Our program has a broad and flexible research focus that includes health services and outcomes-based research, clinical and translational research, as well as basic science research opportunities within OHSU community. Our goal is to provide an opportunity to garner a meaningful research experience during the critical years of residency training.
Residents are encouraged to concurrently enroll into the Human Investigations Program (HIP), a training component within the institutional CTSA, also known as the Oregon Clinical and Translational Research Institute. Enroll in the Masters of Clinical Research Track or the Certificate Track. The residency is structured so concurrent participating in research activities are conducted such that all ACGME and ABR requirements are met. The length of the training program is not altered with research endeavors.
Our 2021-2022 resident research projects:
Workflow automation, quality improvement, autosegmentation, imaging informatics
My research focuses on evaluating new software solutions for autosegmentation (computer-assisted target delineation) in radiation therapy planning and methods for improving the quality and efficiency of radiation plan review.
Outcomes of carotid-sparing IMRT for T1 glottic cancer: Comparison with conventional radiation. Mohamed ASR, Smith BD, Smith JB, Sevak P, Malek JS, Kanwar A, Browne T, Gunn GB, Garden AS, Frank SJ, Morrison WH, Phan J, Zafereo M, Skinner H, Lai SY, Hutcheson KA, Lewin JS, Hessel AE, Thekdi AA, Weber RS, Fuller CD, Rosenthal DI. Laryngoscope. 2020 Jan;130(1):146-153. doi: 10.1002/lary.27873.
Artificial Intelligence in Radiation Oncology. Deig CR, Kanwar A, Thompson RF. Hematol Oncol Clin North Am. 2019 Dec;33(6):1095-1104. doi: 10.1016/j.hoc.2019.08.003. Epub 2019 Sep 11. Review.
Imaging-Genomic Study of Head and Neck Squamous Cell Carcinoma: Associations Between Radiomic Phenotypes and Genomic Mechanisms via Integration of The Cancer Genome Atlas and The Cancer Imaging Archive. Zhu Y, Mohamed ASR, Lai SY, Yang S, Kanwar A, Wei L, Kamal M, Sengupta S, Elhalawani H, Skinner H, Mackin DS, Shiao J, Messer J, Wong A, Ding Y, Zhang L, Court L, Ji Y, Fuller CD. JCO Clin Cancer Inform. 2019 Feb;3:1-9. doi: 10.1200/CCI.18.00073.
Neoadjuvant therapy in pancreatic cancer, hepatocellular carcinoma, liver SBRT, upper gastrointestinal malignancies
My research team focuses on determining the perioperative safety, efficacy, and role of neoadjuvant therapy in patients with pancreatic adenocarcinoma. We are also investigating the impact of sarcopenia on clinical and surgical outcomes as well as metabolic recovery during neoadjuvant therapy. In patients with unresectable hepatocellular carcinoma, our team designed a randomized prospective clinical trial comparing Y-90 TARE to SBRT that will initially enroll patients at Oregon Health & Science University and the Portland VA Medical Center .
Networking and Applying to Radiation Oncology During A Pandemic: Cross-Sectional Survey of Medical Student Concerns. Pollom EL, Sandhu N, Deig CR, Obeid JP, Miller JA, Kahn JM. Adv Radiat Oncol. 2021 Feb 4;6(3):100643. doi: 10.1016/j.adro.2021.100643. PMID: 33748546; PMCID: PMC7966834.
Radiation Oncology Virtual Education Rotation (ROVER) for Medical Students. Kahn JM, Sandhu N, von Eyben R, Deig C, Obeid JP, Miller JA, Pollom E.Int J Radiat Oncol Biol Phys. 2021 Apr 9:S0360-3016(21)00359-X. doi: 10.1016/j.ijrobp.2021.03.057.
Artificial Intelligence in Radiation Oncology. Deig CR, Kanwar A, Thompson RF. Hematol Oncol Clin North Am. 2019 Dec;33(6):1095-1104. doi: 10.1016/j.hoc.2019.08.003.
Arthur Hung, M.D.
Definitive radiation and hormonal therapy in prostate cancer, brachytherapy, genitourinary and gynecologic malignancies
My research focuses on the role of ADT de-escalation in the management of patients with intermediate-risk prostate cancer. Additional interests include evaluating the impact of risk-group upstaging on clinical outcomes in prostate cancer, and the integration of checklist-based quality improvement strategies for expanding brachytherapy programs.
Impact of Enlarged Nonhypermetabolic Lymph Nodes on Outcomes After Stereotactic Body Radiotherapy for Early-Stage Non-Small-Cell Lung Cancer. Verma V, Schonewolf CA, Cushman TR, Post CM, Doms A, Berman AT, DeVries M, Katz SI, Simone CB 2nd.Clin Lung Cancer. 2018 Nov;19(6):502-510. doi: 10.1016/j.cllc.2018.07.005. Epub 2018 Jul 25.PMID: 30111509
National Practice Patterns for Clinical T1N0 Nasopharyngeal Cancer in the Elderly: A National Cancer Data Base Analysis. Post CM, Lin C, Adeberg S, Gupta M, Zhen W, Verma V.Anticancer Res. 2018 Mar;38(3):1651-1657. doi: 10.21873/anticanres.12397.PMID: 29491098
Current Practice Patterns Surrounding Fertility Concerns in Stage I Seminoma Patients: Survey of United States Radiation Oncologists. Post CM, Jain A, Degnin C, Chen Y, Craycraft M, Hung AY, Jaboin JJ, Thomas CR Jr, Mitin T.J Adolesc Young Adult Oncol. 2018 Jun;7(3):292-297. doi: 10.1089/jayao.2017.0122. Epub 2018 Jan 16.PMID: 29336660
Radiation inducted oxidative stress via metabolic therapy
My research focuses on the role of radiation treatment in combined metabolic therapy by maximizing radiation induced oxidative stress in glioblastoma multiforme (GBM).
Role of Radiation Therapy in Modulation of the Tumor Stroma and Microenvironment. Menon H, Ramapriyan R, Cushman TR, Verma V, Kim HH, Schoenhals JE, Atalar C, Selek U, Chun SG, Chang JY, Barsoumian HB, Nguyen QN, Altan M, Cortez MA, Hahn SM, Welsh JW.Front Immunol. 2019 Feb 15;10:193. doi: 10.3389/fimmu.2019.00193. eCollection 2019.PMID: 30828330 Free PMC article. Review.
MicroRNA-200c increases radiosensitivity of human cancer cells with activated EGFR-associated signaling. Koo T, Cho BJ, Kim DH, Park JM, Choi EJ, Kim HH, Lee DJ, Kim IA.Oncotarget. 2017 Jul 3;8(39):65457-65468. doi: 10.18632/oncotarget.18924. eCollection 2017 Sep 12.
Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: targeting PI3K-AKT-mTOR signaling, HSP90 and histone deacetylases. Choi EJ, Cho BJ, Lee DJ, Hwang YH, Chun SH, Kim HH, Kim IA.BMC Cancer. 2014 Jan 13;14:17. doi: 10.1186/1471-2407-14-17.PMID: 24418474
Quality improvement in radiation oncology
My research focus is on optimizing clinic work flow and procedures to deliver high quality patient centered care in the field of radiation oncology. I also have an interest in creating and adopting sustainable solutions to cancer treatment
Primary MALT Lymphoma of the Breast Treated with Definitive Radiation. Hissourou Iii M, Zia SY, Alqatari M, Strauchen J, Bakst RL.Case Rep Hematol. 2016;2016:1831792. doi: 10.1155/2016/1831792. Epub 2016 May 10.
Women's reproductive health
With Dr. Elshaikh, my research focused on comparative outcomes in women diagnosed with early stage carcinosarcoma compared to uterine serous carcinoma. At OHSU, with Dr. Kahn, I am working in optimizing the pregnancy screening workflow within the radiation oncology department.
Elective Nodal Irradiation for Limited-stage Small-cell Lung Cancer: Survey of US Radiation Oncologists on Practice Patterns. Farrell MJ, Yahya JB, Degnin C, Chen Y, Holland JM, Henderson MA, Jaboin JJ, Harkenrider MM, Thomas CR Jr, Mitin T.Clin Lung Cancer. 2020 Sep;21(5):443-449.e4. doi: 10.1016/j.cllc.2020.02.020. Epub 2020 Mar 7.PMID: 32245625
Prophylactic Cranial Irradiation for Limited-Stage Small-Cell Lung Cancer: Survey of US Radiation Oncologists on Current Practice Patterns Farrell MJ, Yahya JB, Degnin C, Chen Y, Holland JM, Henderson MA, Jaboin JJ, Harkenrider MM, Thomas CR Jr, Mitin T.Clin Lung Cancer. 2018 Jul;19(4):371-376. doi: 10.1016/j.cllc.2018.02.009. Epub 2018 Feb 23.PMID: 29559208
Timing of Thoracic Radiation Therapy With Chemotherapy in Limited-stage Small-cell Lung Cancer: Survey of US Radiation Oncologists on Current Practice Patterns. Farrell MJ, Yahya JB, Degnin C, Chen Y, Holland JM, Henderson MA, Jaboin JJ, Harkenrider MM, Thomas CR Jr, Mitin T.Clin Lung Cancer. 2018 Nov;19(6):e815-e821. doi: 10.1016/j.cllc.2018.04.007. Epub 2018 May 5.PMID: 29857969
Immune response to radiation therapy, Computational Biology
My current research interests are centered on evaluating the interplay between radiation & immunology for the induction durable clinical benefit along with investigating patterns of cancer care and long-term patient outcomes within the VA database.
B7-H3 and PD-L1 Expression Are Prognostic Biomarkers in a Multi-racial Cohort of Patients with Colorectal Cancer. Zhang W, Acuna-Villaorduna A, Kuan K, Gupta S, Hu S, Ohaegbulam K, Albanese J, Kaumaya M, Levy R, Hwang RR, Zang X, Lin J, Liu Q, Maitra R, Goel S.Clin Colorectal Cancer. 2021 Feb 19:S1533-0028(21)00016-5. doi: 10.1016/j.clcc.2021.02.002.
Vitamin D Supplementation in COVID-19 Patients: A Clinical Case Series. Ohaegbulam KC, Swalih M, Patel P, Smith MA, Perrin R.Am J Ther. 2020 Sep/Oct;27(5):e485-e490. doi: 10.1097/MJT.0000000000001222.
Being Here Now: Perspectives of Preliminary Medicine Residents at the Epicenter of the COVID-19 Pandemic. Karp AM, Ohaegbulam KC.Chest. 2020 Oct;158(4):1346-1347. doi: 10.1016/j.chest.2020.06.008.
Resident published research
Rubinstein Research Retreat: October 30, 2021
To register, visit: https://bit.ly/2Sj5n21
Pacific Northwest Workshop on Methods in Radiation Oncology Clinical Trials: date to be announced
Resident Research News
May 18, 2021
Residents presenting the American Society for Radiation Oncology (ASTRO) 63rd Annual Meeting:
Aasheesh Kanwar, M.D., PGY-4
- Oral presentation: Evaluation of Commercial Pelvic Autosegmentation Solutions in Anatomic Edge Cases of Patients Receiving Definitive Radiotherapy for Prostate Cancer (Session: DHI (Digital Health Innovation) 3 – The U-Net & You: Is Segmentation a Solved Problem?)
Jehan Yahya, M.D., PGY-2
- Poster presentation: A robust Comparative Matched Analysis for Survival Endpoints Between Women with Early Stage Uterine Carcinosarcoma and Uterine Sarcoma
Kim Ohaegbulam, M.D., Ph.D., PGY-2
- Poster presentation: Association of Radiation to the Aorta and Blood Pressure Changes (Track: DHI (Digital Health Innovation))
April 21, 2021
Jenna M. Kahn, M.D. and Chris Deig, M.D. will present on Radiation Oncology Virtual Elective Rotation for Medical Students and Residents Implementation of a National Virtual Education Resource at the Annual ROECSG Spring Symposium.