Nancy L. Haigwood, Ph.D., Director
Dr. Haigwood brings 37 years of scientific and leadership experience to the ONPRC. As the fifth Director of the Center (since 2007), Professor in the Pathobiology &Immunology Division, and an Adjunct Professor in the Vaccine & Gene Therapy Institute and in the Department of Molecular Microbiology and Immunology at OHSU, her laboratory continues to make major contributions to research in HIV vaccines and antibody-based therapies. She led the preclinical development of a groundbreaking HIV vaccine while serving as Research Director for the Chiron Corporation in Emeryville, California, and was the founding Director of the Viral Vaccines Program for the Center for Infectious Disease Research and a Professor of Microbiology and Pathobiology at the University of Washington. An innovator by nature, Dr. Haigwood became the first Scientific Ombudsperson at the Fred Hutchinson Cancer Research Center in 2004. She is currently a member of the Board of Scientific Counselors at the NIH Vaccine Research Center and has served as a regular member on NIH Advisory Panels and Study sections, including a recent term on the Council of Councils. She was elected a Fellow of the American Academy of Microbiology in 2014.
Lisa Kendig, Chief Operating Officer
Ms. Kendig joined the primate center in 2013. She started her career at OHSU in 1999 in Central Financial Services. Prior to that, OHSU was her audit client when she was working for a large public accounting firm. She was the Director of Finance for the Research mission at the university for nine years before stepping into the role as the Chief Operating Officer (COO) at the Center. As the COO, she is responsible for directing the operations, finances, grants management, human resources, information systems and facilities for the center.
Charles T. Roberts, Ph.D., Associate Director for Research
Dr. Roberts has focused on insulin and insulin-like growth factor research for the last 30 years. Dr. Roberts was recruited as Associate Director for Research at the ONPRC in May 2007, and directs research programs in non-human primate adipose and islet biology in the Divisions of Cardiometabolic Health and Developmental and Reproductive Science in addition to overseeing ONPRC research support cores and interactions with external investigators. His previous positions include Professor and Associate Chair for Research in the Department of Pediatrics and Doernbecher Children's Hospital at OHSU, Senior Investigator at the Diabetes Branch in NIDDK's intramural research program, and Assistant Professor of Biological Sciences at the University of California, Santa Barbara. Dr. Roberts also holds joint appointments at OHSU as Professor of Medicine, Pediatrics, and Cell, and Developmental, and Cancer Biology. He is currently a member of the Board of Directors of the National Association for Biomedical Research and the External Advisory Board of the UC Irvine Institute for Clinical and Translational Science.
Gregory B. Timmel, D.V.M., M.S., DACLAM, Chief of the ONPRC Division of Comparative Medicine and Associate Director
Dr. Timmel comes to us from Legacy Health, where for the last five years he has been the Director of the Department of Comparative Medicine and Attending Veterinarian at the Legacy Research Institute in Portland, Oregon. He brings with him a wealth of experience in animal medicine, teaching, and mentoring. He received his Doctor of Veterinary Medicine degree from Colorado State University and his Master of Science in Physiology and Behavioral Biology from San Francisco State University. He has practiced small and exotic animal medicine in Arizona and Hawaii. Dr. Timmel worked for five years as a Clinical Veterinarian at the University of California, San Francisco and nine years as Campus Veterinarian at the University of California, Berkeley. He obtained board certification through the American College of Laboratory Animal Medicine (ACLAM) in 2009.
Research division chiefs
Jacob Estes, Ph.D., Chief, Division of Pathobiology & Immunology
Dr. Estes has established an exceptional research program that focuses on the immunopathology and persistence of lentiviral (HIV/SIV) infections. Dr. Estes's group has pioneered novel in situ hybridization, immunopathological and tissue analyses approaches to better understand: i) HIV/SIV transmission and viral establishment, ii) mechanisms underlying pathological inflammation and immune activation, iii) progressive immunopathology of lymphoid tissues, and iv) reservoir biology and viral persistence. In addition, his group generated the first nonhuman primate (NHP) model of experimental acute and chronic colitis that is being explored as a preclinical model of IBD. Dr. Estes received his training at Brigham Young University and the University of Minnesota prior to joining the AIDS and Cancer Virus Program at the Frederick National Laboratory for Cancer Research/NCI/NIH, where he was a Senior Principal Investigator of the Retroviral Immunopathology Section and Head of the Tissue Analysis Core. Dr. Estes joined the ONPRC as the Chief of the Division of Pathobiology &Immunology in 2017 and holds a joint appointment as Professor in the Vaccine and Gene Therapy Institute at OHSU.
Kathleen Grant, Ph.D., Chief, Division of Neuroscience
Dr. Grant over the past two decades has achieved eminence as a leading investigator of the behavioral pharmacology of alcohol abuse and alcoholism. Dr. Grant's laboratory has helped to define the receptor mechanisms that mediate the addictive potential of ethanol in the brain. Further her research has developed a monkey model of alcoholic drinking that is the basis for over 30 laboratories involved in collaborative research on the genetic, physiological, endocrinological and neuropharmacological risk for and consequences of heavy drinking. Dr. Grant directs the consortium on the Integrative Neuroscience Initiative on Stress and Alcoholism funded by NIH and has served on the National Advisory Council for the National Institute on Alcohol Abuse and Alcoholism. After training at the University of Washington, University of Chicago, and the National Institutes of Health she rose up through the faculty ranks at Wake Forest University School of Medicine. Dr. Grant moved to OHSU in 2005 to be jointly appointed in the Department of Behavioral Neuroscience and the ONPRC. In 2011, she became Division Head of Neuroscience and remains actively involved in the Behavioral Neuroscience Department where she will continue to hold an appointment as Professor.
Jon D. Hennebold, Ph.D., Chief, Division of Reproductive & Developmental Sciences
Dr. Hennebold and his research team are leaders in the area of primate reproductive biology, specifically as related to ovarian physiology and processes required for fertilization and early embryonic development. Their research has led to the development of novel strategies for infertility and contraceptive treatments. Dr. Hennebold serves on numerous scientific advisory panels, editorial boards, and NIH study sections. He was recently elected as a member of the Board of Directors for the Society for the Study of Reproduction. Dr. Hennebold came to the ONPRC in 2000 as a Staff Scientist in the Division of Reproductive &Developmental Sciences. In 2002, he was promoted to Assistant Scientist and, since May 2014, has served as the Interim Chief of the Division. He holds joint positions in the Departments of Obstetrics &Gynecology and Physiology &Pharmacology. Dr. Hennebold is actively involved in accelerating reproductive research by promoting interactions between basic and clinical scientists at OHSU and other universities through various leadership roles.
Jonathan Lindner, M.D., Chief, Division of Cardiometabolic Health
Dr. Lindner holds the M. Lowell Edwards Professorship of Cardiology and has expertise in the fields of cardiovascular imaging and microvascular physiology. He also is the Director of Non-invasive Imaging at the Knight Cardiovascular Institute. His research laboratory has pioneered the use of contrast ultrasound for non-invasive molecular imaging of disease and the evaluation of microvascular function/dysfunction. Specific areas of research include: a) application of molecular imaging techniques for early detection of atherosclerosis and evaluation of new therapies for atherosclerosis; (b) molecular imaging of angiogenesis and stem cell therapy; (c) molecular imaging for early diagnosis of myocardial ischemic injury and inflammation; (d) microvascular dysfunction and endothelial abnormalities in atherosclerosis, insulin resistance, and sickle cell disease; and (e) development of new methods for detecting and treating peripheral arterial disease. Dr. Lindner is the President Elect for the American Society of Echocardiography and also serves as an Associate Editor for the Journal of the American Society of Echocardiography. He is on the Board of Directors and serves as the Vice-chair for the Exam Writing Committee for the National Board of Echocardiography.
Donald Conrad, Ph.D., Chief of the Division of Genetics
Dr. Conrad is a world-renowned expert in genetics/genomics and the development of bioinformatics pipelines/platforms for the efficient assessment and management of genetic data. He played a leading role in mapping and characterizing the functional impact of human chromosomal structural variants. He also developed novel statistical methods for identifying de novo point mutations from next-generation sequencing data and used this to estimate germline mutation rates from parent-offspring trios as part of the 1000 genomes project. Another major emphasis of his research includes defining the origins of mutation and the distribution of mutation frequencies that impact gametogenesis, fertilization, and pregnancy. Dr. Conrad received his training at the University of Chicago and the Wellcome Trust Sanger Institute prior to joining Washington University in St. Louis, where he led a successful research group in the Department of Human Genetics. Dr. Conrad joined the ONPRC in 2018 to lead the newly established Division of Genetics.