The ALM Core has a number of different imaging setups that excel at different applications. Below is an overview of instruments located at the South Waterfront in KCRB.
Laser Scanning Confocal, Super Resolution Confocal, and Multiphoton Excitation Microscope
Zeiss LSM 880 with Airy and Fast Airyscan. Laser scanning confocal microscope on an inverted stand. This setup is capable of three different imaging modalities; conventional laser scanning microscopy, super resolution confocal microscopy using Zeiss’ Airyscan detector, and multiphoton excitation microscopy using a chameleon laser for 2-photon excitation.
Spinning Disk Confocal
Yokogawa CSU-X1 on Zeiss Axio Observer. Spinning disk confocal microscope on an inverted imaging stand. Spinning disk confocal imaging outperforms laser-scanning microscopy for live-cell imaging. The system accepts mutli-well plates for image-based screening assays, and also features a widefield mode
High Resolution Widefield
Zeiss AxioScan.Z1 Slide Scanner. Fully automated imaging of routine histological and fluorescent sections.
Live Sample Imaging
The Yokogawa CSU-X1 spinning disk confocal on a Zeiss Axio Observer, the Zeiss LSM 880 with Airy and Fast Airyscan, and the Zeiss Lightsheet Z.1 for aqueous and CLARITY imaging are all equipped with incubation and temperature control systems for live sample imaging.