M.D./Ph.D. Journal Club

Journal Club is a required course for all MD/PhD students and attendance is required. With a few exceptions including holidays and academic breaks, Journal Club is hosted every Wednesday from 1230-130pm PST.

Please email the MD/PhD program to be added to the journal club listserve for weekly updates and most recent information.

Each MD/PhD student will present a journal article of their choosing 1-2 times each year throughout the entirety of their program. Once a month faculty members will present at Journal Club on their research or as a career/professional development session. 

Review Journal Club Guidelines

Upcoming presentations


August 7
Katherine Pelz
Topic: TBD

August 14
Eli Wisdom
Topic: TBD

August 21
Kayla Maanum
Topic: TBD

August 28
Faculty Presenters & Titles:

Alireza (Ali) Karimi, PhD


September 4
Rohan Chaudhari
Topic: TBD

September 11
Faculty Presenters & Titles:

Michael Hutchens, MD, MA

September 18
Amanda Zuckler
Topic: TBD

September 25
Samuel Kim
Topic: TBD


October 2
Topic: TBD

October 9
Zach Yellowman
Topic: TBD









Past presentations


June 29
Xammy Nguyenla
Topic: Gaucher disease protects against tuberculosis

July 6
Kayla Maanum
Topic: Cardiogenic control of affective behavioral state

July 13
Monika Davare, PhD
Topic: Unlocking ROS1 in Cancer: Tyrosine Kinase Inhibitors, Resistance, and Novel Biomarkers

July 20
Hannah Jaeger
Topic: Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface

July 27
Amara Pang
Topic: LAP1 supports nuclear adaptability during constrained melanoma cell migration and invasion

August 3
Mizan Gaillard
Topic: Associations between social behaviors and experiences with neural correlates of implicit emotion regulation in middle childhood

August 10
Joshua Moreau, PhD
Topic: Tissue B cells: making themselves at home in inflammatory skin disease and cancer

August 17
Joyce Kim
Topic: Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I

August 24
Emily Hillhouse, MA, PhD
Topic: Study Smarter Not Harder: Finding Academic Success at OHSU

August 31
Sofia Vignolo
Topic: Bone-matrix mineralization dampens integrin-mediated mechanosignalling and metastatic progression in breast cancer

September 7
Aleksandra Dagunts
Topic: Environment-dependent behavioral traits and experiential factors shape addiction vulnerability

September 14
Luis Diaz
Topic: A gene–environment-induced epigenetic program initiates tumorigenesis

September 21 - CXL (FALL BREAK)

September 28 - CXL

October 5
David Jacoby, MD
Topic: Journal Club Best Practices

October 12
Simone Woodruff
Topic: Medin co-aggregates with vascular amyloid-β in Alzheimer’s disease

October 19
Paige Farris & Wesley Stoller
Topic: Accessing Data Resources: All of Us and Healthy Oregon Project

October 26
Parham Diba
Topic: Aging impairs the neurovascular interface in the heart

November 2
Will Yashar
Topic: Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid Leukemia

November 9
Tanaya Shree, MD, PhD
Topic: “The immunobiology of lymphomas”

November 16
Melanie Piller
Topic: CNS myelination requires VAMP2/3-mediated membrane expansion in oligodendrocytes

November 23 - CXL (BREAK)

November 30
Jacqueline Emathinger
Topic: Design and testing of a humanized porcine donor for xenotransplantation

December 7 - CXL

December 14 - CXL

December 21 - CXL (BREAK)

December 28 - CXL (BREAK)

January 4, 2024 - CXL (BREAK)

January 11
Ashley Anderson
Topic: Systematic investigation of mitochondrial transfer between cancer cells and T cells at single-cell resolution

January 18 - CXL

January 25
Anupriya Agarwal, PhD
Topic: Mechanisms and Intervention Strategies in Premalignant Disorders

February 1
Landon Bayless-Edwards
Topic: Antipsychotic drug efficacy correlates with the modulation of D1 rather than D2 receptor-expressing striatal projection neurons

February 8
Kelly Abshire
Topic: Unraveling the epigenomic and transcriptomic interplay during alcohol-induced anxiolysis

February 15
Moriah Arnold
Topic: PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions

February 22
Andrei Sdrulla, MD, PhD
Topic: Spinal Cord Stimulation: Basics and Beyond

February 29
Gregory Chin
Topic: Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis

March 7
Tanya Korzun
Topic: Navigating Challenges in mRNA Lipid Nanoparticle Therapeutics for Metastatic Epithelial Cancers

March 14
Presenters: Introduction by OASIS followed
David Lewinsohn, MD, PhD
Topic: Recognizing the Mycobacterium tuberculosis Infected Cell:  Lessons Learned from Human CD8+ T cells

March 21
Mady Tung
Topic: Oral delivery of metformin by chitosan nanoparticles for polycystic kidney disease

March 28 - CXL (BREAK)

April 3
Rin Yang
Topic: Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host

April 10
Malik Seals
Topic: The survival and function of IL-10-producing regulatory B cells are negative controlled by SLAMF5

April 17
Gina Bash & Michael Berry (MS4)
Topic: The Residency Quest: From Clinical Rotations to Match Day

April 24
Justin Denny, MD, MPH
Topic: Student Opportunities with OHSU Global in Southeast Asia

May 1
Taitea Dykstra
Topic: Myeloid cell replacement is neuroprotective in chronic experimental autoimmune encephalomyelitis

May 8
Marina Wolf, PhD
Topic: Synaptic mechanisms maintaining persistent cocaine craving

May 15
Jack Henry Kotnik
Topic: Spatial imaging of glycoRNA in single cellswith ARPLA

May 22
TJ Ekstrom
Topic: A spatially resolved timeline of the human maternal–fetal interface

May 29
Steven Adamou
Topic: NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload

June 5
Hanna Minns
Topic: Remote neuronal activity drives glioma progression through SEMA4F

June 12
Faculty Presenters & Titles: 

Megan Ruhland, PhD“Dendritic cell function in anti-tumor immunity"
Katelyn Byrne, PhD“Harnessing CD4 T cell immunity in pancreatic cancer”

June 19
Rick Mathews
Topic: Inflammatory stimuli induce shedding of heparan sulfate from arterial but not venous porcine endothelial cells leading to differential proinflammatory and procoagulant responses

June 26 - CXL


Aug 25:

Topic: Transcriptional Plasticity Drives Leukemia Immune Escape

Presenter:  Will Yashar

Sep 1

Topic: YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion

Presenter: Ashley Anderson

Sep 8

Faculty Presenter: Olina Taratula



Sep 29

Faculty Presenter: David Jacoby, MD

Oct 6

Topic: Highly accurate protein structure prediction with AlphaFold

Presenter: Gavin Young

Oct 13

Topic: Mapping the single-cell transcriptomic response of murine diabetic kidney disease to therapies

Presenter: Jacqueline Emathinger

Oct 20

Topic: Association of a common genetic variant with Parkinson’s disease is mediated by microglia

Presenter: Greg Chin

Oct 27

Faculty Presenter: Leslie Myatt, PhD, FRCOG

Nov 3

Topic: Neutrophil extracellular traps promote fibrous vascular occlusions in chronic thrombosis

Presenter: Rick Mathews

Nov 10

Topic: Alterations in microbiome composition and metabolic byproducts drive behavioral and transcriptional responses to morphine

Presenter: Kelly Abshire



Dec 1

Topic: Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine

Presenter: Tetiana Korzun

Dec 8

Topic: “Translational Models for Transarterial Tumor Therapies"

Presenter: Khashayar Farsad

Dec 15

Topic: Small RNAs are modified with N-glycans and displayed on the surface of living cells

Presenter: Zoe Beach



Jan 12

Topic: High throughput functional variant screens via in vivo production of single-stranded DNA

Presenter: Somya Khare

Jan 19

Topic: Tracing Brain Genotoxic Stress in Parkinson's Disease with a Novel Single-Cell Genetic Sensor

Presenter: Moriah Arnold

Jan 25

Topic: “Blood clotting and the endothelium: the good, bad and the sticky”

Presenter: Owen McCarty, PhD, FAHA

Feb 2

Topic: Genetically engineered myeloid cells rebalance the core immune suppression program in metastasis

Presenter: Rohan Chaudhari

Feb 9

Topic: The metabolic digital twin: theory and applications in improving drug delivery in type 1 diabetes

Presenter: Peter Jacobs, PhD

Feb 16

TopicVagus nerve stimulation drives selective circuit modulation through cholinergic reinforcement

Presenter: Landon Bayless-Edwards

Feb 23

CXL (Inclement Weather)

Mar 2

Topic: Endogenous OT exerts anti-nociceptive and anti-inflammatory effects in rats

Presenter: Jessica Keating

Mar 9

Topic: Neural effects of transcranial magnetic stimulation at the single-cell level

Presenter: Jing Xie

Mar 16

Topic: “Engineering photopharmacology tools to control lipid signaling in excitable cells”

Presenter: James Frank, PhD

Mar 23

Topic: The Golden Years: Clinical Rotations and Applying to Residency

Presenter: MS4 Students


Apr 6

Topic: Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3

Presenter: Katherine Pelz

Apr 13

Topic: Chronic changes in oligodendrocyte sub-populations aftermiddle cerebral artery occlusion in neonatal mice

Presenter: Samuel Kim

Apr 20

Topic: Multiregional single-cell dissection of tumor and immune cells reveals stable lock-and-key features in liver cancer

Presenter: Amanda Zucker

Apr 27

Topic: Network Systems Biology: Mapping Macromolecular Interactions for Drug Discovery”

Presenter: Andrew Emili, PhD

May 4

Topic: Transcutaneous Vagus Nerve Stimulation Ameliorates the Phenotype of Heart Failure With Preserved Ejection Fraction Through Its Anti- Inflammatory Effects

Presenter: Zachary Yellowman

May 11

Topic: Generative Agents: Interactive Simulacra of Human Behavior

Presenter: Eric Cramer

May 18

Topic: “The Oregon Rural Practice-based Research Network (ORPRN)…5Ws and You”

Presenter: Melinda Davis, PhD, MCR


June 1

Topic: Uncovering mechanisms and developing novel therapies for intestinal inflammation

Presenter: Sarah Andres, PhD

June 8

Topic: Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies

Presenter: Jaime Contreras

June 15

Topic: Semaglutide reduces alcohol intake and relapse-like drinking in male and female rats

Presenter: Natasha Warikoo

June 22

Topic: Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function

Presenter: Elias Wisdom


July 7
Presenter: Mizan Gaillard

June 30

Presenter: Joyce Kim

Title:  Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides

Jun 23 

No Journal Club

June 16

Presenter: Luis Diaz

Title: Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis

June 9

Presenter: TheAnh Nguyen

Topic: NLRP3 Inflammasome Inhibition as a Treatment for Post-Myocardial Infarction Microvascular No-Reflow

June 2

Vivek Unni, MD, PhD, Associate Professor, Neurology

Topic: Alpha-synuclein and disease in four vignettes (three scientific & one personal)

May 26

Topic: Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons

Presenter: Aleksandra Dagunts

May 12

Topic: The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow

Presenter: Amara Pang

May 5

Thomas S. Scanlan, PhD

CNS Thyroid Hormone Action for Treating Neurodegenerative Diseases

April 28

Natasha Warikoo

Cannabinoid receptor activation acutely increases synaptic vesicle numbers by activating synapsins in human synapses

April 21

Kayla Maanum

An endogenous opioid circuit determines state-dependent reward consumption

April 14

Eli Wisdom

Endothelial Unc5B controls blood-brain barrier

March 31

Topic: The Golden Years: clinical rotations and applying to residency

Presenter: John Butler, MD, PhD and Kristen Stevens, MD, PhD

March 17

The immunoregulatory landscape of human tuberculosis granulomas

Xammy Nguyenla

March 10

Mechanical allodynia circuitry in the dorsal horn is defined by the nature of the injury

Jessica Keating

March 3

Potency of planarians:  an in vivo model to understand adult stem cells and tumorigenesis
Bret Pearson, PhD, Associate Professor, Pediatrics

February 24

Hannah Jaeger - see 2 articles below

1) Safety and Immunogenicity of an Anti–Zika Virus DNA Vaccine
2) In vivo protection against ZIK V infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine

February 17

Tony Zheng

Massive image-based single-cell profiling reveals high levels of circulating platelet aggregates in patients with COVID-19

February 10

Landon Bayless-Edwards

Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior

January 27 - online

Moriah Arnold

Knocking out alpha-synuclein in melanoma cells dysregulates cellular iron metabolism and suppresses tumor growth

January 20 - online

Eric Cramer

Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19

January 13 - online

Zoe Beach

Whole-blood metabolomics of dementia patients reveal classes of disease-linked metabolites


December 16

Jackie Emathinger

New Creatinine- and Cystatin C–Based Equations to Estimate GFR without Race

December 9

Rick Mathews
Macrophage-derived MMP-8 determines smooth muscle cell differentiation from adventitia stem/progenitor cells and promotes neointima hyperplasia

November 18

Greg Chin

Microglial activation and tau propagate jointly across Braak stages
Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes

November 11

Kelly Abshire

Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

October 28

Sudarshan Iyer

Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis

October 21

Burcu Gurun-Demir

Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML

October 14

Journal Club Best Practices
David Jacoby, MD, Interim Dean, School of Medicine; Program Director, MD/PhD Program

October 7

Building cell-scale maps of biochemical processes: Challenges and Applications
Emek Demir, PhD, Associate Professor, Molecular & Medical Genetics

September 29

Gavin Young

AI for radiographic COVID-19 detection selects shortcuts over signal

September 15

Jackie Emathinger

Self-organization of the in vitro attached human embryo

September 8

Ashley Anderson

Spatially resolved transcriptomics reveals the architecture of the tumor/microenvironment interface

August 25

Will Yashar

Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level

August 18

Gina Calco

Acrobatic squirrels learn to leap and land on tree branches without falling

August 11

Parham Diba

Trem2 restrains the enhancement of tau accumulation and neurodegeneration by B-amyloid pathology

August 4

Computational Precision Oncology at the Knight Cancer Institute
Jeremy Goecks, PhD, Associate Professor, Biomedical Engineering

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution
An Omic and Multidimensional Spatial Atlas from Serial Biopsies of an Evolving Metastatic Breast Cancer

July 28

Tanya Korzun

Post-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles

July 21

Melanie Piller

Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation

July 14

Michael Berry

Partial recovery of visual function in a blind patient after optogenetic therapy
Pre-clinical publication: Optogenetic therapy

July 7

Center for Experimental Therapeutics: Translating Discoveries to Clinic
Sanjay Malhotra, PhD, FRSC, Professor, Cell, Developmental and Cancer Biology

June 30

Agonist specific regulation of GPCRs after chronic opioid treatment
Sweta Adhikary

June 16

Simone Woodruff

Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment

June 9

Luis Diaz

RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation

June 2 - career development

Neuroimmune Interactions in Eosinophilic Asthma
Matt Drake, MD, Assistant Professor, Medicine, Pulmonary & Critical Care

Eosinophils increase airway sensory nerve density in mice and in human asthma
IL-5 Exposure In Utero Increases Lung Nerve Density and Airway Reactivity in Adult Offspring

May 26

Sofia Vignolo

Adipose tissue is a critical regulator of osteoarthritis

May 19

Natasha Warikoo

Endogenous opioids regulate moment-to-moment neuronal communication and excitability

May 5

Exploring cardiovascular development with the fetal sheep model
Sonnet Jonker, PhD, Associate Professor, Medicine, Cardiovascular Medicine

Endocrine and other physiologic modulators of perinatal cardiomyocyte endowment

April 28

Landon Bayless-Edwards

Fast spiking interneuron activity in primate striatum tracks learning of attention cues

April 21

Joyce Kim

Skin-resident innate lymphoid cells converge on a pathogenic effector state

April 14

Moriah Arnold

APOE4 exacerbates a-synuclein pathology and related toxicity independent of amyloid

April 7

Target identification and drug development for rare leukemias

Julia Maxson, PhD, Assistant Professor, Medicine

March 31

MD/PhD Road to Residency

MS4s: Kevin Burfeind, PhD; Jim Goodman, PhD; Anjali Narayanan, PhD; Katy Michaelis, PhD; Elizabeth Swanson, PhD

March 17

Mizan Gaillard

The neurobiology of wellness: H-MRS correlates of agency, flexibility and neuroaffective reserves in healthy young adults

March 10

Aleksandra Dagunts

Facial expressions of emotion states and their neuronal correlates in mice

March 3 - closed event

Babak Nazer, MD, Assistant Professor, Medicine, Cardiovascular Medicine
David Giraud, MEng, Principal Engineer

High-intensity ultrasound catheter ablation achieves deep mid-myocardial lesions in vivo

February 24

Greg Chin

Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism

February 10

Tony Zheng

The Fluid Mechanics of Transcatheter Heart Valve Leaflet Thrombosis in the Neosinus
The Role of Flow Stasis in Transcatheter Aortic Valve Leaflet Thrombosis

February 3

Dissecting Brain Circuitry Using Connectomic and Novel Imaging Approaches
Tianyi Mao, PhD, Associate Professor & Scientist, Vollum Institute

January 27

Brennan Olson

Origin and Function of Stress-Induced IL-6 in Murine Models

January 20

Do substance use disorders drive immune dysregulation? The application of translational immunology to complex human cohorts
Christina Lancioni, MD, Associate Professor, Pediatrics, Infectious Diseases

Altered monocyte phenotype and dysregulated innate cytokine responses among people living with HIV and opioid-use disorder
Alcohol and HIV Effects on the Immune System
Opioids and the immune system – friend or foe
Gut barrier structure, mucosal immunity and intestinal microbiota in the pathogenesis and treatment of HIV infection

January 13

Burcu Gurun-Demir

Single cell mutation analysis of clonal evolution in myeloid malignancies 
Clonal evolution of acute leukemia revealed by high-throughput single cell genomics

January 6

Ali Pincus

Hippocampal Neuropathology of Domoic Acid– Induced Epilepsy in California Sea Lions (Zalophus californianus)
Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice


December 16

Rick Mathews

Abnormally extended ductal tissue into the aorta is indicated by similar histopathology and shared apoptosis in patients with coarctation

December 9

Kim Montaniel, Graduate Student, Phsyiology & Pharmacology

Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoeitic progenitor cells

December 2

A global lipid map defines a network essential for Zika virus replication
Pacific Northwest National Laboratory (PNNL)

November 18

Placental Insufficiency Alters Fatty Acid Metabolism in the Fetal Sheep Heart
Rachel Drake

November 11

Sudarshan Iyer

Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence

November 4
Targeting the Leukemia Microenvironment
Elie Traer, MD, PhD, Associate Professor, Medicine, Hematology & Medical Oncology

October 28

SARS-CoV-2 and mRNA Vaccines
Sam Huang

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

October 21

Gavin Young
An adaptive deep reinforcement learning framework enables curling robots with human-like performance in real-world conditions

October 14

Presentation Best Practices
David Jacoby, MD, Professor & Chair, Medicine and Director, MD/PhD Program

October 7 - Career Development

Chasing Tapeworms: A communicable cause of epilepsy
Seth O'Neal, MD, PhD, Assistant Professor, Public Health

September 30

Modeling hospital-based addiction interventions’ impact on post-discharge mortality
Caroline King

September 16

Racism and Bias in Psychiatric Diagnoses
Mollie Marr

Please read at least one article below in preparation:

Racial and Ethnic Disparities in ADHD Diagnosis and Treatment
Unconscious Bias and the Diagnosis of Disruptive Behavior Disorders and ADHD in African American and Hispanic Youth

September 9

Sunil Joshi

Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia

September 2

Using physiologic and data-driven models to design and evaluate new drug delivery systems
Peter Jacobs, PhD, Associate Professor, Biomedical Engineering

August 26

Take a model, and make it your own!
Nichole Tyler

ARX model for interstitial glucose prediction during and after physical activities

Continuous Glucose Monitoring and Insulin Informed Advisory System with Automated Titration and Dosing of Insulin Reduces Glucose Variability in Type 1 Diabetes Mellitus

August 19

TheAnh Nguyen

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

August 12

Zoe Beach

TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma

August 5

Understanding and Improving Outcomes After Critical Illness
Terri Hough, MD, MS, Division Chief, Pulmonary and Critical Care Medicine

July 29

Ashley Anderson
TMEM16F phospholipid scramblase mediates trophoblast fusion and placental development

July 22

Tanya Korzun
Monocyte-derived multipotent cell delivered programmed therapeutics to reverse idiopathic pulmonary fibrosis

July 15

Mike Berry
Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae

July 8

Sweta Adhikary
A neural basis for tonic suppression of sodium appetite

July 1 - Career Development

Carpe Diem (or how I ended up doing coronavirus research)
Reid Thompson, MD, PhD, Assistant Professor, Radiation Medicine, Biomedical Engineering, CEDAR

June 24

Policing the police: A Journal Club
Sweta Adhikary, Gina Calco, Jim Goodman, Mollie Marr, Natasha Warikoo

Please review the materials below to read/watch before journal club on 6/24:

June 17

Parham Diba

Gut-seeded alpha-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice

June 3

Hypomagnesemia and the renal thiazide-sensitive NaCl cotransporter
Jim McCormick, PhD, Associate Professor, Medicine, Nephrology & Hypertension

May 27

John Butler

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

May 20

Gina Calco

Novel metabolic role for BDNF in pancreatic β-cell insulin secretion

May 13

Will Yashar

Quantum supremacy using a programmable superconducting processor

April 29

Luis Diaz

Progressive Loss of Function in a Limb Enhancer during Snake Evolution

April 22

Natasha Warikoo

Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep

April 8

On the Residency Trail with MS4s, 2019-2020
Cheryl Claunch & Katie Lebold

April 1

Determining  heterogeneity in cancer and in immunotherapy-associated skin-directed adverse events
Rajan Kulkarni, MD, PhD, Associate Professor, Dermatology, CEDAR, Knight Cancer Institute

March 4

Sympathetic contributions to cardiac arrhythmia
Beth Habecker, PhD, Professor, Chemical Physiology & Biochemistry

Targeting protein tyrosine phosphatase Sigma after myocardial infarction restores cardiac sympathetic innervation and prevents arrhythmias

The cardiac sympathetic co-transmitter neuropeptide Y is pro-arrhythmic following ST-elevationmyocardial infarction despite beta-blockade

February 26

The debate on the role of the immune system in hypertension
Jackie Emathinger

February 19

Landon Bayless-Edwards

A potassium channel β-subunit couples mitochondrial electron transport to sleep

February 12

Caroline King

Dynamics of the HIV outbreak and response in Scott County, IN, USA, 2011–15: a modelling study

February 5

I swear by Apollo the Healer, by Asclepius,…Primum non noncere… Remembering the impact of the USPHS Tuskegee Syphilis Trial
Alan Hunter, MD, FACP, Professor & Division Head, Hospital Medicine; Associate Program Director, OHSU Internal Medicine Residency Program

January 29

Rachel Drake

Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition

January 22

Moriah Arnold

Amyloid beta oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes

January 15

Tony Zheng

Microvasculature-on-a-chip for the long-term study of endothelial barrier dysfunction and micro-vascular obstruction in disease

January 8 - Career Development

Challenge and Recovery: How pancreatic cancer impairs physiologic adaptation - with a special focus on designing physician-scientist training

Aaron Grossberg, MD, PhD, Assistant Professor, Radiation Oncology


December 11

Gavin Young

Machine learning analysis of DNA methylation profiles distinguishes primary lung squamous cell carcinomas from head and neck metastases

December 4 - Career Development

The Sweetest Side of Kidney Research
Susan Gurley, MD, PhD, Associate Professor & Division Head, Nephrology & Hypertension

November 20

Brennan Olson
GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

November 13

Practicing medicine in the era of the smart phone
Cymon Kersch & Logan Jones, Senior Internal Medicine Resident
Google Doc Slides

November 6

Inflammatory Microenvironment as Driver of Clonal Selection and Disease Progression in Leukemia
Anupriya Agarwal, PhD, Assistant Professor, Knight Leukemia Center

October 30

Ali Pincus
The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep

October 23
Presenting Well
David Jacoby, MD, Chair & Professor, Medicine; MD/PhD Program Director

October 16

Rick Mathews
Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes

October 9

Sam Huang
Continuous evolution of base editors with expanded target compatibility and improved activity

October 2

Epigenetic Dysfunction in Myeloid Leukemia
Ted Braun, MD, PhD, Instructor, Division of Hematology & Medical Oncology, Knight Cancer Institute

September 25

Burcu Gurun-Demir
Portraits of genetic intra-tumour heterogeneity and subclonal selection across cancer types

September 11

Nichole Tyler
Therapy Decision Support Based on Recommender System Methods

September 4

Ashley Anderson
Niche stiffness underlies the ageing of central nervous system progenitor cells

August 28 - Career Development

Doing What You Love
Donna Hansel, MD, PhD, Chair & Professor, Pathology

August 21

TheAnh Nguyen
Vascular Endothelial Growth Factor Delivery to Placental Basal Plate Promotes Uterine Artery Remodeling in the Primate

August 14

Mollie Marr
Dating the 1700 Cascadia Earthquake: Great Coastal Earthquakes in Native Stories

August 7

Michael Berry
Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells

July 31

Investigating the Neural Circuits of Spinal Cord Stimulation
Andrei Sdrulla, MD, PhD, Assistant Professor, Anesthesiology & Perioperative Medicine

July 24

Sudarshan Iyer
Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

July 17

Gina Calco
Thermal stress induces glycolytic beige fat formation via a myogenic state

July 10

Kristen Stevens
Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features

June 26

John Butler
3MT: Episomes, bad acronyms and h-index: A discussion on the low end of the yield spectrum
Followed by a roundtable discussion

June 19

John Butler
Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro

June 12

Will Yashar
First M87 Event Horizon Telescope Results. I. The Shadow of the Supermassive Black Hole

June 5 - Career Development

Diagnostic Reasoning
Peter Sullivan, MD, FACP, Associate Professor, Division of Hospital Medicine

May 29

Natasha Warikoo
Integrating time from experience in the lateral entorhinal cortex

May 22

Tony Zheng
Contractile forces in platelet aggregates under microfluidic shear gradients reflect platelet inhibition and bleeding risk

May 15

Sweta Adhikary
Restoration of brain circulation and cellular functions hours post-mortem

May 8

Caroline King
The Share Project: Building Capacity of Justice-Involved Individuals, Policymakers, and Researchers to Collectively Transform Health Care Delivery

May 1

ELQ-300 and other anti-malarial medications
Michael Riscoe, PhD, Professor, Molecular Microbiology and Immunology

April 24

Retreat Keynote Speaker Introduction: Sandra Davidge, PhD
Rachel Drake

April 17

Jackie Emathinger
Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming

April 10

Machine Learning
Gavin Young
Dermatologist-level classification of skin cancer with deep neural networks
Deep learning

April 3

In vivo Molecular Imaging in Cardiovascular Research
Jonathan Lindner, MD, Professor, Division of Cardiovascular Medicine; Director, Cardiovascular Imaging, OHSU Knight Cardiovascular Institute; Division Chief, Cardiometabolic Health, Oregon National Primate Research Center

March 20

Alternative splicing regulates antigen presentation to MR1-restricted T cells
Anjali Narayanan

March 13

Chloride channel mutations in primary aldosteronism
Elizabeth Swanson
A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism
CLCN2 chloride channel mutations in familial hyperaldosteronism type II

March 6

Kevin Burfeind
A Homing System Targets Therapeutic T-Cells to Brain Cancer [retracted]

February 27 - Career Development

Creating a Path to Academic Success
Brian Druker, MD, Professor, Division of Hematology & Medical Oncology; Associate Dean, Oncology; Director, OHSU Knight Cancer Institute
The Clinical Investigator: bewitched, bothered, and bewildered - but still beloved

February 20

Sadra Hamedzadeh
Pathogen Elimination by Probiotic Bacillus via Signalling Interference

February 13

Sunil Joshi
A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis

February 6

Macrophage-Tumor cell fusion: Functional impact on tumor progression, early detection, and measure of treatment response
Melissa Wong, PhD, Associate Professor, Cell, Developmental and Cancer Biology

January 30

Ashley Anderson
Biparental Inheritance of Mitochondrial DNA in Humans

January 23

Cymon Kersch
Structural variants in genes associated with human Williams-Beuren syndrome underlie stereotypical hypersociability in domestic dogs

January 16

Rick Mathews
Characterization of the Capillary Endothelial Glycocalyx in the Brain and Potential Contributions to the Blood Brain Barrier

January 9

Molecular Imaging and Therapy for Precision Oncology
Erik Mittra, MD, PhD, CCD, Associate Professor, Diagnostic Radiology, Division of Nuclear Medicine; Section Chief, Nuclear Medicine


December 19

Negative crosstalks between hypoxia and androgen response pathways lead to therapy resistance in prostate cancer
David Qian, PhD, Assistant Professor, Knight Cancer Institute

December 12

Ali Pincus
Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus

December 5

Sam Huang
Meganuclease targeting of PCSK9 in macaque liver leads to stable reduction in serum cholesterol

November 28

Brennan Olson
Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis

November 14

One is the loneliest number: A brief introduction to extant and extinct hominins
Jim Goodman
The genome of the offspring of a Neanderthal mother and a Denisovan father

November 7

Kristen Stevens
Phenotype risk scores identify patients with unrecognized Mendelian disease patterns

October 31 - Career Development

Life After Residency
Dave Lewinsohn, MD, PhD, Professor, Pulmonary & Critical Care Medicine
Deb Lewinsohn, MD, Professor, Pediatrics, Division of Infectious Diseases

October 24

Michael Berry
Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas

October 17

Rachel Drake
Moderate UV Exposure Enhances Learning and Memory by Promoting a Novel Glutamate Biosynthetic Pathway in the Brain

October 10

TheAnh Nguyen
Myocardial Infarction Produces Sustained Proinflammatory Endothelial Activation in Remote Arteries

October 3

Neural control of response against bacterial infections and immune homeostasis
Alejandro Aballay, PhD, Professor & Chair, Molecular Microbiology & Immunology

September 26

Gina Calco
Microglia play an active role in obesity-associated cognitive decline

September 19

Sudarshan Iyer
E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer

September 5

Lymphatic Vessels: Critical Regulators of Peripheral Immune Responses
Amanda Lund, PhD, Assistant Professor, Cell, Developmental & Cancer Biology

August 29

A Discussion of Suicide: mental health, prevention and self-care, and suicide in graduate education
Katy Michaelis
Vital Signs: Trends in State Suicide Rates - United States, 1999–2016 and Circumstances Contributing to Suicide - 27 States, 20152
Preventing Suicide: A Technical Package of Policy, Programs, and Practices
Evidence for a mental health crisis in graduate education
A prevalence study on depression and anxiety in graduate school across disciplines
NEJM piece on suicide in medical school
Breaking the Stigma —A Physician's Perspective on Self-Care and Recovery
Another NEJM reading on mental health in the medical profession
Everything is Awful and I'm Not Okay: Questions to Ask Before Giving Up
A one page primer on self-care for a variety of situations

August 22

Nichole Tyler
Continuous Glucose Monitoring and Insulin Informed Advisory System with Automated Titration and Dosing of Insulin Reduces Glucose Variability in Type 1 Diabetes Mellitus

August 15

How to Present a Journal Club
David Jacoby, MD, Program Director, MD/PhD Program; Chair & Professor, Department of Medicine

August 8

Novel Insights into IL-33 Regulation in Allergic Disease
Marsha Wills-Karp, PhD, Chair & Professor, Environmental Health & Engineering, Johns Hopkins University

August 1

Mollie Marr
CheXNet: Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learning

July 25

Allogenic Stem Cell Transplantation in HIV Cure
Jonah Sacha, PhD, Associate Professor, Vaccine and Gene Therapy Institute, Molecular Microbiology and Immunology, Oregon National Primate Research Center

July 18

Sexual Harassment of Women in Academic Sciences, Engineering, and Medicine
Kelsey Priest
Sexual Harassment of Women: Climate, Culture, and Consequences in Academic Sciences, Engineering, and Medicine (2018) 
Sexual harassment is rampant in science —and current policies aren't cutting it, landmark report finds

July 11

Physiological Changes During Long-Duration Space Flight
John Butler
Fluid shifts, vasodilatation and ambulatory blood pressure reduction during long duration spaceflight
Increased core body temperature in astronauts during long-duration space missions

June 20

Sweta Adhikary
A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action

June 13

Caroline King
Socioeconmic Outcomes of Women Who Receive and Women Who Are Denied Wanted Abortions in the United States

June 6

The Human Side of Data: Examining the intersection of data, integrity, and society
Jackie Wirz, PhD, Assistant Dean, School of Medicine Graduate Studies

May 30

Kevin Burfeind
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
Human hippocampal neurogensis persists throughout aging

May 16

Cheryl Claunch
Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes

May 9

Anjali Narayanan
Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair
Killer T Cells show their kinder side

May 2

Molecular and Genetic Mechanisms of Myelin Development and Repair
Kelly Monk, PhD, Senior Scientist & Co-Director, Vollum Institute

April 25

Pre and postnatal determinants of airway hyperreactivity
Katie Lebold

April 18

Cymon Kersch
Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial

April 11

Carsten Schultz, PhD, Professor, Physiology & Pharmacology

April 4

Ali Pincus
The fuzzy logic of network connectivity in mouse visual thalamus

March 28

Burcu Gurun-Demir
Using synthetic templates to design an unbiased multiplex PCR assay

March 21

Gavin Young
Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module

March 14

Panel Discussion: Navigating the Unknown: Shared Decision-Making in the Face of Uncertainty in Science and Clinic
Jenya Zilberman-Rudenko

March 7

Modeling Anxiety in the Laboratory
Bita Moghaddam, PhD, Professor & Chair, Behavioral Neuroscience

February 28

Retreat Keynote Speaker Introduction: Cindy McEvoy, MD, MCR
Elizabeth Swanson

February 21

Jackie Emathinger
Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice

February 7

Light: A window into pain in the brain
Mary Heinricher, PhD, Professor, Neurological Surgery

January 31

Tony Zheng
Accelerating bacterial growth detection and antimicrobial susceptibility assessment in integrated picoliter droplet platform

January 24

Sam Huang
Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes

January 17

Jim Goodman
Stress-induced unfolded protein response contributes to Zika virus–associated microcephaly

January 10

Rachel Drake
Transcription Factor EB Controls Metabolic Flexibility during Exercise

January 3 

Molecular mechanisms of axon degeneration
Marc Freeman, PhD, Senior Scientist & Director, Vollum Institute