounds, smell and touches that describe the outside world; how this information is integrated with prior experience; and how appropriate motor outputs are generated. This requires not only knowledge of the cellular and molecular properties of nervous tissue, but an understanding of the response properties of the subsystems and their interconnections. Some of the approaches used to study these issues include immunocytochemical and histological localization of proteins, in situ hybridization to localize RNAs, intracellular and extracellular recording of activity in neural tissues, analysis of neural metabolism, monitoring of animal behavior, and computer modeling of systems behavior.

Areas of strength within the systems/computational subdiscipline are:

For more information on NGP faculty involved in this work, click on the links to these investigators.

    • Faculty Appointments

      • Professor of Molecular Microbiology and Immunology, School of Medicine
    • Areas of interest

      • host-pathogen interactions, neural-immune communications, neuroinflammation, infections, bacterial pathogenesis, organismal response to infections
    • Faculty Appointments

      • Professor of Physiology and Pharmacology, School of Medicine
    • Faculty Appointments

      • Professor, Oregon Institute of Occupational Health Sciences
      • Professor of Behavioral Neuroscience, School of Medicine
    • Areas of interest

      • Circadian Rhythms
      • Sleep
      • Synaptic Transmission
      • Suprachiasmatic Nucleus
      • Neural Network Activity
    • Faculty Appointments

      • Professor of Physiology and Pharmacology, School of Medicine
    • Areas of interest

      • autonomic
      • electrophysiology
      • synaptic transmission
    • Faculty Appointments

      • Associate Professor of Integrative Biosciences, School of Dentistry
    • Areas of interest

      • Development and Plasticity of Neuronal Circuits
    • Faculty Appointments

      • Professor of Otolaryngology - Head and Neck Surgery, School of Medicine
    • Areas of interest

      • Hair-cell transduction
      • Hair-bundle development
    • Faculty Appointments

      • Professor, Vollum Institute
    • Areas of interest

      • zebrafish genetics
      • electrophysiology
      • ion channel function
      • imaging
    • Faculty Appointments

      • Associate Professor of Otolaryngology - Head and Neck Surgery, School of Medicine
      • Associate Professor of Cell, Developmental and Cancer Biology, School of Medicine
    • Areas of interest

      • Fate of otic epithelial progenitors in the mouse otic vesicle
      • Lineage relationships of sensory and nonsensory cells in the mouse inner ear
      • Molecular regulation of sensory organ formation
    • Faculty Appointments

      • Associate Professor of Otolaryngology - Head and Neck Surgery, School of Medicine
    • Areas of interest

      • Representation of speech and other natural sounds in auditory cortex
      • Learning and attention-driven changes in auditory representation
      • Biological mechanisms underlying neural computations
    • Faculty Appointments

      • Professor of Neurological Surgery, School of Medicine
    • Faculty Appointments

      • Assistant Professor, Vollum Institute
      • Assistant Professor of Behavioral Neuroscience, School of Medicine
    • Areas of interest

      • neurotransmitter release
      • short-term synaptic plasticity
      • neural circuits
      • presynaptic calcium sensors
    • Faculty Appointments

      • Professor of Neurology, School of Medicine
    • Faculty Appointments

      • Associate Professor, Vollum Institute
    • Areas of interest

      • basal ganglia circuit analysis
      • cortical-subcortical interactions
      • optogenetics
      • genetically engineered calcium indicators
      • two-photon calcium imaging
    • Faculty Appointments

      • Professor of Behavioral Neuroscience, School of Medicine
    • Areas of interest

      • Neuroethology
      • Molecular neuroscience
      • Speech and Language
      • Vocal learning
      • Central auditory processing
      • Learning and memory
      • Neurogenomics
    • Faculty Appointments

      • Professor of Behavioral Neuroscience, School of Medicine
      • Professor of Psychiatry, School of Medicine
    • Areas of interest

      • Determinants of risky and impulsive decision-making
      • Alcohol, nicotine and marijuana use
      • Neurobiology of choice
      • Behavioral genetics of impulsivity
      • Behavioral economics
    • Faculty Appointments

      • Associate Professor of Physiology and Pharmacology, School of Medicine
    • Faculty Appointments

      • Associate Professor of Cell, Developmental and Cancer Biology, School of Medicine
    • Areas of interest

      • zebrafish axonal transport neuron development lateral line sensory systems
    • Faculty Appointments

      • Professor of Otolaryngology - Head and Neck Surgery, School of Medicine
    • Areas of interest

      • Hearing function and hearing loss
      • Cochlear physiology
    • Faculty Appointments

      • Associate Professor of Otolaryngology - Head and Neck Surgery, School of Medicine
      • Associate Professor of Biomedical Engineering, School of Medicine
    • Areas of interest

      • Pitch and speech perception in humans
      • Computational modeling of auditory perception
      • Auditory neurophysiology
      • Binaural fusion
      • Auditory object formation and segregation
    • Faculty Appointments

      • Professor of Medicine, Division of Pulmonary and Critical Care Medicine, School of Medicine
      • Professor of Physiology and Pharmacology, School of Medicine
    • Faculty Appointments

      • Professor of Otolaryngology - Head and Neck Surgery, School of Medicine
    • Areas of interest

      • Brainstem circuits that process acoustic signals
      • Synaptic physiology: How do cells and synapses preserve information provided by the ear?
    • Faculty Appointments

      • Professor, Vollum Institute
      • Professor of Physiology and Pharmacology, School of Medicine
    • Areas of interest

      • exocytosis and endocytosis of synaptic vesicles
      • short and long-term plasticity in the retina and brainstem
      • electrophysiology of auditory pathway
      • ribbon synapses
    • Faculty Appointments

      • Professor, Vollum Institute
    • Areas of interest

      • neurogenesis
      • hippocampal microcircuits
      • glutamate receptors
      • epilepsy
      • regeneration and repair
      • synaptic transmission
    • Faculty Appointments

      • Professor, Vollum Institute
    • Areas of interest

      • opiate desensitization and tolerance
      • receptor trafficking
      • dendrodendritic transmission
    • Faculty Appointments

      • Assistant Professor, Vollum Institute
    • Areas of interest

      • neurodevelopment
      • axon guidance
      • neuronal migration
      • synaptogenesis
      • neural circuitry
    • Faculty Appointments

      • Associate Professor, Vollum Institute
    • Areas of interest

      • photoactivated localization microscopy (PALM)
      • two-photon fluorescence lifetime imaging microscopy (2PFLIM)
      • fluorescence resonance energy transfer (FRET) microscopy
      • protein and signaling dynamics during plasticity
      • in vivo imaging of neuromodulation and subcellular signaling in awake animals