Current Studies

A researcher tests samples in the Shin Lab at OHSU

The Department of Urology supports an array of research efforts led by faculty in the areas of laboratory-based translational science, outcomes research, and clinical trials. Each of our faculty have grounded commitments to furthering the research mission of the department, and many of the current efforts in clinical research are filling a much needed role of treating, managing, and preventing urologic disorders among our patients and all others suffering from urologic conditions.

Here are a few of the current projects led by Urology faculty:

Flexible ureteroscopy durability and cost

PI: Brian Duty

This is a multi-center prospective study examining the durability and cost of use associated with reusable flexible ureteroscopes.

Extracorporeal shock wave lithotripsy in the Pacific Northwest

PI: Brian Duty

This is a retrospective cohort study describing the ESWL experience in the Pacific Northwest through data analysis on cases from the largest ESWL device group in the region.

Imaging prostatic lipids to distinguish aggressive prostate cancer

Co-I: Christopher Amling and Mark Garzotto

This is a prospective trial examining the ability of MRSI to detect, through imaging of concentrated areas of lipid presence within the prostate, aggressive prostate cancer, and distinguish this from lower risk disease.

Assessing prostate cancer outcomes in rural and urban Oregon

PI: Christopher Amling

This is a retrospective cohort study examining the prevalence and patterns of prostate cancer diagnoses and treatments in the state of Oregon through analysis of data extracted from the state cancer registry.

Vasal fluid evaluation at time of vasectomy reversal

PI: Jason Hedges

The purpose of this study is to evaluate the vasal fluid protein composition found in the male patient at the time of vasectomy reversal, determine if the composition differs between patients of varying operative findings, and learn whether this analysis can further predictive ability.

Impact of inflatable penile prosthesis insertion on lower urinary tract symptoms

PI: Jason Hedges

The objective of this study is to evaluate the effect of IPP placement on patient LUTS, through an analysis of two institutions' cohorts of patients undergoing this procedure.

Fertility registry

Co-PI: Jason Hedges and Eugene Fuchs

This is a prospective multi-institutional registry collecting data on male patients seeking fertility consultations.

Identifying tumor-specific markers from blood and urine from patients undergoing treatment for solid cancers

PI: Theresa Koppie

This study identifies novel markers in the urine and blood for patients with various types of solid organ cancers.

Recent publications

Cowan NG, Chen Y, Downs TM, Bochner BH, Apolo AB, Porter MP, La Rochelle JC,Amling CL, Koppie TM. Neoadjuvant chemotherapy use in bladder cancer: a survey of current practice and opinions. Adv Urol. 2014;2014:746298.

VanDlac AA, Cowan NG, Chen Y, Anderson RE, Conlin MJ, La Rochelle JC, AmlingCL, Koppie TM. Timing, incidence and risk factors for venous thromboembolism inpatients undergoing radical cystectomy for malignancy: a case for extended duration pharmacological prophylaxis. J Urol. 2014 Apr;191(4):943-7.

Coakley FV, Foster BR, Farsad K, Hung AY, Wilder KJ, Amling CL, Caughey AB.Pelvic applications of MR-guided high intensity focused ultrasound. Abdom Imaging. 2013 Oct;38(5):1120-9.

Barry JM. Words of wisdom. Re: Radical prostatectomy versus observation for localized prostate cancer. Eur Urol. 2012 Dec;62(6):1196.

Cullen TJ, McCarthy MP, Lasarev MR, Barry JM, Stadler DD. Body mass index and the development of new-onset diabetes mellitus or the worsening of pre-existing diabetes mellitus in adult kidney transplant patients. J Ren Nutr. 2014Mar;24(2):116-22.

Sung J, Barry JM, Jenkins R, Rozansky D, Iragorri S, Conlin M, Al-Uzri A. Alemtuzumab induction with tacrolimus monotherapy in 25 pediatric renal transplant recipients. Pediatric Transplant. 2013 Dec;17(8):718-25.

Duty B, Conlin M, Wagner M, Bayne A, Adams G ,Fuchs E: Supracostal Tubeless Percutaneous Nephrolithotomy: A Retrospective Cohort Study. J Endourol 2013; Mar;27(3):294-7.

Duty BD, Conlin MJ, Fuchs EF, Barry JM. The current role of endourologic management of renal transplantation complications. Adv Urol. 2013;2013:246520.doi: 10.1155/2013/246520.

Morey AF, Brandes S, Dugi DD 3rd, Armstrong JH, Breyer BN, Broghammer JA,Erickson BA, Holzbeierlein J, Hudak SJ, Pruitt JH, Reston JT, Santucci RA, Smith TG 3rd, Wessells H; American Urological Association. Urotrauma: AUA guideline. JUrol. 2014 Aug;192(2):327-35.

Thakar HJ, Dugi DD 3rd. Skin grafting of the penis. Urol Clin North Am. 2013Aug;40(3):439-48.

Duty BD, Kreshover JE, Richstone L, Kavoussi LR. Review of Appendiceal On-lay Flap in the Management of Complex Ureteral Strictures in Six Patients. BJU Int.2014 Jan 28.

Elsamra SE, Fakhoury M, Motato H, Friedlander JI, Moreira DM, Hillelsohn J,Duty B, Okeke Z, Smith AD. The surgical spectacle: a survey of urologists viewing live case demonstrations. BJU Int. 2014 Apr;113(4):674-8.

Ostrowski KA, Polackwich AS, Kent J, Conlin MJ, Hedges JC, Fuchs EF. Higher Outcomes of Vasectomy Reversal for Men with the Same Female Partner as Before the Vasectomy. J Urol. 2014 Jul 31.

Paduch DA, Brannigan RE, Fuchs EF, Kim ED, Marmar JL, Sandlow JI. The laboratory diagnosis of testosterone deficiency. Urology. 2014 May;83(5):980-8.doi: 10.1016/j.urology.2013.12.024.

Ostrowski KA, Polackwich AS, Conlin MJ, Hedges JC, Fuchs EF. Impact of Gross and Microscopic Vasal Fluid During Vasectomy Reversal on Pregnancy. J Urol. 2015 Jan 13.

Ostrowski KA, Polackwich AS, Kent J, Conlin MJ, Hedges JC, Fuchs EF. Higher outcomes of vasectomy reversal in men with the same female partner as before vasectomy. J Urol. 2015 Jan;193(1):245-7

Prostate cancer diagnosis is associated with an increased risk of erectile dysfunction after prostate biopsy. Helfand BT, Glaser AP, Rimar K, Zargaroff S, Hedges JC, McGuire BB, Catalona WJ, McVary KT. BJU Int. 2012 May 28.

Polackwich AS, Ostrowski KA, Hedges JC. Testosterone replacement therapy and prostate health.  Curr Urol Rep. 2012 Dec;13(6):441-6.

Sheth KR, Sharma V, Helfand BT, Cashy J, Smith K, Hedges JC, Köhler TS, Woodruff TK, Brannigan RE. Improved fertility preservation care for male patients with cancer after establishment of formalized oncofertility program J Urol. 2012 Mar;187(3):979-86.

Hedges JC. Penile rehabilitation after radical prostatectomy: pro. J Urol. 2012 Jan;187(1):15-6.

Sharma V, Zargaroff S, Sheth KR, Le BV, Dupree JM, Sandlow JI, Polackwich AS, Hedges JC, Fuchs EF, Goldstein M, Brannigan RE. Relating Economic Conditions toVasectomy and Vasectomy Reversal Frequencies: a Multi-Institutional Study. JUrol. 2014 Jan 11.  

Swanson D, Polackwich AS, Helfand B, Masson P, Hwong J, Dugi DD, Martinez Acevedo A,  Hedges JC, McVary K. Penile Fracture: Outcomes of Early Surgical Intervention. Urology, November 2014.

Tadros N, Hecht S, Ostrowski K, Hedges JC. AUA Update Series on the subject of Anatomy of the Testes and Surgical Considerations. (2014)

Keegan KA, Schupp CW, Chamie K, Hellenthal NJ, Evans CP, Koppie TM. Histopathology of surgically treated renal cell carcinoma: survival differences by subtype and stage. J Urol. 2012 Aug;188(2):391-7.

Yap SA, Schupp CW, Chamie K, Evans CP, Koppie TM. Effect of age on transitional cell carcinoma of the upper urinary tract: presentation, treatment, and outcomes. Urology. 2011 Jul;78(1):87-92.

Sajadi KP, Goldman HB. Female urology: Growing evidence for robotic prolapsesurgery. Nat Rev Urol. 2013 Oct;10(10):560-2.

Alas A, Sajadi KP, Goldman HB, Anger JT. The rapidly increasing usefulness of social media in urogynecology. Female Pelvic Med Reconstr Surg. 2013Jul-Aug;19(4):210-3.

Sajadi KP, Lin DL, Steward JE, Balog B, Dissaranan C, Zaszczurynski P, Gill BC, Jiang HH, Kerns JM, Damaser MS. Pudendal nerve stretch reduces external urethral sphincter activity in rats. J Urol. 2012 Oct;188(4):1389-95.

Sajadi KP, Goldman HB. Bladder augmentation and urinary diversion for neurogenic LUTS: current indications. Curr Urol Rep. 2012 Oct;13(5):389-93.

Suriano F, Conlin MJ, Buscarini M. Feasibility of felt application forrenorrhaphy after laparoscopic partial nephrectomy. Minerva Urol Nefrol. 2014Mar;66(1):83-5.

Gordon RR, Wu M, Huang CY, Harris WP, Sim HG, Lucas JM, Coleman I, Higano CS, Gulati R, True LD, Vessella R, Lange PH, Garzotto M, Beer TM, Nelson PS.Chemotherapy-induced monoamine oxidase expression in prostate carcinoma functionsas a cytoprotective resistance enzyme and associates with clinical outcomes. PLoSOne. 2014 Sep 8;9(9):e104271.

Barnett CM, Heinrich MC, Lim J, Nelson D, Beadling C, Warrick A, Neff T,Higano CS, Garzotto M, Qian D, Corless CL, Thomas GV, Beer TM. Genetic profiling to determine risk of relapse-free survival in high-risk localized prostate cancer. Clin Cancer Res. 2014 Mar 1;20(5):1306-12.

Ansbaugh N, Shannon J, Mori M, Farris PE, Garzotto M. Agent Orange as a risk factor for high-grade prostate cancer. Cancer. 2013 Jul 1;119(13):2399-404.

Garzotto M, Hung AY. Advances in the multimodality management of high-risk prostate cancer. Surg Oncol Clin N Am. 2013 Apr;22(2):375-94.

Bayne AP, Skoog SJ. Nocturnal enuresis: an approach to assessment and treatment. Pediatr Rev. 2014 Aug;35(8):327-34; quiz 335.

Hoberman A, Greenfield SP, Mattoo TK, Keren R, Mathews R, Pohl HG, Kropp BP, Skoog SJ, Nelson CP, Moxey-Mims M, Chesney RW, Carpenter MA. Antimicrobial prophylaxis for children with vesicoureteral reflux. N Engl J Med. 2014 Jun 19;370(25):2367-76.

Heckler AM, Sung J, Watters S, Martinez Acevedo A, Conlin M, Skoog S. The long-term incidence of urinary tract infection after endoscopic management of vesicoureteral reflux. Urology. 2014 Jun;83(6):1383-7.

Watters ST, Sung J, Skoog SJ. Endoscopic treatment for vesicoureteral reflux: how important is technique? J Pediatr Urol. 2013 Dec;9(6 Pt B):1192-7.

Polackwich AS, Skoog SJ, Austin JC. Long-term follow-up after endoscopic treatment of vesicoureteral reflux with dextranomer/hyaluronic acid copolymer in  patients with neurogenic bladder. J Urol. 2012 Oct;188(4 Suppl):1511-5.

Cameron MH, Bethoux F, Davis N, Frederick M. Botulinum toxin for symptomatictherapy in multiple sclerosis. Curr Neurol Neurosci Rep. 2014 Aug;14(8):463.