MR Dementia Brain WWO Neuro Protocol

Last updated: 4/15/22
Charge as: Brain WWO
Scanner preference: 3T only
Coil: Head

Exam data must include: Age/DOB, Exam Date, Gender, and ID

  • Landmark at nasion/glabella (±50mm), you must re-landmark in the brain if another body part is scanned first.
  • Keep the 3D box as straight as possible.
  • No patients with shunts or major artifact-causing items.
  • Braces are usually okay, if there is not a great deal of motion, keep head tightly padded.
  • Kyphosis prop up hips not head coil.
  • Keep patient at Isocenter For patients with small heads and long necks or large heads:
    • Keep FOV box positioned higher than normal but not beyond ±50mm from glabella
    • May need to reduce/enlarge the FOV for the individual (not beyond 24 - 25.6)
    • FOV must include all of scalp, nose and chin.

Required Scan Parameters

NeuroQuant System-specific Parameter Details

Following parameters remain consistent:

1. Plane – sagittal
2. Mode – 3D
3. T1 weighted - Always
4. Matrix – 192 x 192
5. NEX / NSA – 1
6. Slice thickness – 1.2 mm
7. Spacing – 1.2 mm
8. Number of slices – 160 - 170
9. FOV 24 – 25.6

NOTE: Some NeuroQuant parameters vary depending on scanner manufacturer & field strength

NeuroQuant Failures (And How to Avoid Them)

Patient Motion

  • Run NeuroQuant sagittal 3D first
  • Pad head securely
  • Use all motion reduction techniques except changing scan parameters


  • Surgical resections, shunts, metal (some are not compatible)
  • Incompatible with NeuroQuant
  • Tumors > 15cc
  • Contrast media - scan Non Contrast


  • Follow recommended scan parameters

Tissue contrast Error

  • Put saline bags on either side of patient's head
  • Sat bands
  • Follow recommended scan parameters

Incorrect landmark

  • Must landmark at nasion/glabella
  • Can be ± 50mm from Nasion - should be as close as possible in all 3 planes
  • Re - landmark, if C-spine was done first as part of a double study

Network Issue

  • Echo test failure – call your network admin
  • Resend series
  • Error report “Series is missing slices”

Unsupported MR Sequence

  • Delete incorrect series from queue monitor
  • Resend Sag 3D T1 series

Sending Neuroquant Images

Step 1. No Post Processing or Reformatting
Do not reformat or do any post-processing to the NeuroQuant Series. This will cause errors in the DICOM tags that can cause NeuroQuant to reject the Images.

Step 2. Send Images Immediately to the Appropriate Node
As soon as you acquire the NQ series, send it to the appropriate node. This allows processing time while the study is completed. NQ processing takes about 15-30 minutes

  • Multiple Sclerosis: Send to NQ_MS.
  • Epilepsy: Send to NQ_EPILEPSY
  • Dementia: Send to NQ_DEMENTIA

Step 3. Check to make sure the correct report(s) are generated in PACS. If there are errors, email Joe and Wayne.

  • NQ_MS. Generates 1 report: Multistructure Atrophy
  • NQ_EPILEPSY. Generates 3 reports: Age-Related Atrophy, Multistructure Atrophy, and Triage Brain Atrophy 
  • NQ_DEMENTIA. Generates 3 reports: Hippocampal Asymmetry, Multistructure Atrophy, and Triage Brain Atrophy
Plane Weighting Mode Slice (mm) Gap (mm) FAT SAT FOV (cm) MPR Notes
SAG T1 3D TFE 1.2 (160-170 slices) 0 no 24-25.6 no Send to NQ_Dementia. See specific NeuroQuant 3D T1 scan parameters above.
AXIAL T2 3D TSE 1 0 no 23 no Angle to Corpus. Cover at least 1cm above vertex through skull base. Cover entire nose.
AXIAL DWI EPI 3 0.3 YES 23 no Angle to Corpus. Cover Skull Base to Vertex. Send only B1000 & ADC.
AXIAL SWI 3D GRE 2 -1 no 23 no Angle to Corpus. Cover skull base to vertex. Ok to add slices.
Contrast Injection
SAG T2 FLAIR 3D IR-TSE 1 0 YES 23 AXIAL, COR Angle to interhemispheric fissure. Cover ears and nose. Spacing and gap are variable.
SAG T1 3D TSE 1 0 YES 23 AXIAL, COR Angle to interhemispheric fissure. Cover at least 1cm above vertex through skull base. Cover entire nose.