The Integrated Pathology Core (IPC) provides investigators with state-of-the-art histology and light microscopy imaging and analysis through extensive expertise, services, data analysis, and access to advanced equipment. Services provided include routine histology, cryosectioning, immunohistochemistry, next-generation RNAScope/DNAScope in situ hybridization, advanced light (bright field and multi-spectral confocal) microscopy, digital whole-slide imaging, quantitative image analysis, and laser-capture microdissection. Core personnel are available at every stage of histology and microscopy-based experiments, from planning to training, troubleshooting, and quality control.
The Core has an extensive resource of tissue-based analyses and techniques including multiplexed immunohistochemical and immunofluorescence staining and RNA/DNAScope in situ hybridization. In addition to routine and automated histology equipment, advanced histology techniques are supported by a Biocare IntelliPATH automated stainer for immunohistochemistry. Imaging and microscopy capabilities include a Leica Stellaris 8 confocal, a Keyence BZ-X810 Fluorescence Microscope, and an ArcturusXT laser-capture microdissection system. Image analysis is supported by multiple platforms including the HALO Image Analysis suite (Indica Lab, Corrales, NM), an advanced quantitative image analysis package that supports unique tissue-specific and disease-specific applications.