Ov D. Slayden

Disorders of the reproductive tract including tubal infertility, endometriosis and excessive uterine bleeding continue to levy a heavy burden on women's health. In order to identify new therapies for the treatment and prevention of these disorders we must advance our fundamental knowledge regarding basic physiology of the reproductive tract.                

The Slayden laboratory investigates factors that mediate the action of estrogens and progestogens in the reproductive tract. Techniques including immunohistochemistry, ligand binding, western blotting, Real-time PCR and in situ hybridization are applied to understand the cyclic effects of ovarian hormones on the uterus, oviduct and cervix. Recent studies include immunohistochemistry of estrogen receptor-1 (ESR-1) and G protein coupled- estrogen receptor 1 (GPR30; GPER) in the primate endometrium. This basic knowledge of reproductive tract physiology is being utilized to develop novel long-acting and permanent contraceptives for women, and to develop new therapies for reproductive tract disorders.

Studies in Dr. Slayden's laboratory have focused extensively on the application of progesterone receptor antagonists (PRAs) to regulate cellular function within the reproductive tract. These studies include the use of PRAs to control uterine bleeding in women who use progestin releasing intrauterine devices.

Another area of interest for the Slayden lab is endometriosis. Endometriosis is a disorder in which endometrium-like tissues form lesions at sites outside the uterus. Like women, macaques and baboons develop endometriosis, and Dr. Slayden's laboratory is investigating the effects of endometriosis on cyclic changes in the reproductive tract. Dr. Slayden and colleagues have demonstrated that both nonhuman primate and human endometriosis can be engrafted into immunodeficient mice to provide a unique model for the evaluation of anti-endometriotic therapies on the human disease.



Ov Daniel Slayden is an Associate Professor in the Division of Reproductive Sciences at Oregon National Primate Research Center and has joint appointments in the Department of Obstetrics and Gynecology, and in Physiology and Pharmacology in the School of Medicine, OHSU. Dr. Slayden is a co-Investigator and Scientific Director of the Oregon Permanent Contraception Research Center (OPERM).  He received his B.A. and M.A. degrees in Biology from Sonoma State University, and earned a Ph.D. in Biochemistry and Animal Science at Oregon State University. Dr. Slayden moved to the Center in1991 after being awarded a Reproductive Biology Training Fellowship through the Department of Physiology at OHSU.             


KEY PUBLICATIONS                

Slayden, OD, Lee, DO, Yao, S, and Jensen, JT. (2016) Polidocanol induced tubal occlusion in nonhuman primates: Immunohistochemical detection of collagen I-V. Contraception 10.1016/j.contraception.2016.07.003. PMID: 27417518. PMC in process

Franasiak, JM, Burns, KA, Slayden,O, Yuan, L, Fritz, MA, Korach, KS, Lessey, BA, and Young, SL. (2015) Endometrial CXCL13 expression is cycle regulated in humans and aberrantly expressed in humans and Rhesus macaques with endometriosis. Reprod Sci 22, 442-451. PMCID: PMC4812688.

Keator CS, Mah K, Slayden OD. (2012) Alterations in progesterone receptor membrane component 2 (PGRMC2) in the endometrium of macaques afflicted with advanced endometriosis. Mol Hum Reprod 18:308-319.  PMC3358041

Keator CS, Lindner JR, Belcik JT, Bishop CV, Slayden OD. (2011) Contrast-enhanced ultrasound reveals real-time spatial changes in vascular perfusion during early implantation in the macaque uterus. Fertil Steril 95:1316-1321. PMC3070443



See a full listing of Dr. Slayden's publications