Oregon Health & Science University offers an ACGME-accredited one-year fellowship in Molecular Genetic Pathology, a subspecialty jointly accredited by the American Board of Pathology and the American Board of Medical Genetics.
The MGP fellow will gain a working knowledge of all current clinical and translational research molecular diagnostic procedures including DNA and RNA extraction, Southern blots, in situ hybridization/FISH, comparative genomic hybridization, mutation scanning methods, qualitative and quantitative amplification methods, gene-specific DNA sequencing, and high-throughput next generation (massively parallel) DNA sequencing. These technologies are applied in a wide spectrum of clinical settings including cancer, infectious disease, inherited disease (Mendelian, trinucleotide repeats, and complex), HLA-typing and identification.
The MGP fellow will learn to analyze and interpret molecular data from clinical cases, and to compose and communicate diagnostic reports. These molecular results will be correlated with clinical, laboratory, morphologic, immunophenotypic and cytogenetic findings.
Exposure to ethical issues, lab quality assurance and lab administration are an additional part of the MGP curriculum. The MGP fellow will also learn to design and implement translational research projects aimed at understanding the molecular basis of disease or translating such basic discoveries into improved patient care.
An optional second year of full time research may be available to interested and eligible fellows.
Mission Statement and Program Aims
The mission of the OHSU Molecular Genetic Pathology Fellowship program is to train pathologists who are prepared to incorporate molecular medicine into private practice, or as a focus in an academic career. Our mission is consistent with OHSU’s mission of healing, teaching, and discovery.
The OHSU Molecular Genetic Pathology fellowship trains physicians with special expertise in molecular diagnostics who will become clinical consultants on issues relating to the application of DNA/RNA technology in a wide variety of clinical settings. The trainees will be prepared to direct clinical diagnostic laboratories by applying the knowledge and skills that they have acquired in clinical molecular diagnostics, in research, and in laboratory administration. In particular, their fundamental understanding of basic and applied principles of the molecular genetics of disease should allow them to continue to read the literature, understand new molecular methods to be introduced in future years, and become life-long teachers and learners. Training in Molecular Genetic Pathology is provided through didactic seminars; hands-on experience with laboratory techniques; preparation of clinical cases for sign-out under the supervision of qualified faculty; interaction with clinicians, counselors, and laboratory scientists; and research projects.
Candidates must have an MD degree (or equivalent), and have either completed training in an ACGME-accredited residency in Medical Genetics or Pathology (AP and/or CP). Applicants must be legally able to work in the U.S., or eligible to obtain work authorization, and are expected to take and pass the ABP molecular genetic pathology examination upon graduation.