• Parappilly, M. S.;  Chin, Y.;  Whalen, R. M.;  Anderson, A. N.;  Robinson, T. S.;  Strgar, L.;  Sutton, T. L.;  Conley, P.;  Klocke, C.;  Gibbs, S. L.;  Chang, Y. H.;  Wu, G.;  Wong, M. H.; Skalet, A. H., Circulating Neoplastic-Immune Hybrid Cells Predict Metastatic Progression in Uveal Melanoma. Cancers (Basel) 2022, 14(19). PubMed
  • Eng, J.;  Bucher, E.;  Hu, Z.;  Zheng, T.;  Gibbs, S. L.;  Chin, K.; Gray, J. W., A framework for multiplex imaging optimization and reproducible analysis. Commun Biol 2022, 5 (1), 438. PubMed
  • Barth, C. W.;  Shah, V. M.;  Wang, L. G.;  Masillati, A. M.;  Al-Fatease, A.;  Husain Rizvi, S. Z.;  Antaris, A. L.;  Sorger, J.;  Rao, D. A.;  Alani, A. W. G.; Gibbs, S. L., A clinically relevant formulation for direct administration of nerve specific fluorophores to mitigate iatrogenic nerve injury. Biomaterials 2022, 284, 121490. PubMed


  • McMahon, N. P.;  Solanki, A.;  Wang, L. G.;  Montaño, A. R.;  Jones, J. A.;  Samkoe, K. S.;  Tichauer, K. M.; Gibbs, S. L., TRIPODD: a Novel Fluorescence Imaging Platform for In Situ Quantification of Drug Distribution and Therapeutic Response. Mol Imaging Biol 2021, 23 (5), 650-664. PubMed
  • Jones, J. A.;  McMahon, N. P.;  Zheng, T.;  Eng, J.;  Chin, K.;  Kwon, S.;  Nederlof, M. A.;  Gray, J. W.; Gibbs, S. L., Oligonucleotide conjugated antibody strategies for cyclic immunostaining. Sci Rep 2021,11 (1), 23844. PubMed
  • House, B. J.;  Kwon, M. J.;  Schaefer, J. M.;  Barth, C. W.;  Solanki, A.;  Davis, S. C.; Gibbs, S. L., Clinically relevant dual probe difference specimen imaging (DDSI) protocol for freshly resected breast cancer specimen staining. BMC Cancer 2021, 21 (1), 440. PubMed
  • Byrd, B. K.;  Strawbridge, R. S.;  Wells, W.;  Barth, C.;  Gibbs, S.; Davis, S. C., A method for validating depth-resolved biodistributions in topically-stained specimen with multi-channel fluorescence cryo-imaging. Proc SPIE Int Soc Opt Eng 2021, 11625PubMed
  • Barth, C. W.;  Shah, V. M.;  Wang, L. G.;  Antaris, A. L.;  Klaassen, A.;  Sorger, J.;  Rao, D. A.;  Kerr, D. A.;  Henderson, E. R.;  Alani, A. W. G.; Gibbs, S. L., Clinically translatable formulation strategies for systemic administration of nerve-specific probes. Adv Ther (Weinh) 2021, 4 (7). PubMed
  • Azari, F.;  Kennedy, G.;  Bernstein, E.;  Hadjipanayis, C.;  Vahrmeijer, A.;  Smith, B.;  Rosenthal, E.;  Sumer, B.;  Tian, J.;  Henderson, E.;  Lee, A.;  Nguyen, Q.;  Gibbs, S.;  Pogue, B.;  Orringer, D.; Charalampaki, C.;  Martin, L.;  Tanyi, J.;  Lee, M.;  Lee, J. Y.; Singhal, S., Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings. J Biomed Opt 2021, 26 (5). PubMed


  • Wang, L. G.;  Barth, C. W.;  Kitts, C. H.;  Mebrat, M. D.;  Montano, A. R.;  House, B. J.;  McCoy, M. E.;  Antaris, A. L.;  Galvis, S. N.;  McDowall, I.;  Sorger, J. M.; Gibbs, S. L., Near-infrared nerve-binding fluorophores for buried nerve tissue imaging. Sci Transl Med 2020, 12 (542). PubMed
  • Solanki, A.;  Wang, L.;  Korber, J.;  McMahon, N.;  Tichauer, K.;  Samkoe, K. S.; Gibbs, S. L., Intracellular paired agent imaging enables improved evaluation of tyrosine kinase inhibitor target engagement. Proc SPIE Int Soc Opt Eng 2020, 11219PubMed
  • Solanki, A.;  King, D.;  Thibault, G.;  Wang, L.; Gibbs, S. L., Quantification of fluorophore distribution and therapeutic response in matched in vivo and ex vivo pancreatic cancer model systems. PLoS One 2020, 15 (2), e0229407. PubMed
  • Montano, A. R.;  Wang, L. G.;  Barth, C. W.;  Shams, N. A.;  Kumarapeli, K.; Gibbs, S. L., In Vivo Nerve-Specificity of Rhodamines and Si-rhodamines. Proc SPIE Int Soc Opt Eng 2020, 11222PubMed
  • Meng, B.;  Folaron, M. R.;  Byrd, B. K.;  Samkoe, K. S.;  Strawbridge, R. S.;  Barth, C.;  Gibbs, S. L.; Davis, S. C., Topical dual-probe staining using quantum dot-labeled antibodies for identifying tumor biomarkers in fresh specimens. PLoS One 2020, 15 (3), e0230267. PubMed
  • McMahon, N. P.;  Solanki, A.;  Jones, J.;  Kwon, S.;  Chang, Y. H.;  Chin, K.;  Nederlof, M. A.;  Gray, J. W.; Gibbs, S. L., Fluorescent Imaging for In Situ Measurement of Drug Target Engagement and Cell Signaling Pathways. Proc SPIE Int Soc Opt Eng 2020,11219PubMed
  • McMahon, N. P.;  Jones, J. A.;  Kwon, S.;  Chin, K.;  Nederlof, M. A.;  Gray, J. W.; Gibbs, S. L., Oligonucleotide conjugated antibodies permit highly multiplexed immunofluorescence for future use in clinical histopathology. J Biomed Opt 2020, 25 (5), 1-18. PubMed
  • Iizuka, S.;  Leon, R. P.;  Gribbin, K. P.;  Zhang, Y.;  Navarro, J.;  Smith, R.;  Devlin, K.;  Wang, L. G.; Gibbs, S. L.;  Korkola, J.;  Nan, X.; Courtneidge, S. A., Crosstalk between invadopodia and the extracellular matrix. Eur J Cell Biol 2020, 99 (7), 151122. PubMed
  • Barth, C. W.; Gibbs, S. L., Fluorescence Image-Guided Surgery - a Perspective on Contrast Agent Development. Proceedings of SPIE--the International Society for Optical Engineering 2020, 11222PubMed


  • Wang, L. G.;  Barth, C. W.;  Combs, J. R.;  Montano, A. R.; Gibbs, S. L., Investigation of Oxazine and Rhodamine Derivatives as Peripheral Nerve Tissue Targeting Contrast Agent for In Vivo Fluorescence Imaging. Proc SPIE Int Soc Opt Eng 2019, 10862. PubMed
  • Schaefer, J. M.;  Barth, C. W.;  Davis, S. C.; Gibbs, S. L., Diagnostic performance of receptor-specific surgical specimen staining correlates with receptor expression level. J Biomed Opt 2019, 24 (2), 1-9. PubMed
  • Samkoe, K. S.;  Schultz, E.;  Solanki, A.;  Wang, L.;  Korber, J.;  Tichauer, K. M.; Gibbs, S. L., Simultaneous extracellular and intracellular quantification of EGFR using paired-agent imaging in an in ovo tumor model. Proc SPIE Int Soc Opt Eng 2019, 10859PubMed
  • Munhenzva, I. R.;  Barth, C. W.;  Sibrian-Vazquez, M.;  Wang, L. G.;  Escobedo, J. O.;  Gibbs, S. L.; Strongin, R. M., Assessment of human pancreas cancer tissue and precursor lesions via a fluorophore with inherent PDAC selectivity. Methods (San Diego, Calif.) 2019, 168, 35-39. PubMed
  • McMahon, N.;  Jones, J.;  Eng, J.;  Kwon, S.;  Chang, Y. H.;  Thibault, G.;  Chin, K.;  Nederlof, M.;  Gray, J.; Gibbs, S. L., Signal removal methods for highly multiplexed immunofluorescent staining using antibody conjugated oligonucleotides. Proc SPIE Int Soc Opt Eng 2019, 10881PubMed
  • House, B. J.;  Schaefer, J. M.;  Barth, C. W.;  Davis, S. C.; Gibbs, S. L., Diagnostic Performance of Receptor-Specific Surgical Specimen Staining Correlate with Receptor Expression Level. Proc SPIE Int Soc Opt Eng 2019, 10862PubMed
  • Folaron, M. R.;  Strawbridge, R. R.;  Samkoe, K. S.;  Gibbs, S. L.; Davis, S. C., Effect of staining temperature on topical dual stain imaging of tissue specimens for tumor identification. Proc SPIE Int Soc Opt Eng 2019, 10862PubMed


  • Bittel AM, Saldivar IS, Dolman NJ, Nan X, Gibbs SL. Superresolution microscopy with novel BODIPY-based fluorophores. PLoS One. 2018 Oct 26;13(10):e0206104. PubMed
  • Korber JR, Barth CW, Gibbs SL. Nile Red derivatives enable improved ratiometric imaging for nerve-specific contrast. J. of Biomedical Optics, 23(7), 076002 (2018). PubMed
  • Bittel AM, Davis AM, Wang L, Nederlof MA, Escobedo JO, Strongin RM, Gibbs SL. Varied Length Stokes Shift BODIPY-Based Fluorophores for Multicolor Microscopy. Scientific Reports, Volume 8, Article number: 4590 (2018). PubMed
  • Huang T, Phelps C, Wang J, Lin LJ, Bittel A, Scott Z, Jacques S, Gibbs SL, Gray JW, Nan X. Simultaneous Multicolor Single-Molecule Tracking with Single-Laser Excitation via Spectral Imaging. Biophysical Journal, Volume 114, Issue 2, 23 January 2018, Pages 301-310. PubMed


  • Barth CW, Schaefer JM, Rossi VM, Davis SC, Gibbs SL. Optimizing fresh specimen staining for rapid identification of tumor biomarkers during surgery. Theranostics. 2017. 7(19):4722-4734. PubMed
  • Barth CW, Gibbs SL. Direct Administration of Nerve-Specific Contrast to Improve Nerve Sparing Radical Prostatectomy. Theranostics. 2017 Jan 7;7(3):573-593. PubMed
  • Wang L, Barth CW, Sibrian-Vazquez M, Escobedo JO, Lowry M, Muschler J, Li H, Gibbs SL, Strongin RM. Far-Red and Near-Infrared Seminaphthofluorophores for Targeted Pancreatic Cancer Imaging. ACS Omega. 2017 Jan 31;2(1):154-163. PubMed
  • Creech MK, Wang J, Nan X, Gibbs SL. Superresolution Imaging of Clinical Formalin Fixed Paraffin Embedded Breast Cancer with Single Molecule Localization Microscopy. Sci Rep. 2017 Jan 18;7:40766. PubMed


  • Bittel AM, Nickerson A, Saldivar IS, Dolman NJ, Nan X, Gibbs SL. Methodology for Quantitative Characterization of Fluorophore Photoswitching to Predict Superresolution Microscopy Image Quality. Sci Rep. 2016 Jul 14;6:29687. PubMed


  • Hackman KM, Doddapaneni BS, Barth CW, Wierzbicki IH, Alani AW, Gibbs SL. Polymeric Micelles as Carriers for Nerve-Highlighting Fluorescent Probe Delivery. Mol Pharm. 2015 Dec 7;12(12):4386-94. PubMed
  • Bao K, Nasr KA, Hyun H, Lee JH, Gravier J, Gibbs SL, Choi HS. Charge and Hydrophobicity Effects of NIR Fluorophores on Bone-Specific Imaging. Theranostics. 2015;5(6):609-17. PubMed
  • Gibbs SL, Genega E, Salemi J, Kianzad V, Goodwill HL, Xie Y, Oketokoun R, Khurd P, Kamen A, Frangioni JV. Near-Infrared Fluorescent Digital Pathology for the Automation of Disease Diagnosis and Biomarker Assessment. Mol Imaging. 2015;14(0):1-9. PubMed


  • Wang YX, Choi Y, Chen Z, Laurent S, Gibbs SL. Molecular Imaging: from bench to clinic. Biomed Res Int. 2014: 357258. PubMed.
  • Inou K, Gibbs SL, Liu F, Lee JH, Xie Y, Ashitate Y, Fiuii H, Frangioni JV, Choi HS. Microscopic Validation of Macroscopic In Vivo Images Enabled by Same-Slide Optical and Nuclear Fusion. J Nuc Med. 2014;55(11): 1899-904. PubMed.


  • Davis SC, Gibbs SL, Gunn JR, Pogue BW. Topical dual-tracer specimen difference imaging for rapid intra-operative tumor identification in fresh specimens. Opt Lett. 2013, 38(23):5184-5187. PubMed.
  • Gibbs SL, Xie Y, Goodwill HL, Nasr KA, Ashitate YA, Madigan VJ, Siclovan TM, Zavodszky M, Tan Hehir CA, Frangioni JV. Structure-Activity Relationship of Nerve-Highlighting Fluorophores. PLoS One. 2013, 8(9): e73493. PubMedView PDF.
  • Choi HS, Gibbs SL, Lee JH, Kim SH, Ashitate Y, Liu F, Hyun H, Park G, Xie Y, Bae S, Henary M, Frangioni JV. Targeted zwitterionic near-infrared fluorophores for improved optical imaging. Nat Biotechnol. 2013, 31(2):148-53. PubMed.


  • Gibbs SL. Near infrared fluorophores for image-guided surgery. Quant Imaging Med Surg. 2012;2(3):177-187. PubMed. View PDF.
  • Liu F, Lunsford EP, Tong J, Ashitate Y, Gibbs SL, Yu J, Choi HS, Henske EP, Frangioni JV. Real-time monitoring of tumorigenesis, dissemination, & drug response in a preclinical model of lymphangioleiomyomatosis/tuberous sclerosis complex. PLoS One.2012;7(6):e38589. PubMedView PDF.
  • Khullar OV, Griset AP, Gibbs-Strauss SL, Chirieac LR, Zubris KA, Frangioni JV, Grinstaff MW, Colson YL. Nanoparticle migration and delivery of Paclitaxel to regional lymph nodes in a large animal model. J Am Coll Surg. 2012;214(3):328-37. PubMedView PDF.


  • Samkoe KS, Yang HH, Gibbs-Strauss SL, Hekmatyar SK, O’Hara JA, Kauppinen RA, Pogue BW. Protoporphyin IX fluorescence contrast in invasive glioblastoma is linearly correlated with Gd enhanced MR image contrast but provides better positive predictive value. J Biomed Opt. 2011;16(9)096008. PubMedView PDF.
  • Gibbs-Strauss SL, Nasr K, Fish KM, Khullar O, Siclovan T, Barnhard NE, Tan Hehir CA, Frangioni JV. Nerve-Highlighting Fluorescent Contrast Agents for Image-Guided Surgery. Mol Imaging. 2011;10(2):91-101. PubMed.
  • Mieog JS, Troyan SL, Hutteman M, Donohoe KJ, van der Vorst JR, Stockdale A, Liefers GJ, Choi HS, Gibbs-Strauss SL, Putter H, Gioux S, Kuppen PJ, Ashitate Y, Lowik CW, Smit VT, Oketokoun R, Ngo LH, van de Velde CJ, Frangioni JV, Vahrmeijer AL. Towards Optimization of Imaging System and Lymphatic Tracer for Near-Infrared Fluorescent Sentinel Lymph Node Mapping in Breast Cancer. Ann Surg Oncol. 2011;18(9):2483-91. PubMedView PDF.
  • Khurd P, Grady L, Oketokoun R, Sundar H, Gejera T, Gibbs-Strauss S, Frangioni JV, Kamen A. Global error minimization in image mosaicing using graph connectivity and its applications in microscopy. J Pathol Inform. 2011;2:S8. Epub 2012 Jan 19. PubMedView PDF.


  • Khurd P, Bahlmann C, Maday P, Kamen A, Gibbs-Strauss S, Genega EM, Frangioni JV. Computer-Aided Gleason Grading of Prostate Cancer Histopathological Images Using Texton Forests. Proc IEEE Int Symp Biomed Imaging. 2010:636-639. PubMedView PDF.
  • Davis SC, Samkoe KS, O’Hara JA, Gibbs-Strauss SL, Paulsen KD, Pogue BW. Comparing implementations of magnetic resonance-guided fluorescence molecular tomography for diagnostic classification of brain tumors. J Biomed Opt. 2010;15(5):051602. PubMedView PDF.
  • Pogue BW, Gibbs-Strauss S, Valdes P, Samkoe KS, Paulsen KD. Review of Neurosurgical Fluorescence Imaging Methodologies. IEEE J Sel Top Quantum Electron. 2010;16(3):493-505. PubMedView PDF.
  • Zubris KA, Khullar OV, Griset AP, Gibbs-Strauss S, Frangioni JV, Colson YL, Grinstaff MW. Ease of Synthesis, Controllable Sizes, and In vivo Large-Animal-Lymph Migration of Polymeric Nanoparticles. Chem Med Chem. 2010;5(9):1435-8. PubMedView PDF.
  • Pogue BW, Samkoe KS, Gibbs-Strauss SL, Davis SC. Fluorescent molecular imaging and dosimetry tools in photodynamic therapy. Methods Mol Biol. 2010;635:207-22. PubMedView PDF.
  • Gibbs-Strauss SL, Vooght C, Fish KM, Siclovan T, Barnhard NE, Lomnes S, Tan Hehir CA, Frangioni JV. Molecular Imaging Agents Specific for the Annulus Fibrosis of the Intervertebral Disk. Mol Imaging. 2010; 9(3):128-40. PubMed.
  • Davis SC, Samkoe KS, O’Hara JA, Gibbs-Strauss SL, Payne HL, Hoopes PJ, Paulsen KD, Pogue BW. MRI-coupled fluorescence tomography quantifies EGFR activity in brain tumors. Acad Radiol. 2010;17(3):271-6. PubMed.
  • Winer J, Choi HS, Gibbs-Strauss SL, Colson YL, Frangioni JV. Intraoperative Localization of Insulinoma and Normal Pancreas using Invisible Near-Infrared Fluorescent Light. Ann Surg Oncol. 2010;17(4):1094-100. PubMedView PDF.
  • Gibbs-Strauss SL, Samkoe KS, O’Hara JA, Davis SC, Hoopes PJ, Hasan T, Pogue BW. Detecting Epidermal Growth Factor Receptor Positive Tumor Activity In Vivo During Cetuximab Therapy of Murine Glioma. Acad Radiol. 2010;17(1):7-17. PubMedView PDF.


  • Gibbs-Strauss SL, Rosenberg M, Clough BL, Troyan SL, Frangioni JV. First-In-Human Clinical Trials of Imaging Devices: An Example from Optical Imaging. Conf Proc IEEE Eng Med Biol Soc. 2009:2001-4. PubMedView PDF.
  • Ly HQ, Hoshino K, Pomerantseva I, Kawase Y, Yoneyama R, Takewa Y, Fortier A, Gibbs-Strauss SL, Vooght C, Frangioni JV, Hajjar RJ. In vivo myocardial distribution of multipotent progenitor cells following intracoronary delivery in a swine model of myocardial infarction. Eur Heart J. 2009;30(23):2861-8. PubMedView PDF.
  • Troyan SL, Kianzad V, Gibbs-Strauss SL, Gioux S, Matsui A, Oketokoun R, Ngo L, Khamene A, Azar F, Frangioni JV. The FLARE™ Intraoperative Near-Infrared Fluorescence Imaging System: A First-in-Human Clinical Trial in Breast Cancer Sentinel Lymph Node Mapping. Ann Surg Oncol. 2009;16(10):2943-52. PubMedView PDF.
  • Kepshire DS, Gibbs-Strauss SL, O’Hara JA, Hutchins M, Mincu N, Leblond F, Khayat M, Dehghani H, Srinivasan S, Pogue BW. Imaging of glioma tumor growth with endogenous fluorescence tomography. J Biomed Opt. 2009; 14(3):030501. PubMedView PDF.
  • Skourou C, Hoopes PJ, Gibbs-Strauss SL, Gladstone DJ, Strawbridge R, Paulsen KD. High dose rate radiation treatment of experimental intramuscular prostate carcinoma. Int J Radiat Biol. 2009;85(4):330-7. PubMedView PDF.
  • Gibbs-Strauss SL, O’Hara JA, Srinivasan S, Hoopes PJ, Hasan T, Pogue BW. Diagnostic Detection of Diffuse Glioma Tumors in vivo with Molecular Fluorescent Probe-Based Transmission Spectroscopy. Med Phys. 2009;36(3):974-83. PubMedView PDF.
  • Gibbs-Strauss SL, O’Hara JA, Hoopes PJ, Hasan T, Pogue BW. Noninvasive Measurement of Aminolevulinic Acid–induced Protoporphyrin IX Fluorescence Allows Detection of Murine Glioma in vivoJ Biomed Opt. 2009;14(1):014007. PubMedView PDF.

2008 and Earlier

  • Davis SC, Springett R, Leussler C, Mazurkewitz P, Tuttle S, Gibbs-Strauss SL, Jiang SS, Dehghani H, Pogue BW, Paulsen KD. Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue. Rev Sci Instrum. 2008;79(6): 064302. PubMedView PDF.
  • Gibbs SL, Chen B, O’Hara JA, Hoopes PJ, Hasan T, Pogue BW. Protoporphyrin IX Level Correlates with Number of Mitochondria, but Increases in Production Correlate with Tumor Cell Size. Photochem Photobiol. 2006;82(5):1334-41. PubMed.
  • Pogue BW, Gibbs SL, Chen B, Savellano M. Fluorescence Imaging In Vivo: Raster Scanned Point-Source Imaging Provides More Accurate Quantification than Broad Beam Geometries. Technol Cancer Res Treat. 2004;3(1):15-21. PubMed.