Our immune system relies upon rapid and robust signaling responses to the detection of an invading pathogen. In these signaling pathways, information is relayed through post-translational modifications such as protein ubiquitination. Unfortunately for us, many pathogens have the remarkable ability to subvert host signaling responses and thus evade detection. Work in our lab focuses on the mechanisms by which pathogens manipulate the host ubiquitin signaling response. We use biochemical and structural biology techniques to understand the molecular details of these host-pathogen interactions, with the goal of learning more about the requirements for infection and immunity.