Mitin Lab

Dr. Mitin at a computer

Timur Mitin, M.D., Ph.D. is an associate professor with the Department Radiation Medicine and serves as medical director Tuality/OHSU Cancer Center in Hillsboro, Oregon. Dr. Mitin was born in Moscow, Russia and came to the United States at the age of sixteen.  He received his medical and doctorate degrees from Tufts University and completed his residency training at the Harvard Radiation Oncology Program.

His research and clinical interests are in the treatment of genitourinary malignancies, especially bladder preservation therapy for patients with muscle-invasive bladder cancer. 

clincal research

Advancement of clinical knowledge requires a self-perpetuating loop that consists of clinical trials, evaluation of the adoption of the results of the studies by medical providers, determination of knowledge gaps and barriers to implementation of new evidence, and generation of a new set of clinical trials. 

We are involved in all phases of the Clinical Research Loop.

The major leaps in clinical care are achieved through meticulously designed and executed clinical trials that either prove and disprove a benefit to a new intervention. As a laboratory of Clinical Research in the Department of Radiation Medicine, we study ways to improve the efficacy of radiation therapy –by investigating the role of RT in new areas, questioning the role of RT in other areas, learning to target RT more precisely with novel imaging modalities, determining how RT can be combined with novel systemic agents. Most of our prospective studies are done in collaboration with other departments. 

Below is the list of some of our studies in various phases of design, preparation, patient accrual and analysis:

  • Adjuvant radiation therapy for patients with Dupuytren's Contractures after surgical or enzymatic release of advanced contractures
  • Localization of involved regional lymph nodes with USPIO-MRI in Esophageal Cancer
  • Localization of involved regional lymph nodes with USPIO-MRI in Rectal Cancer
  • Addition of Bladder-directed radiation therapy to Immunotherapy in metastatic bladder cancer
  • Combination of Conventionally and Hypofractionated Radiation Therapy with Immunotherapy in Stage II/III non-operable NSCLC
  • Alternating Electric Fields as an Alternative to Prophylactic Cranial Irradiation in patients with Small Cell Lung Cancer
  • Assessment of effect of Palliative Radiation Oncology (PRADO) clinic model on outcomes of patients with incurable malignancies.

The adoption of results of clinical trials in the real world is not immediate and may be hindered by lack of knowledge, financial and other barriers. We conduct National Cancer Data Base analyses to determine the patterns of treatments and outcomes for common malignancies where standard of care has been established through rigorous clinical trials, as well as rare conditions, in which clinical trials are not possible. 

Below is the list of NCDB projects we have conducted with our colleagues:

  • Rectal Cancer (Cancer Journal)
  • Gallbladder Cancer (Lancet)
  • Breast Angiosarcoma

Despite clinical evidence from published clinical trials, the daily practice of medicine by providers may be in a stark contrast to established guidelines. Large retrospective population-based analysis cannot capture the most current views and practices of treating physicians. Survey-based analysis of current patterns of treatment, with evaluation of association of respondents' characteristics, knowledge base, allows us to determine the future direction for clinical trials.

Some of our survey-based analysis work is presented below:

  • Seminoma   
  • ES-SCLC   
  • LS-SCLC   
  • Prostate   
  • Breast Angiosarcoma   
  • Esophagus   
  • Bladder   
  • Rectal cancer

Wencesley Paez, Ph.D.

Dr. Paez began his first tenure at OHSU in 2008 working with  Dr. Bruce Wolfe on various industry and NIH-sponsored research trials, while also co-authoring peer-reviewed manuscripts. He was an OHSU President's Award Nominee and Rose Award recipient in 2011, and was a former Ted R. Lilly-Knight Cancer Institute CURE Program Research Mentor. He holds a Doctor of Medicine, and a BS in Biology with a Minor in Chemistry. 

September 15, 2019

Timur Mitin, M.D., Ph.D. was a speaker at the Joint RUSSCO-ASTRO-SPRO Session on Palliative Radiation Therapy in Incurable Patients: Keeping Symptoms Down and Hope High at the 2019 ASTRO Annual Meeting in Chicago, Illinois.

May 21, 2019

Timur Mitin, M.D., Ph.D., medical director of the Tuality/OHSU Cancer Center was interviewed for by OHSU Blogs about a treatment option that will improve outcomes for patients with bladder cancer who cannot tolerate surgery or chemotherapy. Read about helping more bladder cancer patients preserve a functioning bladder.

November 13, 2018

Timur Mitin, M.D., Ph.D. was interviewed for the Cancer Network's article, The Verdict on IMRT Plus Doxorubicin in Unresectable Thyroid Cancer.

August 31, 2018

Timur Mitin, M.D., Ph.D. is co-PI of CRUK (Cancer Research UK)-OHSU/Cancer Early Detection Advanced Research Center (CEDAR) Spark Award for his proposal titled "Amplicon deep sequencing of urinary DNA for the early detection of recurrence following chemoradiotherapy for muscle-invasive bladder cancer ("AmpseqUr-RT"). The $20,000.00 grant award is based upon the novel hypothesis that earlier detection of recurrence in patients with muscle-invasive bladder cancer who have undergone chemoradiotherapy. As such, Dr. Mitin and his team will assess the diagnostic utility of AmpseqUR in this setting. AmpseqUr utilizes the commonest urothelial bladder cancer-associated somatic mutations and amplifies the loci of interest by multiplex PCR and identifies mutations by targeted next-generation sequencing of the amplicons. 

June 5, 2018

Timur Mitin, M.D., Ph.D. presented Prostate Radiotherapy in Newly-Diagnosed Metastatic Hormone-Sensitive Prostate Cancer at the 2018 ASCO Annual Meeting in Chicago, Illinois.  

February 15, 2018

Timur Mitin, M.D., Ph.D., medical director of the Tuality/OHSU Cancer Center was interviewed for by OHSU Blogs  about applying the ProtecT Trial data to minority populations. The ProtecT trial is led by researchers at the Universities of Oxford and Bristol at nine centers in the United Kingdom.

May 9, 2016

Dr. Timur Mitin, with the assistance of Dr. Shushan Rana, has received a 2016-17 Research Seed Grant from the RSNA Research & Education Foundation from the Radiology Research Faculty Grant Study Section for his application titled "Novel Imaging of Lymph Nodes in Patients with Rectal Cancer Using Ferumoxytol-enhanced MRI". Congratulations to Drs. Mitin and Rana.

March 21, 2015

Drs. Timur Mitin and Alex Guimaraes are co-PIs of the 2015 Michael J. Newton Esophageal Cancer Research award from the Newton Foundation Esophageal Cancer Translational Research Program. The grant is titled, “Novel Imaging of Lymph Nodes in Patients with Esophageal Cancer Using Ferumoxytol-enhanced Magnetic Resonance Imaging”.

SBRT for Localized Prostate Cancer: Is it Ready for Take-Off? Mitin T, Henry A, Choudhury A, Chen RC, Pinkawa M, Spratt DE. Int J Radiat Oncol Biol Phys. 2019 Nov 1;105(3):618-620. doi: 10.1016/j.ijrobp.2019.07.008. No abstract available.

Enhancing Career Paths for Tomorrow's Radiation Oncologists. Vapiwala N, Thomas CR Jr, Grover S, Yap ML, Mitin T, Shulman LN, Gospodarowicz MK, Longo J, Petereit DG, Ennis RD, Hayman JA, Rodin D, Buchsbaum JC, Vikram B, Abdel-Wahab M, Epstein AH, Okunieff P, Goldwein J, Kupelian P, Weidhaas JB, Tucker MA, Boice JD Jr, Fuller CD, Thompson RF, Trister AD, Formenti SC, Barcellos-Hoff MH, Jones J, Dharmarajan KV, Zietman AL, Coleman CN. Int J Radiat Oncol Biol Phys. 2019 Sep 1;105(1):52-63. doi: 10.1016/j.ijrobp.2019.05.025. Epub 2019 May 22. Review.

The role of biomarkers in bladder preservation management of muscle-invasive bladder cancer. Mitin T, Choudhury A. World J Urol. 2019 Sep;37(9):1767-1772. doi: 10.1007/s00345-018-2480-7. Epub 2018 Sep 14.

Evolving Practice Patterns in the Use of Prophylactic Cranial Irradiation for Extensive-Stage Small Cell Lung Cancer. Gjyshi O, Ludmir EB, Pezzi TA, Boyce-Fappiano D, Dursteler AE, Mitin T, Lin SH. JAMA Netw Open. 2019 Aug 2;2(8):e199135. doi: 10.1001/jamanetworkopen.2019.9135. No abstract available.

Adjuvant vs. salvage radiation therapy in men with high-risk features after radical prostatectomy: Survey of North American genitourinary expert radiation oncologists. McClelland S 3rd, Sandler KA, Degnin C, Chen Y, Mitin T. Can Urol Assoc J. 2019 May;13(5):E132-E134. doi: 10.5489/cuaj.5470. Epub 2018 Oct 15.

Dramatic polarization in genitourinary expert opinions regarding the clinical utility of positron emission tomography (PET) imaging in prostate cancer. Sandler KA, McClelland S 3rd, Degnin C, Chen Y, Mitin T. Int Braz J Urol. 2019 Jan-Feb;45(1):23-31. doi: 10.1590/S1677-5538.IBJU.2018.0208.

Postoperative Radiation Therapy in Localized Prostate Cancer: When, How Much, and How Fast? Mitin T, Nguyen PL. Int J Radiat Oncol Biol Phys. 2019 Feb 1;103(2):289-292. doi: 10.1016/j.ijrobp.2018.08.003.