Nancy L. Haigwood, Ph.D.

  • Professor, Oregon National Primate Research Center
  • Molecular Microbiology and Immunology Graduate Program, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine

Biography

Dr. Haigwood earned her B.S. with Honors in Zoology and her Ph.D. in molecular biology and immunology at the University of North Carolina at Chapel Hill. She completed a postdoctoral fellowship in virology at The Johns Hopkins University, after which she spent 17 years in the biotechnology and pharmaceutical sector. Her laboratory was at Chiron Corporation (Novartis) in Emeryville, California, and at the Bristol-Myers Squibb Pharmaceutical Research Institute in Seattle, Washington.  From 1994-2007, she was a Professor of Microbiology and Pathobiology at the University of Washington and Member at SBRI (now Seattle Children’s). Since 1986, her research has been primarily on HIV and AIDS in nonhuman primate models, with a focus on vaccine discovery and the use of HIV neutralizing antibodies to treat infants exposed to HIV. This research was pivotal in establishing the value of passive antibody therapy to treat and clear HIV infection in infants exposed at birth or by breastfeeding, and this therapy is currently showing great promise in clinical testing. She was recruited to OHSU in 2007 to become the fifth director of the Oregon National Primate Research Center (2002-2022) and a Professor of Pathobiology & Immunology, where she has led a highly funded research program until her planned retirement as Professor Emerita in April 2026. In recognition of her scientific achievements, she was elected to the American Academy of Microbiology in 2014. Dr. Haigwood served for many years on councils and review panels at the National Institutes of Health as a volunteer board member for the Cascade AIDS Project and for ARCS Oregon. She is an advocate for science education and outreach to the public and serves as the steering committee chair for the U.S. Animal Research Openness Initiative. She currently chairs the Scientific Review Committee for the Medical Research Foundation and serves on the OHSU Foundation Board.

Education and training

  • Degrees

    • Ph.D., 1980, University of North Carolina at Chapel Hill
  • Fellowship

    • Postdoctoral fellowship, Johns Hopkins University, 1979-1981

Memberships and associations:

  • American Society for Microbiology
  • American Association of Immunologists
  • International AIDS Society
  • Associate Editor, Journal of Virology 2000-2016
  • Editorial Board, AIDS, 2009-10 and 2016-present
  • Office of AIDS Research Advisory Council, 2002-2005
  • US-Japan Cooperative Medical Science Program (AIDS panel); retired U.S. Chairman, 2003-10
  • Board of Scientific Counselors, NCI, NIH 2006-2008
  • Scientific Advisory Committee, International AIDS Vaccine Initiative, 2007-2012
  • NIH Council of Councils, 2013-2015
  • National Association for Biomedical Research, Executive Board 2013-2016
  • Board of Scientific Counselors, Vaccine Research Center, NIAID, NIH 2011-2021
  • Achievement Rewards for College Scientists (ARCS) Foundation Oregon, 2017-present
  • U.S. Animal Research Openness Initiative, Chairman, 2020-present
  • Oregon Health & Science University Foundation Board of Trustees, 2023-present
  • American Society for Microbiology Council on Microbial Sciences (COMS), 2023-2027

Areas of interest

  • HIV and AIDS
  • SARS Coronavirus-2
  • Transmission of HIV to children (perinatal transmission)
  • Nonhuman primate models for human disease
  • Antibody-based therapies for infectious diseases
  • Viral vaccines
  • Viral pathogenesis and immunity

Honors and awards

  • Bachelor of Science with Honors in Zoology, 1973
  • Alpha Epsilon Delta honor society
  • Irene F. Lee Award, UNC Outstanding Senior Woman, 1973
  • Fellow of the American Academy of Microbiology, 2014
  • Australasian Society for Immunology Visiting Speaker, 2017
  • Cascade AIDS Project 2017 Action Award in recognition of outstanding volunteer service to this AIDS service organization
  • The Buster & Nancy D. Alvord Award to Dr. Nancy L. Haigwood and the U.S. Animal Research Openness Initiative, Northwest Association for Biomedical Research, September 22, 2022
  • Cascade AIDS Project 2022 “Hero of HIV” individual award

Publications

Selected publications

  •     Steimer KS, Scandella CJ, Skiles PV, Haigwood NL. Neutralization of divergent HIV-1 isolates by conformation-dependent human antibodies to Gp120. Science. 1991 Oct 4;254(5028):105-8. doi: 10.1126/science.1718036. PMID: 1718036.
  •     Igarashi T, Brown C, Azadegan A, Haigwood N, Dimitrov D, Martin MA, Shibata R. Human immunodeficiency virus type 1 neutralizing antibodies accelerate clearance of cell-free virions from blood plasma. Nat Med. 1999 Feb;5(2):211-6. doi: 10.1038/5576. PMID: 9930870.
  •     Ng CT, Jaworski JP, Jayaraman P, Sutton WF, Delio P, Kuller L, Anderson D, Landucci G, Richardson BA, Burton DR, Forthal DN, Haigwood NL. Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques. Nat Med. 2010 Oct;16(10):1117-9. doi: 10.1038/nm.2233. Epub 2010 Oct 3. PMID: 20890292; PMCID: PMC2952052.
  •     Jaworski JP, Kobie J, Brower Z, Malherbe DC, Landucci G, Sutton WF, Guo B, Reed JS, Leon EJ, Engelmann F, Zheng B, Legasse A, Park B, Dickerson M, Lewis AD, Colgin LM, Axthelm M, Messaoudi I, Sacha JB, Burton DR, Forthal DN, Hessell AJ, Haigwood NL. Neutralizing polyclonal IgG present during acute infection prevents rapid disease onset in simian-human immunodeficiency virus SHIVSF162P3-infected infant rhesus macaques. J Virol. 2013 Oct;87(19):10447-59. PMID: 23885083; PMCID: PMC3807376.
  •    Hessell AJ, Jaworski JP, Epson E, Matsuda K, Pandey S, Kahl C, Reed J, Sutton WF, Hammond KB, Cheever TA, Barnette PT, Legasse AW, Planer S, Stanton JJ, Pegu A, Chen X, Wang K, Siess D, Burke D, Park BS, Axthelm MK, Lewis A, Hirsch VM, Graham BS, Mascola JR, Sacha JB, Haigwood NL. Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques. Nat Med. 2016 Apr;22(4):362-8.  Epub 2016 Mar 21. PMID: 26998834; PMCID: PMC498310
  •     Hessell AJ, Powell R, Jiang X, Luo C, Weiss S, Dussupt V, Itri V, Fox A, Shapiro MB, Pandey S, Cheever T, Fuller DH, Park B, Krebs SJ, Totrov M, Haigwood NL, Kong XP, Zolla-Pazner S. Multimeric Epitope-Scaffold HIV Vaccines Target V1V2 and Differentially Tune Polyfunctional Antibody Responses. Cell Rep. 2019 Jul 23;28(4):877-895.e6. doi: 10.1016/j.celrep.2019.06.074. PMID: 31340151; PMCID: PMC6666430.
  •     Shapiro MB, Cheever T, Malherbe DC, Pandey S, Reed J, Yang ES, Wang K, Pegu A, Chen X, Siess D, Burke D, Henderson H, Lewinsohn R, Fischer M, Stanton JJ, Axthelm MK, Kahl C, Park B, Lewis AD, Sacha JB, Mascola JR, Hessell AJ, Haigwood NL. Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity. Nat Commun. 2020 Jan 7;11(1):70. doi: 10.1038/s41467-019-13972-y. PMID: 31911610; PMCID: PMC6946664.
  •  Streblow DN, et al. Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology. Nat Commun. 2023 Nov 3;14(1):7062. doi: 10.1038/s41467-023-42440-x. PMID: 37923717; PMCID: PMC10624670.
  •     Shapiro MB, Ordonez T, Pandey S, Mahyari E, Onwuzu K, Reed J, Sidener H, Smedley J, Colgin LM, Johnson A, Lewis AD, Bimber B, Sacha JB, Hessell AJ, Haigwood NL. Immune perturbation following SHIV infection is greater in newborn macaques than in infants. JCI Insight. 2024 Aug 27;9(19):e144448. doi: 10.1172/jci.insight.144448. PMID: 39190496; PMCID: PMC11466190.
  •    Pitchai FNN, Tanner EJ, Khetan N, Vasen G, Levrel C, Kumar AJ, Pandey S, Ordonez T, Barnette P, Spencer D, Jung SY, Glazier J, Thompson C, Harvey-Vera A, Son HI, Son HI, Strathdee SA, Holguin L, Urak R, Burnett J, Burgess W, Busman-Sahay K, Estes JD, Hessell A, Fennessey CM, Keele BF, Haigwood NL, Weinberger LS. Engineered deletions of HIV replicate conditionally to reduce disease in nonhuman primates. Science. 2024 Aug 9;385(6709):eadn5866. Epub 2024 Aug 9. PMID: 39116226; PMCID: PMC11545966