Emergency Medicine

SIREN Resources

SIREN Coordinating Center Website - https://siren.network/

March 2020

Ellen Underwood, MS will present: Dmitrienki A and D’Agostino RB. Multiplicity Considerations in Clinical Trials. NEJM 2018;378:2115-22.

Valerie Durkalski-Mauldin, PhD will present: Yadav K and Lewis RJ. Gatekeeping Strategies for Avoiding False-Positive Results in Clinical Trials with Many Comparisons. JAMA 2017;318(14):1385-86.

Additional Reading: US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, CBER, & Center for Biologics Evaluation and Research. (DRAFT) Guidance for Industry. January 2017.

March 2019

Valerie Durkalski-Mauldin,PhD  will present: Woodcock J and LaVange LM. Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both. NEJM 2017;377:62-70. 

Jordan Elm, PhD will present: Hemming K, Haines TP, Chilton PJ, Girling AJ, and Lilford RJ. The Stepped Wedge Cluster Randomised Trial: Rationale, Design, Analysis, and Reporting. BMJ 2015;351:h391.

January 2019

Kees Polderman, MD will present: Cooper J, Nichol AD, Bailey M, Bernard S, Cameron PA, Pili-Floury S, et al. Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients with Severe Traumatic Brain Injury. JAMA 2018;320(21):2211-20. 


TBA will present: Moseby-Knappe M, Mattsson N, Nielsen N, Zetterberg H, Blennow K, Dankiewicz J, et al. Serum Neurofilament Light Chain for Prognosis of Outcome After Cardiac Arrest. JAMA 2018 Oct 29. doi: 10.1001/jamaneurol.2018.3223. [Epub ahead of print]