M.D./Ph.D. Journal Club
Journal Club is a required course for all M.D./Ph.D. students and attendance is required. With a few exceptions including holidays and academic breaks, Journal Club is hosted every Wednesday from 3-4pm PST.
Please email the M.D./Ph.D. program to be added to the journal club listserve for weekly updates and most recent information.
Each M.D./Ph.D. student will present a journal article of their choosing 1-2 times each year throughout the entirety of their program. Once a month faculty members will present at Journal Club on their research or as a career/professional development session.
Upcoming presentations
July
July 2, 2025
Presenter: Malik Seals
Topic: Programming tissue-sensing T cells that deliver therapies to the brain
July 9, 2025
Faculty Presenter: Markus Grompe, M.D.
Topic: Fanconi’s Anemia – Pathophysiology and Treatment, a journey of 34 years
July 16, 2025
Presenter: Natasha Warikoo
Topic: Opioid Receptors Modulate Inhibition within the Prefrontal Cortex through Dissociable Cellular and Molecular Mechanisms
July 23, 2025
Presenter: Steven Adamou
Topic: Structure of the native myosin filament in the relaxed cardiac sarcomere
July 30, 2025
Presenter: Hyuntae Byun
Topic: Trichomonas vaginalis extracellular vesicles suppress IFNε-mediated responses driven by its intracellular bacterial symbiont Mycoplasma hominis
August
August 6, 2025
Presenter: TJ Ekstrom
Topic: Spatiotemporal analysis of human intestinal development at single-cell resolution
August 13, 2025
Presenter: Jack Henry Kotnik
Topic: Barcoded Rabies In Situ Connectomics for high-throughput reconstruction of neural circuits
August 20, 2025
Presenter: Program Leadership
Topic: How Journal Club
August 27, 2025
Presenter: Zheng Xia, Ph.D.
Topic: Unlocking Knowledge from Large-Scale Biomedical Data with Machine Learning
September
September 3, 2025
Presenter: Julie Doberne, M.D., Ph.D.
Topic: Computer Vision in Surgery
September 10, 2025
Presenter: Eric Cramer
Topic: A stratification system for breast cancer based on basoluminal tumor cells and spatial tumor architecture
September 17, 2025 - CANCELLED
September 24, 2025 - NO JOURNAL CLUB
October
October 1, 2025
Presenter: Hanna Minns
Topic: Glioblastoma remodelling of human neural circuits decreases survival
October 8, 2025
Faculty Presenters:
Laura Heiser, Ph.D. Systems approaches for identifying more effective cancer treatments
Brian Scottoline, M.D., Ph.D. Human Milk as a Biological System
October 15, 2025
Presenter: Katherine Pelz
Topic: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination
October 22, 2025
Presenter: Kayla Maanum
Topic: Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors
October 29, 2025
Presenter: Rohan Chaudhari
Topic: Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity
November
November 5, 2025
Presenter: Alexander Davies, D.V.M., Ph.D.
Topic: Seeing is believing: Live imaging of spatiotemporal tumor-host interactions and drug responses
November 12, 2025
Presenter: Jessica Keating
Topic: Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease
November 19, 2025
Presenter: Amanda Zucker
Topic: FGFR2 Abrogation Intercepts Pancreatic Ductal Adenocarcinoma Development
November 26, 2025 - CANCELLED
December
December 3, 2025
Presenter: OASIS
Topic: OASIS Resources for MD/PhD Student Success
December 10, 2025
Presenter: Xammy Huu Wrynla
Topic: BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance
December 17, 2025
Presenter: Eli Wisdom
Topic: Systematic profiling reveals betaine as an exercise mimetic for geroprotection
December 24, 2025 - NO JOURNAL CLUB
December 31, 2025 - NO JOURNAL CLUB
January
January 7, 2026
Presenter: Aleksandra Dagunts
Topic: TBD
January 14, 2026
Presenter: Julia Maxson, PhD
Topic: TBD
January 21, 2026
Presenter: Sam Kim
Topic: TBD
January 28, 2026
Presenter: Luke Whitcomb
Topic: TBD
February
February 4, 2026
Presenter: Jaime Contreras
Topic: TBD
February 11, 2026
Presenter: TBD
Topic: TBD
February 18, 2026
Presenter: Amara Pang
Topic: TBD
February 25, 2026
Presenter: Julie Huffaker
Topic: TBD
March
March 4, 2026
Presenter: TBD
Topic: TBD
March 11, 2026
Presenter: Kevin Mueller
Topic: TBD
March 18, 2026
Presenter: Owen Doyle
Topic: TBD
March 25, 2026 - NO JOURNAL CLUB
April
April 1, 2026
Presenter: Taitea Dykstra
Topic: Androgen deprivation therapy exacerbates Alzheimer’s-associated cognitive decline via increased brain immune cell infiltration
April 8, 2026
Presenter: TBD
Topic: TBD
April 15, 2026
Presenter: TBD
Topic: TBD
April 22, 2026
Presenter: TBD
Topic: TBD
April 29, 2026
Presenter: TBD
Topic: TBD
May
May 6, 2026
Presenter: TBD
Topic: TBD
May 13, 2026
Presenter: TBD
Topic: TBD
May 20, 2026
Presenter: TBD
Topic: TBD
May 27, 2026
Presenter: TBD
Topic: TBD
June
June 3, 2026
Presenter: TBD
Topic: TBD
June 10, 2026
Presenter: TBD
Topic: TBD
June 17, 2026
Presenter: TBD
Topic: TBD
June 24, 2026 - NO JOURNAL CLUB
Past presentations
2024/2025
July 3, 2024
Presenter: Zoe Beach
Topic: Distinct roles of TREM2 in central nervous system cancers and peripheral cancers
July 10
Presenter: Eric Cramer
Topic: Calibrating agent-based models to tumor images using representation learning
July 17
Presenter: Natasha Warikoo
Topic: Maturation and circuit integration of transplanted human cortical organoids
July 24
Presenter: Jessica Keating
Topic: Genetic screening and metabolomics identify glial adenosine metabolism as a therapeutic
target in Parkinson’s disease
July 31
Faculty Presenters & Titles:
Amy Moran, Ph.D.: “What does sex have to do with IT?”
Shawn Chavez, Ph.D.: “Cross-species comparison of the molecular mechanisms mediating preimplantation embryogenesis and placentation in primates”
August 7
Presenter: Katherine Pelz
Topic: Chronic stress increases metastasis via neutrophil- mediated changes to the microenvironment
August 14
Presenter: Eli Wisdom
Topic: APOE4 homozygosity represents a distinct genetic form of Alzheimer’s disease
August 21
Presenter: Kayla Maanum
Topic: Neural circuit basis of placebo pain relief
August 28
Faculty Presenters & Titles:
Alireza (Ali) Karimi, PhD: "Ocular Biomechanics from the Posterior Pole to the Anterior Segment"
OASIS: "OASIS Career Advising"
September 4
Presenter: Rohan Chaudhari
Topic: Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy
September 11
Faculty Presenters & Titles:
Michael Hutchens, M.D., M.A. "Efficacy of Cilastatin Sodium for Prolonged Care in a Large Animal Crush Syndrome Model"
Ahmed Raslan, M.D., F.A.A.N.S. “High Density neural recording in Humans”
September 18
Presenter: Xammy Nguyenla
Topic: Early cellular mechanisms of type I interferon-driven susceptibility to tuberculosis
September 25 - NO JOURNAL CLUB
October 2
Presenter: Amanda Zucker
Topic: Patient-derived mini-colons enable long-term modeling of tumor–microenvironment complexity
October 9
Presenter: Zach Yellowman
Topic: Aberrant activation of hippocampal astrocytes causes neuroinflammation and cognitive decline in mice
October 16
Faculty Presenters & Titles:
Arpiar Saunders, Ph.D. “High-throughput analysis of neural circuit organization and host-virus interactions using viral genomic technologies”
Zachary Beattie, Ph.D. “ORCATECH: Ecologically Valid, Longitudinal Research”
October 23
Presenter: Luis Diaz
Topic: A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer
October 30
Presenter: Samuel Kim
Topic: Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions
November 6
Faculty Presenter & Title:
Gregory Scott, M.D., Ph.D. “Catching early Parkinson’s Disease from clinical history and a GI biopsy”
November 13
Presenter: Aleksandra Dagunts
Topic: Molecular Engineering of Acoustic Protein Nanostructures
November 20
Presenter: Sofia Vignolo
Topic: Angiogenesis is uncoupled from osteogenesis during calvarial bone regeneration
November 27
Presenter: Amara Pang
Topic: Spatial proteomics identifies JAKi as treatment for a lethal skin disease
December 4
Faculty Presenters & Titles:
Paul Schipper, M.D., F.A.C.S., F.A.C.C.P. “How can I be of use to you?
December 11
Presenter: Mizan Gaillard
Topic: Classification of Suicide Attempt Risk Using Environmental and Lifestyle Factors in 3 Large Youth Cohorts
December 18
Presenter: Joyce Kim
Topic: MAIT cell plasticity enables functional adaptation that drives antibacterial immune protection
January 8, 2025
*CANCELED*
January 15, 2025
Faculty Presenters & Titles:
Melissa Hirose Wong, Ph.D. Macrophage-tumor cell fusion hybrids: A unique neoplastic cell population and their impact on tumor biology
Xubo Song, Ph.D. Foundation models and multimodal AI – from data to discovery
January 22, 2025
Presenter: Parham Diba
Topic: Recruited macrophages elicit atrial fibrillation
January 29, 2025
Presenter: Hannah Jaeger
Topic: Zika virus oncolytic activity requires CD8+ T cells and is boosted by immune checkpoint blockade
February 5, 2025
Presenter: Luke Whitcomb
Topic: Ketone Bodies Attenuate Wasting in Models of Atrophy
February 12, 2025
Faculty Presenters & Titles:
Randy Woltjer, M.D., Ph.D. Brain changes with aging and disease
David Huang, M.D., Ph.D. Development of functional optical coherence tomography at OHSU
February 19, 2025
Presenter: Samuel King
Topic: Rewiring cancer drivers to activate apoptosis
February 26, 2025
Presenter: Simone Woodruff
Topic: Inhibiting Ca2+ channels in Alzheimer’s disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia
March 5, 2025
Faculty Presenters & Titles:
Karen Morris & Cesar Tapia-Chavez Introduction to On Track at the Knight! (On Track OHSU! Program )
Yabing Chen, Ph.D., M.B.A., F.A.H.A. Vascular stiffness and aging: A pan-vascular view
March 12, 2025
Presenter: Kareem Woods
Topic: Circulating myeloid-derived MMP8 in stress susceptibility and depression
March 19, 2025
Presenter: Bianca Hoang-Dang
Topic: An Amygdala-Hippocampus Subnetwork that Encodes Variation in Human Mood
March 26, 2025 - NO JOURNAL CLUB
April 2, 2025
Presenter: Peter Tran
Topic: pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise
April 9, 2025
Presenter: Gavin Young
Topic: Path to Residency
April 16, 2025
Presenter: Melanie Piller
Topic: Oligodendrocyte–axon metabolic coupling is mediated by extracellular K+ and maintains axonal health
April 23, 2025
Presenter: Rodaba Rahim
Topic: GDF15 linked to maternal risk of nausea and vomiting during pregnancy
April 30, 2025
Faculty Presenters & Titles:
Bonnie Nagle, Ph.D. Decoding Risk for Internalizing Psychopathology in Youth: Findings from Big Data
Christina Lancioni, M.D. Babies, Bottles, Bugs & Drugs: making the most of your career as a physician-scientist
May 7, 2025
Presenter: Gregory Chin
Topic: In vivo reprogramming of circuit connectivity in postmitotic neocortical neurons
May 14, 2025
Presenter: Landon Bayless-Edwards
Topic: Stochastic neuropeptide signals compete to calibrate the rate of satiation
May 21, 2025
Presenter: Kelly Abshire
Topic: Midbrain ghrelin receptor signalling regulates binge drinking in a sex specific manner
May 28, 2025
Presenter: Jing Xie
Topic: Maternal anxiety during pregnancy is associated with weaker prefrontal functional connectivity in adult offspring
June 4, 2025
Presenter: Madelynn Tung
Topic: Fucoidan and topography modification improved in situ endothelialization on acellular synthetic vascular grafts
June 11, 2025
Faculty Presenters & Titles:
Reid Thompson, M.D., Ph.D. Towards Safer AI Model Generalizability
Aaron Grossberg, M.D., Ph.D. A long time to be gone and a short time to be here
June 18, 2025
Presenter: Rin Yang
Topic: Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseases
June 25, 2025 - NO JOURNAL CLUB
2023/2024
June 29
Presenter: Xammy Nguyenla
Topic: Gaucher disease protects against tuberculosis
July 6
Presenter: Kayla Maanum
Topic: Cardiogenic control of affective behavioral state
July 13
Presenter: Monika Davare, PhD
Topic: Unlocking ROS1 in Cancer: Tyrosine Kinase Inhibitors, Resistance, and Novel Biomarkers
July 20
Presenter: Hannah Jaeger
Topic: Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface
July 27
Presenter: Amara Pang
Topic: LAP1 supports nuclear adaptability during constrained melanoma cell migration and invasion
August 3
Presenter: Mizan Gaillard
Topic: Associations between social behaviors and experiences with neural correlates of implicit emotion regulation in middle childhood
August 10
Presenter: Joshua Moreau, PhD
Topic: Tissue B cells: making themselves at home in inflammatory skin disease and cancer
August 17
Presenter: Joyce Kim
Topic: Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I
August 24
Presenter: Emily Hillhouse, MA, PhD
Topic: Study Smarter Not Harder: Finding Academic Success at OHSU
August 31
Presenter: Sofia Vignolo
Topic: Bone-matrix mineralization dampens integrin-mediated mechanosignalling and metastatic progression in breast cancer
September 7
Presenter: Aleksandra Dagunts
Topic: Environment-dependent behavioral traits and experiential factors shape addiction vulnerability
September 14
Presenter: Luis Diaz
Topic: A gene–environment-induced epigenetic program initiates tumorigenesis
September 21 - CXL (FALL BREAK)
September 28 - CXL
October 5
Presenter: David Jacoby, MD
Topic: Journal Club Best Practices
October 12
Presenter: Simone Woodruff
Topic: Medin co-aggregates with vascular amyloid-β in Alzheimer’s disease
October 19
Presenter: Paige Farris & Wesley Stoller
Topic: Accessing Data Resources: All of Us and Healthy Oregon Project
October 26
Presenter: Parham Diba
Topic: Aging impairs the neurovascular interface in the heart
November 2
Presenter: Will Yashar
Topic: Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid Leukemia
November 9
Presenter: Tanaya Shree, MD, PhD
Topic: “The immunobiology of lymphomas”
November 16
Presenter: Melanie Piller
Topic: CNS myelination requires VAMP2/3-mediated membrane expansion in oligodendrocytes
November 23 - CXL (BREAK)
November 30
Presenter: Jacqueline Emathinger
Topic: Design and testing of a humanized porcine donor for xenotransplantation
December 7 - CXL
December 14 - CXL
December 21 - CXL (BREAK)
December 28 - CXL (BREAK)
January 4, 2024 - CXL (BREAK)
January 11
Presenter: Ashley Anderson
Topic: Systematic investigation of mitochondrial transfer between cancer cells and T cells at single-cell resolution
January 18 - CXL
January 25
Presenter: Anupriya Agarwal, PhD
Topic: Mechanisms and Intervention Strategies in Premalignant Disorders
February 1
Presenter: Landon Bayless-Edwards
Topic: Antipsychotic drug efficacy correlates with the modulation of D1 rather than D2 receptor-expressing striatal projection neurons
February 8
Presenter: Kelly Abshire
Topic: Unraveling the epigenomic and transcriptomic interplay during alcohol-induced anxiolysis
February 15
Presenter: Moriah Arnold
Topic: PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions
February 22
Presenter: Andrei Sdrulla, MD, PhD
Topic: Spinal Cord Stimulation: Basics and Beyond
February 29
Presenter: Gregory Chin
Topic: Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis
March 7
Presenter: Tanya Korzun
Topic: Navigating Challenges in mRNA Lipid Nanoparticle Therapeutics for Metastatic Epithelial Cancers
March 14
Presenters: Introduction by OASIS followedDavid Lewinsohn, MD, PhD
Topic: Recognizing the Mycobacterium tuberculosis Infected Cell: Lessons Learned from Human CD8+ T cells
March 21
Presenter: Mady Tung
Topic: Oral delivery of metformin by chitosan nanoparticles for polycystic kidney disease
March 28 - CXL (BREAK)
April 3
Presenter: Rin Yang
Topic: Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host
April 10
Presenter: Malik Seals
Topic: The survival and function of IL-10-producing regulatory B cells are negative controlled by SLAMF5
April 17
Presenter: Gina Bash & Michael Berry (MS4)
Topic: The Residency Quest: From Clinical Rotations to Match Day
April 24
Presenter: Justin Denny, MD, MPH
Topic: Student Opportunities with OHSU Global in Southeast Asia
May 1
Presenter: Taitea Dykstra
Topic: Myeloid cell replacement is neuroprotective in chronic experimental autoimmune encephalomyelitis
May 8
Presenter: Marina Wolf, PhD
Topic: Synaptic mechanisms maintaining persistent cocaine craving
May 15
Presenter: Jack Henry Kotnik
Topic: Spatial imaging of glycoRNA in single cellswith ARPLA
May 22
Presenter: TJ Ekstrom
Topic: A spatially resolved timeline of the human maternal–fetal interface
May 29
Presenter: Steven Adamou
Topic: NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload
June 5
Presenter: Hanna Minns
Topic: Remote neuronal activity drives glioma progression through SEMA4F
June 12
Faculty Presenters & Titles:
Megan Ruhland, PhD: “Dendritic cell function in anti-tumor immunity"
Katelyn Byrne, PhD: “Harnessing CD4 T cell immunity in pancreatic cancer”
June 19
Presenter: Rick Mathews
Topic: Inflammatory stimuli induce shedding of heparan sulfate from arterial but not venous porcine endothelial cells leading to differential proinflammatory and procoagulant responses
June 26 - CXL
2022/2023
Aug 25:
Topic: Transcriptional Plasticity Drives Leukemia Immune Escape
Presenter: Will Yashar
Sep 1
Topic: YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion
Presenter: Ashley Anderson
Sep 8
Faculty Presenter: Olina Taratula
Sep 15 - CANCELLED
Sep 22 - FALL BREAK
Sep 29
Faculty Presenter: David Jacoby, MD
Oct 6
Topic: Highly accurate protein structure prediction with AlphaFold
Presenter: Gavin Young
Oct 13
Topic: Mapping the single-cell transcriptomic response of murine diabetic kidney disease to therapies
Presenter: Jacqueline Emathinger
Oct 20
Topic: Association of a common genetic variant with Parkinson’s disease is mediated by microglia
Presenter: Greg Chin
Oct 27
Faculty Presenter: Leslie Myatt, PhD, FRCOG
Nov 3
Topic: Neutrophil extracellular traps promote fibrous vascular occlusions in chronic thrombosis
Presenter: Rick Mathews
Nov 10
Presenter: Kelly Abshire
Nov 17 (NO JOURNAL CLUB)
Nov 24 (NO JOURNAL CLUB)
Dec 1
Topic: Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine
Presenter: Tetiana Korzun
Dec 8
Topic: “Translational Models for Transarterial Tumor Therapies"
Presenter: Khashayar Farsad
Dec 15
Topic: Small RNAs are modified with N-glycans and displayed on the surface of living cells
Presenter: Zoe Beach
Dec 22 (NO JOURNAL CLUB)
Dec 29 (NO JOURNAL CLUB)
Jan 12
Topic: High throughput functional variant screens via in vivo production of single-stranded DNA
Presenter: Somya Khare
Jan 19
Topic: Tracing Brain Genotoxic Stress in Parkinson's Disease with a Novel Single-Cell Genetic Sensor
Presenter: Moriah Arnold
Jan 25
Topic: “Blood clotting and the endothelium: the good, bad and the sticky”
Presenter: Owen McCarty, PhD, FAHA
Feb 2
Topic: Genetically engineered myeloid cells rebalance the core immune suppression program in metastasis
Presenter: Rohan Chaudhari
Feb 9
Topic: The metabolic digital twin: theory and applications in improving drug delivery in type 1 diabetes
Presenter: Peter Jacobs, PhD
Feb 16
Topic: Vagus nerve stimulation drives selective circuit modulation through cholinergic reinforcement
Presenter: Landon Bayless-Edwards
Feb 23
CXL (Inclement Weather)
Mar 2
Topic: Endogenous OT exerts anti-nociceptive and anti-inflammatory effects in rats
Presenter: Jessica Keating
Mar 9
Topic: Neural effects of transcranial magnetic stimulation at the single-cell level
Presenter: Jing Xie
Mar 16
Topic: “Engineering photopharmacology tools to control lipid signaling in excitable cells”
Presenter: James Frank, PhD
Mar 23
Topic: The Golden Years: Clinical Rotations and Applying to Residency
Presenter: MS4 Students
Mar 30 (NO JOURNAL CLUB - SPRING BREAK)
Apr 6
Presenter: Katherine Pelz
Apr 13
Presenter: Samuel Kim
Apr 20
Presenter: Amanda Zucker
Apr 27
Topic: “Network Systems Biology: Mapping Macromolecular Interactions for Drug Discovery”
Presenter: Andrew Emili, PhD
May 4
Presenter: Zachary Yellowman
May 11
Topic: Generative Agents: Interactive Simulacra of Human Behavior
Presenter: Eric Cramer
May 18
Topic: “The Oregon Rural Practice-based Research Network (ORPRN)…5Ws and You”
Presenter: Melinda Davis, PhD, MCR
May 25 (NO JOURNAL CLUB - CANCELLATION)
June 1
Topic: Uncovering mechanisms and developing novel therapies for intestinal inflammation
Presenter: Sarah Andres, PhD
June 8
Presenter: Jaime Contreras
June 15
Topic: Semaglutide reduces alcohol intake and relapse-like drinking in male and female rats
Presenter: Natasha Warikoo
June 22
Presenter: Elias Wisdom
2021/2022
Presenter: Melanie Piller
Aug 11
Faculty Presenter: Joshua Walker, M.D., Ph.D., OHSU MD PhD Alumni
Topic: Engineering immunogenic cell death in cancer
August 4
Presenter: Sofia Vignolo
Presenter: Simone Woodruff
Title: Activated endothelial cells induce a distinct type of astrocytic reactivity
July 28
Presenter: Parham Diba
June 30
Presenter: Joyce Kim
Title: Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides
Jun 23
No Journal Club
June 16
Presenter: Luis Diaz
Title: Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis
June 9
Presenter: TheAnh Nguyen
Topic: NLRP3 Inflammasome Inhibition as a Treatment for Post-Myocardial Infarction Microvascular No-Reflow
June 2
Vivek Unni, MD, PhD, Associate Professor, Neurology
Topic: Alpha-synuclein and disease in four vignettes (three scientific & one personal)
May 26
Presenter: Aleksandra Dagunts
May 12
Presenter: Amara Pang
May 5
Thomas S. Scanlan, PhD
CNS Thyroid Hormone Action for Treating Neurodegenerative Diseases
April 28
Natasha Warikoo
April 21
Kayla Maanum
An endogenous opioid circuit determines state-dependent reward consumption
April 14
Eli Wisdom
Endothelial Unc5B controls blood-brain barrier
integrity
March 31
Topic: The Golden Years: clinical rotations and applying to residency
Presenter: John Butler, MD, PhD and Kristen Stevens, MD, PhD
March 17
The immunoregulatory landscape of human tuberculosis granulomas
Xammy Nguyenla
March 10
Mechanical allodynia circuitry in the dorsal horn is defined by the nature of the injury
Jessica Keating
March 3
Potency of planarians: an in vivo model to understand adult stem cells and tumorigenesis
Bret Pearson, PhD, Associate Professor, Pediatrics
February 24
Hannah Jaeger - see 2 articles below
1) Safety and Immunogenicity of an Anti–Zika Virus DNA Vaccine
2) In vivo protection against ZIK V infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine
February 17
Tony Zheng
February 10
Landon Bayless-Edwards
Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior
January 27 - online
Moriah Arnold
January 20 - online
Eric Cramer
Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19
January 13 - online
Zoe Beach
Whole-blood metabolomics of dementia patients reveal classes of disease-linked metabolites
2020/2021
December 16
Jackie Emathinger
New Creatinine- and Cystatin C–Based Equations to Estimate GFR without Race
December 9
November 18
Greg Chin
Microglial activation and tau propagate jointly across Braak stages
Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes
November 11
Kelly Abshire
October 28
Sudarshan Iyer
October 21
Burcu Gurun-Demir
Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML
October 14
Journal Club Best Practices
David Jacoby, MD, Interim Dean, School of Medicine; Program Director, MD/PhD Program
October 7
Building cell-scale maps of biochemical processes: Challenges and Applications
Emek Demir, PhD, Associate Professor, Molecular & Medical Genetics
September 29
Gavin Young
AI for radiographic COVID-19 detection selects shortcuts over signal
September 15
Jackie Emathinger
Self-organization of the in vitro attached human embryo
September 8
Ashley Anderson
Spatially resolved transcriptomics reveals the architecture of the tumor/microenvironment interface
August 25
Will Yashar
Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level
August 18
Gina Calco
Acrobatic squirrels learn to leap and land on tree branches without falling
August 11
Parham Diba
Trem2 restrains the enhancement of tau accumulation and neurodegeneration by B-amyloid pathology
August 4
Computational Precision Oncology at the Knight Cancer Institute
Jeremy Goecks, PhD, Associate Professor, Biomedical Engineering
The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution
An Omic and Multidimensional Spatial Atlas from Serial Biopsies of an Evolving Metastatic Breast Cancer
July 28
Tanya Korzun
July 21
Melanie Piller
July 14
Michael Berry
Partial recovery of visual function in a blind patient after optogenetic therapy
Pre-clinical publication: Optogenetic therapy
July 7
Center for Experimental Therapeutics: Translating Discoveries to Clinic
Sanjay Malhotra, PhD, FRSC, Professor, Cell, Developmental and Cancer Biology
June 30
Agonist specific regulation of GPCRs after chronic opioid treatment
Sweta Adhikary
June 16
Simone Woodruff
Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment
June 9
Luis Diaz
RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation
June 2 - career development
Neuroimmune Interactions in Eosinophilic Asthma
Matt Drake, MD, Assistant Professor, Medicine, Pulmonary & Critical Care
Eosinophils increase airway sensory nerve density in mice and in human asthma
IL-5 Exposure In Utero Increases Lung Nerve Density and Airway Reactivity in Adult Offspring
May 26
Sofia Vignolo
Adipose tissue is a critical regulator of osteoarthritis
May 19
Natasha Warikoo
Endogenous opioids regulate moment-to-moment neuronal communication and excitability
May 5
Exploring cardiovascular development with the fetal sheep model
Sonnet Jonker, PhD, Associate Professor, Medicine, Cardiovascular Medicine
Endocrine and other physiologic modulators of perinatal cardiomyocyte endowment
April 28
Landon Bayless-Edwards
Fast spiking interneuron activity in primate striatum tracks learning of attention cues
April 21
Joyce Kim
Skin-resident innate lymphoid cells converge on a pathogenic effector state
April 14
Moriah Arnold
APOE4 exacerbates a-synuclein pathology and related toxicity independent of amyloid
April 7
Target identification and drug development for rare leukemias
Julia Maxson, PhD, Assistant Professor, Medicine
March 31
MD/PhD Road to Residency
MS4s: Kevin Burfeind, PhD; Jim Goodman, PhD; Anjali Narayanan, PhD; Katy Michaelis, PhD; Elizabeth Swanson, PhD
March 17
Mizan Gaillard
March 10
Aleksandra Dagunts
Facial expressions of emotion states and their neuronal correlates in mice
March 3 - closed event
Babak Nazer, MD, Assistant Professor, Medicine, Cardiovascular Medicine
David Giraud, MEng, Principal Engineer
High-intensity ultrasound catheter ablation achieves deep mid-myocardial lesions in vivo
February 24
Greg Chin
Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism
February 10
Tony Zheng
The Fluid Mechanics of Transcatheter Heart Valve Leaflet Thrombosis in the Neosinus
The Role of Flow Stasis in Transcatheter Aortic Valve Leaflet Thrombosis
February 3
Dissecting Brain Circuitry Using Connectomic and Novel Imaging Approaches
Tianyi Mao, PhD, Associate Professor & Scientist, Vollum Institute
January 27
Brennan Olson
Origin and Function of Stress-Induced IL-6 in Murine Models
January 20
Do substance use disorders drive immune dysregulation? The application of translational immunology to complex human cohorts
Christina Lancioni, MD, Associate Professor, Pediatrics, Infectious Diseases
Altered monocyte phenotype and dysregulated innate cytokine responses among people living with HIV and opioid-use disorder
Alcohol and HIV Effects on the Immune System
Opioids and the immune system – friend or foe
Gut barrier structure, mucosal immunity and intestinal microbiota in the pathogenesis and treatment of HIV infection
January 13
Burcu Gurun-Demir
Single cell mutation analysis of clonal evolution in myeloid malignancies
Clonal evolution of acute leukemia revealed by high-throughput single cell genomics
January 6
Ali Pincus
Hippocampal Neuropathology of Domoic Acid– Induced Epilepsy in California Sea Lions (Zalophus californianus)
Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice
2019/2020
December 16
Rick Mathews
December 9
Kim Montaniel, Graduate Student, Phsyiology & Pharmacology
December 2
A global lipid map defines a network essential for Zika virus replication
Pacific Northwest National Laboratory (PNNL)
- Fikadu Tafesse, PhD, Assistant Professor, Molecular Microbiology & Immunology
- Jennifer Kyle, PhD, Biomedical Scientist, PNNL
November 18
Placental Insufficiency Alters Fatty Acid Metabolism in the Fetal Sheep Heart
Rachel Drake
November 11
Sudarshan Iyer
Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence
November 4
Targeting the Leukemia Microenvironment
Elie Traer, MD, PhD, Associate Professor, Medicine, Hematology & Medical Oncology
October 28
SARS-CoV-2 and mRNA Vaccines
Sam Huang
An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults
October 21
October 14
Presentation Best Practices
David Jacoby, MD, Professor & Chair, Medicine and Director, MD/PhD Program
October 7 - Career Development
Chasing Tapeworms: A communicable cause of epilepsy
Seth O'Neal, MD, PhD, Assistant Professor, Public Health
September 30
Modeling hospital-based addiction interventions’ impact on post-discharge mortality
Caroline King
September 16
Racism and Bias in Psychiatric Diagnoses
Mollie Marr
Please read at least one article below in preparation:
Racial and Ethnic Disparities in ADHD Diagnosis and Treatment
Unconscious Bias and the Diagnosis of Disruptive Behavior Disorders and ADHD in African American and Hispanic Youth
September 9
Sunil Joshi
September 2
Using physiologic and data-driven models to design and evaluate new drug delivery systems
Peter Jacobs, PhD, Associate Professor, Biomedical Engineering
August 26
Take a model, and make it your own!
Nichole Tyler
ARX model for interstitial glucose prediction during and after physical activities
August 19
TheAnh Nguyen
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
August 12
Zoe Beach
August 5
Understanding and Improving Outcomes After Critical Illness
Terri Hough, MD, MS, Division Chief, Pulmonary and Critical Care Medicine
July 29
Ashley Anderson
TMEM16F phospholipid scramblase mediates trophoblast fusion and placental development
July 22
Tanya Korzun
Monocyte-derived multipotent cell delivered programmed therapeutics to reverse idiopathic pulmonary fibrosis
July 15
Mike Berry
Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae
July 8
Sweta Adhikary
A neural basis for tonic suppression of sodium appetite
July 1 - Career Development
Carpe Diem (or how I ended up doing coronavirus research)
Reid Thompson, MD, PhD, Assistant Professor, Radiation Medicine, Biomedical Engineering, CEDAR
June 24
Policing the police: A Journal Club
Sweta Adhikary, Gina Calco, Jim Goodman, Mollie Marr, Natasha Warikoo
Please review the materials below to read/watch before journal club on 6/24:
- AVDS Code of Conduct
- Please watch at least one:
- 13th by Ava DuVernay (can also be found on Netflix)
- Police: Last Week Tonight with John Oliver
- Please read at least one:
June 17
Parham Diba
June 3
Hypomagnesemia and the renal thiazide-sensitive NaCl cotransporter
Jim McCormick, PhD, Associate Professor, Medicine, Nephrology & Hypertension
May 27
John Butler
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight
May 20
Gina Calco
Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
May 13
Will Yashar
Quantum supremacy using a programmable superconducting processor
April 29
Luis Diaz
Progressive Loss of Function in a Limb Enhancer during Snake Evolution
April 22
Natasha Warikoo
Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep
April 8
On the Residency Trail with MS4s, 2019-2020
Cheryl Claunch & Katie Lebold
April 1
Determining heterogeneity in cancer and in immunotherapy-associated skin-directed adverse events
Rajan Kulkarni, MD, PhD, Associate Professor, Dermatology, CEDAR, Knight Cancer Institute
March 4
Sympathetic contributions to cardiac arrhythmia
Beth Habecker, PhD, Professor, Chemical Physiology & Biochemistry
February 26
The debate on the role of the immune system in hypertension
Jackie Emathinger
February 19
Landon Bayless-Edwards
A potassium channel β-subunit couples mitochondrial electron transport to sleep
February 12
Caroline King
Dynamics of the HIV outbreak and response in Scott County, IN, USA, 2011–15: a modelling study
February 5
I swear by Apollo the Healer, by Asclepius,…Primum non noncere… Remembering the impact of the USPHS Tuskegee Syphilis Trial
Alan Hunter, MD, FACP, Professor & Division Head, Hospital Medicine; Associate Program Director, OHSU Internal Medicine Residency Program
January 29
Rachel Drake
January 22
Moriah Arnold
Amyloid beta oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes
January 15
Tony Zheng
January 8 - Career Development
Challenge and Recovery: How pancreatic cancer impairs physiologic adaptation - with a special focus on designing physician-scientist training
Aaron Grossberg, MD, PhD, Assistant Professor, Radiation Oncology
2018/2019
December 11
Gavin Young
December 4 - Career Development
The Sweetest Side of Kidney Research
Susan Gurley, MD, PhD, Associate Professor & Division Head, Nephrology & Hypertension
November 20
Brennan Olson
GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance
November 13
Practicing medicine in the era of the smart phone
Cymon Kersch & Logan Jones, Senior Internal Medicine Resident
Google Doc Slides
November 6
Inflammatory Microenvironment as Driver of Clonal Selection and Disease Progression in Leukemia
Anupriya Agarwal, PhD, Assistant Professor, Knight Leukemia Center
October 30
Ali Pincus
The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep
October 23
Presenting Well
David Jacoby, MD, Chair & Professor, Medicine; MD/PhD Program Director
October 16
Rick Mathews
Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes
October 9
Sam Huang
Continuous evolution of base editors with expanded target compatibility and improved activity
October 2
Epigenetic Dysfunction in Myeloid Leukemia
Ted Braun, MD, PhD, Instructor, Division of Hematology & Medical Oncology, Knight Cancer Institute
September 25
Burcu Gurun-Demir
Portraits of genetic intra-tumour heterogeneity and subclonal selection across cancer types
September 11
Nichole Tyler
Therapy Decision Support Based on Recommender System Methods
September 4
Ashley Anderson
Niche stiffness underlies the ageing of central nervous system progenitor cells
August 28 - Career Development
Doing What You Love
Donna Hansel, MD, PhD, Chair & Professor, Pathology
August 21
TheAnh Nguyen
Vascular Endothelial Growth Factor Delivery to Placental Basal Plate Promotes Uterine Artery Remodeling in the Primate
August 14
Mollie Marr
Dating the 1700 Cascadia Earthquake: Great Coastal Earthquakes in Native Stories
August 7
Michael Berry
Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells
July 31
Investigating the Neural Circuits of Spinal Cord Stimulation
Andrei Sdrulla, MD, PhD, Assistant Professor, Anesthesiology & Perioperative Medicine
July 24
Sudarshan Iyer
Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer
July 17
Gina Calco
Thermal stress induces glycolytic beige fat formation via a myogenic state
July 10
Kristen Stevens
Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features
June 26
John Butler
3MT: Episomes, bad acronyms and h-index: A discussion on the low end of the yield spectrum
Followed by a roundtable discussion
June 19
June 12
Will Yashar
First M87 Event Horizon Telescope Results. I. The Shadow of the Supermassive Black Hole
June 5 - Career Development
Diagnostic Reasoning
Peter Sullivan, MD, FACP, Associate Professor, Division of Hospital Medicine
May 29
Natasha Warikoo
Integrating time from experience in the lateral entorhinal cortex
May 22
May 15
Sweta Adhikary
Restoration of brain circulation and cellular functions hours post-mortem
May 8
May 1
ELQ-300 and other anti-malarial medications
Michael Riscoe, PhD, Professor, Molecular Microbiology and Immunology
April 24
Retreat Keynote Speaker Introduction: Sandra Davidge, PhD
Rachel Drake
April 17
Jackie Emathinger
Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming
April 10
Machine Learning
Gavin Young
Dermatologist-level classification of skin cancer with deep neural networks
Deep learning
April 3
In vivo Molecular Imaging in Cardiovascular Research
Jonathan Lindner, MD, Professor, Division of Cardiovascular Medicine; Director, Cardiovascular Imaging, OHSU Knight Cardiovascular Institute; Division Chief, Cardiometabolic Health, Oregon National Primate Research Center
March 20
Alternative splicing regulates antigen presentation to MR1-restricted T cells
Anjali Narayanan
March 13
Chloride channel mutations in primary aldosteronism
Elizabeth Swanson
A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism
CLCN2 chloride channel mutations in familial hyperaldosteronism type II
March 6
Kevin Burfeind
A Homing System Targets Therapeutic T-Cells to Brain Cancer [retracted]
February 27 - Career Development
Creating a Path to Academic Success
Brian Druker, MD, Professor, Division of Hematology & Medical Oncology; Associate Dean, Oncology; Director, OHSU Knight Cancer Institute
The Clinical Investigator: bewitched, bothered, and bewildered - but still beloved
February 20
Sadra Hamedzadeh
Pathogen Elimination by Probiotic Bacillus via Signalling Interference
February 13
Sunil Joshi
A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis
February 6
Macrophage-Tumor cell fusion: Functional impact on tumor progression, early detection, and measure of treatment response
Melissa Wong, PhD, Associate Professor, Cell, Developmental and Cancer Biology
January 30
Ashley Anderson
Biparental Inheritance of Mitochondrial DNA in Humans
January 23
January 16
January 9
Molecular Imaging and Therapy for Precision Oncology
Erik Mittra, MD, PhD, CCD, Associate Professor, Diagnostic Radiology, Division of Nuclear Medicine; Section Chief, Nuclear Medicine
2017/2018
December 19
Negative crosstalks between hypoxia and androgen response pathways lead to therapy resistance in prostate cancer
David Qian, PhD, Assistant Professor, Knight Cancer Institute
December 12
December 5
Sam Huang
Meganuclease targeting of PCSK9 in macaque liver leads to stable reduction in serum cholesterol
November 28
Brennan Olson
Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis
November 14
One is the loneliest number: A brief introduction to extant and extinct hominins
Jim Goodman
The genome of the offspring of a Neanderthal mother and a Denisovan father
November 7
Kristen Stevens
Phenotype risk scores identify patients with unrecognized Mendelian disease patterns
October 31 - Career Development
Life After Residency
Dave Lewinsohn, MD, PhD, Professor, Pulmonary & Critical Care Medicine
Deb Lewinsohn, MD, Professor, Pediatrics, Division of Infectious Diseases
October 24
Michael Berry
Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas
October 17
Rachel Drake
Moderate UV Exposure Enhances Learning and Memory by Promoting a Novel Glutamate Biosynthetic Pathway in the Brain
October 10
TheAnh Nguyen
Myocardial Infarction Produces Sustained Proinflammatory Endothelial Activation in Remote Arteries
October 3
Neural control of response against bacterial infections and immune homeostasis
Alejandro Aballay, PhD, Professor & Chair, Molecular Microbiology & Immunology
September 26
Gina Calco
Microglia play an active role in obesity-associated cognitive decline
September 19
Sudarshan Iyer
E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer
September 5
Lymphatic Vessels: Critical Regulators of Peripheral Immune Responses
Amanda Lund, PhD, Assistant Professor, Cell, Developmental & Cancer Biology
August 29
A Discussion of Suicide: mental health, prevention and self-care, and suicide in graduate education
Katy Michaelis
Vital Signs: Trends in State Suicide Rates - United States, 1999–2016 and Circumstances Contributing to Suicide - 27 States, 20152
Preventing Suicide: A Technical Package of Policy, Programs, and Practices
Evidence for a mental health crisis in graduate education
A prevalence study on depression and anxiety in graduate school across disciplines
Kathryn
NEJM piece on suicide in medical school
Breaking the Stigma —A Physician's Perspective on Self-Care and Recovery
Another NEJM reading on mental health in the medical profession
Everything is Awful and I'm Not Okay: Questions to Ask Before Giving Up
A one page primer on self-care for a variety of situations
August 22
August 15
How to Present a Journal Club
David Jacoby, MD, Program Director, MD/PhD Program; Chair & Professor, Department of Medicine
August 8
Novel Insights into IL-33 Regulation in Allergic Disease
Marsha Wills-Karp, PhD, Chair & Professor, Environmental Health & Engineering, Johns Hopkins University
August 1
Mollie Marr
CheXNet: Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learning
July 25
Allogenic Stem Cell Transplantation in HIV Cure
Jonah Sacha, PhD, Associate Professor, Vaccine and Gene Therapy Institute, Molecular Microbiology and Immunology, Oregon National Primate Research Center
July 18
Sexual Harassment of Women in Academic Sciences, Engineering, and Medicine
Kelsey Priest
Sexual Harassment of Women: Climate, Culture, and Consequences in Academic Sciences, Engineering, and Medicine (2018)
Sexual harassment is rampant in science —and current policies aren't cutting it, landmark report finds
July 11
Physiological Changes During Long-Duration Space Flight
John Butler
Fluid shifts, vasodilatation and ambulatory blood pressure reduction during long duration spaceflight
Increased core body temperature in astronauts during long-duration space missions
June 20
Sweta Adhikary
A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action
June 13
Caroline King
Socioeconmic Outcomes of Women Who Receive and Women Who Are Denied Wanted Abortions in the United States
June 6
The Human Side of Data: Examining the intersection of data, integrity, and society
Jackie Wirz, PhD, Assistant Dean, School of Medicine Graduate Studies
May 30
Kevin Burfeind
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
Human hippocampal neurogensis persists throughout aging
May 16
Cheryl Claunch
Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes
May 9
Anjali Narayanan
Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair
Killer T Cells show their kinder side
May 2
Molecular and Genetic Mechanisms of Myelin Development and Repair
Kelly Monk, PhD, Senior Scientist & Co-Director, Vollum Institute
April 25
Pre and postnatal determinants of airway hyperreactivity
Katie Lebold
April 18
April 11
Carsten Schultz, PhD, Professor, Physiology & Pharmacology
April 4
Ali Pincus
The fuzzy logic of network connectivity in mouse visual thalamus
March 28
Burcu Gurun-Demir
Using synthetic templates to design an unbiased multiplex PCR assay
March 21
Gavin Young
Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module
March 14
Panel Discussion: Navigating the Unknown: Shared Decision-Making in the Face of Uncertainty in Science and Clinic
Jenya Zilberman-Rudenko
March 7
Modeling Anxiety in the Laboratory
Bita Moghaddam, PhD, Professor & Chair, Behavioral Neuroscience
February 28
Retreat Keynote Speaker Introduction: Cindy McEvoy, MD, MCR
Elizabeth Swanson
February 21
Jackie Emathinger
Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice
February 7
Light: A window into pain in the brain
Mary Heinricher, PhD, Professor, Neurological Surgery
January 31
January 24
January 17
Jim Goodman
Stress-induced unfolded protein response contributes to Zika virus–associated microcephaly
January 10
Rachel Drake
Transcription Factor EB Controls Metabolic Flexibility during Exercise
January 3
Molecular mechanisms of axon degeneration
Marc Freeman, PhD, Senior Scientist & Director, Vollum Institute