The profound success of pathogens such as Mycobacterium tuberculosis and HIV in causing disease depends on their ability to successfully utilize the host’s cellular machinery for their own advantage to avert its immune system. Understanding these pathways or processes essential for the life cycle of these pathogens is crucial, as it represents potential targets for new drug strategies.
Lab news and events
So excited to share our new study that is published at JAMA. We show that the immune response of the Pfizer COVID-19 vaccine is age-dependent. Thanks to our Collaborators- the Curlin and Messer lab. Here is the link to the Article.
Dr. Anthony Fauci, chief medical adviser to President Joe Biden, called out our findings that show people previously infected with the novel coronavirus stand to get a much greater benefit of protection against new variants if they’re vaccinated. Watch the White House briefing from May 4 (he shares our work about 14 minutes into the full video).
In collaboration with the lab of Eric Barklis we published a new study in the Virology Journal. We showed that nanobodies that bind the HIV-1 Capsid protein block viral assembly and infectivity. Our findings demonstrate the feasibility of targeting HIV proteins, including the Gag/Capsid, with nanobodies to inhibit HIV-1 infection. Here is the link to the Article.
Our pre-print that shows the escape of SARS-CoV-2 variants (UK/B.1.1.7 and South Africa/B.1.351) from humoral immunity elicited by vaccine and natural infections is now in medRxiv.
From TB to COVID-19: An OHSU lab uses alpaca antibodies to shift gears
Zika Virus: Master Membrane Manipulator. Click here to read our blog.
Our paper that describes the role of Sphingolipids in the entry of M. tuberculosis is now accepted for publication in mBio. See the accepted manuscript in Biorxiv.
Our collaborative work with the lab of Sarah Fortune (Harvard School of Public Health) and Bryan Bryson (MIT) on the mechanism of how GM-CSF signaling controls Mycobacterium tuberculosis infection is published in Nature Communications.
Event: Fikadu G. Tafesse is giving a talk about our recent work on the Webinar Series on Sphingolipid Biology.
Event: Fikadu G. Tafesse is one of the invited speakers at the upcoming SLB meeting "Host-Microbial Interactions in Health and Disease: The Good, the Bad and the Ugly"
Event: Our PacTB (Pacific Tuberculosis Pathogenesis and Host-Response Research Retreat) meeting this year is in UC Berkley
Congratulations to the Tafesse lab. They've received a grant from the Bill & Melinda Gates Foundation for their research project, Nanobodies as a Targeted-Therapeutic Against Mtb.
Professor Tafesse is featured as part of OHSU's Onward campaign.
Flaviviruses, such as Zika and Dengue virus, manipulate the lipid content of host cells to replicate and cause disease. Read our new review.
Highlights of our recent work by different News outlets
- Reuters: Vaccine protects COVID-19 survivors against variants; virus' spike protein damages blood vessels
- The Lund Report: Variants Spread And Cases Rise In Oregon, Increasing Need For Vaccination
- Portland Business Journal: OHSU study shows Covid vaccine less effective against variants of concern
- OHSU: Vaccination protects previously infected people from coronavirus variants