Holly received her B.S. degree in Micro/Molecular Biology from Portland State University (2012). She is currently in Cheryl Maslen's lab where she is studying one of major consequences of chromosomal aneuploidies, cardiovascular defects/disease. In Down syndrome, atrioventricular septal defect is increased 2000x, while in Turner syndrome, aortic defects and diseases are increased 100x. Using sequencing and medical data, she is identifying genes and mutations that might be disease-causing.This will allow them to predict who will need medical or operative treatment and to identify protein targets to direct drug development. Holly enjoys wakeboarding, soccer, and rock-hunting in her off time.
Michael grew up in the hilly suburbs of San Francisco, California and studied biology at UC Santa Barbara. Returning to northern California, Michael completed a masters degree focusing in molecular endocrinology at the University of San Francisco and briefly worked in electronic medical devices and web optimization software before joining OHSU as a graduate student in Molecular and Medical Genetics. Michael is a member of the Spellman Lab and is interested in understanding the cancer genome as well as supporting development of computational approaches to incorporate many types of high dimensional data into fundamental biological analyses. In addition to his devotion to science, Michael enjoys competitive cycling and classical guitar.
Asia Mitchell graduated in 2008 from Chatham University, in Pittsburgh, PA, with a Bachelor's of Science in Biochemistry, and subsequently, in 2009, completed a Graduate Certificate in Biomedical Informatics at the University of Pittsburgh. She came to OHSU soon after to work in the lab of Dr. Amanda Vinson, and then began her graduate studies, in 2011, through the Program in Molecular & Cellular Biosciences at OHSU. In June of 2012, Asia joined the lab of Paul Spellman, Ph.D. and is pursuing a degree in Molecular and Medical Genetics. She is currently working on elucidating receptor tyrosine kinase signaling disruption in luminal and basal subtypes of breast cancer. Ultimately, Asia would like to develop a research career focused on personalize or precision medicine within academia.
Ryan Mulqueen graduated from SUNY Stony Brook University in 2014 with a B.S. in Interdisciplinary Biology. While in his undergraduate studies, he had varied research interest. He began his research career studying the formation of social hierarchies in African cichlids in the lab of Ivan Chase, Ph.D., where he helped develop the system to codify behaviors of dominance. He then moved on to study the speciation of native drosophilids under the instruction of Walter Eanes, Ph.D. This work became the focus of his undergraduate thesis, in which he analyzed the morphology of drosophila sex-combs intraspecifically, interspecifically, and in previously undocumented interspecies hybridizations. Ryan joined OHSU's graduate program in Molecular and Cellular Biosciences in the fall of 2014. In the spring of 2015, Ryan became a member of the labs of both Brian O'Roak, Ph.D. and Andrew Adey, Ph.D., under a joint-mentorship program. Ryan is interested in studying the roles of somatic mosaicism and epigenetic factors in the developing brain. To this end, Ryan's ongoing work involves the improvement of high-throughput single-cell epigenetic protocols and enhanced neuronal population targeting in transgenic lines.
John Powers was born and raised in Beaverton, Oregon. He received his Bachelors of Science in Biology with minors in chemistry and molecular biology from Washington State University in 2011. He is currently a graduate student in the Molecular and Medical Genetics Department. As a member of Dr. Hiroyuki Nakai's lab, his current work focuses on the development of novel adeno-associated virus (AAV) vectors and AAV vector mediated approaches for ocular diseases. His main project aims to identify optimal neuroprotection and gene therapy approaches for inherited eye diseases. When not in lab, John enjoys hiking, camping, and spending time with family and friends.
Daelyn was raised in Sugar Land, Texas and moved to the Pacific Northwest when she was a senior in high school. She received her Bachelors of Science with honors from Portland State University in 2014 and quickly matriculated into the Program of Molecular and Cellular Biosciences here at Oregon Health &Science University. She joined the Harding Laboratory in the Molecular and Medical Genetics Department and is passionate about improving therapies for people with rare disorders. Her primary focus is centered around gene therapy efforts for the treatment of phenylketonuria, the most common inborn error of metabolism, which is currently treated with life-long dietary management. When patients go off of this arduous diet, they suffer severe neurological complications. For her thesis, she aims to address the current limitations of PKU gene therapy to help facilitate its movement into the clinic. In her spare time, she likes to compete in triathlons and marathons, explore nature around her home in Camas, and play with her five Labrador Retrievers, Cordelia, Dallas, Lily, Marley, and Abigail.
Jimi Rosenkrantz received a Bachelors of Science degree in Molecular, Cell & Developmental Biology in 2010 from the University of California, Santa Cruz. After completing her undergraduate studies, Jimi worked as a research technician in the laboratory of Dr. David Haussler. In 2014 she began her graduate studies through the Program in Molecular & Cellular Bioscience at OHSU. In January 2015, she joined the Molecular and Medical Genetics Department as a graduate student in Dr. Lucia Carbone & Dr. Shawn Chavez's laboratories. Her current research is focused on investigating the level, mechanism and consequences of somatic aneuploidy and retrotransposon activity in the developing embryo and in the adult brain. Jimi is interested in pursuing a career as an independent researcher focused on better understanding humans and human disease using DNA sequencing technologies and comparative genomic studies, with an ultimate goal of advancing molecular diagnostics and therapeutics options available clinically. In her free time, Jimi enjoys exploring the Pacific Northwest, socializing with friends, and drinking a beer on her front porch with her cat, Jaspurr, by her side.
Kristóf was born in Budapest, Hungary. There he received his Bachelor of Science degree in physics from Eötvös Loránd University in 2011. Subsequently, his interests shifted towards evolutionary biology and he got his Master of Science degree from the University of Edinburgh in 2012. For his final project there he studied the "faster X" effect in populations undergoing recent bottlenecks. In parallel he completed a Master's degree at Eötvös Loránd University in Biophysics, where he earned his degree in 2014. His thesis project involved modeling speciation in segragated populations using adaptive dynamics, a branch of frequency dependent population genetics. Following that he came to OHSU for his graduate studies within the Program in Molecular & Cellular Biosciences. He joined the Adey Lab in June 2015, where he currently analyses single cell sequencing data to study structural variation in normal and diseased tissues.