Advanced Topics in Genome Sciences | 3 credits
Course Directors: Anupriya Agarwal, Ph.D. and Shawn Chavez, Ph.D.
This course is designed to provide in-depth coverage of topics in Genome Sciences such as the use of genetic systems to probe complex problems, genetic approaches to identify novel genotype-phenotype associations, molecular genetics, single-cell profiling, CRISPR/cas9 editing, and quantitative genetics. Focus areas may include gene regulatory mechanisms and genome regulation underlying development, regeneration, degeneration, stem cell fitness, cancer evolution, and cancer predisposition syndromes. Emphasis will be on recent insights and emerging technologies. Readings will be based on selected reviews and articles from the current literature. Interactive discussions will involve critical analyses of recent research papers.
Epigenetics | 3 credits
Course Directors: Lucia Carbone, Ph.D., Andrew Adey, Ph.D.
This course is focused on discussions involving both students and lecturers and covers topics such as: Waddington epigenetic landscape and cell fate, Epigenetics mechanisms: DNA methylation &histone modifications, Non-coding RNAs and epigenetics, X-inactivation and monoallelic expression, Chromatin structure and organization, Epigenetic inheritance: somatic, meiotic and trans-generational, Genomic imprinting, Epigenetic Reprogramming and Environmental epigenetics.
Genetic Basis of Human Disease | 3 credits
Course Director: Sue Richards, Ph.D., Wojciech Wiszniewski, M.D., Ph.D.
A team of faculty experts discusses topics including chromosomal basis of disease, cancer genetics, disorders of energy metabolism, amino acid disorders, blood coagulation disorders, congenital heart defects, disorders of extracellular matrix, platelet disorders, endocrine disorders and stem cell/gene therapy. Format is reading, journal club, and conference style.
Gene and Cell Therapy | 2 credits
Course Directors: Hiroyuki Nakai, M.D., Ph.D., Cary Harding, M.D.
The course presents an introductory overview of various gene delivery systems and cell-based approaches;advances in DNA/RNA/peptide delivery, cellular genome engineering and understanding the biology of cells as therapeutics;applications of gene delivery technologies and cell transplantation with a focus on translational research and current issues in gene and cell therapy and regenerative medicine. The course consists of lectures by experts in the relevant fields in a lecture/paper discussion format. Students will be required to write an NIH style research proposal on a relevant topic of their choice and expected to have an oral presentation during the course.
First year curriculum:
Second year curriculum:
Please note, these courses only apply to second year PMCB students. For students enrolled in PBMS, please see the PBMS Program Curriculum.
|Course Name||Course Number||Credits||When|
|Advanced Topics in Genome Sciences||MGEN 622/CANB 622||3||F|
|Journal Club||MGEN 605/606||1||F, W, Sp|
|Departmental Seminar||MGEN 607A||1||F, W, Sp|
|Departmental Grand Rounds||MGEN 611||1||F, W, Sp|
|Genetic Basis of Disease||MGEN 623||3||Sp|
All courses offered by MMG
For full list of offered courses, please see the MMG Student Handbook.
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