Hiroko H. Dodge, Ph.D.

  • Professor of Neurology, School of Medicine

Biography

Hiroko Dodge is Professor of Neurology and Co-Associate Director for the NIH-Layton Aging and Alzheimer’s Disease Center.  She has been directing the Biostatistics and Data Management Core at the Oregon ADC over 15 years.  Between 2009 and 2019, she simultaneously directed the Data Core at Michigan Alzheimer’s Disease Center at University of Michigan while she served as the endowed Professor of Neurology at University of Michigan, Ann Arbor, MI. 

In addition to her statistical expertise, her research interests cover a wide range of areas, including behavioral intervention against cognitive decline, epidemiology of dementia and cross cultural comparisons on healthy cognitive aging. Over the past 10 years, she has been conducting a series of NIH funded behavioral intervention randomized controlled trials to examine whether social interactions through internet/webcams can improve cognitive functions. Her current NIH funded R01 has been recruiting social isolated older adults (aged 75 and over) collaborating with Meals on Wheels programs and other organizations.  The current project is found here: I-CONECT (Internet-based Conversational Engagement Clinical Trial). She also has been actively conducting research in Japan: she has a research cohort of healthy older old in Okinawa, Japan, who have been followed since 2007, collaborating with the Okinawa Centenarian Study. This cohort has been providing opportunities for researchers to examine factors associated with healthy cognitive aging.

She is the founding chair of a Professional Interest Area (PIA) entitled "Clinical Trials Advancements and Outcomes" in the International Society to Advance Alzheimer's Research (ISTAART, an international AD research organization sponsored by the Alzheimer's Association). This PIA creates an international researchers' forum where innovative clinical trial approaches, developments of outcomes sensitive to trial effects, and unique non-pharmacological trials are being introduced and discussed. She holds Fellow status at the Gerontological Society of America and serves as statistical and senior editors for multiple dementia journals

SELECTED ACTIVE GRANTS

Conversational engagement as a means to delay Alzheimer's disease onset: Phase II
The study, funded by the R01 AG051628 grant, examines conversational engagement delivered using webcam and internet program could improve cognitive functions and identifies optimal duration and frequency of conversational engagement required to see the improvement. Targeted subjects are socially isolated seniors aged 75 and older with normal cognition recruited mainly from the Meals on Wheels program. This is a multi-center study being conducted at Portland, Oregon and Detroit, Michigan. The Principal Investigator is Dr. Hiroko Dodge. 

Web-enabled social interaction to delay cognitive decline among seniors with MCI: Phase I
This study, funded by the R01 AG056102, examines social interactions could improve cognitive functions among those with Mild Cognitive Impairment (MCI). This is a multi-center study being conducted at Portland, Oregon and Detroit, Michigan. The Principal Investigator is Dr. Hiroko Dodge. 
                            
Identification of Mild Cognitive Impairment using machine learning from language and behavior markers
The goal of this study, funded by the RF1AG072449 grant, is to discover language and behavior markers signaling early-stage MCI, as well as integrate the markers into effective machine learning models for the detection of MCI. The Principal Investigators are Drs. Dodge, Zhou, and Wang.    

White matter hyperintensity-associated astrocytopathy in Alzheimer’s disease and vascular cognitive impairment: A targeted histopathologic study using postmortem 7T MRI
The goal of this project, funded by the R01AG056712 grant, is to investigate how cerebrovascular disease, manifested as white matter hyperintensities, is associated with changes in astroglial phenotypes and that these changes contribute both to white matter injury and to regionally associated AD pathologies. The Principal Investigators of this project are Dr. Silbert and Dr. Woltjer. Hiroko Dodge is a co-investigator.

Home and community-based service use, health outcomes, and health care costs for people with Alzheimer’s disease and related dementia
The major goal of this project, funded by the R01 AG069782 grant, is to assess elements of state Medicaid policies associated with an increase in home and community-based service use by people with Alzheimer’s disease and related dementia as well as to assess when home and community-based service is appropriately used to keep them safe in the community. The Principal Investigator is Dr. Kim and Dr. Dodge is the co-investigator.

Oregon Alzheimer’s Disease Research Center
The goal of this Center, funded in part by the P30AG066518 grant, is to facilitate AD research by providing core resources for clinical and basic research, fostering interdisciplinary collaboration, sharing resources and expertise, mentoring new professionals, raising awareness and providing education. Cores: Administrative, Clinical, Data, Biomarkers, Neuropathology, Outreach Recruitment & Education, Neuroimaging, and Digital Technology; Research Education Component. Dr. Jeff Kaye is the Principal Investigator. Dr. Hiroko Dodge's role at the Center is as the Co-Associate Director and the Director of the Biostatistics and data management core.

Home and community-based service use, health outcomes, and health care costs for people with Alzheimer’s disease and related dementia
The major goal of this project, funded by the R01AG069782 grant, is to assess elements of state Medicaid policies associated with an increase in home and community-based service use by people with Alzheimer’s disease and related dementia as well as to assess when home and community-based service is appropriately used to keep them safe in the community. The Principal Investigator is Dr. Kim. Dr. Hiroko Dodge is the Co-investigator.    

Oregon Roybal Center for CAre Support Translational Research Advantaged by Integrating Technology
The goals of ORCASTRAIT are to: 1) Support a unique organizational infrastructure that enables and accelerates the process of developing, translating and disseminating innovative care provider interventions facilitated by technology while fostering cross-disciplinary and institutional collaborations and cooperation, 2) Advance timely, real-world development of care support intervention research, 3) Provide structured, but flexible educational opportunities to advance the research workforce attuned to integrating technology in dementia care intervention research. ORCASTRAIT is funded by the P30AG024978 grant. Dr. Jeff Kaye is the Principal Investigator. Dr. Hiroko Dodge is the Co-investigator.

Role of impaired cognitive states and risk factors in conversion to mixed dementias
The SMART (Statistical Modeling of Aging and Risk of Transitions) renewal proposes to obtain Medicare claims data on its participants to determine the severity of diabetes, hypertension, and other comorbidities that have not been investigated, such as renal disease, with a focus on improving the prediction of who is at risk for a transition to an impaired cognitive state and mixed dementia pathology. This project was funded by the 2R01 AG038651 grant. The Principal Investigators (PI) are Drs. Kryscio and Abner. Dr Dodge is the OHSU site PI. 

Education

  • Ph.D., 1992, Pennsylvania State University
  • Ph.D., 1992, Pennsylvania State University

Areas of interest

  • Preventions against cognitive decline and dementia (pharmacological and behavioral)
  • Early detections of Alzheimer’s Disease/ Normal cognitive aging
  • Longitudinal data analysis
  • Epidemiology of dementia and mild cognitive impairment
  • Cross national comparisons on factors associated with healthy cognitive aging
  • Application of demographic methods to clinical research
  • Social Epidemiology

Publications

Publications

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