Our program has a broad and flexible research focus that includes health services and outcomes-based research, clinical and translational research, as well as basic science research opportunities within OHSU community. Our goal is to provide an opportunity to garner a meaningful research experience during the critical years of residency training.
Residents are encouraged to concurrently enroll into the Human Investigations Program (HIP), a training component within the institutional CTSA, also known as the Oregon Clinical and Translational Research Institute. Enroll in the Masters of Clinical Research Track or the Certificate Track. The residency is structured so concurrent participating in research activities are conducted such that all ACGME and ABR requirements are met. The length of the training program is not altered with research endeavors.
Our 2019-2020 resident research projects:
Jerry Jaboin, M.D., Ph.D.
Pediatric Cancer and Brain Cancer
My current pediatric projects focus on developing ways to improve care delivery for pediatric patients receiving radiotherapy. I also have projects investigating stereotactic radiosurgery outcomes with attention to combined modality treatments such as targeted and immunotherapies.
Concurrent Radiosurgery and Immune Checkpoint Inhibition: Improving Regional Intracranial Control for Patients With Metastatic Melanoma. Murphy B, Walker J, Bassale S, Monaco D, Jaboin J, Ciporen J, Taylor M, Dai Kubicky C. Am J Clin Oncol. 2019 Mar;42(3):253-257. doi: 10.1097/COC.0000000000000509.
Prophylactic Aortic Stent Prevents Massive Hemorrhage and Hematemesis After Definitive Esophageal Chemoradiation in a Patient With Pretreatment Aortic Involvement. Murphy B, Azarbal A, Schenning RC, Bensch K, Sukumar M, Stelzer K, Nabavizadeh N. Pract Radiat Oncol. 2019 Sep - Oct;9(5):e447-e451. doi: 10.1016/j.prro.2019.05.008.
Marka Crittenden, M.D., Ph.D.
Immune response to radiation therapy, cancer, blood coagulation
My research focuses on the regulation of adaptive immune responses myeloid cells that infiltrate tumors following radiation therapy. I am specifically interested in how components of blood coagulation and anticoagulants influence the myeloid and adaptive immune responses following radiation.
Role of the immunosuppressive microenvironment in immunotherapy. Tormoen GW, Crittenden MR, Gough MJ. Adv Radiat Oncol. 2018 Oct 23;3(4):520-526. doi: 10.1016/j.adro.2018.08.018. eCollection 2018 Oct-Dec. Review.
A Temporal Examination of Platelet Counts as a Predictor of Prognosis in Lung, Prostate, and Colon Cancer Patients. Sylman JL, Boyce HB, Mitrugno A, Tormoen GW, Thomas IC, Wagner TH, Lee JS, Leppert JT, McCarty OJT, Mallick P. Sci Rep. 2018 Apr 26;8(1):6564. doi: 10.1038/s41598-018-25019-1.
The Predictive Value of Inflammation-Related Peripheral Blood Measurements in Cancer Staging and Prognosis. Sylman JL, Mitrugno A, Atallah M, Tormoen GW, Shatzel JJ, Tassi Yunga S, Wagner TH, Leppert JT, Mallick P, McCarty OJT. Front Oncol. 2018 Mar 21;8:78. doi: 10.3389/fonc.2018.00078. eCollection 2018. Review.
Nima Nabavizadeh, M.D. and Reid Thompson, M.D., Ph.D.
Clinical and Imaging Informatics
My research focuses on the application of clinical and imaging informatics (radiomics) to improve prediction of treatment response and radiation toxicities. Also, potential applications of artificial intelligence in the radiation oncology clinical workflow. Current projects include evaluation of auto segmentation algorithms of genitourinary structures and reviewing institutional outcomes following radiotherapy in the pediatric population.
Outcomes of carotid-sparing IMRT for T1 glottic cancer: Comparison with conventional radiation. Mohamed ASR, Smith BD, Smith JB, Sevak P, Malek JS, Kanwar A, Browne T, Gunn GB, Garden AS, Frank SJ, Morrison WH, Phan J, Zafereo M, Skinner H, Lai SY, Hutcheson KA, Lewin JS, Hessel AE, Thekdi AA, Weber RS, Fuller CD, Rosenthal DI. Laryngoscope. 2019 Feb 12. doi: 10.1002/lary.27873.
Imaging-Genomic Study of Head and Neck Squamous Cell Carcinoma: Associations Between Radiomic Phenotypes and Genomic Mechanisms via Integration of The Cancer Genome Atlas and The Cancer Imaging Archive. Zhu Y, Mohamed ASR, Lai SY, Yang S, Kanwar A, Wei L, Kamal M, Sengupta S, Elhalawani H, Skinner H, Mackin DS, Shiao J, Messer J, Wong A, Ding Y, Zhang L, Court L, Ji Y, Fuller CD. JCO Clin Cancer Inform. 2019 Feb;3:1-9. doi: 10.1200/CCI.18.00073.
Machine Learning Applications in Head and Neck Radiation Oncology: Lessons From Open-Source Radiomics Challenges. Elhalawani H, Lin TA, Volpe S, Mohamed ASR, White AL, Zafereo J, Wong AJ, Berends JE, AboHashem S, Williams B, Aymard JM, Kanwar A, Perni S, Rock CD, Cooksey L, Campbell S, Yang P, Nguyen K, Ger RB, Cardenas CE, Fave XJ, Sansone C, Piantadosi G, Marrone S, Liu R, Huang C, Yu K, Li T, Yu Y, Zhang Y, Zhu H, Morris JS, Baladandayuthapani V, Shumway JW, Ghosh A, Pöhlmann A, Phoulady HA, Goyal V, Canahuate G, Marai GE, Vock D, Lai SY, Mackin DS, Court LE, Freymann J, Farahani K, Kaplathy-Cramer J, Fuller CD. Front Oncol. 2018 Aug 17;8:294. doi: 10.3389/fonc.2018.00294. eCollection 2018.
Nima Nabavizadeh, M.D.
Exploring the role of cell free DNA as a biomarker to detect and monitor malignancies. Also, refining our understanding of SBRT as a tool to treat early stage non-small cell lung cancer and hepatocellular carcinoma.
Prospectively comparing outcomes using SBRT and Y-90 for definitive treatment of HCC, using cfDNA as a biomarker in colorectal, early stage NSCLC, and esophageal cancers, and reviewing outcomes following neoadjuvant chemoRT in borderline resectable and resectable pancreatic cancer.
Predictors of Nodal and Metastatic Failure in Early Stage Non-small-cell Lung Cancer After Stereotactic Body Radiation Therapy. Cerra-Franco A, Liu S, Azar M, Shiue K, Freije S, Hinton J, Deig CR, Edwards D, Estabrook NC 3rd, Ellsworth SG, Huang K, Diab K, Langer MP, Zellars R, Kong FM, Wan J, Lautenschlaeger T. Clin Lung Cancer. 2018 Dec 29. pii: S1525-7304(18)30353-X. doi: 10.1016/j.cllc.2018.12.016.
An advanced case of extramammary Paget disease: Safe and effective treatment in an inoperable elderly patient using extensive en face electron irradiation. Valle L, Deig C, Wright R, High W. JAAD Case Rep. 2018 Dec 9;5(1):72-74. doi: 10.1016/j.jdcr.2018.08.010. eCollection 2019 Jan.
Histology, Tumor Volume, and Radiation Dose Predict Outcomes in NSCLC Patients After Stereotactic Ablative Radiotherapy. Shiue K, Cerra-Franco A, Shapiro R, Estabrook N, Mannina EM, Deig CR, Althouse S, Liu S, Wan J, Zang Y, Agrawal N, Ioannides P, Liu Y, Zhang C, DesRosiers C, Bartlett G, Ewing M, Langer MP, Watson G, Zellars R, Kong FM, Lautenschlaeger T. J Thorac Oncol. 2018 Oct;13(10):1549-1559. doi: 10.1016/j.jtho.2018.06.007. Epub 2018 Jun 27.
Resident published research
Resident Research News
October 23, 2019
Blair Murphy, M.D. attended the The 51th Congress of the “Société Internationale d'Oncologie Pédiatrique” (SIOP) in Lyon, France. The conference aim is to bring together pediatric and radiation oncologists, surgeons, nurses, and survivors and families to engage in cutting-edge science, engaging debates and networking.
September 16, 2019
Aasheesh Kanwar, M.D., Blair Murphy, M.D., Chris Deig, M.D. and Garth Tormoen, M.D., PhD attended the 61st ASTRO annual meeting. Drs. Murphy, Deig and Tormoen were presenters. Radiation Medicine Presentations
July 24, 2019
Aasheesh Kanwar, MD, PGY-3 resident, attended the inaugural State of Data Science in Radiation Oncology Workshop in Bethesda, Maryland. The workshop highlighted the major domains of data science knowledge and research within the field of radiation oncology.
June 22, 2019
PGY-2 resident, Chris Deig, MD, attended the 21st Methods in Clinical Cancer Research (MCCR) in Zeist, Netherlands. The workshop is designed to educate and train early-career investigators in the best practices of clinical trial design.