Graduate Program Curriculum


Advanced Topics in Genome Sciences, MGEN 622  | 3 credits

Course Directors: Anupriya Agarwal, Ph.D., Shawn Chavez, Ph.D. and Haijiao Zhang, M.D.

This course is designed to provide in-depth coverage of topics in Genome Sciences such as the use of genetic systems to probe complex problems, genetic approaches to identify novel genotype-phenotype associations, molecular genetics, single-cell profiling, CRISPR/cas9 editing, and quantitative genetics. Focus areas may include gene regulatory mechanisms and genome regulation underlying development, regeneration, degeneration, stem cell fitness, cancer evolution, and cancer predisposition syndromes. Emphasis will be on recent insights and emerging technologies. Readings will be based on selected reviews and articles from the current literature. Interactive discussions will involve critical analyses of recent research papers.

Applied Epigenetics, MGEN 6253 credits

Course Directors: Lucia Carbone, Ph.D., and Andrew Adey, Ph.D.

This course is focused on discussions involving both students and lecturers and covers topics such as: Waddington epigenetic landscape and cell fate, Epigenetics mechanisms: DNA methylation &histone modifications, Non-coding RNAs and epigenetics, X-inactivation and monoallelic expression, Chromatin structure and organization, Epigenetic inheritance: somatic, meiotic and trans-generational, Genomic imprinting, Epigenetic Reprogramming and Environmental epigenetics.

Genetic Basis of Human Disease MGEN 623 | 3 credits

Course Directors: Amy Yang, M.D., and Brian O’Roak, Ph.D.

A team of faculty experts discusses topics including chromosomal basis of disease, cancer genetics, disorders of energy metabolism, amino acid disorders, blood coagulation disorders, congenital heart defects, disorders of extracellular matrix, platelet disorders, endocrine disorders, and stem cell/gene therapy. Format is reading, journal club, and conference style.

Gene and Cell Therapy, MGEN 624 | 2 credits

Course Directors: Renee Ryals, Ph.D., and Cary Harding, M.D.

This course presents an overview of various gene delivery systems (viral and non-viral), cell-based therapeutic approaches, and their clinical applications. This course will review the most clinically advanced gene- and cell-therapeutics, promising pre-clinical approaches, and common challenges associated with gene- and cell-therapies.

Mechanisms/Cancer Jrnl Club, MGEN 605F/606 | 1 credit

Course Directors: David Qian, Ph.D.

This course introduces students to the critical analysis of original research articles in Cancer Biology. Papers will be analyzed in terms of background, hypothesis, appropriate use of experimental methods, and objective interpretations of results. Covers a wide range of papers in biophysics, biochemistry, genetics, immunology, cell and biology, and pharmacology with an emphasis on seminal discoveries in cancer.

Molecular/Medical Genetics J.C., MGEN 605E | 1 credit

Course Director: Amanda McCullough, Ph.D.

Departmental Seminar Series, MGEN 607 | 1 credit

Course Director: Melanie Gillingham, Ph.D., R.D., L.D.

Genome Sciences integrates basic science and clinical faculty across OHSU who work in disciplines of genetics and genomics, epigenetics, rare disease genetics, genome technologies and computational biology, stem cell and developmental biology, cancer genetics, and gene therapy. The interdisciplinary nature of this seminar series is based on the combined basic science and clinical composition of the Department of Molecular & Medical Genetics that will cultivate interactions between the basic sciences and the clinical researchers and practitioners. The goals of the Genome Sciences Seminar Series are to facilitate interactions among faculty and trainees and to provide an opportunity to expand breadth and depth of knowledge in a variety of Genetic research areas that both complement and expand attendees areas of research focus.

This is a weekly seminar series, with presentations by external and internal genetics researchers that introduces students to new cutting-edge genome research performed in preeminent labs around the country.

Departmental Grand Rounds, MGEN 611 | 1 credit

Course Directors: Amy Yang, M.D., and Jon Zonana, M.D.

Molecular & Medical Genetics Grand Rounds are designed to present and discuss genetic disorders, genomics, and clinical medicine topics. Our department comprises individuals working in clinical medicine and basic science; clinical and translational research topics are presented. During this series, we hear presentations from clinical faculty, research faculty, clinical case presentations, and invited OHSU and outside speakers.

For students enrolled in PBMS, please see the PBMS Program Curriculum.

All courses offered by MMG

For full list of offered courses, please see the MMG Student Handbook.

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