Neurological Emergencies Treatment Trials (NETT)

The Neurological Emergencies Treatment Trials (NETT) is an interdisciplinary research network dedicated to reducing the burden of acute injuries and illnesses affecting the brain, spinal cord, and peripheral nervous system.


The Neurological Emergencies Treatment Trials (NETT) Network was an NIH created network dedicated to neurologic emergency care research studies. NETT was funded from 2012-2018, however a few of the NETT based trials had ongoing research activity after the official end date.  Final closeout of the last active study (ESETT) is expected in 2020. 

The NETT was made up of 17 "Hub" institutions nationwide, each having at least three "Spoke" hospitals. The NETT Network was an interdisciplinary, including, but not limited to, emergency physicians, neurologists, and neurosurgeons. 

OHSU was a primary hub site for NETT. As a hub site, OHSU coordinated study participation at multiple local and regional sites and participated in all NETT research trials.  These trials study many different kinds of neurologic issues, such as traumatic brain injury, stroke, or seizure.

Dr. Craig Warden, Department of Emergency Medicine, was the Principle Investigator(PI) of the OHSU hub network from 2012-2019.  Dr. Mohamud Daya is the current PI.  Jennifer Cook is the hub project manager.

Contact Information

Jennifer Cook
Phone: (503) 494-1230
Fax: (503) 494-4640

Previous Research

ProTECTProgesterone for the Treatment of Traumatic Brain Injury (Experimental Clinical Treatment Trial) 

Registered with NCT00822900

ProTECT results were published in the December 10, 2014 issue of the New England Journal of Medicine
View the Results
Read the OHSU press release


RAMPART - Rapid Anticonvulsant Medication Prior to Arrival Trial

Registered with NCT00809146 

RAMPART results were published in the February 16, 2012 issue of the New England Journal of Medicine
View the Results

Learn more about RAMPART

Established Status Epilepticus Treatment Trial (ESETT)

ESETT Results Published

New Publications

3/20/20 - An new publication discussing the effectiveness of the drugs tested in the ESETT trial was published in March in The Lancet, titled: Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial 

Primary Publication

The ESETT Trial was conducted at OHSU from November 2015-June 2018, and OHSU enrolled 9 subjects locally, and 2 at our satellite site, University of Utah (Dr. Scott Younquist, PI).


Kapur et al. “Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus,” New England Journal of Medicine, November 28, 2019.

This study was supported by the NINDS (U01NS088034, U01NS088023, U01NS056975, U01NS059041, and U01NS073476).

Read the OHSU Press Release

Visit the national ESETT site

Graphic depicting the results of the ESETT Trial.  384 subjects were enrolled with benzodiazepine-refractory status epilepticus. Results: Researchers found the absence of clinically evident seizures and improved responsiveness at 60 minutes 47% of the time with Levetiracetam, 45% of the time with Fosphenytoin, and 46% of the time with Valproate.  No significant difference in rates of seizure cessation or in safety were found between the 3 drugs tested.
(c) 2019 Massachusetts Medical Society

Secondary/Tertiary Papers

Researchers - do you have an idea for a secondary manuscript utilizing the ESETT data?  Review the Ideas spreadsheet, and submit your proposal.  Links below.  If you have any trouble accessing these resources, please contact the e-mail below assistance. 

Ideas Spreadsheet - This spreadsheet includes two tabs: 1) The first tab includes proposed ideas that need authors to help develop and complete them (most of them are unclaimed and need leaders) and 2) The second tab includes useful links (ex. protocol, publication SOP, CRF study book, and the proposal submission form that is also linked below).

Proposal Submission Form - Submit this form with any new ideas not included on the Ideas Spreadsheet

If you have any questions please email