The profound success of pathogens such as Mycobacterium tuberculosis and HIV in causing disease depends on their ability to successfully utilize the host’s cellular machinery for their own advantage to avert its immune system. Understanding these pathways or processes essential for the life cycle of these pathogens is crucial, as it represents potential targets for new drug strategies.
Lab news and events
Our paper that identifies a metabolic network with critical roles in Zika virus replication is now in preprint. Huge congrats to Hans and Jules; and thanks to our fantastic collaborators at PNNLab and Ed Dennis at UCSD. See the paper at Biorxiv.
Our paper that describes the role of Sphingolipids in the entry of M. tuberculosis is now in Biorxiv.
Our mini review regarding how pathogenic fungi usurp the host lipids during host entry is published in Journal of Fungi
Our Method paper on Visualization and Quantification of Phagocytosis is now published in Methods Mol Biol.
Our collaborative work with the lab of Sarah Fortune (Harvard School of Public Health) and Bryan Bryson (MIT) on the mechanism of how GM-CSF signaling controls Mycobacterium tuberculosis infection is published in Nature Communications.
Our collaborative work with the lab of Joost Holthuis is published in Nature Communications.
Event: Fikadu G. Tafesse is one of the invited speakers at the upcoming SLB meeting "Host-Microbial Interactions in Health and Disease: The Good, the Bad and the Ugly"
Event: Our PacTB (Pacific Tuberculosis Pathogenesis and Host-Response Research Retreat) meeting this year is in UC Berkley
Congratulations to the Tafesse lab. They've received a grant from the Bill & Melinda Gates Foundation for their research project, Nanobodies as a Targeted-Therapeutic Against Mtb.
Professor Tafesse is featured as part of OHSU's Onward campaign.
Flaviviruses, such as Zika and Dengue virus, manipulate the lipid content of host cells to replicate and cause disease. Read our new review.
Video: Phagocytosis of Candida albicans by dendritic cells.