Research

Fluorescent kidney histology
Image credit: Ryan Cornelius, PhD

Our research programs address fundamental questions related to kidney function in health and disease. We employ a variety of experimental model systems ranging from yeast to humans.

Our basic science faculty use a wide array of techniques, including molecular biology, genetics, biochemistry, and microscopy, to study the physiology of the kidney and the mechanistic bases of kidney disease and hypertension. Our clinical research faculty utilize varying epidemiologic and clinical research techniques to strengthen our knowledge of kidney disease. As a division, we aim to transform our findings into the improved treatment of renal diseases in collaboration with the Oregon Clinical and Translational Research Institute.

Basic Science Research

  • Genetic factors in systemic water balance and clinical disorders of water and electrolyte balance (Cohen Lab)
  • Role of COP9 signalosome in kidney disease and hypertension (Cornelius Lab)
  • Interactions between diet, genes, and aldosterone in causing and treating high blood pressure (Ellison Lab)
  • Causes and treatment of diuretic resistance and kidney tubule remodeling (Ellison Lab)
  • Pathologic mechanisms of hypertensive and diabetic kidney disease (Gurley Lab)
  • Role of pericyte angiotensin receptor signaling in kidney disease (Gurley Lab)
  • Role of proximal tubule megalin in rhabdomyolysis-induced acute kidney injury (Hutchens Lab)
  • Pathologic mechanisms of acute cardiorenal syndromes (Hutchens Lab)
  • Molecular regulation of sodium and potassium homeostasis (McCormick Lab)

Clinical Research

Glomerulonephritis and Renal Pathology

  • Oral steroids in IgA, NefIgArd randomized clinical trial (Rupali Avasare)
  • Glomerulonephritis clinical outcomes (Rupali Avasare)
  • Clinical-pathologic disease correlations in diabetic nephropathy, Trident Cohort Study (Rupali Avasare)
  • Renal pathology and clinical correlations (Nicole Andeen)

Transplant Medicine

  • Cytomegalovirus exposure, transplant allocation, and outcomes in deceased donor kidney transplantation (Joseph Lockridge)
  • Immunosuppression and rejection rates in African American kidney transplant recipients  (Joseph Lockridge)
  • Estimating GFR in kidney donors pre- and post-donation (Raghav Wusirika)

CKD/ESRD

  • Quality improvement in dialysis outcomes (Pavan Chopra)
  • Depression associated with chronic dialysis (Pavan Chopra)
  • Development of multidisciplinary electronic care plans for chronic kidney disease (Pavan Chopra)
  • Off-target effects of anti-proteinuric therapy (Cohen Lab)
  • Streamlining care for thrombosed vascular access (Raghav Wusirika)
  • Acid-base balance in chronic kidney disease including observational and interventional studies (Raphael Kalani)
  • Diabetes and chronic kidney disease in Native Hawaiians and Other Pacific Islanders (Raphael Kalani)

Hypertension

  • Renal denervation for hypertension, SPYRAL-ON randomized clinical trial (Jose Rueda and Rob Rope)
  • Kidney disease and hypertension in older adults (Jessica Weiss)
  • Development of clinical decision support tools in hypertension (Rob Rope)

Other

  • Pricing and availability of pharmaceuticals (Cohen Lab)
  • Million Veteran Program and All of Us Research Programs on genotype-phenotype investigations (Cohen Lab)

Ellison Lab

SGLT2 inhibitors, hemodynamics, and kidney protection

Ellison, D.H.

Distal convoluted tubule Cl - concentration is modulated via K + channels and transporters

Xiao-Tong Su, Nathan J Klett, Avika Sharma, Charles N Allen, Wen-Hui Wang, Chao-Ling Yang, David H Ellison

Renal COP9 Signalosome Deficiency Alters CUL3-KLHL3-WNK Signaling Pathway

Ryan J. Cornelius, Jinge Si, Catherina A. Cuevas, Jonathan W. Nelson, Brittany D.K. Gratreak, Ruggero Pardi, Chao-Ling Yang and David H. Ellison

Potassium (K+) intake modulates NCC activity via the K+ channel, Kir4.1

Ming-Xiao Wang, Catherina Cuevas Gallardo, Xiao-Tong Su, Peng Wu, ZhongXiuzi Gao, Dao-Hong Lin, James A. McCormick, Chao-Ling Yang, Wen-Hui Wang, and David H. Ellison

More from the Ellison Lab...

thin lighter gray line

Gurley Lab

Local and downstream actions of proximal tubule angiotensin II signaling on Na + transporters in the mouse nephron

Jonathan W Nelson, Alicia A McDonough, Zhidan Xiang, Donna L Ralph, Joshua A Robertson, Jorge F Giani, Kenneth E Bernstein, Susan B Gurley

Advances in use of mouse models to study the renin-angiotensin system

Jacqueline M Emathinger, Jonathan W Nelson, Susan B Gurley

Blood Pressure Regulation by the Angiotensin Type 1 Receptor in the Proximal Tubule

Marloes C van Haaster, Alicia A McDonough, Susan B Gurley

Angiotensin Receptor Signaling and Prostate Tumor Growth in Mice

Jem Scott-Emuakpor, Emma Allot , Stacy A Johnson , Lauren E Howard, Everardo Macias, Stephen J Freedland, Susan B Gurley

More from the Gurley lab...

thin lighter gray line

McCormick Lab

Molecular Mechanisms of Renal Magnesium Reabsorption

David H Ellison, Yujiro Maeoka, James A McCormick

Roles of WNK4 and SPAK in K+-mediated dephosphorylation of the NaCl cotransporter

Anindit Mukherjee, Chao-Ling Yang, James A McCormick, Kevin Martz, Avika Sharma, David H Ellison

NaCl cotransporter activity and Mg 2+ handling by the distal convoluted tubule

Yujiro Maeoka, James A McCormick

Mg 2+ Restriction Downregulates NCC Through NEDD4-2 and Prevents Its Activation by Hypokalemia

Mohammed Z Ferdaus, Anindit Mukherjee, Jonathan W Nelson, Philip J Blatt, Lauren N Miller, Andrew S Terker, Olivier Staub, Dao-Hong Lin, James A McCormick

Cullin-Ring Ubiquitin Ligases in Kidney Health and Disease

Ryan J Cornelius, Mohammed Z Ferdaus, Jonathan W Nelson, James A McCormick

More from the McCormick Lab...

Recent Trainee Publications

De novo thrombotic microangiopathy in two kidney transplant recipients from the same deceased donor: A case series

Daniel Roberts, Ingrid Siegman, Nicole Andeen, David Woodland, Thomas Deloughery, Jose Rueda, Ali Olyaei, Shehzad Rehman, Doug Norman, Joe Lockridge

Cytomegalovirus Serologic Matching in Deceased Donor Kidney Allocation Optimizes High- And Low-Risk (D+R- And D-R-) Profiles and Does Not Adversely Affect Transplant Rates

Joe Lockridge, Daniel Roberts, Ali Olyaei, Brie N Noble, Eric Langewisch, Shehzad Rehman, Megan Stack, David Scott, Susan Orloff, Carley Shaut, Brent Gardner, William Bennett, Doug Norman

Acute kidney injury in a patient with Monoclonal Gammopathy

Janie Luong, Nicole Andeen, Robert Rope, Rebecca Silbermann, Mazdak Khalighi, Rupali Avasare.

Nephrotoxicity of Select Rheumatologic Drugs

Tyler Woodell, Rupali S. Avasare

thin lighter gray line

Clinical Publications

The Clone Wars: Diagnosing and Treating Dysproteinemic Kidney Disease in the Modern Era

Rupali S Avasare, Nicole K Andeen, Andrea Havasi, Jonathan J Hogan

New onset diabetes after kidney transplantation in Asian Americans – Is there an increased risk?

Joseph B. Lockridge, Joseph B.Pryor, Megan N.Stack, Shehzad S.Rehman, Douglas J.Norman, Angelo M.DeMattos, Ali J.Olyaei

Letter regarding: "A Case of Gross Hematuria and IgA Nephropathy Flare-Up Following SARS-CoV-2 Vaccination"

Ken Park, Scott Miyake, Cynthia Tai, Mindy Tseng, Nicole K Andeen, Vanderlene L Kung

DNA J homolog subfamily B member 9 and other advances in fibrillary glomerulonephritis

Nicole K Andeen, Rupali S Avasare

Anti-LRP2 nephropathy with concurrent kidney infiltration by lymphoma

Ashley Gamayo, Douglas Hecox, Lance Dicker, Lisa Vecchiarelli, Philipp W Raess, Mazdak Khalighi, Nicole K Andeen

Metabolic Acidosis and Subclinical Metabolic Acidosis in CKD

Kalani L Raphael

Estimated GFR Variability and Risk of Cardiovascular Events and Mortality in SPRINT (Systolic Blood Pressure Intervention Trial)

Rakesh Malhotra, Ronit Katz, Vasantha Jotwani, Adhish Agarwal, Debbie L Cohen, William C Cushman, Areef Ishani, Anthony A Killeen, Dalane W Kitzman, Suzanne Oparil, Vasilios Papademetriou, Chirag R Parikh, Kalani L Raphael, Michael V Rocco, Leonardo J Tamariz, Paul K Whelton, Jackson T Wright Jr, Michael G Shlipak, Joachim H Ix

Depression Screening Tools for Patients with Kidney Failure: A Systematic Review

Karli Kondo , Jennifer R Antick , Chelsea K Ayers, Devan Kansagara, Pavan Chopra

Assessing Acid-Base Status in Patients With CKD: Does Measurement of Blood pH Matter?

Kalani L Raphael, Jeffrey A Kraut

Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19, and the Renin-Angiotensin System: Pressing Needs and Best Research Practices

Matthew A Sparks, Andrew M South, Andrew D Badley, Carissa M Baker-Smith, Daniel Batlle, Biykem Bozkurt, Roberto Cattaneo, Steven D Crowley , Louis J Dell'Italia, Andria L Ford, Kathy Griendling, Susan B Gurley, Scott E Kasner, Joseph A Murray, Karl A Nath, Marc A Pfeffer, Janani Rangaswami, W Robert Taylor, Vesna D Garovic

Membranous nephropathy in patients with HIV: a report of 11 cases

Vivek Charu, Nicole Andeen, Vighnesh Walavalkar, Jessica Lapasia, Jin-Yon Kim, Andrew Lin, Richard Sibley, John Higgins, Megan Troxell, Neeraja Kambham

Abundant CD8+ Tumor Infiltrating Lymphocytes and beta-2-microglobulin Are Associated With Better Outcome and Response to interleukin-2 Therapy in Advanced Stage Clear Cell Renal Cell Carcinoma

Dale Davis, Maria S Tretiakova, Chris Kizzar, Randy Woltjer, Victoria Krajbich, Scott S Tykodi, Christian Lanciault, Nicole K Andeen

Risks and Impact of Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers on SARS-CoV-2 Infection in Adults: A Living Systematic Review

Katherine Mackey, MD, MPP, Valerie J. King, MD, MPH, Susan Gurley, MD, PhD, Michael Kiefer, MD, Erik Liederbauer, MD, Kathryn Vela, MLIS, AHIP, Payten Sonnen, BS, Devan Kansagara, MD, MC

Enemy Action in the Distal Convoluted Tubule

David H. Ellison and Shih-Hua Lin

Global Health Training Opportunities in North American Nephrology Fellowships

Robert Rope, Jeffrey Perl, Shuchi Anand, International Society of Nephrology North American and Caribbean Regional Board

Biopsy-proven Thrombotic Microangiopathy Without Schistocytosis on Peripheral Blood Smear: A Cautionary Tale

Catherine R Murphree, Nga N Nguyen, Joseph J Shatzel, Sven R Olson, Paul D Chung, Joseph B Lockridge, Nicole K Andeen, Thomas G DeLoughery

Mechanistic Insights Into Loop Diuretic Responsiveness in Heart Failure

David H Ellison

Collapsing Glomerulopathy in Older Adults

Benjamin Kukull, Rupali S Avasare, Kelly D Smith, Donald C Houghton, Megan L Troxell, Nicole K Andeen

When to Stop Eculizumab in Complement-Mediated Thrombotic Microangiopathies

Sven R Olson, Eric Lu, Emilio Sulpizio, Joseph J Shatzel, Jose F Rueda, Thomas G DeLoughery

Industry Payments to Physician Specialists Who Prescribe Repository Corticotropin

Daniel M. Hartung, PharmD, MPH; Kirbee Johnston, MPH; David M. Cohen, MD; Thuan Nguyen, MD, PhD; Atul Deodhar, MD; Dennis N. Bourdette, MD

thin lighter gray line

Effect of oral sodium bicarbonate on calcium-phosphate nephrolithiasis risk in chronic kidney disease.

Kalani Poster

Prolonged dietary potassium restriction increases NCC activity and DCT length to maintain electrolyte balance.

SU Kidney Week
Kidney Week 2020 Poster
Xiao-Tong Su, Turgay Saritas, Chao-Ling Yang, Paul Welling, and David H. Ellison

A novel, inducible, distal convoluted tubule (DCT)-specific, NaCl cotransporter (NCC)-driven Cre-recombinase mouse model.

2020 ASN
Click on the poster for more information.

Nrf2 Deletion Attenuates Kidney Injury Caused by Cullin Ring Ligase Dysfunction

Poster for ASN
Click on the poster for more information.

The Distal Convoluted Tubule Serves As a Potassium Switch In an intracellular Chloride Dependent Mechanism

XTS poster
Click on the poster for more information.

DNAJB9 protein accumulation in fibrillary glomerulonephritis is not due to local RNA upregulation

DNAJB9 protein poster

Dietary Mg2+ restriction downregulates NCC through a SPAK-independent pathway

 Dietary Mg2+ restriction downregulates NCC through a SPAK-independent pathway

Calcineurin in the distal convoluted tubule plays a key role in tacrolimus-induced hypomagnesemia and hypercalciuria

Tacolimus poster BDKG
Click on the poster for more information.
    • Degrees

      • B.A., 2007, Johns Hopkins University
      • M.D., 2012, Oregon Health & Science University
    • Areas of interest

      • Renal Pathology
    • Degrees

      • B.S., 2005, Massachusetts Institute of Technology
      • M.D., 2009, New York University School of Medicine
    • Areas of interest

      • Glomerulonephritis clinical outcomes
    • Degrees

      • B.S., 1974, Stanford University
      • M.D., 1978, Rush Medical College
    • Additional associations

      • Program in Molecular and Cellular Biosciences, School of Medicine
    • Areas of interest

      • Translational medicine
      • Nephrology
    • Degrees

      • B.A., 1990, University of Mississippi
      • Ph.D., 1994, University of Mississippi
      • M.D., 1998, Washington University School of Medicine
    • Additional associations

      • M.D./Ph.D. Program Committee, School of Medicine
    • Areas of interest

      • Chronic Kidney Disease
      • Diabetic Kidney Disease
      • Physiology
      • Pharmacology
      • Pathologic mechanisms of hypertensive and diabetic kidney disease
      • Sodium homeostasis in blood pressure regulation
    • Areas of interest

      • Cardiovascular Critical Care
      • Surgical Critical Care
      • Acute Cardiorenal Syndrome
      • Cardiac Arrest and Cardiopulmonary Resuscitation
      • Acute Kidney Injury to Chronic Kidney Disease Transition
      • Renal Physiology
    • Degrees

      • B.S., 1996, University of Edinburgh
      • Ph.D., 2000, University of Edinburgh
    • Additional associations

      • Program in Molecular and Cellular Biosciences, School of Medicine

Our department welcomes earnest students and researchers of all backgrounds in our mission to elucidate the mechanisms of disease in the human kidney. Openings in our lab are in a constant state of flux and depend on mentorship availability, commitment levels, and the nature of the projects we are focusing on. Please contact us for the most up-to-date information.

Student Volunteers

Undergraduate or recent grads are welcome to reach out about gaining laboratory experience as volunteers at any time to assist us in certain projects.

  • A background in biology and laboratory experience is preferred, but not required. 
  • Availability requirements depend on the nature of each individual project, but at least a 3 month commitment is preferred.
  • Ability to align with mentor schedules and be punctual is critical to success.
  • Research techniques to be mastered will likely include immunofluorescence of kidney tissue and Western blotting.
The OHSU School of Medicine has launched a new Ph.D. Program in Biomedical Sciences that provides a flexible and interdisciplinary training experience that prepares students to make significant contributions to biomedical research in diverse scientific careers. Listen to our students and faculty talk about the opportunities and experience at OHSU, then learn more here: http://www.ohsu.edu/YourPhD

Lamfrom Biomedical Research Building

3215 SW Pavilion Loop
Portland, Oregon 97239