M.D./Ph.D. Journal Club

Journal Club is a required course for all MD/PhD students and attendance is required. With a few exceptions including holidays and academic breaks, Journal Club is hosted every Wednesday from 12-1pm in MacKenzie Hall, room 2201. These presentations are open to the public. 

Each MD/PhD student will present a journal article of their choosing 1-2 times each year throughout the entirety of their program. Students ready to defend may use their journal club presentation as a time to run through their dissertation. Approximately once a month a faculty member will present at Journal Club on their research or as a career/professional development session. 

Review Journal Club Guidelines

Upcoming presentations

November 13

Practicing medicine in the era of the smart phone
Cymon Kersch & Logan Jones, Senior Internal Medicine Resident
Google Doc Slides

November 20

Brennan Olson
GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

November 27

No Journal Club: Thanksgiving Break

December

December 4 - Career Development

Susan Gurley, MD, PhD, Associate Professor & Division Head, Nephrology & Hypertension

December 11

Gavin Young

December 18

No Journal Club: Winter Break

December 25

No Journal Club: Winter Break

January

January 8

Aaron Grossberg, MD, PhD, Assistant Professor, Radiation Oncology

January 15

Tony Zheng

January 22

Moriah Arnold

January 29

Rachel Drake

February

February 5

Beth Habecker, PhD, Professor, Chemical Physiology & Biochemistry

February 12

Caroline King

February 19

Landon Bayless-Edwards

February 26

Jackie Emathinger

March

March 4

Alan Hunter, MD, Professor & Division Head, Hospital Medicine; Associate Program Director, OHSU Internal Medicine Residency Program

March 11

Sweta Adhikary

March 18

Sunil Joshi

March 25

Spring Break: No Journal Club

Past presentations

2019

November 6

Inflammatory Microenvironment as Driver of Clonal Selection and Disease Progression in Leukemia
Anupriya Agarwal, PhD, Assistant Professor, Knight Leukemia Center

October 30

Ali Pincus
The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep

October 23
Presenting Well
David Jacoby, MD, Chair & Professor, Medicine; MD/PhD Program Director

October 16

Rick Mathews
Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes

October 9

Sam Huang
Continuous evolution of base editors with expanded target compatibility and improved activity

October 2

Epigenetic Dysfunction in Myeloid Leukemia
Ted Braun, MD, PhD, Instructor, Division of Hematology & Medical Oncology, Knight Cancer Institute

September 25

Burcu Gurun-Demir
Portraits of genetic intra-tumour heterogeneity and subclonal selection across cancer types

September 11

Nichole Tyler
Therapy Decision Support Based on Recommender System Methods

September 4

Ashley Anderson
Niche stiffness underlies the ageing of central nervous system progenitor cells

August 28 - Career Development

Doing What You Love
Donna Hansel, MD, PhD, Chair & Professor, Pathology

August 21

TheAnh Nguyen
Vascular Endothelial Growth Factor Delivery to Placental Basal Plate Promotes Uterine Artery Remodeling in the Primate

August 14

Mollie Marr
Dating the 1700 Cascadia Earthquake: Great Coastal Earthquakes in Native Stories

August 7

Michael Berry
Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells

July 31

Investigating the Neural Circuits of Spinal Cord Stimulation
Andrei Sdrulla, MD, PhD, Assistant Professor, Anesthesiology & Perioperative Medicine
 

July 24

Sudarshan Iyer
Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

July 17

Gina Calco
Thermal stress induces glycolytic beige fat formation via a myogenic state

July 10

Kristen Stevens
Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features

June 26

John Butler
3MT: Episomes, bad acronyms and h-index: A discussion on the low end of the yield spectrum
Followed by a roundtable discussion

June 19

John Butler
Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro

June 12

Will Yashar
First M87 Event Horizon Telescope Results. I. The Shadow of the Supermassive Black Hole

June 5 - Career Development

Diagnostic Reasoning
Peter Sullivan, MD, FACP, Associate Professor, Division of Hospital Medicine

May 29

Natasha Warikoo
Integrating time from experience in the lateral entorhinal cortex

May 22

Tony Zheng
Contractile forces in platelet aggregates under microfluidic shear gradients reflect platelet inhibition and bleeding risk

May 15

Sweta Adhikary
Restoration of brain circulation and cellular functions hours post-mortem

May 8

Caroline King
The Share Project: Building Capacity of Justice-Involved Individuals, Policymakers, and Researchers to Collectively Transform Health Care Delivery

May 1

ELQ-300 and other anti-malarial medications
Michael Riscoe, PhD, Professor, Molecular Microbiology and Immunology

April 24

Retreat Keynote Speaker Introduction: Sandra Davidge, PhD
Rachel Drake

April 17

Jackie Emathinger
Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming

April 10

Machine Learning
Gavin Young
Dermatologist-level classification of skin cancer with deep neural networks
Deep learning

April 3

In vivo Molecular Imaging in Cardiovascular Research
Jonathan Lindner, MD, Professor, Division of Cardiovascular Medicine; Director, Cardiovascular Imaging, OHSU Knight Cardiovascular Institute; Division Chief, Cardiometabolic Health, Oregon National Primate Research Center

March 20

Alternative splicing regulates antigen presentation to MR1-restricted T cells
Anjali Narayanan

March 13

Chloride channel mutations in primary aldosteronism
Elizabeth Swanson
A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism
CLCN2 chloride channel mutations in familial hyperaldosteronism type II

March 6

Kevin Burfeind
A Homing System Targets Therapeutic T-Cells to Brain Cancer [retracted]

February 27 - Career Development

Creating a Path to Academic Success
Brian Druker, MD, Professor, Division of Hematology & Medical Oncology; Associate Dean, Oncology; Director, OHSU Knight Cancer Institute
The Clinical Investigator: bewitched, bothered, and bewildered - but still beloved

February 20

Sadra Hamedzadeh
Pathogen Elimination by Probiotic Bacillus via Signalling Interference

February 13

Sunil Joshi
A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis

February 6

Macrophage-Tumor cell fusion: Functional impact on tumor progression, early detection, and measure of treatment response
Melissa Wong, PhD, Associate Professor, Cell, Developmental and Cancer Biology

January 30

Ashley Anderson
Biparental Inheritance of Mitochondrial DNA in Humans

January 23

Cymon Kersch
Structural variants in genes associated with human Williams-Beuren syndrome underlie stereotypical hypersociability in domestic dogs

January 16

Rick Mathews
Characterization of the Capillary Endothelial Glycocalyx in the Brain and Potential Contributions to the Blood Brain Barrier

January 9

Molecular Imaging and Therapy for Precision Oncology
Erik Mittra, MD, PhD, CCD, Associate Professor, Diagnostic Radiology, Division of Nuclear Medicine; Section Chief, Nuclear Medicine

2018

December 19

Negative crosstalks between hypoxia and androgen response pathways lead to therapy resistance in prostate cancer
David Qian, PhD, Assistant Professor, Knight Cancer Institute

December 12

Ali Pincus
Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus

December 5

Sam Huang
Meganuclease targeting of PCSK9 in macaque liver leads to stable reduction in serum cholesterol

November 28

Brennan Olson
Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis

November 14

One is the loneliest number: A brief introduction to extant and extinct hominins
Jim Goodman
The genome of the offspring of a Neanderthal mother and a Denisovan father

November 7

Kristen Stevens
Phenotype risk scores identify patients with unrecognized Mendelian disease patterns

October 31 - Career Development

Life After Residency
Dave Lewinsohn, MD, PhD, Professor, Pulmonary & Critical Care Medicine
Deb Lewinsohn, MD, Professor, Pediatrics, Division of Infectious Diseases

October 24

Michael Berry
Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas

October 17

Rachel Drake
Moderate UV Exposure Enhances Learning and Memory by Promoting a Novel Glutamate Biosynthetic Pathway in the Brain

October 10

TheAnh Nguyen
Myocardial Infarction Produces Sustained Proinflammatory Endothelial Activation in Remote Arteries

October 3

Neural control of response against bacterial infections and immune homeostasis
Alejandro Aballay, PhD, Professor & Chair, Molecular Microbiology & Immunology

September 26

Gina Calco
Microglia play an active role in obesity-associated cognitive decline

September 19

Sudarshan Iyer
E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer

September 5

Lymphatic Vessels: Critical Regulators of Peripheral Immune Responses
Amanda Lund, PhD, Assistant Professor, Cell, Developmental & Cancer Biology

August 29

A Discussion of Suicide: mental health, prevention and self-care, and suicide in graduate education
Katy Michaelis
Vital Signs: Trends in State Suicide Rates - United States, 1999–2016 and Circumstances Contributing to Suicide - 27 States, 20152
Preventing Suicide: A Technical Package of Policy, Programs, and Practices
Evidence for a mental health crisis in graduate education
A prevalence study on depression and anxiety in graduate school across disciplines
Kathryn 
NEJM piece on suicide in medical school
Breaking the Stigma —A Physician's Perspective on Self-Care and Recovery
Another NEJM reading on mental health in the medical profession
Everything is Awful and I'm Not Okay: Questions to Ask Before Giving Up
A one page primer on self-care for a variety of situations

August 22

Nichole Tyler
Continuous Glucose Monitoring and Insulin Informed Advisory System with Automated Titration and Dosing of Insulin Reduces Glucose Variability in Type 1 Diabetes Mellitus

August 15

How to Present a Journal Club
David Jacoby, MD, Program Director, MD/PhD Program; Chair & Professor, Department of Medicine

August 8

Novel Insights into IL-33 Regulation in Allergic Disease
Marsha Wills-Karp, PhD, Chair & Professor, Environmental Health & Engineering, Johns Hopkins University

August 1

Mollie Marr
CheXNet: Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learning

July 25

Allogenic Stem Cell Transplantation in HIV Cure
Jonah Sacha, PhD, Associate Professor, Vaccine and Gene Therapy Institute, Molecular Microbiology and Immunology, Oregon National Primate Research Center

July 18

Sexual Harassment of Women in Academic Sciences, Engineering, and Medicine
Kelsey Priest
Sexual Harassment of Women: Climate, Culture, and Consequences in Academic Sciences, Engineering, and Medicine (2018) 
Sexual harassment is rampant in science —and current policies aren't cutting it, landmark report finds

July 11

Physiological Changes During Long-Duration Space Flight
John Butler
Fluid shifts, vasodilatation and ambulatory blood pressure reduction during long duration spaceflight
Increased core body temperature in astronauts during long-duration space missions

June 20

Sweta Adhikary
A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action

June 13

Caroline King
Socioeconmic Outcomes of Women Who Receive and Women Who Are Denied Wanted Abortions in the United States

June 6

The Human Side of Data: Examining the intersection of data, integrity, and society
Jackie Wirz, PhD, Assistant Dean, School of Medicine Graduate Studies

May 30

Kevin Burfeind
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
Human hippocampal neurogensis persists throughout aging

May 16

Cheryl Claunch
Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes

May 9

Anjali Narayanan
Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair
Killer T Cells show their kinder side

May 2

Molecular and Genetic Mechanisms of Myelin Development and Repair
Kelly Monk, PhD, Senior Scientist & Co-Director, Vollum Institute

April 25

Pre and postnatal determinants of airway hyperreactivity
Katie Lebold

April 18

Cymon Kersch
Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial

April 11

Carsten Schultz, PhD, Professor, Physiology & Pharmacology

April 4

Ali Pincus
The fuzzy logic of network connectivity in mouse visual thalamus

March 28

Burcu Gurun-Demir
Using synthetic templates to design an unbiased multiplex PCR assay

March 21

Gavin Young
Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module

March 14

Panel Discussion: Navigating the Unknown: Shared Decision-Making in the Face of Uncertainty in Science and Clinic
Jenya Zilberman-Rudenko

March 7

Modeling Anxiety in the Laboratory
Bita Moghaddam, PhD, Professor & Chair, Behavioral Neuroscience

February 28

Retreat Keynote Speaker Introduction: Cindy McEvoy, MD, MCR
Elizabeth Swanson

February 21

Jackie Emathinger
Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice

February 7

Light: A window into pain in the brain
Mary Heinricher, PhD, Professor, Neurological Surgery

January 31

Tony Zheng
Accelerating bacterial growth detection and antimicrobial susceptibility assessment in integrated picoliter droplet platform

January 24

Sam Huang
Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes

January 17

Jim Goodman
Stress-induced unfolded protein response contributes to Zika virus–associated microcephaly

January 10

Rachel Drake
Transcription Factor EB Controls Metabolic Flexibility during Exercise

January 3 

Molecular mechanisms of axon degeneration
Marc Freeman, PhD, Senior Scientist & Director, Vollum Institute