Welcome to the Multiscale Microscopy Core
The Multiscale Microscopy Core is a state-of-the-art electron microscopy core that was established in 2013 through the collaborative efforts of the OHSU Center for Spatial Systems Biomedicine and Hillsboro-based FEI. It provides imaging services, technical support and training to academic and corporate users. The MMC offers multiple levels of service that correspond with the analysis and/or training each user desires. Training on the instruments can be provided for individuals who anticipate having long-term EM projects. Microscope access is granted by three different mechanisms and priority is given in the following order: internal academic users (OHSU faculty and affiliates), external academic users (a proposal is submitted for review and approval) and external confidential/corporate users (no proposal review).
FEI Helios G3 DualBeam™ Scanning Electron Microscope
Thermo Fisher Volume Scope II
- FEI CorrSight™
- FEI Tecnai™ with iCorr™ - Integrated Light and Transmission Electron Microscope
- New: Recently upgraded with a NanoSprint12S-B AMT cMOS camera
- FEI Vitrobot
- Pelco EasiGlow 91000 Glow Discharge Cleaning System
- Leica ACE600 Coater
- Leica Critical Point Dryer CPD300
- UC7 Ultramicrotome
- RMC-Boeckeler ASH-100
Recent upgrades in MMC instrumentation include:
The Multiscale Microscopy Core has been awarded a grant from the M.J. Murdock Charitable Trust for the purchase of a Helios Nanolab G5 UX Focused Ion Beam-Scanning Electron Microscope (FIB-SEM) equipped with Energy-Dispersive X-ray (EDX) Spectroscopy and a cryo-stage for cryogenic analysis of samples. This new instrument will expand the services that the Multiscale Microscopy Core can provide the OHSU research community through the addition of room-temperature elemental analysis and the ability to analyze frozen hydrated samples by SEM (2D) or FIB-SEM (3D), with the possibility of preparing lamellae for high-throughput in-situ structural biology. OHSU researchers will be able to use this instrument to study and quantify biological structures across the Ångström to centimeter size range. The M.J. Murdock Charitable Trust awarded $550,000 and OHSU will contribute approximately $800,000 toward to support this equipment.