The profound success of pathogens such as Mycobacterium tuberculosis and HIV in causing disease depends on their ability to successfully utilize the host’s cellular machinery for their own advantage to avert its immune system. Understanding these pathways or processes essential for the life cycle of these pathogens is crucial, as it represents potential targets for new drug strategies.
Lab news and events
Our collaborative work with the lab of Sarah Fortune (Harvard School of Public Health) and Bryan Bryson (MIT) on the mechanism of how GM-CSF signaling controls Mycobacterium tuberculosis infection is published in Nature Communications.
Our collaborative work with the lab of Joost Holthuis is published in Nature Communications.
Our paper that describes the role of Sphingolipids in the entry of M. tuberculosis is now in Biorxiv.
Congratulations to the Tafesse lab. They've received a grant from the Bill & Melinda Gates Foundation for their research project, Nanobodies as a Targeted-Therapeutic Against Mtb.
Professor Tafesse is featured as part of OHSU's Onward campaign.
Flaviviruses, such as Zika and Dengue virus, manipulate the lipid content of host cells to replicate and cause disease. Read our new review.