Molecular and Medical Genetics Genome Science Seminar Series
The Genome Sciences Hub integrates basic science and clinical faculty across OHSU who work in disciplines of genetics and genomics, epigenetics, rare disease genetics, genome technologies and computational biology, stem cell and developmental biology, cancer genetics, and gene therapy. Faculty within the Hub apply multidisciplinary approaches, including single gene and single cell technologies, gene therapies, transcriptional pathway and whole genome analyses, and animal models of disease.
The interdisciplinary nature of this Hub is based on the combined basic science and clinical composition of the Department of Molecular & Medical Genetics that will cultivate interactions between the basic sciences and the clinical researchers and practitioners. The goals of the Genome Sciences Seminar Series are to facilitate interactions among faculty and trainees and to provide an opportunity to expand breadth and depth of knowledge in a variety of Genetic research areas that both complement and expand attendees areas of research focus. The Genome Sciences seminar will host 4 to 5 outside speakers for the benefit of the entire OHSU science community. We will also host OHSU faculty and trainees or students and postdoctoral fellows throughout the year.
Time: Mondays, September through June 12-1pm
Streaming live via WebEx.
Email MMGoffice@ohsu.edu for links
September 25, 2023
Seminar Title: “T2T-scale genome assemblies: shining a light on repeats, dynamic centromeres and chromosome evolution”
Presented by: Presented by: Rachel J. O’Neill, P.h.D. Department of Molecular and Cell Biology, University of Connecticut
October 2, 2023
Seminar Title: “Accessing Data Resources: All of Us and the Health Oregon Project.”
Presented by: Wesley Stoller and Paige Farris, Knight Cancer Institute, OHSU
October 9, 2023
No Molecular and Medical Genetics Genome Science Seminar
October 16, 2023
Seminar Title: “Effects of Maternal Western-Style Diet on Fetal Hematopoiesis and Immunity in Rhesus Macaques.”
Presented by: Oleg Varlamov, Ph.D. Oregon National Primate Research Center, OHSU
October 23, 2023
Seminar Title: “Molecular basis for maternal inheritance of human mitochondrial DNA”.
Presented by: Dmitry Temiakov, Ph.D, Dept. Biochemistry & Molecular Biology, Thomas Jefferson University
October 30, 2023
Seminar Title: “Single-cell RNA-seq provides high-resolution identification and characterization of antigen-specific T cells”
Presented by: Benjamin Bimber, Ph.D. Oregon National Primate Research Center, OHSU
November 6, 2023
Seminar Title: “Cell Type Evolution and Vulnerabilities in the Primate Brain”
Presented by: Alex Pollen, Ph.D. Department of Neurology University of California-San Francisco
November 13, 2023
Seminar Title: "Epigenetic dysfunction in myeloid leukemias"
Presented by: Julia Maxson, Ph.D., OHSU Knight Cancer Institute, School of Medicine, OHSU
November 20, 2023
No Molecular and Medical Genetics Genome Science Seminar
November 27, 2023
Seminar Title: “Vertical and horizontal transmission of mtDNA”
Presented by: Shoukhrat Mitalipov, Ph.D., Oregon National Primate Research Center, OHSU
December 4, 2023
No Molecular and Medical Genetics Genome Science Seminar
December 11, 2023
Seminar Title: "Diverse molecular and neurodevelopmental phenotypes across the Tbr1 allelic spectrum"
Presented by: Marissa Co, Ph.D., Molecular and Medical Genetics, OHSU
December 18, 2023
No Molecular and Medical Genetics Genome Science Seminar
December 25, 2023
No Molecular and Medical Genetics Genome Science Seminar
January 1, 2024
No Molecular and Medical Genetics Genome Science Seminar
January 8, 2024
Seminar Title: Urea Cycle Disorders: From Diet Assessment to Gene Therapy
Presented by: Cary O. Harding, MD and Melanie B. Gillingham, PhD, RD
January 15, 2024
No Molecular and Medical Genetics Genome Science Seminar
January 22, 2024
Seminar Title: "Leveraging rare disease models to advance scientific and therapeutic discovery"
Presented by: Ashleigh E Schaffer, PhD, Department of Genetics and Genome Sciences and Center for RNA Science and Therapeutics Case Western Reserve University
January 29, 2024
Seminar Title: "Targeting haploinsufficient essential genes for the treatment of -7/del(7q)hematological malignancies"
Presented by: Haijiao Zhang, M.D., Division of Oncological Sciences, Knight Cancer Institute, OHSU
February 5, 2024
Seminar Title: "Schizophrenia and glycosylation: from genes to neurobiology to treatments"
Presented by: Robert Mealer, M.D., Ph.D., Psychiatry, OHSU
February 12, 2024
Presented by: Kevin MacPherson, Molecular and Medical Genetics, OHSU
February 19, 2024
No Molecular and Medical Genetics Genome Science Seminar
February 26, 2024
Seminar Title: "Reciprocal genomic disorders: rare variant windows into brain development and disease"
Presented by: Xander Nuttle, Ph.D., MMG faculty candidate visiting from Center for Genomic Medicine, Massachusetts General Hospital
March 4, 2024
Seminar Title: "From synapse to behavior: astrocyte-neuron interactions in neurodevelopment and Rett Syndrome"
Presented by: Krissy Lyon, Ph.D., MMG Faculty candidate visiting from The Salk Institute for Biological Studies
March 11, 2024
Seminar Title: "Stem Cells, Trabecular Meshwork, and Primary Open Angle Glaucoma"
Presented by: Mary Kelley Ph.D., Casey Eye Institute, OHSU
March 18, 2024
Seminar Title: "SCN2A related autism and epilepsy: from mouse and hiPSCs models to genetic medicine"
Presented by: Yang Yang, Ph.D., Department of Medicinal Chemistry and Molecular Pharmacology at Purdue University
March 25, 2024
No Molecular and Medical Genetics Genome Science Seminar
April 1, 2024
Seminar Title: "No brain? No problem! Using planarians to understand brain regeneration at the single-cell level"
Presented by: Bret Pearson, Ph.D., Professor of Pediatrics, School of Medicine, OHSU
April 2, 2024
Seminar Title: “Understanding and Targeting Energy Failure in Neurodegeneration”
Presented by: Neal Bennett, Ph.D., MMG faculty candidate visiting from Gladstone Institute of Neurological Disease at UCSF
April 8, 2024
Seminar Title: "Fast night thoughts on liver-directed gene editing"
Presented by: Cary Harding, M.D., Molecular and Medical Genetics, OHSU
April 15, 2024
Seminar Title: "CoMo DB: CoMorbdity DataBase of Severe Male Infertility in Multiple Model Organisms".
Presented by: Caitlin Peaslee, Graduate Program in Biomedical Sciences Students, Molecular and Medical Genetics, OHSU
April 22, 2024
Seminar Title: "High-throughput single cell whole genome sequencing: A key to understanding cancer development"
Presented by: Konstantin Queitsch, Graduate Program in Biomedical Sciences Students, School of Medicine, Molecular and Medical Genetics, OHSU
April 29, 2024
Seminar Title: "Understanding how mutations in microbial signaling molecules control infection vs. autoimmunity"
Presented by: Ruth Napier, Molecular Microbiology and Immunology, School of Medicine, OHSU
May 6, 2024
Seminar Title:
Presented by: To Be Announced
May 13, 2024
Seminar Title:
Presented by: Kathryn Chatfield, MD, PhD, University of Colorado
May 20, 2024
Seminar Title:
Presented by: Eve Lowenstein, Molecular and Medical Genetics, OHSU
May 27, 2024
No Molecular and Medical Genetics Genome Science Seminar
June 3, 2024
Seminar Title:
Presented by: To Be Announced
June 10, 2024
Seminar Title:
Presented by: Michael Martinez, Molecular and Medical Genetics, OHSU
September 26, 2022
Seminar Title: "Evolution of ultra low specificity S100 proteins"
Presented by: Michael Harms, PhD
October 3, 2022
Seminar Title: "Investigations into the Behavioral, Cognitive, and Neurophysiological Phenotypes of PKU Mice"
Presented by: Cary Harding
October 10, 2022
No Molecular and Medical Genetics Genome Science Seminar
October 17, 2022
Seminar Title: "Investigating genome topology through the lens of evolution"
Presented by: Lucia Carbone, PhD
October 24, 2022
No Molecular and Medical Genetics Genome Science Seminar
October 31, 2022
No Molecular and Medical Genetics Genome Science Seminar
November 7, 2022
Presented by: Joel Meyer, PhD
November 14, 2022
Seminar Title: "Healthy Oregon Project: Origination, Status, and Opportunities"
Presented by: Paul Spellman, PhD
November 21, 2022
No Molecular and Medical Genetics Genome Science Seminar
November 28, 2022
Seminar Title: "Programming and reprogramming of pancreatic cancer"
Presented by: Jungsun Kim, PhD, Assistant Professor
December 5, 2022
Seminar Title: "Gaucher Disease: How a Rare Disease Provides a Window into Common Neurodegenerative Disorders"
Presented by: Ellen Sidransky, M.D.
December 12, 2022
Seminar Title: Critical windows of DNA methylation loss after Assisted Reproductive Technology
Presented by: Lisa Vrooman
December 19, 2022
No Molecular and Medical Genetics Genome Science Seminar
December 26, 2022
No Molecular and Medical Genetics Genome Science Seminar
January 2, 2023
No Molecular and Medical Genetics Genome Science Seminar
January 9, 2023
No Molecular and Medical Genetics Genome Science Seminar
January 16, 2023
No Molecular and Medical Genetics Genome Science Seminar
January 23, 2023
Seminar Title: Investigation of the role of TUBGCP4 and TUBGCP6 in the development of the retinal vasculature
Presented by: Lesley Everett
January 30, 2023
Seminar Title: "Advances in Single-cell Combinatorial Indexing in Neuroscience and Cancer"
Presented by: Andrew Adey PhD, Associate Professor Molecular and Medical Genetics
February 6, 2023
Seminar Title: “The arc of a career: PKAN pathogenesis and treatment”
Presented by: Susan Hayflick, M.D., Ph.D. Chair, Department of Molecular & Medical Genetics
Professor, Departments of Molecular & Medical Genetics, Pediatrics, and Neurology, Oregon Health & Science University
February 13, 2023
Seminar Title: "LCHADD chorioretinopathy: pathophysiology and potential treatments"
Presented by: Melanie Gillingham, PhD Associate Professor of Molecular and Medical Genetics, School of Medicine
February 20, 2023
No Molecular and Medical Genetics Genome Science Seminar
February 27, 2023
Seminar Title: "Post-Translational Activation of MYC Promotes Aggressive, Liver Metastatic Pancreatic Ductal Adenocarcinoma"
Presented by: Rosie Sears, Ph.D. Professor of Molecular and Medical Genetics, School of Medicine
March 6, 2023
Seminar Title: "Investigating the role of the Amyloid Precursor Protein Intracellular Domain in Sleep and Circadian Disruption"
Presented by: Dani Long, PhD Postdoctoral Scholar CR.Oregon Institute of Occupational Health Science
March 13, 2023
Seminar Title: "In Vivo Expansion of Gene-Edited Hepatocytes for Liver-Directed Gene and Cell Therapy"
Presented by: Anne Vonada, Graduate Student
March 20, 2023
No Molecular and Medical Genetics Genome Science Seminar
March 27, 2023
No Molecular and Medical Genetics Genome Science Seminar
April 3, 2023
Seminar Title: "Gamma Prime Fibrinogen and COVID-19: Who Knew?"
Presented by:David H. Farrell, Professor
April 10, 2023
Seminar Title: “Characterizing the chorioretinopathy in a LCHADD mouse model”
Presented by: Shannon Babcock, Graduate Student, Department of Molecular and Medical Genetics, OHSU
April 17, 2023
Seminar Title: "Optimizing Lipid Nanoparticles for Gene Editing in the Retina"
Presented by: Renee Ryals, PhD Assistant Professor, Department of Ophthalmology Casey Eye Institute Oregon Health & Science University
April 24, 2023
Seminar Title: “Investigating the Formation and Rupture of Micronuclei and the Consequence of Cytosolic DNA Release in Early Mammalian Embryogenesis”
Presented by: Jacqueline Budrewicz, Department of Molecular and Medical Genetics, OHSU
May 1, 2023
Seminar Title: "Succeses and Challenges of CRISPR/CAS9 Gene Editing in Vivo"
Presented by: Lev Fedorov, PhD, Res Assist Professor Director of the Transgenic Core Lab (TMM),USR program, OHSU
May 8, 2023
Seminar Title: "Rethinking the roles of p53 in tumor suppression"
Presented by: Wei Gu, Ph.D., Professor, Dept of Pathology and Cell Biology and Institute of Cancer Genetics, Columbia University
May 15, 2023
Seminar Title: "Chromatin Accessibility Profiling of Human Pancreatic Tumors Reveals Epigenetic Features of Transcriptional Subtype and Malignancy"
Presented by: Kevin MacPherson, Graduate Student, Department of Molecular and Medical Genetics, OHSU
May 22, 2023
Seminar Title: “Single-cell, single-virion genomic methods for studying brain cell connectivity & host-virus interactions”
Presented by: Arpiar Sanders, PhD Assistant Professor in the Saunders Lab Vollum Institute, OHSU
May 29, 2023
No Molecular and Medical Genetics Genome Science Seminar
June 5, 2023
Seminar Title: "A Mutation-Independent CRISPR/Cas9-mediated Gene Integration Approach to Treat Murine PKU"
Presented by: Michael Martinez, Graduate Student, Department of Molecular and Medical Genetics, OHSU
June 12, 2023
Seminar Title: "Validating actin-related candidate gene from single-cell sequencing data using behavioral assays in Drosophila tauopathy model"
Presented by: Eve Lowenstein, Graduate Student, Department of Molecular and Medical Genetics, OHSU
September 27, 2021
Presented by: Abdenour Soufi, Ph.D
Seminar Title: "Mechanistic insights into controlling cell identity by transcription factors"
October 4,2021
Presented by: R. Stephen Lloyd, PhD
Seminar Title: "Drivers of hepatocellular carcinogenesis – roles of DNA repair and replication"
October 11, 2021
Presented by: John Brigande, PhD
Seminar Title: "Gene Therapy for Congenital Deafness"
October 18, 2021
No Molecular and Medical Genetics Genome Science Seminar
October 25, 2021
Presented by: Dwight Koeberl, MD, PhD
Seminar Title: "AAV gene therapy for glycogen storage diseases"
November 1, 2021
Presented by: Oleg Varlamov, PhD
Seminar Title: "Maternal Diet Modulates Developmental Hematopoiesis in Rhesus Macaques"
November 8, 2021
Presented by: Eric Goetzman, PhD
Seminar Title: “Alternative medium-chain fatty acid therapies”
November 15, 2021
Presented by: Claudio Mello MD, PhD
Seminar Title: “Comparative genomics provides insights into lineage-specific features in birds”
November 22, 2021
No Molecular and Medical Genetics Genome Science Seminar
November 29, 2021
Presented by: Mushui Dai, PhD
Seminar Title: "A novel SUMO ligase function of USP36 in ribosome biogenesis."
December 6, 2021
Presented by: Joshua Saldivar, PhD
Seminar Title: “Nuclear dynamics coordinating DNA replication and transcription”
December 13, 2021
No Molecular and Medical Genetics Genome Science Seminar
December 20, 2021
No Molecular and Medical Genetics Genome Science Seminar
December 27, 2021
No Molecular and Medical Genetics Genome Science Seminar
January 3, 2022
No Molecular and Medical Genetics Genome Science Seminar
January 10, 2022
Presented by: Daniel Liefwalker, PhD
Seminar Title: "Lipid biosynthesis is a metabolic liability in oncogene-driven hematopoietic malignancies"
January 17, 2022
No Molecular and Medical Genetics Genome Science Seminar
January 24, 2022
Presented by: Marissa Co, PhD
Seminar Title: “Shared and distinct functional effects of patient-specific Tbr1 mutations on cortical development"
January 31, 2022
Presented by: Ayumu Konno Ph.D.
Seminar Title: "Cell type-specific promoters in brain cells for AAV vectors"
February 7, 2022
Presented by: Taisuke Furusho, PhD
Seminar Title: "AAV mediated gene therapy for kidney disease"
February 14, 2022
Presented by: Scott Kennedy
Seminar Title: "Mysteries of Mitochondrial Mutagenesis"
February 21, 2022
No Molecular and Medical Genetics Genome Science Seminar
February 28, 2022
No Molecular and Medical Genetics Genome Science Seminar
March 7, 2022
No Molecular and Medical Genetics Genome Science Seminar
March 14, 2022
Presented by: Gurkan Galip Yardimci
Seminar Title: "Characterization of cell state via modeling of multi-omics data"
March 21, 2022
No Molecular and Medical Genetics Genome Science Seminar
March 28, 2022
No Molecular and Medical Genetics Genome Science Seminar
April 4, 2022
Presented by: Anne Vonada
Seminar Title: “Drug-Mediated Expansion of Gene-Edited Hepatocytes In Vivo”
April 11, 2022
No Molecular and Medical Genetics Genome Science Seminar
April 18, 2022
Presented by: Eve Lowenstein
Seminar Title: "Investigating nuclear organization in a Drosophila melanogaster human tauopathy model"
April 25, 2022
Presented by: Kevin MacPherson
Seminar Title: "Single cell analysis of pancreatic ductal adenocarcinoma"
May 2, 2022
Presented by: Steve S Rich, PhD
Seminar Title: "From Bench to Bedside to Community in Type 1 Diabetes"
May 9, 2022
Presented by: Tiffany DeVine
Seminar Title: "LCHAD deficiency in an iPSC-derived Retinal Pigment Epithelium model"
May 16, 2022
Presented by: Zinab Doha
Seminar Title: "Modeling the heterogeneity and therapeutic response of Triple-negative breast cancer''
May 23, 2022
Presented by: Shannon Babcock
Seminar Title: "Studying Molecular Mechanisms of LCHADD Chorioretinopathy Using LCHADD Mouse Model"
May 30, 2022
No Molecular and Medical Genetics Genome Science Seminar
June 6, 2022
Presented by: Michael Martinez
Seminar Title: "Methods to Enhance In Vivo Gene Editing for Treatment of Phenylketonuria"
June 13, 2022
No Molecular and Medical Genetics Genome Science Seminar
October 5, 2020
Presented by: Thomas M. Vondriska, Ph.D. University of California
Seminar Title: "A chromatin structural model for complex cardiovascular disease"
October 12, 2020
Presented by: Gail Mandel, Ph.D., Senior Scientist, Vollum Institute
Seminar Title: "Rett syndrome: Insights from a rare disorder"
October 19, 2020
Presented by: Jonathan Brody, Ph.D. Director of Surgical Research
Seminar Title: "Can we target an element of pancreatic cancer cells’ pro-survival phenotype?"
October 26, 2020
Presented by: Nathalie Pamir, Ph.D., Depts. of Medicine & Biochemistry
Seminar Title: "High density lipoprotein in cardiovascular disease and stroke among Whites and Blacks: The good cholesterol not so good in Blacks"
November 2, 2020
Presented by: Lea M. Starita, Ph.D. Research Assistant Professor, Genome Sciences, University of Washington
Seminar Title: "Getting to community surveillance for COVID-19"
November 9, 2020
Presented by: Ellen Langer, Ph.D., OHSU
Seminar Title: "A role for the prolyl isomerase PIN1 in fibroblast activation in pancreatic cancer"
November 16, 2020
Presented by: Allison Allen, M.D
Seminar Title: "cfDNA for Monogenic Disorders"
November 30, 2020
Presented by: Dr. Alejandro Lomniczi, Research Assistant Professor, Oregon National Primate Research Center
Seminar Title: "Epigenetic Writers, Readers and Erasers in the Control of Female Puberty"
December 7, 2020
Presented by: Cedric Feschotte, Ph.D. Professor, Department of Molecular Biology and Genetics, Cornell University
Seminar Title: "Fighting Fire with Fire: Endogenous Retroviruses Boost Human Immunity"
January 11, 2021
Presented by: Rita Cervera Juanes, Ph.D., OHSU
Seminar Title: "Investigating the neuroepigenome to identify targets for the treatment of alcohol use disorders"
January 25, 2021
Presented by: Adam Krieg, Ph.D., OHSU
Seminar Title: "Physiological Hypoxia As a Regulator of Ovarian Biology"
February 1, 2021
Presented by: Jared Fischer, Ph.D., OHSU
Seminar Title: "Nanomaterials for enhanced viral vector delivery and cancer detection"
February 8, 2021
Presented by: Brenden O'Connell, Ph.D.
February 22, 2021
Presented by: Megan Dennis, Ph.D., UC Davis
Seminar Title: "Using zebrafish to test neurodevelopmental genes important in human disease and evolution"
March 8, 2021
Presented by: Elaine A. Ostrander, Ph.D.
Seminar Title: “Four legs, fuzzy coat, a tail and a woof: How evolution got there”
March 15, 2021
Presented by: Casey Thornton, MMG Graduate Student, Andrew Adey Lab
Seminar Title: "Characterizing glial chromatin accessibility in the human cortex and hippocampus"
April 5, 2021
Presented by: Kevin Costello, Graduate Student, Beckman Research Institute at City of Hope
Seminar Title: "The role of Transposable elements in regulation and evolution"
April 12, 2021
April 19, 2021
Seminar Title: "mRNA therapy for Inborn Error of Metabolism disorders"
April 26, 2021
Presented by: Eve Lowenstein, MMG Graduate Student Adey Lab
Seminar Title: "Effects of frontotemporal dementia associated Tau mutations on nuclear organization in a Drosophila melanogaster human tauopathy model"
May 3, 2021
Presented by: Sara Gosline, Ph.D., P.N.N.L.
Seminar Title: “Harnessing the power of ‘omics in rare disease: Lessons from building cohorts, model systems, and algorithms in Neurofibromatosis 1”
May 10, 2021
Presented by: Alejandro Aballay, Ph.D. Chair, Molecular Microbiology and Immunology, School of Medicine
Seminar Title: "C. elegans as a model host to study the role of the neural-gut axis in immune response against bacterial pathogenetic disease models"
May 17, 2021
Presented by: Carsten Shultz, Ph.D., Chair, Chemical Physiology and Biochemistry, School of Medicine
Seminar Title: "Lessons learned from genetic disease models"
May 24, 2021
Presented by: Zinab Doha, MMG Graduate Student
Seminar Title: "Myc Regulation of The Therapeutic Responses in Triple-Negative Breast Cancer"
June 7, 2021
Presented by: Hisham Mohammed, Ph.D Assistant Professor, Medical and Molecular Genetics
Seminar Title: "Multi-omics single-cell approach reveals transcriptional and epigenetic plasticity in hormone driven cancers "