Selected Publications

Killing Mycobacterium tuberculosis In Vitro: What Model Systems Can Teach Us.
Keiser TL, Purdy GE. Microbiol Spectr. 2017 Jun;5(3). doi: 10.1128/microbiolspec.TBTB2-0028-2016. PMID: 28597814

The Mycobacterium tuberculosis MmpL11 cell wall lipid transporter is important for biofilm formation, intracellular growth and non-replicating persistence.
Wright CC, Hsu FF, Arnett E, Dunaj JL, Davidson PM, Pacheco SA, Harriff MJ, Lewinsohn DM, Schlesinger LS, Purdy GE.
Infect Immun. 2017 May 15. pii: IAI.00131-17. doi: 10.1128/IAI.00131-17. [Epub ahead of print] PMID: 28507063

Diphenylether-Modified 1,2-Diamines with Improved Drug Properties for Development against Mycobacterium tuberculosis.
Foss MH, Pou S, Davidson PM, Dunaj JL, Winter RW, Pou S, Licon MH, Doh JK, Li Y, Kelly JX, Dodean RA, Koop DR, Riscoe MK, Purdy GE. ACS Infect Dis. 2016 Jul 8;2(7):500-8. doi: 10.1021/acsinfecdis.6b00052. Epub 2016 May 13. PMID: 27626102

Structural basis for the regulation of the MmpL transporters of Mycobacterium tuberculosis.
Delmar, J.A. Chou, T-H, Wright, C.C., Licon,, M.H., Doh, J.K., Radhakrishnan, A., Kumar, N., Lei, H-T., Bolla, J.R., Rajashankar, K.R., Su, C-C., Purdy, G.E. and E. W. Yu. 2015. J. Biol. Chem. 290: 28559–28574. PMID 26396194 PMC4653710.

Crystal structure of the Mycobacterium tuberculosis transcriptional regulator Rv0302.
Chou, T-H, Delmar, J.A. Wright, C.C., Radhakrishnan, A., Kumar, N., Lei, H-T., Bolla, J.R., Rajashankar, K.R., Su, C-C., Purdy, G.E. and E. W. Yu. 2015. Protein Science. 24: 1942–1955. PMID 26362239

Confinement-Induced Drug-Tolerance in Mycobacteria Mediated by an Efflux Mechanism.
Luthuli, B.B., G.E. Purdy and F.K. Balagadde. 2015. PLOS ONE 10(8):e0136231. PMID 26295942 PMC4546595

Crystal Structure of the transcriptional regulator Rv0678 of Mycobacterium tuberculosis.
Radhakrishnan, A., N. Kumar, C. Wright, T-H Chou, J.R. Bolla, C-C. Su, K.R. Rajashankar, L. Messerle, G.E. Purdy, and E.W. Yu. J. Biol. Chem. 289(23):16526-16540. PMID: 24737322

The MmpL11 transporter contributes to mycobacterial cell wall biosynthesis and biofilm formation in M. smegmatis. 
Pacheco, S.A., F.F. Hsu, K.M. Powers, and G.E. Purdy. 2013. J. Biol. Chem. 288:24213-24222. PMID 238369904.

Characterization of mycobacterial triacylglycerols and the unusual monomeromycolyl diacylglycerols from Mycobacterium smegmatis biofilms by linear ion-trap multiple-stage and high-resolution mass spectrometry with electrospray ionization.
Purdy, G.E., Pacheco, S.A., Turk, J., and F.F. Hsu. 2013. Anal. Bioanal. Chem. 405(23), 7415–26. PMID: 23852148

Autophagic killing effects against Mycobacterium tuberculosis by alveolar macrophages from young and aged Rhesus macaque.
Pacheco, S.A., Powers, K.M., Engelmann, Messaoudi, I. and G.E. Purdy. 2013. PLoS ONE 8(6): e66985. doi:10.1371/journal.pone.0066985. PMID 23825603

Structural and functional characterization of mycobactericidal ubiquitin-derived peptides in model and bacterial membranes.
Foss, M.H., Powers, K. M., and G.E. Purdy. 2012. Biochemistry, 51(49):9922-9. PMID:23173767 PMC3567233 

Structural Elucidation of Glycopeptidolipid of Mycobacterium smegmatis by High Resolution Multiple-stage Linear Ion-trap Mass Spectrometry with Electrospray Ionization.
Hsu, F.F., Pacheco, S., Turk, J. and G. Purdy. 2012. J Mass Spectrom. 47(10):1269-81. PMID: 23019158 PMC3462375

Escape from the phagosome: the explanation for MHC-I processing of mycobacterial antigens? 
Harriff, M., Purdy, G.E. and D.M. Lewinsohn. 2012. Front. Immun. 3:40. doi: 10.3389/fimmu.2012.00040. PMID: 22566923 PMC3342008