Portland Alcohol Research Center Publications

In Press

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To request a reprint, please e-mail: mitchesu@ohsu.edu

In Press / Submitted Center Publications

Pedersen M., Des Rosier Grant, A., Harrington J., Belcourt A., Thomas A., Hoagland S., Lewis J.P., Plenty Sweetgrass-She Kills R., Conroy-Ben O., Brodt E., Chief K., Johnson-Jennings M., Green Mink K., Milligan-McClellan K., Calhoun M., Ozburn A., Simonds V., Chase S., Tsosie R., Wu K., Brown B. Co-Developing and Implementing an Indigenous Mentoring Program for Native American Faculty in STEM. Accepted for publication in the Journal of Diversity in Higher Education, 7/24/2023.

Grigsby K, Usmani Z, Anderson J, Ozburn A. Development and Implementation of a Dependable, Simple, and Cost effective (DSC), Open-source Running Wheel in High Drinking in the Dark and Heterogeneous Stock/Northport mice. Accepted for publication in Frontiers in Behavioral Neuroscience, 12/14/23


2024 Center Publications

Ozburn, A.R., and Spencer, S.M. 2024. Repurposing anti-inflammatory medications for alcohol and substance use disorders. Neuropsychopharmacology, 49, 317-318.

2023 Center Publications

Lewis, S.A., Cinco, I.R., Doratt, B.M., Blanton, M.B., Hoagland, C., Newman, N., Davies, M., Grant, K. A., Messaoudi, I. 2023. Chronic alcohol consumption dysregulates innate immune response to SARS-CoV-2 in the lung. EBioMedicine, 97, 104812.

Lewis, S.A., Doratt, B.M., Qiao, Q., Blanton, M., Grant, K.A., and Messaoudi, I. 2023. Integrated single cell analysis shows chronic alcohol drinking disrupts monocyte differentiation in the bone marrow. Stem Cell Reports, 18, 1884-1897.

Baker, E.J., Moore, S., Gonzales, S.W., and Grant, K.A. 2023. Long-term drinking stability in the open-access self-administration monkey model. Alcohol, 113, 41-48.

Ford, M.M., George, B.E., Van Laar, V.S., Holleran, K.M., Naidoo, J., Hadaczek, P., Vanderhooft, L. E., Peck, E. G., Dawes, M. H., Ohno, K., Bringas, J., McBride, J. L., Samaranch, L., Forsayeth, J. R., Jones, S. R., Grant, K. A., Bankiewicz, K. S. 2023. GDNF gene therapy for alcohol use disorder in male non-human primates. Nat Med, 29, 2030-2040.

Hashimoto, J.G., Singer, M.L., Goeke, C.M., Zhang, F., Song, Y., Xia, K., Linhardt, R. J., Guizzetti, M. 2023. Sex differences in hippocampal structural plasticity and glycosaminoglycan disaccharide levels after neonatal handling. Exp Neurol, 361, 114313.

Hashimoto, J.G., Zhang, X., and Guizzetti, M. 2023. Ethanol-induced transcriptional and translational changes in Aldh1l1-Egfp/Rpl10a cortical astrocyte cultures. Front Neurosci, 17, 1193304.

Krishnan, H.R., Vallerini, G.P., Gavin, H.E., Guizzetti, M., Rizavi, H.S., Gavin, D.P., Sharma, R. P. 2023. Effects of alcohol and PARP inhibition on RNA ribosomal engagement in cortical excitatory neurons. Front Mol Neurosci, 16, 1125160.

Roqué, P.J., Barria, A., Zhang, X., Hashimoto, J.G., Costa, L.G., and Guizzetti, M. 2023. Synaptogenesis by Cholinergic Stimulation of Astrocytes. Neurochem Res, 48, 3212-3227.

Hitzemann, R., Ozburn, A.R., Lockwood, D.R., and Phillips, T.J. 2023 Modeling Brain Gene Expression in Alcohol Use Disorder with Genetic Animal Models. Curr Top Behav Neurosci. doi:10/1007/7854_2023_455.

Morales, A.M., Gilbert, S., Hart, E., Jones, S.A., Boyd, S.J., Mitchell, S.H., Nagel, B. J. 2023. Alcohol-induced changes in mesostriatal resting-state functional connectivity are linked to sensation seeking in young adults. Alcohol Clin Exp Res (Hoboken), 47, 659-667.

Grigsby, K.B., Mangieri, R.A., Roberts, A.J., Lopez, M.F., Firsick, E.J., Townsley, K.G., Beneze, A., Bess, J., Eisenstein, T. K., Meissler, J. J., Light, J. M., Miller, J., Quello, S., Shadan, F., Skinner, M., Aziz, H. C., Metten, P., Morrisett, R. A., Crabbe, J. C., Roberto, M., Becker, H. C., Mason, B. J., Ozburn, A. R. 2023. Preclinical and clinical evidence for suppression of alcohol intake by apremilast. J Clin Invest, 133.


2022 Center Publications

Allen DC, Jimenez VA, Carlson TL, Walter NA, Grant KA, Cuzon Carlson VC. (2022) Characterization of DREADD receptor expression and function in rhesus macaques trained to discriminate ethanol. Neuropsychopharmacology, 47(4), 857–865. https://doi.org/10.1038/s41386-021-01181-5  PMID: 34654906

Anderson, J.Q., Darakjian, P., Hitzemann, R., Lockwood, D.R., Phillips, T.J., and Ozburn, A.R. 2022. Brain gene expression differences related to ethanol preference in the collaborative cross founder strains. Front Behav Neurosci, 16, 992727

Bloch, S., Holleran, K. M., Kash, T. L., Vazey, E. M., Rinker, J. A., Lebonville, C. L., O'Hara, K., Lopez, M. F., Jones, S. R., Grant, K. A., Becker, H. C., & Mulholland, P. J. (2022). Assessing negative affect in mice during abstinence from alcohol drinking: Limitations and future challenges. Alcohol, 100, 41–56. https://doi.org/10.1523/JNEUROSCI.0816-21.2022  PMID: 35181404

Borrego MB, Chan AE, Ozburn AR. Regulation of alcohol drinking by ventral striatum and extended amygdala circuitry. Neuropharmacology. 2022 Jul 1;212:109074. doi: 10.1016/j.neuropharm.2022.109074. Epub 2022 Apr 26. PMID: 35487273

Borrego MB, Grigsby KB, Townsley KG, Chan A, Firsick EJ, Tran A, Savarese A, Ozburn AR. Central nucleus of the amygdala projections onto the nucleus accumbens core regulate binge-like alcohol drinking in a CRF-dependent manner. Neuropharmacology. 2022 Feb 1;203:108874. doi: 10.1016/j.neuropharm.2021.108874. Epub 2021 Nov 5. PMID: 34748860

C.M. Goeke, X. Zhang, J.G. Hashimoto, M. Guizzetti. Astrocyte tissue plasminogen activator expression during brain development and its role in hippocampal neuron neurite outgrowth. (2022) Neuroscience Letters. 769: 136422. https://doi.org/10.1016/j.neulet.2021.136422  PMID: 34968722

Crabbe JC, Hack WR, Ozburn AR, Savarese AM, Metten P. Long-term alcohol drinking in High Drinking in the Dark mice is stable for many months and does not show alcohol deprivation effects. Addict Biol. 2022 Jan;27(1):e13074. doi: 10.1111/adb.13074. Epub 2021 Jul 5. PMID: 34227188

Grant, K. A., Newman, N. N., Gonzales, S. W., & Cuzon Carlson, V. C. (2022). Impact of putamen inhibition by DREADDs on schedule-induced drinking in rhesus monkeys. Journal Experimental Analysis of Behavior, 117(3), 493–504. https://doi.org/10.1002/jeab.761  PMID: 35411949

Grant, K. A., Newman, N., Lynn, C., Davenport, C., Gonzales, S., Cuzon Carlson, V. C., & Kroenke, C. D. (2022). Brain functional connectivity mapping of behavioral flexibility in rhesus monkeys. The Journal of Neuroscience, JN-RM-0816-21. Advance online publication. https://doi.org/10.1523/JNEUROSCI.0816-21.2022 PMID: 35552233

Hitzemann, R., Bergeson, S.E., Berman, A.E., Bubier, J.A., Chesler, E.J., Finn, D.A., Hein, L., Hoffman, P., Holmes, A., Kisby, B.R., Lockwood, D., Lodowski, K.H., McManus, M., Owen, J.A., Ozburn, A.R., Panthagani, P., Ponomarev, I., Saba, L., Tabakoff, B., Walchale, A., Williams, R.W. and Phillips, T.J. (2022) Sex differences in the brain transcriptome related to alcohol effects and alcohol use disorder. Biol Psychiatry 91:43-52. PMCID: PMC8558111

Lo JO, Schabel MC, Roberts VHJ, Morgan TK, Fei SS, Gao L, Ray KG, Lewandowski KS, Newman NP, Bohn JA, Grant KA, Frias AE, Kroenke CD. Effects of early daily alcohol exposure on placental function and fetal growth in a rhesus macaque model. Am J Obstet Gynecol. 2022 Jan;226(1):130.e1-130.e11. doi: 10.1016/j.ajog.2021.07.028. Epub 2021 Aug 5. PMID: 34364844; PMCID: PMC8748286

Moore S, Radunskaya A, Zollinger E, Grant KA, Gonzales S, Walter NAR, Baker EJ. Pairing food and drink: A physiological model of blood ethanol levels for a variety of drinking behaviors. Math Biosci. 2022 Mar;345:108778. doi: 10.1016/j.mbs.2022.108778. Epub 2022 Jan 13. PMID: 3503350

Patel RR, Varodayan FP, Herman MA, Jimenez V, Agnore R, Gao L, Bajo M, Cuzon Carlson VC, Walter NA, Fei SS, Grant KA, Roberto M. (2022) Synaptic effects of IL-1β and CRF in the central amygdala after protracted alcohol abstinence in male rhesus macaques. Neuropsychopharmacology. 47:847-856 PMID: 34837077

Savarese AM, Grigsby KB, Jensen BE, Borrego MB, Finn DA, Crabbe JC, Ozburn AR. Front Behav Neurosci. Corticosterone Levels and Glucocorticoid Receptor Gene Expression in High Drinking in the Dark Mice and Their Heterogeneous Stock (HS/NPT) Founder Line. 2022 May 12;16:821859. doi: 10.3389/fnbeh.2022.821859. eCollection 2022. PMID: 35645743

Savarese, A.M., Metten, Phillips, T.J., Jensen, B.E., Crabbe, J.C. and Ozburn, A.R. (2022) Midazolam, methamphetamine, morphine, and nicotine intake in High Drinking in the Dark (HDID) mice. Addict Biol, in press.


2021 Center Publications

Cervera-Juanes R, Darakjian P, Ball M, Kohama SG, Urbanski HF. Effects of estradiol supplementation on the brain transcriptome of old rhesus macaques maintained on an obesogenic diet. GeroScience. 2021 October 13. PubMed PMID: 34642852; DOI: 10.1007/s11357-021-00453-8.

Crabbe JC, Hack WR, Ozburn AR, Savarese AM, Metten P. Long-term alcohol drinking in High Drinking in the Dark mice is stable for many months and does not show alcohol deprivation effects. Addiction biology. 2021 July 5:e13074. PubMed PMID: 34227188; DOI: 10.1111/adb.13074.

Grant KA, Newman N, Gonzales S, Shnitko TA. Replicability in measures of attentional set-shifting task performance predicting chronic heavy drinking in rhesus monkeys. Alcohol (Fayetteville, N.Y.). 2021 November;96:93-98. PubMed PMID: 34509594; PubMed Central PMCID: PMC8722702; DOI: 10.1016/j.alcohol.2021.08.006.

Hitzemann R, Bergeson SE, Berman AE, Bubier JA, Chesler EJ, Finn DA, Hein M, Hoffman P, Holmes A, Kisby BR, Lockwood D, Lodowski KH, McManus M, Owen JA, Ozburn AR, Panthagani P, Ponomarev I, Saba L, Tabakoff B, Walchale A, Williams RW, Phillips TJ. Sex Differences in the Brain Transcriptome Related to Alcohol Effects and Alcohol Use Disorder. Biological psychiatry. 2021 May 1. PubMed PMID: 34274109; DOI: 10.1016/j.biopsych.2021.04.016.

Savarese AM, Ozburn AR, Barkley-Levenson AM, Metten P, Crabbe JC. The impact of Drinking in the Dark (DID) procedural manipulations on ethanol intake in High Drinking in the Dark (HDID) mice. Alcohol (Fayetteville, N.Y.). 2021 June;93:45-56. PubMed PMID: 33556460; PubMed Central PMCID: PMC8113115; DOI: 10.1016/j.alcohol.2021.02.001.

Stafford AM, Yamamoto BK, Phillips TJ. Combined and sequential effects of alcohol and methamphetamine in animal models. Neuroscience and biobehavioral reviews. 2021 September 17;131:248-269. PubMed PMID: 34543650; DOI: 10.1016/j.neubiorev.2021.09.019.

Walter N, Cervera-Juanes R, Zheng C, Darakjian P, Lockwood D, Cuzon-Carlson V, Ray K, Fei S, Conrad D, Searles R, Grant K, Hitzemann R. Effect of chronic ethanol consumption in rhesus macaques on the nucleus accumbens core transcriptome. Addict Biol. 2021 Sep;26(5):e13021. doi: 10.1111/adb.13021. Epub 2021 May 4. PMID: 33942443; PMCID: PMC8588809


2020 Center Publications

Crabbe JC, Ozburn AR, Hitzemann R., Spence SE, Hack WR, Schlumbohm JP, Metten P (2020) Tetracycline derivatives reduce binge alcohol consumption in High Drinking in the Dark mice, Brain, Behavior, & Immunity - Health. 4(100061).  https://doi.org/10.1016/j.bbih.2020.100061.

Savarese AM, Crabbe JC (2020) Addiction. In Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, 6th ed. Rosenberg RN, Pascual JN, editors. Elsevier/Academic Press: San Diego CA. 

Stafford AM, Reed C, Phillips TJ. Non-genetic factors that influence methamphetamine intake in a genetic model of differential methamphetamine consumption. Psychopharmacology. 237(11): 3315-3336. PMID: 32833064

Hitzemann R, Phillips TJ, Lockwood DR, Darakjian P, Searles RP. Phenotypic and gene expression features associated with variation in chronic ethanol consumption in heterogeneous stock collaborative cross mice. Genomics. 112: 4516-4524. PMID: 32771621

Kozell LB, Lockwood D, Darakjian P, Edmunds S, Shepherdson K, Buck KJ, Hitzemann R (2020) RNA-Seq Analysis of Genetic and Transcriptome Network Effects of Dual-Trait Selection for Ethanol Preference and Withdrawal Using SOT and NOT Genetic Models. Alcohol Clin Exp Res 44:820-830. PMID: 32090358

Liu Z, Wang X, Newman N, Grant KA, Studholme C, Kroenke CD (2020) Anatomical and diffusion MRI brain atlases of the fetal rhesus macaque brain at 85, 110 and 135 days gestation. Neuroimage. 206:116310. PMCID: PMC6980966  [Available on 2021-02-01]

Ozburn AR, Metten P, Potretzke S, Townsley KG, Blednov YA, Crabbe JC (2020) Effects of Pharmacologically Targeting Neuroimmune Pathways on Alcohol Drinking in Mice Selectively Bred to Drink to Intoxication. Alcohol Clin Exp Res 44:553-566. PMCID: PMC7018604  [Available on 2021-02-01]

Pozhidayeva DY, Farris SP, Goeke CM, Firsick EJ, Townsley KG, Guizzetti M, Ozburn AR (2020) Chronic Chemogenetic Stimulation of the Nucleus Accumbens Produces Lasting Reductions in Binge Drinking and Ameliorates Alcohol-Related Morphological and Transcriptional Changes. Brain Sci 10(2).  PMCID: PMC7071376

Savarese AM, Ozburn AR, Metten P, Schlumbohm JP, Hack WR, LeMoine K, Hunt H, Hausch F, Bauder M, Crabbe JC (2020) Targeting the Glucocorticoid Receptor Reduces Binge-Like Drinking in High Drinking in the Dark (HDID-1) Mice. Alcohol Clin Exp Res. Mar 10. doi: 10.1111/acer.14318. [Epub ahead of print] PMID: 32154593.

Shnitko TA, Gonzales SW, Newman N, Grant KA (2020) Behavioral Flexibility in Alcohol-Drinking Monkeys: The Morning After. Alcohol Clin Exp Res 44:729-737. PMID: 31984521

Varlamov O, Bucher M, Myatt L, Newman N, Grant KA (2020) Daily Ethanol Drinking Followed by an Abstinence Period Impairs Bone Marrow Niche and Mitochondrial Function of Hematopoietic Stem/Progenitor Cells in Rhesus Macaques. Alcohol Clin Exp Res. Mar 27. doi: 10.1111/acer.14328. [Epub ahead of print] PMID: 32220015

Walter NAR, Zheng CL, Searles RP, McWeeney SK, Grant KA, Hitzemann R (2020) Chronic Voluntary Ethanol Drinking in Cynomolgus Macaques Elicits Gene Expression Changes in Prefrontal Cortical Area 46. Alcohol Clin Exp Res 44:470-478. PMCID: PMC7018568


2019 Center Publications

Allen DC, Grant KA (2019) Discriminative stimulus effects and metabolism of ethanol in Rhesus monkeys. Alcoholism, Clinical and Experimental Research 43:1909-1917. PMCID: PMC6721990  [Available on 2020-09-01]

Bickel WK, Crabbe JC, Sher KJ (2019) What is addiction? How can animal and human research be used to advance research, diagnosis, and treatment of alcohol and other substance use disorders? Alcoholism, Clinical and Experimental Research 43:6-21. PMCID: PMC6445393  [Available on 2020-01-01]

Crabbe JC, Metten P, Savarese AM, Ozburn AR, Schlumbohm JP, Spence SE, Hack WR (2019) Ethanol conditioned taste aversion in High Drinking in the Dark mice. Brain Sciences 9:e2. PMCID: PMC6356868

Cunningham CL (2019) Genetic relationships between ethanol-induced conditioned place aversion and other ethanol phenotypes in 15 inbred mouse strains. Brain Sciences 9:e209. PMCID: PMC6721285

Cuzon Carlson VC, Ford MM, Carlson TL, Lomniczi A, Grant KA, Ferguson B, Cervera-Juanes RP (2019) Modulation of Gpr39, a G-protein coupled receptor associated with alcohol use in non-human primates, curbs ethanol intake in mice. Neuropsychopharmacology 44:1103-1113. PMCID: PMC6461847  [Available on 2020-05-01]

Dozier BL, Stull CA, Baker EJ, Ford MM, Jensen JP, Finn DA, Grant KA (2019) Chronic ethanol drinking increases during the luteal menstrual cycle phase in rhesus monkeys: implication of progesterone and related neurosteroids. Psychopharmacology 236:1817-1828. PMCID: PMC6606379  [Available on 2020-06-01]

Ferguson LB, Zhang L, Kircher D, Wang S, Mayfield RD, Crabbe JC, Morrisett RA,Harris RA, Ponomarev I. (2019) Dissecting brain networks underlying alcohol binge drinking using a systems genomics approach. Molecular Neurobiology 56:2791-2810. PMCID: PMC6459809

Hartmann MC, Holbrook SE, Haney MM, Crabbe JC, Rosenwasser AM (2019) Affective behavior in Withdrawal Seizure-Prone and Withdrawal Seizure-Resistant mice during long-term alcohol abstinence. Alcoholism, Clinical and Experimental Research 43:1478-1485. PMCID: PMC6602866  [Available on 2020-07-01]

Hitzemann R, Iancu OD, Reed C, Baba H, Lockwood DR, Phillips TJ (2019) Regional analysis of the brain transcriptome in mice bred for high and low methamphetamine consumption. Brain Sciences 9:e155. PMCID: PMC6681006

Jimenez VA, Wang X, Newman N, Walter NAR, Gonzales S, Lo JO, Ford MM, Cuzon Carlson VC, Grant KA, Kroenke CD (2019) Detecting neurodevelopmental effects of early-gestation ethanol exposure: A nonhuman primate model of ethanol drinking during pregnancy. Alcoholism, Clinical and Experimental Research 43:250-261. PMCID: PMC6370522

Jones SA, Nagel BJ (2019) Altered frontostriatal white matter microstructure is associated with familial alcoholism and future binge drinking in adolescence. Neuropsychopharmacology 44:1076-1083. PMCID: PMC6461789  [Available on 2020-05-01]

Kahler-Quesada AM, Grant KA, Walter NAR, Newman N, Allen MR, Burr DB, Branscum AJ, Maddalozzo GF, Turner RT, Iwaniec UT (2019) Voluntary Chronic Heavy Alcohol Consumption in Male Rhesus Macaques Suppresses Cancellous Bone Formation and Increases Bone Marrow Adiposity. Alcohol Clin Exp Res 43:2494-2503. PMCID: PMC6904502  [Available on 2020-12-01]

Nipper MA, Jensen JP, Helms ML, Ford MM, Crabbe JC, Rossi DJ, Finn DA (2019) Genotype differences in sensitivity to the anticonvulsant effect of the synthetic neurosteroid ganaxolone during chronic ethanol withdrawal. Neuroscience 397:127-137. PMID: 30513375 [PMC Journal – In Process]

Rosenwasser AM, McCulley III WD, Hartmann MC, Fixaris MC, Crabbe JC (2019) Suppression of voluntary ethanol intake in mice under constant light and constant darkness. Alcohol doi.org/10.1016/j.alcohol.2019.05.009. PMID: 31175946 [PMC Journal – In Process]

Shabani S, Schmidt B, Ghimire B, Houlton SK, Hellmuth L, Mojica E, Phillips TJ (2019) Depression-like symptoms of withdrawal in a genetic mouse model of binge methamphetamine intake. Genes, Brain, and Behavior 18:e12533 [Epub ahead of print]. PMCID: PMC6399044  [Available on 2020-03-01]

Shnitko TA, Gonzales SW, Grant KA (2019) Low cognitive flexibility as a risk for heavy alcohol drinking in non-human primates. Alcohol 74:95-104. PMCID: PMC6202248  [Available on 2020-02-01]

Xu T, Sturgeon D, Ramirez JSB, Froudist-Walsh S, Margulies DS, Schroeder CE, Fair DA, Milham MP (2019) Interindividual variability of functional connectivity in awake and anesthetized Rhesus Macaque monkeys. Biol Psychiatry Cogn Neurosci Neuroimaging 4:543-553. PMID: 31072758 [PMC Journal – In Process] Free open access: https://www.sciencedirect.com/science/article/pii/S2451902219300667?via%3Dihub


2018 Center Publications

Allen DC, Ford MM, Grant KA (2018) Cross-species translational findings in the discriminative stimulus effects of ethanol. Current Topics in Behavioral Neurosciences 39:95-111. PMCID: PMC5612861

Aoun EG, Jimenez VA, Vendruscolo LF, Walter NAR, Barbier E, Ferrulli A, Haass-Koffler CL, Darakjian P, Lee MR, Addolorato G, Heilig M, Hitzemann R, Koob GF, Grant KA, Leggio L (2018) A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans. Molecular Psychiatry 23:1466-1473. PMCID: PMC5668213

Colville AM, Iancu OD, Lockwood DR, Darakjian P, McWeeney SK, Searles R, Zheng C, Hitzemann R (2018) Regional Differences and Similarities in the Brain Transcriptome for Mice Selected for Ethanol Preference From HS-CC Founders. Frontiers in Genetics 9:300. PMCID: PMC6120986

Crabbe JC (2018) Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research. Gerlai RT, editor. Using signals of directional selection to guide discovery, pp 243-263, San Diego CA: Academic Press.

Cunningham CL, Shields CN (2018) Effects of multi-modal cues on conditioned place preference in C57BL/6J and DBA/2J mice. Psychopharmacology 235:3535-3543. PMCID: PMC6298874 [Available on 2019-12-01]

Farris SP, Riley BP, Williams RW, Mulligan MK, Miles MF, Lopez MF, Hitzemann R, Iancu OD, Colville A, Walter NAR, Darakjian P, Oberbeck DL, Daunais JB, Zheng CL, Searles RP, McWeeney SK, Grant KA, Mayfield RD (2018) Cross-species molecular dissection across alcohol behavioral domains. Alcohol 72:19-31. PMCID: PMC6309876

Gavin DP, Hashimoto JG, Lazar NH, Carbone L, Crabbe JC, Guizzetti M (2018) Stable Histone Methylation Changes at Proteoglycan Network Genes Following Ethanol Exposure. Frontiers in Genetics 9:346. PMCID: PMC6125400

Huckans M, Wilhelm CJ, Phillips TJ, Huang ET, Hudson R, Loftis JM. (2018) Parallel Effects of Methamphetamine on Anxiety and CCL3 in Humans and a Genetic Mouse Model of High Methamphetamine Intake. Neuropsychobiology 75:169-177. PMCID: PMC5911417

Iancu OD, Colville A, Walter NAR, Darakjian P, Oberbeck DL, Daunais JB, Zheng CL, Searles RP, McWeeney SK, Grant KA, Hitzemann R (2018) On the relationships in rhesus macaques between chronic ethanol consumption and the brain transcriptome. Addiction Biology 23:196-205. PMCID: PMC5671907

Iancu OD, Colville AM, Wilmot B, Searles R, Darakjian P, Zheng C, McWeeney S, Kawane S, Crabbe JC, Metten P, Oberbeck D, Hitzemann R (2018) Gender-Specific Effects of Selection for Drinking in the Dark on the Network Roles of Coding and Noncoding RNAs. Alcoholism, Clinical and Experimental Research, ePub May 22. PMCID: PMC6250599 [Available on 2019-11-22]

Kafkafi N, Agassi J, Chesler EJ, Crabbe JC, Crusio WE, Eilam D, Gerlai R, Golani I, Gomez-Marin A, Heller R, Iraqi F, Jaljuli I, Karp NA, Morgan H, Nicholson G, Pfaff DW, Richter SH, Stark PB, Stiedl O, Stodden V, Tarantino LM, Tucci V, Valdar W, Williams RW, Würbel H, Benjamini Y. Reproducibility and replicability of rodent phenotyping in preclinical studies. Neuroscience and Biobehavioral Reviews 87:218-232. PMCID: PMC6071910

Kovacs-Balint Z, Feczko E, Pincus M, Earl E, Miranda-Dominguez O, Howell B, Morin E, Maltbie E, Li L, Steele J, Styner M, Bachevalier J, Fair D, Sanchez M (2018) Early developmental trajectories of functional connectivity along the visual pathways in Rhesus monkeys. Cerebral Cortex. October 1 [Epub ahead of print]. PMCID: PMC6644858  [Available on 2020-07-22]

Metten P, Schlumbohm JP, Huang LC, Greenberg GD, Hack WR, Spence SE, Crabbe JC (2018) An alcohol withdrawal test battery measuring multiple behavioral symptoms in mice. Alcohol 68:19-35. PMCID: PMC5839916

Morales AM, Jones SA, Ehlers A, Lavine JB, Nagel BJ (2018) Ventral striatal response during decision making involving risk and reward is associated with future binge drinking in adolescents. Neuropsychopharmacology 43:1884-1890. PMCID: PMC6046057

Müller-Oehring EM, Kwon D, Nagel BJ, Sullivan EV, Chu W, Rohlfing T, Prouty D, Nichols BN, Poline JB, Tapert SF, Brown SA, Cummins K, Brumback T, Colrain IM, Baker FC, De Bellis MD, Voyvodic JT, Clark DB, Pfefferbaum A, Pohl KM1 (2018) Influences of age, sex, and moderate alcohol drinking on the intrinsic functional architecture of adolescent brains. Cereb Cortex 28:1049-1063. PMCID: PMC6059181

Purohit K, Parekh PK, Kern J, Logan RW, Liu Z, Huang Y, McClung CA, Crabbe JC, Ozburn AR (2018) Pharmacogenetic Manipulation of the Nucleus Accumbens Alters Binge-Like Alcohol Drinking in Mice. Alcoholism, Clinical and Experimental Research 42:879-888. PMCID: PMC6034712

Shnitko TA, Gonzales SW, Grant KA (2018) Low cognitive flexibility as a risk for heavy alcohol drinking in non-human primates. Alcohol 74:95-104. PMCID: PMC6202248 [Available on 2020-02-01]

Xu T, Falchier A, Sullivan EL, Linn G, Ramirez JSB, Ross D, Feczko E, Opitz A, Bagley J, Sturgeon D, Earl E, Miranda-Domínguez O, Perrone A, Craddock RC, Schroeder CE, Colcombe S, Fair DA, Milham MP (2018)  Delineating the macroscale areal organization of the Macaque cortex in vivo. Cell Reports 23:429-441. PMCID: PMC6157013


2017 Center Publications

Beattie MC, Maldonado-Devincci AM, Porcu P, O'Buckley TK, Daunais JB, Grant KA, Morrow AL (2017) Voluntary ethanol consumption reduces GABAergic neuroactive steroid (3α,5α)3-hydroxypregnan-20-one (3α,5α-THP) in the amygdala of the cynomolgus monkey. Addiction Biology 22:318-330. PMCID: PMC4896863

Böger CA, Gorski M, McMahon GM, Xu H, Chang YC, van der Most PJ, Navis G, Nolte IM, de Borst MH, Zhang W, Lehne B, Loh M, Tan ST, Boerwinkle E, Grams ME, Sekula P, Li M, Wilmot B, Moon JG, Scheet P, Cucca F, Xiao X, Lyytikäinen LP, Delgado G, Grammer TB, Kleber ME, Sedaghat S, Rivadeneira F, Corre T, Kutalik Z, Bergmann S, Nielson CM, Srikanth P, Teumer A, Müller-Nurasyid M, Brockhaus AC, Pfeufer A, Rathmann W, Peters A, Matsumoto M, de Andrade M, Atkinson EJ, Robinson-Cohen C, de Boer IH, Hwang SJ, Heid IM, Gögele M, Concas MP, Tanaka T, Bandinelli S, Nalls MA, Singleton A, Tajuddin SM, Adeyemo A, Zhou J, Doumatey A, McWeeney S, Murabito J, Franceschini N, Flessner M, Shlipak M, Wilson JG, Chen G, Rotimi CN, Zonderman AB, Evans MK, Ferrucci L, Devuyst O, Pirastu M, Shuldiner A, Hicks AA, Pramstaller PP, Kestenbaum B, Kardia SLR, Turner ST, Study LC, Briske TE, Gieger C, Strauch K, Meisinger C, Meitinger T, Völker U, Nauck M, Völzke H, Vollenweider P, Bochud M, Waeber G, Kähönen M, Lehtimäki T, März W, Dehghan A, Franco OH, Uitterlinden AG, Hofman A, Taylor HA, Chambers JC, Kooner JS, Fox CS, Hitzemann R, Orwoll ES, Pattaro C, Schlessinger D, Köttgen A, Snieder H, Parsa A, Cohen DM (2017) NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality.. Journal of the American Society of Nephrology 28:2311-2321. PMCID: PMC5533231

Buck KJ, Chen G, Kozell LB (2017) Limbic circuitry activation in ethanol withdrawal is regulated by a chromosome 1 locus. Alcohol 58:153-160. PMCID: PMC5253306

Colville AM, Iancu OD, Oberbeck DL, Darakjian P, Zheng CL, Walter NA, Harrington CA, Searles RP, McWeeney S, Hitzemann RJ. (2017) Effects of selection for ethanol preference on gene expression in the nucleus accumbens of HS-CC mice. Genes, Brain, and Behavior 16:462-471.  PMCID: PMC5671806

Crabbe JC, Ozburn AR, Metten P, Barkley-Levenson A, Schlumbohm JP, Spence SE, Hack WR, Huang LC (2017) High Drinking in the Dark (HDID) mice are sensitive to the effects of some clinically relevant drugs to reduce binge-like drinking. Pharmacology, Biochemistry, and Behavior 160:55-62. PMCID: PMC5603423

Font L, Houck CA, Cunningham CL (2017) Naloxone effects on extinction of ethanol- and cocaine-induced conditioned place preference in mice. Psychopharmacology. June 26. PMCID: 5668213

Giardino WJ, Rodriguez ED, Smith ML, Ford MM, Galili D, Mitchell SH, Chen A, Ryabinin AE (2017) Control of chronic excessive alcohol drinking by genetic manipulation of the Edinger-Westphal nucleus urocortin-1 neuropeptide system. Translational Psychiatry 7(1):e1021. PMCID: PMC5299395

Grayson DS, Fair DA (2017) Development of large-scale functional networks from birth to adulthood: a guide to neuroimaging literature. Neuroimage 160:15-31. PMCID: PMC5538933

Hashimoto JG, Gavin DP, Wiren KM, Crabbe JC, Guizzetti M (2017). Prefrontal cortex expression of chromatin modifier genes in male WSP and WSR mice changes across ethanol dependence, withdrawal, and abstinence. Alcohol 60:83-94. PMCID: PMC5497775

Hasler BP, Franzen PL, de Zambotti M, Prouty D, Brown SA, Tapert SF, Pfefferbaum A, Pohl KM, Sullivan EV, De Bellis MD, Nagel BJ, Baker FC, Colrain IM, Clark DB (2017) Eveningness and Later Sleep Timing Are Associated with Greater Risk for Alcohol and Marijuana Use in Adolescence: Initial Findings from the National Consortium on Alcohol and Neurodevelopment in Adolescence Study. Alcoholism, Clinical and Experimental Research 41:1154-1165. PMCID: PMC5488322

Hitzemann R, Oberbeck D, Iancu O, Darakjian P, McWeeney S, Spence S, Schlumbohm J, Metten P, Crabbe J (2017) Alignment of the transcriptome with individual variation in animals selectively bred for High Drinking-In-the-Dark (HDID). Alcohol 60:115-120. PMCID: PMC5526361

Jensen JP, Nipper MA, Helms ML, Ford MM, Crabbe JC, Rossi DJ, Finn DA. (2017) Ethanol withdrawal-induced dysregulation of neurosteroid levels in plasma, cortex, and hippocampus in genetic animal models of high and low withdrawal. Psychopharmacology 234:2793-2811. PMCID: PMC5990276

Jimenez VA, Allen DC, McClintick MN, Grant KA (2017) Social setting, social rank and HPA axis response in cynomolgus monkeys. Psychopharmacology 234:1881-1889. PMCID: PMC5451300

Jimenez VA, Grant KA. (2017) Studies using macaque monkeys to address excessive alcohol drinking and stress interactions. Neuropharmacology 122:127-135. PMCID: PMC5492942

Jimenez VA, Porcu P, Morrow AL, Grant KA (2017) Adaptations in Basal and Hypothalamic-Pituitary-Adrenal-Activated Deoxycorticosterone Responses Following Ethanol Selfadministration in Cynomolgus Monkeys. Frontiers in Endocrinology 8:19. PMCID: PMC5292619

Jones SA, Steele JS, Nagel BJ (2017) Binge drinking and family history of alcoholism are associated with an altered developmental trajectory of impulsive choice across adolescence. Addiction 112:1184-1192. PMCID: PMC5461183

Mangold CA, Masser DR, Stanford DR, Bixler GV, Pisupati A, Giles CB, Wren JD, Ford MM, Sonntag WE, Freeman WM (2017) CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging. The journals of gerontology. Series A, Biological sciences and medical sciences. 72:16-29. PMCID: PMC5155655

Mangold CA, Wronowski B, Du M, Masser DR, Hadad N, Bixler GV, Brucklacher RM, Ford MM, Sonntag WE, Freeman WM (2017) Sexually divergent induction of microglialassociated neuroinflammation with hippocampal aging. Journal of Neuroinflammation 14:141. PMCID: PMC5521082

Mitchell SH (2017) Devaluation of outcomes due to their cost: Extending discounting models beyond delay. Nebraska Symposium on Motivation 64:145-161.  PMID: 30351562

Mitchell SH (2017) Quantifying impatience using models of delay discounting in substance use disorders. Am J Drug Alcohol Abuse 43:234-236. PMCID: PMC6581187

Nimitvilai S, Uys JD, Woodward JJ, Randall PK, Ball LE, Williams RW, Jones BC, Lu L, Grant KA, Mulholland PJ (2017) Orbitofrontal Neuroadaptations and Cross-Species Synaptic Biomarkers in Heavy-Drinking Macaques. Journal of Neuroscience 37:3646-3660. PMCID: PMC5373140

Pina MM, Cunningham CL (2017) Ethanol-seeking behavior is expressed directly through an extended amygdala to midbrain neural circuit. Neurobiology of Learning and Memory 137:83-91. PMCID: PMC5214453

Shnitko TA, Allen DC, Gonzales SW, Walter NA, Grant KA. (2017) Ranking Cognitive Flexibility in a Group Setting of Rhesus Monkeys with a Set-Shifting Procedure. Frontiers in Behavioral Neuroscience 11:55. PMCID: PMC5362606

Smith ML, Walcott AT, Heinricher MM, Ryabinin AE (2017) Anterior cingulate cortex contributes to alcohol withdrawal-induced and socially transferred hyperalgesia. eNeuro 4(4): ENEURO.0087-17.2017. PMCID: PMC5526654


2016 Center Publications

Barkley-Levenson AM, Ryabinin AE, Crabbe JC (2016) Neuropeptide Y response to alcohol is altered in nucleus accumbens of mice selectively bred for drinking to intoxication. Behavioural Brain Research 302:160-70. PMCID: PMC4769649

Carim-Todd L, Mitchell SH, Oken BS (2016) Impulsivity and Stress Response in Nondependent Smokers (Tobacco Chippers) in Comparison to Heavy Smokers and Nonsmokers. Nicotine & Tobacco Research 18:547-56. PMCID: PMC5896825

Chesler EJ, Gatti DM, Morgan AP, Strobel M, Trepanier L, Oberbeck D, McWeeney S, Hitzemann R, Ferris M, McMullan R, Clayshultle A, Bell TA, Pardo-Manuel de Villena F, Churchill GA (2016) Diversity Outbred Mice at 21: Maintaining Allelic Variation in the Face of Selection. G3 (Bethesda) 6:3893-3902. PMCID: PMC5144960

Cozzoli DK, Courson JA, Rostock C, Campbell RR, Wroten MG, McGregor H, Caruana AL, Miller BW, Hu J-H, Zhang PW, Xiao B, Worley PF, Crabbe JC, Finn DA, Szumlinski KK (2016) Protein kinase C epsilon activity in the nucleus accumbens and central nucleus of the amygdala mediates binge alcohol. Biol Psychiatry 79:443-51. PMCID: PMC4561036

Crabbe JC (2016) Progress With Nonhuman Animal Models of Addiction. Journal of Studies on Alcohol and Drugs 77:696-9. PMCID: PMC5015466

Crabbe J.C., Phillips T.J. (2016) Genetic animal models. In: K. Sher (Ed). The Oxford Handbook of Substance Use Disorders, Vol. 1, Part Two: The Neurobiology and Genetics of Substance Use and Dependence, Chapter 8. New York: Oxford University Press.

Crabbe JC, Schlumbohm JP, Hack W, Barkley-Levenson AM, Metten P, Lattal KM (2016) Fear conditioning in mouse lines genetically selected for binge-like ethanol drinking. Alcohol 52:25-32. PMCID: PMC4855306

Greenberg GD, Crabbe JC (2016) Gene Targeting Studies of Hyperexcitability and Affective States of Alcohol Withdrawal in Rodents. Bell RL, Rahman S, editors, in International Review of Neurobiology 126: 357-390, Burlington: Academic Press. PMID: 27055618 (book chapter)

Greenberg GD, Huang LC, Spence SE, Schlumbohm JP, Metten P, Ozburn AR, Crabbe JC (2016) Nest building is a novel method for indexing severity of alcohol withdrawal in mice. Behavioural Brain Research 302:182-90. PMCID: PMC5456259

Greenberg GD, Phillips TJ, Crabbe JC (2016) Effects of acute alcohol withdrawal on nest building in mice selectively bred for alcohol withdrawal severity. Physiology & Behavior 165:257-66. PMCID: PMC5245172

Hadad N, Masser DR, Logan S, Wronowski B, Mangold CA, Clark N, Otalora L, Unnikrishnan A, Ford MM, Giles CB, Wren JD, Richardson A, Sonntag WE, Stanford DR, Freeman W (2016) Absence of genomic hypomethylation or regulation of cytosinemodifying enzymes with aging in male and female mice. Epigenetics & Chromatin 9:30. PMCID: PMC4942942

Hashimoto JG, Wiren KM, Wilhelm CJ (2016) A neurotoxic alcohol exposure paradigm does not induce hepatic encephalopathy. Neurotoxicology and Teratology 56:35-40. PMCID: PMC4939898

Kruse L.C., Buck K.J.  (2016) The role of the substantia nigra pars reticulata in sedative-hypnotic withdrawal. Neuropathology of Drug Addiction and Substance Misuse, Vol 3, pp.345-355, London: Academic Press.

Pina MM, Cunningham CL (2016) Involvement of ventral tegmental area ionotropic glutamate receptors in the expression of ethanol-induced conditioned place preference. Behavioural Brain Research 313:23-9. PMCID: PMC5098339

Ryabinin AE, Giardino WJ (2016) The corticotropin releasing factor system and alcohol consumption. In: V.B. Patel (Ed.) Molecular Aspects of Alcohol and Nutrition, 1st Edition, 201-212, Oxford: Elsevier.

Shabani S, Houlton SK, Hellmuth L, Mojica E, Mootz JR, Zhu Z, Reed C, Phillips TJ (2016) A mouse model for binge-level methamphetamine use. Frontiers in Neuroscience 10:493. PMCID: PMC5090006

Shi X, Walter NA, Harkness JH, Neve KA, Williams RW, Lu L, Belknap JK, Eshleman AJ, Phillips TJ, Janowsky A (2016) Genetic polymorphisms affect mouse and human trace amine-associated receptor 1 function. PLoS 11:e0152581. PMCID: PMC4816557

Siciliano CA, Calipari ES, Yorgason JT, Lovinger DM, Mateo Y, Jimenez VA, Helms CM, Grant KA, Jones SR (2016) Increased presynaptic regulation of dopamine neurotransmission in the nucleus accumbens core following chronic ethanol self-administration in female macaques. Psychopharmacology 233:1435-43. PMCID: PMC4814331

Siciliano CA, Calipari ES, Yorgason JT, Mateo Y, Helms CM, Lovinger DM, Grant KA, Jones SR (2016). Chronic ethanol self-administration in macaques shifts dopamine feedback inhibition to predominantly D2 receptors in nucleus accumbens core. Drug and Alcohol Dependence 158:159-63. PMCID: PMC4698076

Smith ML, Hostetler CM, Heinricher MM, Ryabinin AE (2016) Social transfer of pain in mice. Science Advances 2:e1600855. PMCID: PMC5072181

Smith ML, Li J, Cote DM, Ryabinin AE (2016) Effects of isoflurane and ethanol administration on c-Fos immunoreactivity in mice. Neuroscience 316:337-343. PMCID: PMC4742382

Tipps ME, Raybuck JD, Kozell LB, Lattal KM, Buck KJ (2016) G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 Knock-Out Mice Show Enhanced Ethanol Reward. Alcoholism, Clinical and Experimental Research 40:857-64. PMCID: PMC4820358


2015 Center Publications

Alarcón, G., Cservenka, A., Rudolf, M., Fair, D., Nagel, B.J. (2015). Developmental sex differences in resting state functional connectivity of amygdala sub-regions. NeuroImage, 15, 235-44. PMCID: PMC4461484

Barkley-Levenson AM, Crabbe JC (2015) Distinct ethanol drinking microstructure in two replicate lines of mice selectively bred for drinking to intoxication. Genes Brain & Behav 14:398-410.    PMCID: PMC4749147  Online erratum/correction, DOI: 10.1111/gbb.12284

Barkley-Levenson AM, Crabbe, JC (2015) Genotypic and sex differences in anxiety-like behavior and alcohol-induced anxiolysis in High Drinking in the Dark selected mice. Alcohol 49:29-36. PMCID: PMC4342118

Barkley-Levenson, A.M., Cunningham, C.L., Smitasin, P.J., Crabbe, J.C. (2015) Rewarding and aversive effects of ethanol in High Drinking in the Dark selectively bred mice. Addiction Biology 20:80-90.  PMCID: PMC3866216

Cservenka A, Gillespie AJ, Michael PG, Nagel BJ (2015) Family history density of alcoholism relates to left nucleus accumbens volume in adolescent girls. J Stud Alcohol Drugs 76:47-56. PMCID: PMC4263780

Cunningham CL, Pina MM. Alcohol preference tests. (2015) In LH Price and I Stolerman (Eds.), Encyclopedia of Psychopharmacology, Part 1 (2nd edition). Berlin Heidelberg: Springer-Verlag, pp. 79-83.

Ford M.M., Nickel J.D., Kaufman M.N., Finn D.A. (2015) Null mutation of 5α-reductase type I alters ethanol consumption patterns in a sex-dependent manner. Behavior Genetics 45:341-53. PMCID: PMC4425631

Gomez JL, Cunningham CL, Finn DA, Young EA, Helpenstell LK, Schuette LM, Fidler TL, Kosten TA, Ryabinin AE (2015) Differential effects of ghrelin antagonists on alcohol drinking and reinforcement in mouse and rat models of alcohol dependence. Neuropharmacology 97:182-93. PMCID: PMC4537402

Gubner N., Cunningham C.L., Phillips T.J. (2015) Nicotine enhances the locomotor stimulating but not the conditioned rewarding effect of ethanol in DBA/2J mice. Alcohol Clin Exp Res 39:64-72. PMCID: PMC4312001

Gubner N.R., McKinnon C.S., Phillips T.J. (2015) Effects of varenicline on ethanol-induced conditioned place preference, locomotor stimulation and sensitization. Alcohol Clin Exp Res 38:3033-42. PMCID: PMC4293040

Gubner NR, Phillips TJ (2015) Effects of nicotine on ethanol-induced locomotor sensitization: A model of neuroadaptation. Behavioural Brain Research 288:26-32. PMCID: PMC4442015

Harkness JH, Shi X, Janowsky A, Phillips TJ (2015) Trace amine-associated receptor 1 regulation of methamphetamine intake and related traits. Neuropsychopharmacology 40:2175-2184. PMCID: PMC4613607

Iancu OD, Colville A, Oberbeck D, Darakjian P, McWeeney SK, Hitzemann R. (2015) Cosplicing network analysis of mammalian brain RNA-Seq data utilizing WGCNA and Mantel correlations. Front Genet. May 13;6:174.  PMCID: PMC4429622

Milner LC, Shirley RL, Kozell LB, Walter NA, Kruse LC, Komiyama NH, Grant SGN, Buck KJ (2013). Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz’s role in ethanol withdrawal and support its role in voluntary ethanol consumption. Addiction Biology 20:143-7.  PMCID: PMC3997615

Mitchell SH, Wilson VB, Karalunas SL (2015) Comparing hyperbolic, delay-amount sensitivity and present-bias models of delay discounting. Behavioral Processes 114:52-62.  PMCID: PMC4404224

Ozburn AR, Janowsky AJ, Crabbe JC (2015) Commonalities and distinctions among mechanisms of addiction to alcohol and other drugs. Alcoholism, Clinical and Experimental Research 39:1863-77. PMCID: PMC4594192

Park HJ, Ran Y, Jung JI, Holmes O, Price AR, Smithson L, Ceballos-Diaz C, Han C, Wolfe MS, Daaka Y, Ryabinin AE, Kim SH, Hauger RL, Golde TE, Felsenstein KM (2015) The stress response neuropeptide CRF increases amyloid-β production by regulating γ-secretase activity. EMBO J 34:1674-86. PMCID: PMC4475401

Peraza J, Cservenka A, Herting MM, Nagel BJ (2015) Atypical parietal lobe activity to subliminal faces in youth with a family history of alcoholism. The American Journal of Drug and Alcohol Abuse 41:139-45. PMCID: PMC4666297

Pflibsen L, Stang KA, Sconce MD, Wilson VB, Hood RL, Meshul CK, Mitchell SH (2015) Executive function deficits and glutamatergic protein alterations in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. J Neuroscience Research 93:1849-64. PMCID: PMC4618105

Philibin SD, Crabbe JC  Addiction. In: Rosenberg's Molecular and Genetic Basis Of Neurologic and Psychiatric Disease, 5th ed. (Pascual JN, Rosenberg RN, Eds), Elsevier/Academic Press, San Diego CA, pp1321-1329.

Phillips TJ, Reed C, Pastor R (2015) Preclinical evidence implicating corticotropin-releasing factor signaling in ethanol consumption and neuroadaptation. Genes, Brain, and Behavior 14:98-135. PMCID: PMC4851463

Phillips TJ, Shabani S (2015) An animal model of differential genetic risk for methamphetamine intake. Frontiers in Neuroscience 9:327. PMCID: PMC4585292

Pina MM, Young EA, Ryabinin AE, Cunningham CL (2015) The bed nucleus of the stria terminalis regulates ethanol-seeking behavior in mice. Neuropharmacology 99:627-38. PMCID: PMC4668125

Ramaker, M. J., Strong-Kaufman, M. N., Ford, M. M., Phillips, T. J., & Finn, D. A. (2015). Effect of nucleus accumbens shell infusions of ganaxolone or gaboxadol on ethanol consumption in mice. Psychopharmacology  232:1415-26. PMCID: PMC4412309

Ryabinin AE, Giardino WJ. Molecular Aspects of Alcohol and Nutrition. 1st ed. Patel VB, editor. San Diego CA. Elsevier/Academic Press; 2015. ) The corticotropin releasing factor system and alcohol consumption; pp. 201-212.

Siciliano CA, Calipari ES, Cuzon Carlson VC, Helms CM, Lovinger DM, Grant KA, Jones SR. Voluntary Ethanol Intake Predicts κ-Opioid Receptor Supersensitivity and Regionally Distinct Dopaminergic Adaptations in Macaques. J. Neuroscience 2015; 35:5959-68. PMCID: PMC4397597

Smith, M.L., Li, J., Ryabinin, A.E. (2015)  Increased alcohol consumption in Urocortin 3 knockout mice is unaffected by chronic inflammatory pain. Alcohol and Alcoholism 50:132-9. PMCID: PMC4327342

Tanchuck-Nipper MA, Ford MM, Hertzberg A, Beadles-Bohling A, Cozzoli DK, Finn DA (2015). Sex Differences in Ethanol's Anxiolytic Effect and Chronic Ethanol Withdrawal Severity in Mice with a Null Mutation of the 5alpha-Reductase Type 1. Behav Genet 45:354-367.  PMCID: PMC4417087

Tipps ME, Raybuck JD, Buck KJ, Lattal KM (2015) Acute ethanol withdrawal impairs contextual learning and enhances cued learning. Alcohol Clin Exp Res 39:282-290. PMCID: PMC4331355

Wilhelm CJ, Hashimoto JG, Roberts ML, Bloom SH, Beard DK, Wiren KM (2015) Females uniquely vulnerable to alcohol-induced neurotoxicity show altered glucocorticoid signaling. Brain Research 1601:102-16. PMCID: PMC4362524

Weafer J, Mitchell SH, de Wit H  (2014) Recent translational findings on impulsivity in relation to drug abuse. Current Addiction Reports 1:289-300.  PMCID: PMC4323183

Zheng CL, Wilmot B, Walter NA, Oberbeck D, Kawane S, Searles RP, McWeeney SK, Hitzemann R (2015) Splicing landscape of the eight collaborative cross founder strains.BMC Genomics. Feb 5;16:52.  PMCID: PMC4320832


2014 Center Publications

Alarcón G, Cservenka A, Fair DA, Nagel BJ (2014) Sex differences in the neural substrates of spatial working memory during adolescence are not mediated by endogenous testosterone. Brain Research 1593:40-54. PMCID: PMC4252582

Anacker AM, Ahern TH, Hostetler CM, Dufour BD, Smith ML, Cocking DL, Li J, Young LJ, Loftis JM, Ryabinin AE (2014) Drinking alcohol has sex-dependent effects on pair bond formation in prairie voles. Proc Natl Acad Sci USA 111:6052-6057. PMCID: PMC4000860

Anacker, A. M., Smith, M. L., & Ryabinin, A. E. (2014). Establishment of stable dominance interactions in prairie vole peers: relationships with alcohol drinking and activation of the paraventricular nucleus of the hypothalamus. Soc Neurosci 9: 484-494.  PMCID: PMC24963825

Asquith M, Pasala S, Engelmann F, Haberthur K, Meyer C, Park B, Grant KA, Messaoudi I (2014) Chronic ethanol consumption modulates growth factor release, mucosal cytokine production, and microRNA expression in nonhuman primates. Alcohol Clin Exp Res 38:980-993. PMCID: PMC3984381

Baker EJ1, Farro J, Gonzales S, Helms C, Grant KA (2014) Chronic alcohol self-administration in monkeys shows long-term quantity/frequency categorical stability. Alcoholism, Clinical and Experimental Research 38:2835-2843. PMCID: PMC4244650

Barkley-Levenson, A.M., Crabbe, J.C. (2014) High Drinking in the Dark mice: A genetic model of drinking to intoxication. Alcohol 48:217-223.  PMCID: PMC4016107

Bohlen M, Hayes ER, Bohlen B, Bailoo J, Crabbe JC, Wahlsten D (2014) Experimenter effects on behavioral test scores of eight inbred mouse strains under the influence of ethanol. Behav Brain Res 272:46-54 .  PMCID: PMC4968576

Bubier JA, Jay JJ, Baker CL, Bergeson SE, Ohno H, Metten P, Crabbe JC, Chesler EJ (2014) Identification of a QTL in Mus musculus for Alcohol Preference, Withdrawal and Ap3m2 Expression Using Integrative Functional Genomics and Precision Genetics. Genetics 197:1377–1393PMCID: PMC4125407

Buck KJ, Walter NAR, Denmark DL (2014) Genetic variability of respiratory complex abundance, organization, and activity in mouse brain. Genes, Brain and Behavior 13:135-143.  PMCID:PMC3946880

Burnett EJ, Grant KA, Davenport AT, Hemby SE, Friedman DP (2014) The effects of chronic ethanol self-administration on hippocampal 5-HT1A receptors in monkeys. Drug Alcohol Depend 136:135-142.  PMCID: PMC3962821

Cozzoli DK, Courson J, Wroten MG, Greentree DI, Lum EN, Campbell RR, Thompson AB, Maliniak D, Worley PF, Jonquieres G, Klugmann M, Finn DA, Szumlinski KK. (2014) Binge alcohol drinking by mice requires intact group 1 metabotropic glutamate receptor signaling within the central nucleus of the amygdala. Neuropsychopharmacology 39:435-44. PMCID: PMC3870786

Cozzoli, D. K., Strong-Kaufman, M. N., Tanchuck, M. A., Hashimoto, J. G., Wiren, K. M., & Finn, D. A. (2014). The Effect of mGluR5 Antagonism During Binge Drinking on Subsequent Ethanol Intake in C57BL/6J Mice: Sex- and Age-Induced Differences. Alcoholism: Clinical and Experimental Research, 38:730-738.  PMCID: PMC5041302

Cozzoli, D. K., Tanchuck-Nipper, M. A., Kaufman, M. N., Horowitz, C. B., & Finn, D. A. (2014) Environmental stressors influence limited-access ethanol consumption by C57BL/6J mice in a sex-dependent manner. Alcohol 48:741-54.  PMCID: PMC4371601

Crabbe JC (2014) The Genetic Complexity of Alcohol Drinking in Rodents, In A.B.C. Noronha, C. Cui, R.A. Harris and J.C. Crabbe (Eds.). Neurobiology of Alcohol Dependence, 1st Edition, Elsevier Inc., Oxford UK, pp. 355-371.

Crabbe JC (2014) Mouse genetic models relevant for alcohol use disorders. In S. Pietropaulo, F. Sluyter, and W.E. Crusio (Eds.). Handbook of Behavior Genetics of the Mouse, Vol. 2, Genetic Mouse Models of Neurobehavioral Disorders, Cambridge University Press, Cambridge UK, pp 293-302.

Crabbe, J. C. (2014). Rodent models of genetic contributions to motivation to abuse alcohol. Nebr Symp Motiv 61: 5-29.

Crabbe, J. C. (2014). Use of animal models of alcohol-related behavior. Handb Clin Neurol 125: 71-86.

Crabbe, J. C., Metten, P., Belknap, J. K., Spence, S. E., Cameron, A. J., Schlumbohm, J. P., Huang, L.C., Barkley-Levenson, A.M., Ford, M.M., & Phillips, T. J. (2014). Progress in a replicated selection for elevated blood ethanol concentrations in HDID mice. Genes Brain Behav, 13(2), 236-246.  PMCID: PMC3923418

Cservenka A, Casimo K, Fair DA, Nagel BJ (2014) Resting state functional connectivity of the nucleus accumbens in youth with a family history of alcoholism. Psychiatry Research 221:210-219. PMCID: PMC3943736

Cservenka A, Fair DA, Nagel BJ (2014) Emotional processing and brain activity in youth at high risk for alcoholism. Alcoholism, Clinical and Experimental Research 38:1912-23. PMCID: PMC4867220

Cunningham CL (2014) Genetic Relationship Between Ethanol-Induced Conditioned Place Preference and Other Ethanol Phenotypes in 15 Inbred Mouse Strains. Behavioral Neuroscience 128:430-445.  PMCID: PMC4107118

Cunningham, C. L., & Zerizef, C. L. (2014). Effects of combining tactile with visual and spatial cues in conditioned place preference. Pharmacol Biochem Behav, 124, 443-450.  PMCID: PMC4170852

Dobbs LK, Cunningham CL. (2014) The role of the laterodorsal tegmental nucleus in methamphetamine conditioned place preference and locomotor activity. Behavioural Brain Research 265:198-202. PMCID: PMC4020626

Dreumont SE, Cunningham CL (2014) Effects of acute withdrawal on ethanol-induced conditioned place preference in DBA/2J mice. Psychopharmacology 231:777-785.    PMCID: PMC3910420 

Fritz BM, Cordero KA, Barkley-Levenson AM, Metten P, Crabbe JC, Boehm SL (2014) Genetic relationship between predisposition for binge alcohol consumption and blunted sensitivity to adverse effects of alcohol in mice. Alcohol Clin Exp Res 38:1284-1292.  PMCID: PMC3999212

Gomez, J. L., & Ryabinin, A. E. (2014). The effects of ghrelin antagonists [D-Lys(3) ]-GHRP-6 or JMV2959 on ethanol, water, and food intake in C57BL/6J mice. Alcohol Clin Exp Res 38:2436-2444.  PMCID: PMC4179906

Grant K, Ferguson B, Helms, C, McClintick M. "Drinking to Dependence Risk Factors in Nonhuman Primates," in Neurobiology of Alcohol Dependence, Noronha A, Cui C, Harris A, Crabbe JC, eds., San Diego: Academic Press, 2014, Chapter 20 pp. 408-420

Helms CM, Park B, Grant KA (2014) Adrenal steroid hormones and ethanol self-administration in male rhesus macaques. Psychopharmacology 231:3425-3436.  PMCID: PMC4135005

Helms, C. M., Park, B., & Grant, K. A. (2014). Erratum to: Adrenal steroid hormones and ethanol self-administration in male rhesus macaques. Psychopharmacology 231: 4253.  PMCID: PMC4135005

Helms CM, Rau A, Shaw J, Stull C, Gonzales SW, Grant KA (2014) The effects of age at the onset of drinking to intoxication and chronic ethanol self-administration in male rhesus macaques. Psychopharmacology 231:1853-1861. PMCID: PMC3969395 

Hitzemann R, Bottomly D, Iancu O, Buck K, Wilmot B, Mooney M, Searles R, Zheng C, Belknap J, Crabbe J, McWeeney S (2014) The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits. Mamm Genome 25:12-22.  PMCID: PMC3916704

Hitzemann, R., Darakjian, P., Walter, N., Iancu, O. D., Searles, R., & McWeeney, S. (2014). Introduction to sequencing the brain transcriptome. Int Rev Neurobiol, 116, 1-19. PMCID: PMC4773050

Hostetler CM, Ryabinin AE (2014) Social partners prevent alcohol relapse behavior in prairie voles. Psychoneuroendocrinology 39:152-157.  PMCID: PMC3867132

Kroenke CD, Rohlfing T, Park B, Sullivan EV, Pfefferbaum A, Grant KA (2014) Monkeys that voluntarily and chronically drink alcohol damage their brains: a longitudinal MRI study. Neuropsychopharmacology 39:823-830.  PMCID: PMC3924514

Kruse, L. C., Walter, N. A., & Buck, K. J. (2014). Mpdz expression in the caudolateral substantia nigra pars reticulata is crucially involved in alcohol withdrawal. Genes Brain Behav 13:769-76. PMCID: PMC4241148

Leeman RF, Beseler CL, Helms CM, Patock-Peckham JA, Wakeling VA, Kahler CW (2014) A brief, critical review of research on impaired control over alcohol use and suggestions for future studies. Alcoholism, Clinical and Experimental Research 38:301-308. PMCID: PMC3946792

Metten P, Iancu O, Spence S, Walter N, Oberbeck D, Harrington C, Colville A, McWeeney S, Phillips T, Buck K, Crabbe J, Belknap J, Hitzemann R  (2014) Dual-Trait Selection for Ethanol Consumption and Withdrawal: Genetic and Transcriptional Network Effects. Alcohol Clin Exp Res 38:2915-2924. PMCID: PMC4500109

Miranda-Dominguez, O., Mills, B. D., Carpenter, S. D., Grant, K. A., Kroenke, C. D., Nigg, J. T., & Fair, D. A. (2014). Connectotyping: model based fingerprinting of the functional connectome. PLoS One, 9(11), e111048. PMCID: PMC4227655

Miranda-Dominguez, O., Mills, B. D., Grayson, D., Woodall, A., Grant, K. A., Kroenke, C. D., & Fair, D. A. (2014). Bridging the gap between the human and macaque connectome: a quantitative comparison of global interspecies structure-function relationships and network topology. J Neurosci 34:5552-5563. PMCID: PMC3988411

Mitchell SH (2014) Assessing delay discounting in mice. Curr Protoc Neurosci 66:Unit 8.30.  PMCID: PMC3950305 

Mooney, M., & McWeeney, S. (2014). Data integration and reproducibility for high-throughput transcriptomics. Int Rev Neurobiol 116: 55-71. PMID: 25172471

Moschak TM, Mitchell SH (2014) Partial inactivation of nucleus accumbens core decreases delay discounting in rats without affecting sensitivity to delay or magnitude. Behav Brain Res 268:159-168.  PMCID: PMC4084517

Noronha ABC, Cui C, Harris RA, Crabbe JC, Eds. (2014) Neurobiology of Alcohol Dependence, 1st Edition, Elsevier Inc., Oxford UK.

Olson CR, Owen DC, Ryabinin AE, Mello CV (2014) Drinking songs: alcohol effects on learned song of zebra finches. PLoS One 9:e115427. PMCID: PMC4275239

Phillips, T. J., & Reed, C. (2014). Targeting GABAB receptors for anti-abuse drug discovery. Expert Opin Drug Discov 9:1307-1317.  PMID: 25195620

Pina MM, Cunningham CL (2014) Effects of dopamine receptor antagonists on the acquisition of ethanol-induced conditioned place preference in mice. Psychopharmacology 231:459-468. PMCID: PMC4007149

Pina, M. M., & Cunningham, C. L. (2014). Effects of the novel cannabinoid CB1 receptor antagonist PF 514273 on the acquisition and expression of ethanol conditioned place preference. Alcohol 48:427-431.  PMCID: PMC4188509

Ramaker MJ, Ford MM, Phillips TJ, Finn DA (2014) Differences in the reinstatement of ethanol seeking with ganaxolone and gaboxadol. Neuroscience 272C:180-187.   PMCID: PMC4122668

Snelling C, Tanchuck-Nipper MA, Ford MM, Jensen JP, Cozzoli DK, Ramaker MJ, Helms M, Crabbe JC, Rossi DJ, Finn DA (2014) Quantification of ten neuroactive steroids in plasma in Withdrawal Seizure-Prone and -Resistant mice during chronic ethanol withdrawal. Psychopharmacology.  PMCID: PMC4134998

Thiele, T. E., Crabbe, J. C., & Boehm, S. L., 2nd. (2014). "Drinking in the Dark" (DID): a simple mouse model of binge-like alcohol intake. Curr Protoc Neurosci 68: 9.49.41-49.49.12. PMCID: PMC4142649

Tipps, M. E., Moschak, T. M., & Mitchell, S. H. (2014). Behavioral disinhibition in mice bred for high drinking in the dark (HDID) and HS controls increases following ethanol. Drug Alcohol Depend 136:149-152. PMCID: PMC3956112

Tipps, M. E., Raybuck, J. D., Buck, K. J., & Lattal, K. M. (2014). Delay and trace fear conditioning in C57BL/6 and DBA/2 mice: issues of measurement and performance. Learning and Memory 21:380-393.  PMCID: PMC4105718

Wahlsten D, Crabbe JC (2014) Replicability and reliability of behavioral tests. In W.E. Crusio, F. Sluyter, and R.T. Gerlai (Eds.). Handbook of Behavior Genetics of the Mouse, Vol. 2, Genetics of Behavioral Phenotypes, Cambridge University Press, Cambridge, pp.23-35.

Weafer J, Mitchell SH, de Wit H  (2014) Recent translational findings on impulsivity in relation to drug abuse. Current Addiction Reports 1:289-300.  PMCID: PMC4323183

Wilhelm CJ, Hashimoto JG, Roberts ML, Sonmez MK, Wiren KM (2014) Understandng the addiction cycle: A complex biology with distinct contributions of genotype vs. sex at each stage. Neuroscience 279:168-86.  PMCID: PMC4224688

Young, E. A., Dreumont, S. E., & Cunningham, C. L. (2014). Role of nucleus accumbens dopamine receptor subtypes in the learning and expression of alcohol-seeking behavior. Neurobiol Learn Mem 108:28-37. PMCID: PMC3842358

Zheng, C. L., Kawane, S., Bottomly, D., & Wilmot, B. (2014). Analysis considerations for utilizing RNA-Seq to characterize the brain transcriptome. Int Rev Neurobiol 116:21-54. PMID: 25172470

2013 Center Publications

Anacker, A. M., & Ryabinin, A. E. (2013) Identification of subpopulations of prairie voles differentially susceptible to peer influence to decrease high alcohol intake. Front Pharmacol 4: 84. PMCID: PMC3701123

Belknap, J.K., McWeeney, S., Reed, C., Burkhart-Kasch, S., McKinnon, C.S., Li, N., Baba, H., Scibelli, A.C., Hitzemann, R. and Phillips, T.J. (2013) Genetic factors involved in risk for methamphetamine intake and sensitization. Mammalian Genome 24:446-458.  PMCID:PMC3880562

Barkley-Levenson, A.M., Cunningham, C.L., Smitasin, P.J., Crabbe, J.C. (2013) Rewarding and aversive effects of ethanol in High Drinking in the Dark selectively bred mice. Addiction Biol. epub ahead of print, Jul 30, doi: 10.1111/adb.12079.  PMCID: PMC3866216

Carim-Todd, L., Mitchell, S. H., & Oken, B. S. (2013). Mind-body practices: an alternative, drug-free treatment for smoking cessation? A systematic review of the literature. Drug and Alcohol Dependence 132:399-410.  PMCID: PMC3770754 

Crabbe JC, Kendler KS, Hitzemann RJ (2013) Modeling the diagnostic criteria for alcohol dependence with genetic animal models. Current Topics in Behavioral Neuroscience 13:187-221. PMCID: PMC3371181

Crabbe, J.C., Spence, S.E., Huang, L.C., Cameron, A.-J., Schlumbohm, J.P., Barkley-Levenson, A.M., Metten, P. (2013) Ethanol drinking in Withdrawal Seizure-Prone and –Resistant selected mouse lines. Alcohol 47:381-389.   PMCID: PMC3770535

Cunningham, C. L., Fidler, T. L., Murphy, K. V., Mulgrew, J. A., & Smitasin, P. J. (2013). Time-dependent negative reinforcement of ethanol intake by alleviation of acute withdrawal. Biological Psychiatry 73: 249-255.  PMCID: PMC3552109

Ford MM, Davis NL, McCracken AD, Grant KA. (2013) Contribution of NMDA glutamate and nicotinic acetylcholine receptor mechanisms in the discrimination of ethanol-nicotine mixtures. Behav Pharmacol 24: 617–622.  PMCID:PMC3925192

Ford MM, Steele AM, McCracken AD, Finn DA, Grant KA. (2013) The relationship between adjunctive drinking, blood ethanol concentration and plasma corticosterone across fixed-time intervals of food delivery in two inbred mouse strains. Psychoneuroendocrinology 38:2598-2610.  PMCID:PMC3812349

Giardino, W.J., Ryabinin, A.E. (2013) CRF1 Receptor Signaling Regulates Food and Fluid Intake in the Drinking-in-the-Dark Model of Binge Alcohol Consumption. Alcoholism: Clinical and Experimental Research, 37: 1161-1070.  PMCID: PMC3657581

Gubner, N.R., McKinnon, C.S., Reed, C. and Phillips, T.J. (2013) Accentuating effects of nicotine on ethanol response in mice with high genetic predisposition to ethanol-induced locomotor stimulation. Drug Alcohol Dependence 127:108-114.  PMCID: PMC3505243

Gubner, N.R., Reed, C., McKinnon, C.S. and Phillips, T.J. (2013) Unique genetic factors influence sensitivity to the rewarding and aversive effects of methamphetamine versus cocaine.  Behav Brain Res 256:420-427.  PMCID:PMC3907175

Harkness, J.H., Hitzemann, R.J., Edmunds, S. and Phillips, T.J. (2013) Effects of sodium butyrate on methamphetamine-sensitized locomotor activity. Behav Brain Res 239:139-147.  PMCID: PMC3546510

Helms CM, Gonzales SW, Green HL, Szeliga KT, Rogers LS, Grant KA. (2013) Diurnal pituitary-adrenal activity during schedule-induced polydipsia of water and ethanol in cynomolgus monkeys (Macaca fascicularis). Psychopharmacology 228:541-9.  PMCID: PMC3715599

Hitzemann R, Bottomly D, Darakjian P, Walter N, Iancu O, Searles R, Wilmot B, McWeeney S.  (2013) Genes, behavior and next-generation RNA sequencing. Genes Brain Behav 12:1-12.  PMID: 23194347

Holstein SE, Li N, Eshleman AJ, Phillips TJ (2013) GABAB receptor activation attenuates the stimulant but not mesolimbic dopamine response to ethanol in FAST mice. Behavioural Brain Research 237C:49-58.  PMCID: PMC3500454

Hostetler, C.M., Ryabinin, A.E. (2013) The CRF system and social behavior: a review. Frontiers in Neuroscience, 7: 92. PMCID: PMC3668170

Iancu, O.D., Overbeck, D., Darajkian, P., Metten, P., McWeeney, S., Crabbe, J.C., Hitzemann, R.J. (2013) High Drinking in the Dark selected lines and brain gene coexpression networks. Alcohol. Clin. Exper. Res. 28:1295-1303.  PMCID: PMC3759151

Kroenke CD, Flory GS, Park B, Shaw J, Rau AR, Grant KA. (2013) Chronic Ethanol (EtOH) Consumption Differentially Alters Gray and White Matter EtOH Methyl (1) H Magnetic Resonance Intensity in the Primate Brain. Alcohol Clin Exp Res 37:1325-32.  PMCID: PMC3736995

López-Jiménez A, Walter NA, Giné E, Santos Á, Echeverry-Alzate V, Bühler KM, Olmos P, Giezendanner S, Moratalla R, Montoliu L, Buck KJ, López-Moreno JA. (2013) A spontaneous deletion of α-synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: effects on alcohol consumption. Synapse 67:280-9.  PMCID:PMC3931467

Matthews, A. M., Wilson, V. B., Mitchell, S. H., & Hauser, P. (2013) Smoking characteristics of Veterans enrolled in a large multicenter study of bipolar disorder. Federal Practitioner 30:23-30. Available Free at: https://www.mdedge.com/fedprac/article/75895/mental-health/smoking-characteristics-veterans-bipolar-disorder

McCulley III, W.D., Ascheid, S., Crabbe, J.C., Rosenwasser, A.M. (2013). Selective breeding for ethanol-related traits alters circadian phenotype. Alcohol 47:187-194. PMCID:PMC3617087

Moschak, T. M., & Mitchell, S. H. (2013). Sensitivity to reinforcer delay predicts ethanol's suppressant effects, but itself is unaffected by ethanol. Drug and Alcohol Dependence, 132:22-8. PMCID: PMC3830544

Moschak, T. M., Stang, K. A., & Mitchell, S. H. (2013). Mice bred for severity of acute alcohol withdrawal respond differently in a Go/No-go task. Alcoholism: Clinical & Experimental Research 37:1483-90.  PMCID:PMC4027951

Neve, K.A., Ford, C.P.., Buck, D.C., Grandy, D.K., Neve, R.L. and Phillips, T.J. (2013) Normalizing dopamine D2 receptor-mediated responses in D2 null mutant mice by virus-mediated receptor restoration: comparing D2L and D2S. Neuroscience 248:479-487.  PMCID: PMC3858482

Olsen, R.H.J., Allen, C.N., Derkach, V.A., Phillips, T.J., Belknap, J.K. and Raber, J. (2013) Impaired memory and reduced sensitivity to the circadian period lengthening effects of methamphetamine in mice selected for high methamphetamine consumption. Behav Brain Res 256:197-204.  PMCID:PMC3815974

Phillips, T.J. (2013) Alcoholism. In:  S. Maloy and K. Hughes (Eds.), Brenner’s Encyclopedia of Genetics, 2nd edition, Vol 1. San Diego: Academic Press, Elsevier Inc., pp. 62-64.

Phillips, T. (2013) Coisogenic strain. In:  S. Maloy and K. Hughes (Eds.), Brenner’s Encyclopedia of Genetics, 2nd edition, Vol 2. San Diego: Academic Press, Elsevier Inc., p. 84.

Phillips, T.J. and Gubner, N.R. (2013) Addiction and genes: Animal models. In: eLS (Encyclopedia of Life Sciences). John Wiley & Sons, Ltd: Chichester. Updated version 2. DOI: 10.1002/9780470015902.a0005914.pub2

Raybuck, J. D., McCleery, E. J., Cunningham, C. L., Wood, M. A. & Lattal, K. M. (2013). The histone deacetylase inhibitor sodium butyrate modulates acquisition and extinction of cocaine-induced conditioned place preference. Pharmacology, Biochemistry & Behavior 106:109-116.  PMCID: PMC3691316

Rosenwasser AM, Fixaris MC, Crabbe JC, Brooks PC, Ascheid S (2013) Escalation of intake under intermittent ethanol access in diverse mouse genotypes. Addiction Biology 18:496-507.  PMCID: PMC3508291

Ryabinin AE, Cocking DL, Kaur S (2013) Inhibition of VTA neurons activates the centrally projecting Edinger–Westphal nucleus: Evidence of a stress–reward link? Journal of Chemical Neuroanatomy 54:57-61.  PMCID:PMC3851891

Tanchuck, M.A., He, I., Kaufman, K.R., Snelling, C., Crabbe, J.C., Mark, G.P., Finn, D.A. (2013) Local changes in neurosteroid levels in the substantia nigra reticulata and the ventral tegmental area alter chronic ethanol withdrawal severity in male Withdrawal Seizure-Prone mice. Alcohol. Clin. Exper. Res. 37:784-793.  PMCID: PMC3620817

Wahlsten, D., Crabbe, J.C. (2013) Replicability and reliability of behavioral tests. In W.E. Crusio, F.Sluyter, R.T. Gerlai, S. Pietropaulo (Eds.). Handbook of Behavior Genetics of the Mouse,    Vol. 1, Genetics of Behavioral Phenotypes, Cambridge University Press, Cambridge, pp 23-35.


2012 Center Publications

Ary AA, Cozzoli DK, Finn DA, Crabbe JC, Dehoff MH, Worley PF and Szumlinski KK (2012) Ethanol up-regulates nucleus accumbens neuronal activity dependent pentraxin (Narp): implications for alcohol-induced behavioral plasticity. Alcohol 46:377-387. Free in PubMedCentral  PMCID: PMC3358440

Barkley-Levenson AM, Crabbe JC (2012) Ethanol drinking microstructure of a high drinking in the dark selected mouse line. Alcoholism: Clinical and Experimental Research 36:1330-9.  Free in PubMedCentral  PMCID: PMC3407303

Barkley-Levenson AM, Crabbe, JC (2012) Bridging animal and human models: Translating from (and to) animal genetics. Alcohol Research: Current Reviews 34:325-335.  Free full text link: http://pubs.niaaa.nih.gov/publications/arcr343/325-335.htm

Buck KJ, Milner LC, Denmark DL, Grant SGN and Kozell LB (2012) Discovering Genes Involved in Alcohol Dependence and Other Alcohol Responses. Alcohol Research: Current Reviews 34:367-374.  Free full text link: http://pubs.niaaa.nih.gov/publications/arcr343/367-374.htm

Cozzoli DK, Courson J, Caruana AL, Miller BW, Greentree DI, Thompson AB, Wroten MG, Zhang PW, Xiao B, Hu JH, Klugmann M, Metten P, Worley PF, Crabbe JC, Szumlinski KK (2012) Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under Drinking-in-the-Dark procedures. Alcoholism: Clinical and Experimental Research 36:1623-33. Free in PubMedCentral  PMCID: PMC3382009

Crabbe JC (2012) Translational behaviour-genetic studies of alcohol: are we there yet? Genes Brain and Behavior 11:375-86.  Free in PubMedCentral PMCID: PMC3370065

Crabbe JC, Colville AM, Kruse LM, Cameron AJ, Spence SE, Schlumbohm JP, Huang LC, Metten P (2012) Ethanol Tolerance and Withdrawal Severity in High Drinking in the Dark Selectively Bred Mice.  Alcoholism: Clinical and Experimental Research 36:1152-1161. Free in PubMedCentral PMCID: PMC3349804

Crabbe JC, Harkness JH, Spence SE, Huang LC, Metten P (2012) Intermittent availability of ethanol does not necessarily lead to increased intake in mice.  Alcohol and Alcoholism 47:509-17. Free in PubMedCentral PMCID: PMC3417685

Crabbe JC, Kruse LM, Colville AM, Cameron AJ, Spence SE, Schlumbohm JP, Huang LC, Metten P (2012) Ethanol Sensitivity in High Drinking in the Dark Selectively Bred Mice.  Alcoholism: Clinical and Experimental Research 36:1162-1170. Free in PubMedCentral PMCID: PMC3349784

Crabbe JC, Metten P, Huang LC, Schlumbohm JP, Spence SE, Barkley-Levenson AM, Finn DA, Rhodes JS and Cameron AJ (2012) Ethanol withdrawal-associated drinking and drinking in the dark: Common and discrete genetic contributions, Addiction Genetics 1:3-11. Free in PubMedCentral PMCID: PMC3923583

Cruz, M.T., Herman, M.A., Cote, D.M., Ryabinin, A.E., Roberto, M. (2012) Ghrelin increases GABAergic transmission and interacts with ethanol actions in the rat central nucleus of the amygdala. Neuropsychopharmacology 38:364-375.  Free in PubMedCentral  PMCID: PMC3527109

Cservenka, A., Herting, M.M., Nagel, B.J. (2012) Atypical frontal lobe activity during verbal working memory in youth with a family history of alcoholism. Drug and Alcohol Dependence 123:98-104.Free in PubMedCentral PMCID: PMC3294260

Cservenka, A., Nagel, B.J. (2012) Risky decision-making: An fMRI study of youth at high risk for alcoholism. Alcoholism: Clinical and Experimental Research 36:604-615.  Free in PubMedCentral PMCID: PMC3319339

de Wit H, Phillips TJ. (2012) Do initial responses to drugs predict future use or abuse? Neurosci Biobehav Rev 36:1565-76.  Free in PubMedCentral PMCID: PMC3372699

Ferguson B, Hunter JH, Street SL, Woodall A, Luty J, Grant K (2012) Genetic load is associated with hypothalamic-pituitary-adrenal axis dysregulation in macaques.  Genes Brain and Behavior, Sept 21, ePub ahead of print.  Free in PubMedCentral  PMCID: PMC3595329

Fidler, T. L., Powers, M. S., Ramirez, J. J., Crane, A. T.,  Mulgrew, J. A., Smitasin, P. J., & Cunningham, C. L. (2012) Dependence induced increases in Intragastric Alcohol Consumption (IGAC) in mice. Addiction Biology 17:13-32. Free in PubMedCentral  PMCID: PMC3245375

Fish, E.W., Robinson, J.E., Krouse, M.C., Hodge, C.W., Reed, C., Phillips, T.J. and Malanga, C.J. (2012) Intracranial self-stimulation in FAST and SLOW mice: Effects of alcohol and cocaine. Psychopharmacology 220:719-730. Free in PubMedCentral  PMCID: PMC3289728

Font L, Cunningham CL (2012) Post-retrieval propranolol treatment does not modulate reconsolidation or extinction of ethanol-induced conditioned place preference. Pharmacology, Biochemistry & Behavior 101:222–230. Free in PubMedCentral  PMCID: PMC3324309

Ford, M.M., McCracken, A.D., Wolf, N.T., Ryabinin, A.E., Grant, K.A. (2012) Discrimination of ethanol-nicotine drug mixtures in mice: dual interactive mechanisms of overshadowing and potentiation. Psychopharmacology 224:537-48.  Free in PubMedCentral PMCID: PMC3496813

Foroud T, Phillips TJ (2012) Overview: Assessing the Genetic Risk for Alcohol Use Disorders Alcohol Research: Current Reviews 34:266-272. Free full text link: http://pubs.niaaa.nih.gov/publications/arcr343/266-273.htm

Gallego X, Ruiz-Medina J, Valverde O, Molas S, Robles N, Sabrià J, Crabbe JC, Dierssen M (2012) Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice. Alcohol 46:205-15.  Free in PubMedCentral PMCID: PMC3340912

Giardino, W.J., Cote, D.M., Li, J., Ryabinin, A.E. (2012) Characterization of genetic differences within the centrally-projecting Edinger-Westphal nucleus of C57BL/6J and DBA/2J mice by expression profiling. Frontiers in Neuroanatomy, Epub. 6:5.  Free in PubMedCentral PMCID: PMC3278674

Groblewski, P. A., & Cunningham, C. L. (2012) Repeated microinjections into the medial prefrontal cortex (mPFC) impair extinction of conditioned place preference in mice. Behavioural Brain Research 230:299– 303.  Free in PubMedCentral PMCID: PMC3310337

Groblewski PA, Ryabinin AE, Cunningham CL (2012) Activation and role of the medial prefrontal cortex (mPFC) in extinction of ethanol-induced associative learning in mice.  Neurobiology of Learning and Memory:97:37-46.  Free in PubMedCentral PMCID: PMC3246036

Gubner, N.R., McKinnon, C.S., Reed, C. and Phillips, T.J. (2012) Accentuating effects of nicotine on ethanol response in mice with high genetic predisposition to ethanol-induced locomotor stimulation. Drug and Alcohol Dependence 127:108-114. Free in PubMedCentral PMCID: PMC3505243 

Helms CM, Rossi D, Grant KA (2012)  Neurosteroid effects on sensitivity to ethanol.  Frontiers in Endocrinology (Lausanne) 3:10.  Free in PubMedCentral PMCID: PMC3356014

Helms CM, McClintick MN, Grant KA (2012) Social rank, chronic ethanol self-administration, and diurnal pituitary-adrenal activity in cynomolgus monkeys. Psychopharmacology 224:133-43.  Free in PubMedCentral PMCID: PMC3469782

Hostetler CM, Ryabinin AE (2012) Commentary: Love and addiction: the devil is in the differences. Psychopharmacology 224: 27-29.  PMID: 22948669

Iancu OD, Darakjian P, Kawane S, Bottomly D, Hitzemann R, McWeeney S (2012) Detection of expression quantitative trait Loci in complex mouse crosses: impact and alleviation of data quality and complex population substructure. Frontiers in Genetics 3:157.  Free in PubMedCentral PMCID: PMC3427913

Iancu OD, Kawane S, Bottomly D, Searles R, Hitzemann R, McWeeney S (2012) Utilizing RNA-Seq data for de novo coexpression network inference. Bioinformatics 28:1592-7.  Free in PubMedCentral PMCID: PMC3493127

Kaur, S, Li, J., Stenzel-Poore, M.P., Ryabinin, A.E. (2012) Corticotropin releasing factor acting on corticotropin releasing factor receptor type 1 is critical for binge alcohol drinking in mice. Alcoholism: Clinical and Experimental Research 36:369-376. Free in PubMedCentral PMCID: PMC3235273

Kendler, K.S., Aggen, S., Prescott, C.A., Crabbe, J.C., Neale, M.C. (2012) Evidence for multiple genetic factors underlying the DSM-IV criteria for alcohol dependence. Molecular Psychiatry 17:1306-1315.  Free in PubMedCentral PMCID: PMC3371163

Mackiewicz-Seghete, K., Cservenka, A., Herting, M.M., Nagel, B.J. (2012) Atypical spatial working memory and task-general brain activity in adolescents with a family history of alcoholism. Alcoholism: Clinical and Experimental Research 37:390-398.  Free in PubMedCentral PMCID: PMC3556373

Mitchell SH, Wilson VB (2012) Differences in delay discounting between smokers and nonsmokers remain when both rewards are delayed. Psychopharmacology 219:549–562. Free in PubMedCentral PMCID: PMC3677053

Moschak, T. M., Stang, K. A., Phillips, T. J., & Mitchell, S. H. (2012) Behavioral inhibition in mice bred for high vs low levels of methamphetamine consumption or sensitization. Psychopharmacology 222:353‐65. Free in PubMedCentral PMCID: PMC3383918

Moschak, T. M., & Mitchell, S. H. (2012) Acute ethanol administration and reinforcer magnitude reduction both reduce responding and increase response latency in a Go/No‐Go task. Alcoholism: Clinical and Experimental Research 36:1803‐1810.  Free in PubMedCentral PMCID: PMC3396725

Olson CR, Owen DC, Ryabinin AE, Mello CV (2012) Poster: Drinking Songs! The efficacy of songbirds in alcohol research. Society for Neuroscience Annual Meeting, New Orleans, LA.  SfN story: http://www.newscientist.com/article/dn22389-zebra-finches-sing-sloppily-when-drunk.ht

Pastor, R., Reed, C., Meyer, P.J., McKinnon, C., Ryabinin, A.E. and Phillips, T.J. (2012) Role of corticotropin releasing factor and corticosterone in behavioral sensitization to ethanol.  Journal of Pharmacology and Experimental Therapeutics 341:455-63.  Free in PubMedCentral PMCID: PMC3336812

Philibin SD, Cameron AJ, Schlumbohm, JP, Metten P, Crabbe JC (2012) Ethanol Withdrawal-Induced Motor Impairment in Mice. Psychopharmacology 220:367-378. Free in PubMedCentral PMCID: PMC3310337 

Ryabinin AE (2012) Editorial: Evolutionary Perspectives on animal model of addiction: diverse models are welcome. Journal of Addiction Research and Therapy, 3:e113. doi: 10.4172/2155-6105.1000e113, online article,  Open Access Link

Ryabinin, A.E., Tsoory. M.M., Kozicz, T., Thiele, T.E., Neufeld-Cohen, A., Chen, A., Lowery, E.G., Giardino, W.J., Kaur, S. (2012) Urocortins: CRF’s siblings and their potential role in anxiety, depression and alcohol drinking behavior. Alcohol 46:349-357.  Free in PubMedCentral PMCID: PMC3358480

Wilhelm, C. J., & Mitchell, S. H. (2012) Acute ethanol does not always affect delay discounting in rats selected to prefer or avoid ethanol. Alcohol and Alcoholism 47:518‐24.  Free in PubMedCentral PMCID: PMC3500854

Yankelevitz, R. L., Mitchell, S. H. & Zhang, Y. (2012) Gender differences in factors associated with alcohol drinking: Delay discounting and perception of others' drinking. Drug and Alcohol Dependence 123:273‐6.  Free in PubMedCentral PMCID: PMC3925447


2011 Center Publications

Anacker AM, Loftis JM, Ryabinin AE (2011) Alcohol Intake in Prairie Voles is Influenced by the Drinking Level of a Peer. Alcoholism: Clinical and Experimental Research 35:1884-1890.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158264

Anacker AM, Loftis JM, Kaur S, Ryabinin AE (2011) Prairie voles as a novel model of socially facilitated excessive drinking. Addiction Biology 16:92-107.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950896

Beckley EH, Scibelli AC, Finn DA (2011) Progesterone receptor antagonist CDB-4124 increases depression-like behavior in mice without affecting locomotor ability. Psychoneuroendocrinology 36:824-833.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081939

Bottomly D, Walter NA, Hunter JE, Darakjian P, Kawane S, Buck KJ , Searles RP, Mooney M, McWeeney SK, Hitzemann R (2011) Evaluating gene expression in C57BL/6J and DBA/2J mouse striatum using RNA-Seq and microarrays. PLoS One 6:e17820.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063777

Chen G, Cuzon Carlson VC, Wang J, Beck A, Heinz A, Ron D, Lovinger DM, Buck KJ ( 2011) Striatal involvement in human alcoholism and alcohol consumption, and withdrawal in animal models. Alcoholism: Clinical and Experimental Research 35:1739-1748.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276303

Chen G, Kozell LB, Buck KJ (2011) Substantia nigra pars reticulata is crucially involved in barbiturate and ethanol withdrawal in mice. Behavioural Brain Research 218:152-157.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075943

Crabbe JC, Harris RA, Koob GF (2011) Preclinical studies of alcohol binge drinking. Annals of the New York Acad Sci 1216:24-40.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076900

Crabbe JC, Spence SE, Brown LL, Metten P ( 2011) Alcohol preference drinking in a mouse line selectively bred for high drinking in the dark. Alcohol 45:427-440.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395368

Cunningham CL, Groblewski PA, Voorhees CM (2011) Place conditionig, M. C. Olmstead (Ed.), Animal models of drug addiction (pp. 167-189), Neuromethods, vol. 53. Totowa, NJ: Humana Press.

Fei SS, Wilmarth PA, Hitzemann RJ, McWeeney SK, Belknap JK, David LL (2011) Protein Database and Quantitative Analysis Considerations when Integrating Genetics and Proteomics to Compare Mouse Strains. Journal of Proteome Research 10:2905-2912.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128464

Fidler TL, Dion AM, Powers MS, Ramirez JJ, Mulgrew JA, Smitasin PJ, Crane AT, Cunningham CL (2011) Intragastric self-infusion of ethanol in high- and low-drinking mouse genotypes after passive ethanol exposure. Genes, Brain and Behavior 10:264-275.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070055

Ford MM, Fretwell AM, Anacker AM, Crabbe JC, Mark GP, Finn DA (2011) The influence of selection for ethanol withdrawal severity on traits associated with ethanol self-administration and reinforcement. Alcoholism: Clinical and Experimental Research 35:326-337.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058687

Giardino WJ, Cocking DL, Kaur S, Cunningham CL, Ryabinin AE (2011) Urocortin-1 in the centrally-projecting Edinger-Westphal nucleus is critical for ethanol preference. PLoS ONE.  Free full text link: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0026997

Giardino, W.J., Pastor, R., Anacker, A.M.J., Spangler, E., Cote, D.M., Li, J., Stenzel-Poore, M., Phillips, T.J., Ryabinin, A.E. (2011) Dissection of corticotropin-releasing factor system involvement in locomotor sensitivity to methamphetamine. Genes, Brain and Behavior 10:78-89.    [PARC Animal Core provided animals] Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025045

Giardino, W.J., Ryabinin, A.E. (2011) Commentary: Corticotropin-releasing factor: Innocent until proven guilty. Nature Reviews Neuroscience, 13:70. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365568

Gremel CM, Young EA, Cunningham CL (2011) Blockade of opioid receptors in anterior cingulate cortex disrupts ethanol-seeking behavior in mice. Behavioural Brain Research 219:358-362.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062680

Groblewski PA, Franken FH, Cunningham CL (2011) Inhibition of extracellular signal-regulated kinase (ERK) activity with SL327 does not prevent acquisition, expression, and extinction of ethanol-seeking behavior in mice. Behavioural Brain Research 217:399-407.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019767

Helms CM, Grant KA (2011) The effect of age on the discriminative stimulus effects of ethanol and its GABA(A) receptor mediation in cynomolgus monkeys. Psychopharmacology 216:333-43.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134136

Herting MM, Fair D, Nagel BJ (2011) Altered fronto-cerebellar connectivity in alcohol-naive youth with a family history of alcoholism. Neuroimage 54:2582-2589.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150517

Johnson BA, Messing RO, Charness ME, Crabbe JC, Goldman MS, Harris RA, Kranzler HR, Mitchell MC Jr, Nixon SJ, Riley EP, Schuckit MA, Sher KJ, Thomas JD (2011) Should the reorganization of addiction-related research across all the National Institutes of Health be structural?--The devil is truly in the details. Alcoholism: Clinical and Experimental Research 35:572-580.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068603

Johnson BA, Messing RO, Charness ME, Crabbe JC, Goldman MS, Harris RA et al. (2011) How Should Addiction-Related Research at the National Institutes of Health be Reorganized? Frontiers in Psychiatry 2:2.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098615

Laderas TG, Walter NA, Mooney M, Vartanian K, Darakjian P, Buck K, Harrington CA, Belknap J, Hitzemann R, McWeeney SK (2011) Computational detection of alternative exon usage. Frontiers in Neuroscience 5:69.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097375

Metten P, Brown LL, Crabbe JC. 2011. Limited access ethanol drinking in the dark in adolescent and adult mice. Pharmacology, Biochemistry and Behavior 98:279-285. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057404

Mitchell SH. 2011. The genetic basis of delay discounting and its genetic relationship to alcohol dependence. Behavioral Processes 87:10-17.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081405

Mulligan MK, Rhodes JS, Crabbe JC, Mayfield RD, Adron HR, Ponomarev I. 2011. Molecular profiles of drinking alcohol to intoxication in C57BL/6J mice. Alcoholism: Clinical and Experimental Research 35:659-670.   Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066294

Munn E, Bunning M, Prada S, Bohlen M, Crabbe JC, Wahlsten D. 2011. Reversed light-dark cycle and cage enrichment effects on ethanol-induced deficits in motor coordination assessed in inbred mouse strains with a compact battery of refined tests. Behavioural Brain Research 224:259-71.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159708

Pastor, R., Reed, C., Burkhart-Kasch, S., Li, N., Sharpe, A.L., Coste, S.C., Stenzel-Poore, M.P., Phillips, T.J. (2011) Ethanol concentration-dependent effects and the role of stress on ethanol drinking in corticotropin-releasing factor type 1 and double type 1 and 2 receptor knockout mice. Psychopharmacology 218:169-177.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312392

Pastor, R., Font, L., Miquel, M., Phillips, T.J., Aragon, C.M.G. (2011) Involvement of the beta-endorphin neurons of the hypothalamic arcuate nucleus in ethanol-induced place preference conditioning in mice. Alcoholism: Clinical and Experimental Research 35:1-11.  PMID: 22014186

Phillips TJ, Pastor R, Scibelli AC, Reed C, Tarragón E (2011) Behavioral sensitization to addictive drugs: Clinical relevance and methodological aspects. In J. Raber (ed.), Animal Models of Behavioral Analysis, Neuromethods Vol. 50 (pp. 267-305). Humana Press, New York.

Roselli CE, Finn TJ, Ronnekleiv-Kelly SM, Tanchuck MA, Kaufman KR, Finn DA. 2011. Localization of brain 5a-reductase messenger RNA in mice selectively bred for high chronic alcohol withdrawal severity. Alcohol 45:763-772.  Free full text link:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218258

Voorhees CM, Cunningham CL. 2011. Involvement of the orexin/hypocretin system in ethanol conditioned place preference. Psychopharmacology 214:805-818. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063857

Welsh JP, Han VZ, Rossi DJ, Mohr C, Odagiri M, Daunais JB, Grant KA (2011) Bidirectional plasticity in the primate inferior olive induced by chronic ethanol intoxication and sustained abstinence. Proceedings of the National Academy of Sciences USA 108:10314-10319. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121872


2010 Center Publications

Blednov YA, Ozburn AR, Walker D, Ahmed S, Belknap JK, Harris RA. (2010) Hybrid mice as genetic models of high alcohol consumption. Behavior Genetics 40:93-110. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038337

Boudreau E, Chen G, Li X, Buck K, Hitzemann R, Hickman D. (2010) Intraperitoneal catheter placement for pharmacological imaging studies in conscious mice. Lab Animal (NY) 39:23-25. PMID: 20023678

Chen G, Buck KJ. (2010) Rostroventral caudate putamen involvement in ethanol withdrawal is influenced by a chromosome 4 locus. Genes, Brain and Behavior 9:768-776.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970669

Crabbe JC. (2010) Consilience of rodent and human phenotypes relevant for alcohol dependence. Addiction Biology 15:103-108.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853473

Crabbe JC, Phillips TJ, Belknap JK. (2010) The complexity of alcohol drinking: studies in rodent genetic models. Behavior Genetics 40:737-750.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330823

Crabbe JC, Bell RL, Ehlers CL. (2010) Human and laboratory rodent low response to alcohol: is better consilience possible? Addiction Biology 15:125-144.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853481

Crabbe JC. (2010) Neurogenetic studies of alcohol addiction. Philos Trans R Soc Lond B Biol Sci 363:3201-3211. Reprinted in T.W. Robbins, B.J. Everitt, D.J. Nutt,, (Eds) Neurobiology of Addiction: New Vistas, Oxford University Press, New York, pp. 153-169.

Cservenka A, Spangler E, Cote DM, Ryabinin AE (2010). Postnatal developmental profile of urocortin 1 and cocaine- and amphetamine-regulated transcript in the perioculomotor region of C57BL/6J mice. Brain Research 1319:33-43.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826606

Cunningham CL. (2010) Alcohol preference tests.  In I. Stolerman (Ed.), Encyclopedia of psychopharmacology, Part 1. (pp. 61-64).  Berlin Heidelberg: Springer-Verlag.

Dick D M, Smith G, Olausson P, Mitchell SH, Leeman RF, O'Malley SS, Sher K. (2010) Understanding the construct of impulsivity and its relationship to alcohol use disorders. Addiction Biology 15:217-226.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895996

Ehlers CL, Walter NA, Dick DM, Buck KJ, Crabbe JC. (2010) A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models. Addiction Biology 15:185-199.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848508

Finn DA, Beckley EH, Kaufman KR and Ford MM. (2010) Manipulation of GABAergic steroids: Sex differences in the effects on alcohol drinking- and withdraw-related behaviors. Hormones and Behavior57:12-22.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813380

Flory GS, O'Malley J, Grant KA, Park B, Kroenke CD. (2010) Quantification of ethanol methyl (1)H magnetic resonance signal intensity following intravenous ethanol administration in primate brain. Methods 50:189-198.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828522

Gremel CM, Cunningham CL. (2010) Effects of disconnection of amygdala dopamine and nucleus accumbens N-methyl-d-aspartate receptors on ethanol-seeking behavior in mice. European Journal of Neuroscience 31:148-155.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908034

Gubner NR, Wilhelm CJ, Phillips TJ, Mitchell SH. (2010) Strain differences in behavioral inhibition in a Go/No-go task demonstrated using 15 inbred mouse strains. Alcoholism: Clinical and Experimental Research 34:1353-1362. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336215

Heilig M, Egli M, Crabbe JC, Becker HC. (2010) Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked? Addiction Biology 15:169-184. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268458

Herting MM, Schwartz D, Mitchell SH, Nagel BJ. (2010) Delay discounting behavior and white matter microstructure abnormalities in youth with a family history of alcoholism. Alcoholism: Clinical and Experimental Research 34:1590-1602. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206791

Iancu OD, Darakjian P, Walter NA, Malmanger B, Oberbeck D, Belknap J, McWeeney S, Hitzemann R. (2010) Genetic diversity and striatal gene networks: focus on the heterogeneous stock-collaborative cross (HS-CC) mouse. BMC Genomics 11:585.  Free full text link: http://www.biomedcentral.com/1471-2164/11/585

Kaufman KR, Tanchuck MA, Strong MN, Finn DA. (2010) Replacement with GABAergic steroid precursors restores the acute ethanol withdrawal profile in ADX/GDX mice. Neuroscience 166:5-14.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815158

Lebold KM, Grant KA, Freeman WM, Wiren KM, Miller GW, Kiley C, Leonard SW, Traber MG. (2010) Individual differences in hyperlipidemia and vitamin E status in response to chronic alcohol self-administration in cynomolgus monkeys. Alcoholism: Clinical and Experimental Research 35:474-483. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116096

Leeman RF, Heilig M, Cunningham CL, Stephens DN, Duka T, O'Malley SS. (2010) Ethanol consumption: how should we measure it? Achieving consilience between human and animal phenotypes. Addiction Biology 15:109-124.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861719

Lejuez CW, Magidson JF, Mitchell SH, Sinha R, Stevens MC, deWit H. (2010) Behavioral and biological indicators of impulsivity in the development of alcohol use, problems, and disorders. Alcoholism: Clinical and Experimental Research 34:1334-1345.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182265

Metten P, Sorensen ML, Cameron AJ, Yu CH, Crabbe JC. (2010) Withdrawal severity after chronic intermittent ethanol in inbred mouse strains. Alcoholism: Clinical and Experimental Research 34:1552-1564.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929298

Meyer AC, Rahman S, Charnigo RJ, Dwoskin LP, Crabbe JC, Bardo MT. (2010) Genetics of novelty seeking, amphetamine self-administration and reinstatement using inbred rats. Genes, Brain and Behavior 9:790-798.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965303

Milner LC, Buck KJ. (2010) Identifying quantitative trait loci (QTLs) and genes (QTGs) for alcohol-related phenotypes in mice. International Review of Neurobiology 91:173-204. PMID: 20813243

Pastor R, Kamens HM, McKinnon CS, Ford MM, Phillips TJ. (2010) Repeated ethanol administration modifies the temporal structure of sucrose intake patterns in mice: effects associated with behavioral sensitization. Addiction Biology 15:324-335.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904994

Phillips TJ, Reed C, Burkhart-Kasch S, Li N, Hitzemann R, Yu CH, Brown LL, Helms ML, Crabbe JC, Belknap JK. (2010) A method for mapping intralocus interactions influencing excessive alcohol drinking. Mammalian Genome 21:39-51.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850100

Sher KJ, Dick DM, Crabbe JC, Hutchison KE, O'Malley SS, Heath AC. (2010) Consilient research approaches in studying gene x environment interactions in alcohol research. Addiction Biology 15:200-216.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883915

Stephens DN, Duka T, Crombag HS, Cunningham CL, Heilig M, Crabbe JC. (2010) Reward sensitivity: issues of measurement, and achieving consilience between human and animal phenotypes. Addiction Biology 15:145-168. PMID: 20148777

Tambour S, Crabbe JC. (2010) Pharmacogenetics. In I.P. Stolerman (Ed.). Encyclopedia of Psychopharmacology, Part 16, Springer, New York, pp. 998-1001.


2009 Center Publications

Beckstead MJ, Phillips TJ. (2009) Mice selectively bred for high- or low-alcohol-induced locomotion exhibit differences in dopamine neuron function. J Pharmacol Exp Ther 329:342-9.  Free full text link:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670605

Bohlen M, Cameron A, Metten P, Crabbe JC, Wahlsten D. (2009) Calibration of rotational acceleration for the rotarod test of rodent motor coordination. J Neurosci Methods 178:10-4.  PMID: 19041892

Bunce AE, Griest S, Howarth LC, Beemsterboer P, Cameron W, Carney PA. (2009) Educating youth about research funded by the National Institutes of Health using a partnership between an academic medical center and community-based science museum. J Commun Health 34:262–270.  Free full text link:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748739

Carney PA, Bunce AE, Perrin N, Howarth LC, Beemsterboer P, Griest S, Cameron W. (2009) Educating the public about research funded by the National Institutes of Health using a partnership between an academic medical center and community-based science museum. J Commun Health 34:246–254.  Free full text link:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696630

Chen G, Reilly MT, Kozell LB, Hitzemann R, Buck KJ (2009). Differential activation of limbic circuitry associated with chronic ethanol withdrawal in DBA/2J and C57BL/6J mice.  Alcohol 43:411-420.   Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758300

Cozzoli DK, Goulding SP, Zhang PW, Xiao B, Hu JH, Ary AW, Obara I, Rahn A, Abou-Ziab H, Tyrrel B, Marini C, Yoneyama N, Metten P, Snelling C, Dehoff MH, Crabbe JC, Finn DA, Klugmann M, Worley PF, Szumlinski KK. (2009) Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism. J Neurosci 29:8655-68.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761716

Crabbe JC, Metten P, Rhodes JS, Yu CH, Brown LL, Phillips TJ, Finn DA. (2009) A line of mice selected for high blood ethanol concentrations shows drinking in the dark to intoxication.Biol Psychiatry 65:662-70.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330756

Dhaher R, Finn DA, Oberbeck DL, Yoneyama N, Snelling CC, Wu W, Hitzemann RJ (2009) Electrolytic lesions of the medial nucleus accumbens shell selectively decrease ethanol consumption without altering preference in a limited access procedure in C57BL/6J mice. Pharmacol Biochem Behav 92:335-342. PMID: 19353807

Fidler TL, Oberlin BG, Struthers AM, Cunningham CL. (2009) Schedule of passive ethanol exposure affects subsequent intragastric ethanol self-infusion. Alcoholism: Clinical & Experimental Research 33:1909-1923.   Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883445 

Ford MM, Fretwell AM, Anacker A, Crabbe JC, Mark GP and Finn DA (2009). Withdrawal Seizure-Prone (WSP) and -Resistant (WSR) mice differ in operant responding for ethanol and reinstatement following conditioned cue presentation. Alcohol Clin Exp Res 33:222A.   Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716427

Gremel CM. Cunningham CL. (2009) Involvement of amygdala dopamine- and nucleus accumbens NMDA- receptors in ethanol-seeking behavior in mice. Neuropsychopharmacology 34:1443-1453.   Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678896

Groblewski PA, Lattal KM, Cunningham CL. (2009) Effects of D-Cycloserine on the extinction and reconditioning of ethanol-seeking behavior in mice. Alcoholism: Clinical & Experimental Research  33:772-782.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883465

Helms CM, Rogers LS, Grant KA. (2009) Antagonism of the ethanol-like discriminative stimulus effects of ethanol, pentobarbital, and midazolam in cynomolgus monkeys reveals involvement of specific GABA(A) receptor subtypes. Journal of Pharmacology and Experimental Therapeutics 331:142-152. Free full text link:    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766226

Holstein SE, Dobbs L, Phillips TJ. (2009) Attenuation of the stimulant response to ethanol is associated with enhanced ataxia for a GABA, but not a GABA, receptor agonist. Alcohol Clin Exp Res 33:108-20.  Free full text link:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637353

Hitzemann R, Edmunds S, Wu W, Malmanger B, Walter N, Belknap J, Darakjian P, McWeeney S. (2009) Detection of reciprocal quantitative trait loci for acute ethanol withdrawal and ethanol consumption in heterogeneous stock mice. Psychopharmacology 203:713-22.  PMID: 19052728

Kamens HM, McKinnon CS, Li N, Helms ML, Belknap JK, Phillips TJ (2009) The α3 subunit gene of the nicotinic acetylcholine receptor is a candidate gene for ethanol stimulation. Genes Brain Behav 8:600-609.   Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888607

Kozell LB, Walter NAR, Milner LC, Wickman K, Buck KJ (2009). Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol. Journal of Neuroscience 29:11662–11673.   Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813520

Metten P, Crabbe JC, Belknap JK. (2009) Genetic correlates of morphine withdrawal in 14 inbred mouse strains. Drug Alcohol Depend 99:123-31.   Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573847

Meyer PJ, Meshul CK, Phillips TJ. (2009) Ethanol- and cocaine-induced locomotion are genetically related to increases in accumbal dopamine. Genes Brain Behav 8:346-355. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768278

Scibelli AC, Phillips TJ. (2009) Combined scopolamine and ethanol treatment results in a locomotor stimulant response suggestive of synergism that is not blocked by dopamine receptor antagonists. Alcohol Clin Exp Res 33:435-47.  Free full text link:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857319

Sharpe AL, Phillips TJ. (2009) Central urocortin 3 administration decreases limited-access ethanol intake in nondependent mice. Behav Pharmacol 20:346-51.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908376

Strong MN, Kaufman KR, Crabbe JC, Finn DA. (2009) Sex differences in acute ethanol withdrawal severity after adrenalectomy and gonadectomy in Withdrawal Seizure-Prone and Withdrawal Seizure-Resistant mice. Alcohol 43:367-77.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757068

Strong MN, Yoneyama N, Fretwell AM, Snelling C, Tanchuck MA, Finn DA (2009). “Binge” drinking experience in adolescent mice shows sex differences and elevated ethanol intake in adulthood. Horm Behav [Oct 23, Epub ahead of print].  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883674

Tanchuck MA, Long SL, Ford MM, Hashimoto J, Crabbe JC, Roselli CE, Wiren KM, Finn DA. (2009) Selected Line Difference in the Effects of Ethanol Dependence and Withdrawal on Allopregnanolone Levels and 5alpha-Reductase Enzyme Activity and Expression. Alcohol Clin Exp Res 33:2077-2087. Free full text link:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789917

Walter NA, Bottomly D, Laderas T, Mooney MA, Darakjian P, Searles RP, Harrington CA, McWeeney SK, Hitzemann R, Buck KJ. (2009) High throughput sequencing in mice: a platform comparison identifies a preponderance of cryptic SNPs. BMC Genomics 10:379.  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743714

Wilhelm CJ, Mitchell SH. (2009) Strain differences in delay discounting using inbred rats. Genes Brain Behav 8:426-34.   Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825220


2008 Center Publications

Beckley, E. H., Fretwell, A. M., Tanchuck, M. A., Gililland, K. R., Crabbe, J. C., and Finn, D. A. (2008). Decreased anticonvulsant efficacy of allopregnanolone during ethanol withdrawal in female Withdrawal Seizure-Prone vs. Withdrawal Seizure-Resistant mice. Neuropharmacology 54: 365-374.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2262286

Belknap JK, Metten P, Beckley EH, Crabbe JC. (2008) Multivariate analyses reveal common and drug-specific genetic influences on responses to four drugs of abuse. Trends Pharmacol Sci 29:537-43.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100800

Chen, G., Kozell, L.B., Hitzemann, R., Buck, K.J. (2008) Involvement of the limbic basal ganglia in ethanol withdrawal convulsivity in mice is influenced by a chromosome 4 locus. J Neurosci. 28:9840-9.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276309

Crabbe, J. C. (2008). Review. Neurogenetic studies of alcohol addiction. Philos.Trans.R.Soc.Lond B Biol.Sci. 363: 3201-3211.  Link Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2607330

Crabbe, J. C., Cameron, A. J., Munn, E., Bunning, M., and Wahlsten, D. (2008). Overview of mouse assays of ethanol intoxication. Curr.Protoc.Neurosci. Chapter 9: Unit 9.26.  PMID: 18428672

Cunningham CL, Gremel CM, Groblewski PA. (2008) Genetic influences on conditioned taste aversion. In S Reilly & TR Schachtman (Eds.), Conditioned taste aversion: Behavioral and neural processes (pp. 387-421). New York: Oxford University Press.

Denmark, D. L., Buck, K. J. (2008). Molecular analyses and identification of promising candidate genes for loci on mouse chromosome 1 affecting alcohol physical dependence and associated withdrawal. Genes Brain Behav. 7: 599-608.  PMID: 18363851

Denmark DL, Milner LC, Buck KJ (2008). Interval-specific congenic animals for high-resolution QTL mapping.  Alcohol Research & Health, 31:266-269.  Free full text link: https://pubs.niaaa.nih.gov/publications/arh313/266-269.pdf

Dhaher, R., Finn, D., Snelling, C., and Hitzemann, R. (2008). Lesions of the extended amygdala in C57BL/6J mice do not block the intermittent ethanol vapor-induced increase in ethanol consumption. Alcohol Clin.Exp.Res. 32: 197-208.  PMID: 8162080

Ford MM, Beckley EH, Nickel JD, Eddy S, Finn DA. (2008) Ethanol intake patterns in female mice: influence of allopregnanolone and the inhibition of its synthesis. Drug Alcohol Depend 97:73-85.  PubMed Link   Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577122

Gabriel, K. I. and Cunningham, C. L. (2008). Effects of maternal strain on ethanol responses in reciprocal F1 C57BL/6J and DBA/2J hybrid mice. Genes Brain Behav. 7: 276-287.  PMID: 17711451

Gililland-Kaufman KR, Tanchuck MA, Ford MM, Crabbe JC, Beadles-Bohling AS, Snelling C, Mark GP, Finn DA. (2008) The neurosteroid environment in the hippocampus exerts bi-directional effects on seizure susceptibility in mice. Brain Res 1243:113-23.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613069

Gremel, C. M. and Cunningham, C. L. (2008). Roles of the nucleus accumbens and amygdala in the acquisition and expression of ethanol-conditioned behavior in mice. J.Neurosci. 28: 1076-1084.  Free full text link: https://www.jneurosci.org/content/28/5/1076.long

Groblewski, P. A., Bax, L. S., and Cunningham, C. L. (2008). Reference-dose place conditioning with ethanol in mice: empirical and theoretical analysis. Psychopharmacology 201:97-106.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883454

Hashimoto JG, Wiren KM. (2008) Neurotoxic consequences of chronic alcohol withdrawal: expression profiling reveals importance of gender over withdrawal severity. Neuropsychopharmacology 33:1084-96.   Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019135

Helms, C. M., Gubner, N. R., Wilhelm, C. J., Mitchell, S. H., and Grandy, D. K. (2008). D4 receptor deficiency in mice has limited effects on impulsivity and novelty seeking. Pharmacol.Biochem.Behav. 90: 387-393.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603181

Helms, C. M. and Mitchell, S. H. (2008). Basolateral amygdala lesions and sensitivity to reinforcer magnitude in concurrent chains schedules. Behav.Brain Res. 191: 210-218.  PubMed Link Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475334

Hitzemann, R., Malmanger, B., Belknap, J., Darakjian, P., and McWeeney, S. (2008). Short-term selective breeding for High and Low prepulse inhibition of the acoustic startle response; pharmacological characterization and QTL mapping in the selected lines. Pharmacol.Biochem.Behav. 90:525-33.  Link Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2591930

Hofstetter, J. R., Hitzemann, R. J., Belknap, J. K., Walter, N. A., McWeeney, S. K., and Mayeda, A. R. (2008). Characterization of the quantitative trait locus for haloperidol-induced catalepsy on distal mouse chromosome 1. Genes Brain Behav. 7: 214-223.  PMID: 17696997

Kamens, H. M. and Phillips, T. J. (2008). A role for neuronal nicotinic acetylcholine receptors in ethanol-induced stimulation, but not cocaine- or methamphetamine-induced stimulation. Psychopharmacology (Berl) 196: 377-387.  PMID: 17938890

Kozell, L., Belknap, J. K., Hofstetter, J. R., Mayeda, A., and Buck, K. J. (2008). Mapping a locus for alcohol physical dependence and associated withdrawal to a 1.1 Mb interval of mouse chromosome 1 syntenic with human chromosome 1q23.2-23.3. Genes Brain Behav. 7: 560-567.  PMID: 18363856

Milner, L. C. and Crabbe, J. C. (2008). Three murine anxiety models: results from multiple inbred strain comparisons. Genes Brain Behav. 7: 496-505.  Free full text link: PMID: 18182070

Mulligan, M. K., Ponomarev, I., Boehm, S. L., Owen, J. A., Levin, P. S., Berman, A. E., Blednov, Y. A., Crabbe, J. C., Williams, R. W., Miles, M. F., and Bergeson, S. E. (2008). Alcohol trait and transcriptional genomic analysis of C57BL/6 substrains. Genes Brain Behav. 7: 677-689.  PMID: 18397380

Philibin, S. D., Cameron, A. J., Metten, P., and Crabbe, J. C. (2008). Motor impairment: a new ethanol withdrawal phenotype in mice.  Behav.Pharmacol. 19: 604-614.   PMID: 18690115

Porter, J. H., Walentiny, D. M., Philibin, S. D., Vunck, S. A., and Crabbe, J. C. (2008). A comparison of the discriminative stimulus properties of the atypical antipsychotic drug clozapine in DBA/2 and C57BL/6 inbred mice. Behav.Pharmacol. 19: 530-542.  PMID: 18690107

Reilly, M. T., Milner, L. C., Shirley, R. L., Crabbe, J. C., and Buck, K. J. (2008). 5-HT2C and GABAB receptors influence handling-induced convulsion severity in chromosome 4 congenic and DBA/2J background strain mice. Brain Res. 1198: 124-131.  Link Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2322873

Ryabinin AE, Yoneyama N, Tanchuck MA, Mark GP, Finn DA (2008) Urocortin 1 microinjection into the mouse lateral septum regulates the acquisition and expression of alcohol consumption. Neuroscience 151:780-790.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2262916

Tambour, S., Brown, L.L., Crabbe, J.C. (2008) Gender and Age at Drinking Onset Affect Voluntary Alcohol Consumption but Neither the Alcohol Deprivation Effect nor the Response to Stress in Mice. Alcohol Clin Exp Res. 32:1-7.  PMID: 18828803

Uhl, G. R., Drgon, T., Johnson, C., Fatusin, O. O., Liu, Q. R., Contoreggi, C., Li, C. Y., Buck, K., and Crabbe, J. (2008). "Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice. Biochem.Pharmacol. 75: 98-111.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282179

Walter NAR, McWeeney SK, Peters ST, Belknap JK, Hitzemann R, Buck KJ (2008). SNP masking.  Alcohol Research & Health, 31:270-274. Free full text link: https://pubs.niaaa.nih.gov/publications/arh313/270-271.pdf

Wilhelm CJ, Mitchell SH. (2008) Rats bred for high alcohol drinking are more sensitive to delayed and probabilistic outcomes. Genes Brain Behav 7:705-13.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789313

Yoneyama, N., Crabbe, J. C., Ford, M. M., Murillo, A., and Finn, D. A. (2008). Voluntary ethanol consumption in 22 inbred mouse strains. Alcohol 42: 149-160.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396347


2007 Center Publications

Bhave, S. V., Hornbaker, C., Phang, T. L., Saba, L., Lapadat, R., Kechris, K., Gaydos, J., McGoldrick, D., Dolbey, A., Leach, S., Soriano, B., Ellington, A., Ellington, E., Jones, K., Mangion, J., Belknap, J. K., Williams, R. W., Hunter, L. E., Hoffman, P. L., and Tabakoff, B. (2007). The PhenoGen Informatics website: tools for analyses of complex traits. BMC.Genet. 8: 59.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034588

Beckley EH, Finn DA. (2007) Inhibition of progesterone metabolism mimics the effect of progesterone withdrawal on forced swim test immobility. Pharmacol Biochem Behav 87:412-419.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2020505

Crabbe, J. C. and Cunningham, C. L. (2007). Trait or state? Science 317: 1033-1035.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/17717168

Cunningham, C. L. and Patel, P. (2007). Rapid induction of Pavlovian approach to an ethanol-paired visual cue in mice. Psychopharmacology 192: 231-241.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/17265074

Finn, D. A., Snelling, C., Fretwell, A. M., Tanchuck, M. A., Underwood, L., Cole, M., Crabbe, J. C., and Roberts, A. J. (2007). Increased drinking during withdrawal from intermittent ethanol exposure is blocked by the CRF receptor antagonist D-Phe-CRF(12-41). Alcohol Clin.Exp.Res. 31: 939-949.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/17403068

Ford MM, Fretwell AM, Mark GP, Finn DA. Influence of reinforcement schedule on ethanol consumption patterns in non-food restricted male C57BL/6J mice. Alcohol 41:21-29, 2007. Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2013928

Ford, M. M., Mark, G. P., Nickel, J. D., Phillips, T. J., and Finn, D. A. (2007). Allopregnanolone influences the consummatory processes that govern ethanol drinking in C57BL/6J mice. Behav.Brain Res. 179: 265-272.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906740

Gililland KR, Finn DA. (2007) The impact of gonadectomy and adrenalectomy on acute withdrawal severity in male and female C57BL/6 and DBA/2 mice following a single high dose of ethanol. Alcohol Clin Exp Res 31:1846-1857.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807885

Gorin-Meyer RE, Wiren KM, Tanchuck MA, Long SL, Yoneyama N, Finn DA. (2007) Sex differences in the effect of finasteride on acute ethanol withdrawal severity in C57BL/6J and DBA/2J mice. Neuroscience 146:1302-15.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1963463

Gremel, C. M. and Cunningham, C. L. (2007). Role of test activity in ethanol-induced disruption of place preference expression in mice. Psychopharmacology 191: 195-202.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/17216157

Hill, K. G., Ryabinin, A. E., and Cunningham, C. L. (2007). FOS expression induced by an ethanol-paired conditioned stimulus. Pharmacol.Biochem.Behav. 87: 208-221.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025694

Kamens, H. M. and Crabbe, J. C. (2007). The parallel rod floor test: a measure of ataxia in mice. Nat.Protoc. 2: 277-281.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/17406586

Kliethermes, C. L., Kamens, H. M., and Crabbe, J. C. (2007). Drug reward and intake in lines of mice selectively bred for divergent exploration of a hole board apparatus. Genes Brain Behav. 6:608-618.  PubMed Link:  https://www.ncbi.nlm.nih.gov/pubmed/17147699

Lattal KM (2007) Effects of ethanol on encoding, consolidation, and expression of extinction following contextual fear conditioning. Behav Neurosci 121:1280-1292. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/18085881

Laderas T, McWeeney S  (2007) Consensus framework for exploring microarray data using multiple clustering methods. OMICS 11(1):116-28.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/17411399

Metten, P., Buck, K. J., Merrill, C. M., Roberts, A. J., Yu, C. H., and Crabbe, J. C. (2007). Use of a novel mouse genotype to model acute benzodiazepine withdrawal. Behav.Genet. 37: 160-170.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/17226103

Meyer, P. J. and Phillips, T. J. (2007). Behavioral sensitization to ethanol does not result in cross-sensitization to NMDA receptor antagonists. Psychopharmacology 195:103-115.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/17653696

Ponder, C. A., Kliethermes, C. L., Drew, M. R., Muller, J., Das, K., Risbrough, V. B., Crabbe, J. C., Gilliam, T. C., and Palmer, A. A. (2007). Selection for contextual fear conditioning affects anxiety-like behaviors and gene expression. Genes Brain Behav., Epub – Feb 13.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/17309658

Rhodes, J. S., Ford, M. M., Yu, C. H., Brown, L. L., Finn, D. A., Garland, T., Jr., and Crabbe, J. C. (2007). Mouse inbred strain differences in ethanol drinking to intoxication. Genes Brain Behav. 6: 1-18.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/17233637

Wahlsten, D., Crabbe, J.C. (2007) Behavioral testing. In J.G. Fox, C. Newcomer, A. Smith, S. Barhold, F. Quimby, and M. Davisson (Eds.) The Mouse in Biomedical Research, 2nd Edition, Vol. 3, Normative Biology, Immunology, and Husbandry, Elsevier, Amsterdam, pp. 513-534.

Walter, N. A., McWeeney, S. K., Peters, S. T., Belknap, J. K., Hitzemann, R., and Buck, K. J. (2007). SNPs matter: impact on detection of differential expression. Nat.Methods 4: 679-680.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410665

Wilhelm, C. J., Reeves, J. M., Phillips, T. J., and Mitchell, S. H. (2007). Mouse Lines Selected for Alcohol Consumption Differ on Certain Measures of Impulsivity. Alcohol Clin.Exp.Res. 31:1839-1845. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/17850219


2006 Center Publications

Beadles-Bohling AS, Wiren KM. (2006) Anticonvulsive effects of kappa-opioid receptor modulation in an animal model of ethanol withdrawal. Genes Brain Behav 5:483-96.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16923153

Bice, PJ, Foroud, T, Carr, LG, Zhang, L, Liu, L, Grahame, NJ, Lumeng, L, Li, T-K and Belknap, JK (2006). Identification of QTLs influencing alcohol preference in the High Alcohol Preferring (HAP) and Low Alcohol Preferring (LAP) mouse lines.  Behavior Genetics 36:248-260.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16482403

Cameron WE, McNerney C (2006). Strategy for engaging the Society for Neuroscience in science education. CBE Life Sciences Education 5:91-93.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618521

Coste SC, Heard AD, Phillips TJ, Stenzel-Poore MP (2006). Corticotropin-releasing factor receptor type 2-deficient mice display impaired coping behaviors during stress. Genes Brain Behav. 5(2):131-8.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16507004

Crabbe, J.C. (2006) Identifying genes affecting addiction research in animal models. In B.K. Madras, C.M. Colvis, J.D. Pollock,  J.L. Rutter, D. Shurtleff, and M. von Zastrow, (Eds) Cell Biology of Addiction, Cold Springs Harbor Laboratory Press, New York, pp. 45-61.

Crabbe JC, Metten P, Ponomarev I, Prescott CA, Wahlsten D (2006). Effects of genetic and procedural variation on measurement of alcohol sensitivity in mouse inbred strains. Behav Genet. 36(4):536-52.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16619134

Crabbe JC, Phillips TJ, Harris RA, Arends MA, Koob GF (2006). Alcohol-related genes: contributions from studies with genetically engineered mice. Addict Biol. 11(3-4):195-269. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16961758

Crawshaw LI, Wallace HL, O'Connor CS, Yoda T, Crabbe JC (2006). Tolerance and withdrawal in goldfish exposed to ethanol. Physiol Behav. 87(3):460-8.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16448677

Cunningham, C. L. (2006). If you want to understand alcohol abuse, you must also understand taste aversion conditioning.  Highlights Section, Conditioned Taste Aversion: An Annotated Bibliography.  American University: Washington D.C.

Cunningham, C. L., Gremel, C. M. (2006). Proximal ethanol pretreatment interferes with acquisition of ethanol-induced conditioned place preference. Pharmacol Biochem Behav 85: 612-619.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797418

Cunningham, C. L., Gremel, C. M., Groblewski, P. A. (2006). Drug-induced conditioned place preference and aversion in mice. Nat.Protoc. 1: 1662-1670. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/17487149

Cunningham, C. L., Patel, P., & Milner, L. (2006). Spatial location is critical for conditioning place preference with visual but not tactile stimuli. Behavioral Neuroscience 120:1115–1132.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/17014262

Fidler, T. L., Clews, T. W., & Cunningham, C. L. (2006). Reestablishing an intragastric ethanol self-infusion model in rats. Alcoholism: Clinical & Experimental Research 30, 414-428.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16499482

Finn DA, Beadles-Bohling AS, Beckley EH, Ford MM, Gililland KR, Gorin-Meyer RE and Wiren KM (2006). A new look at the 5-reductase inhibitor finasteride. CNS Drug Rev. 12:53-76.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16834758

Finn DA, Douglass AD, Beadles-Bohling AS, Tanchuck MA, Long SL and Crabbe JC (2006).  Selected line difference in sensitivity to a GABAergic neurosteroid during ethanol withdrawal. Genes Brain Behav. 5:53-63.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16436189

Gremel, C. M., Gabriel, K. I., & Cunningham, C. L. (2006). Topiramate does not affect the acquisition or expression of ethanol conditioned place preference in DBA/2J or C57BL/6J mice Alcoholism: Clinical & Experimental Research 30, 783-790.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16634846

Holstein, S. E. and Phillips, T. J. (2006). GABAB receptor stimulation accentuates the locomotor effects of morphine in mice bred for extreme sensitivity to the stimulant effects of ethanol. Pharmacol.Biochem.Behav. 85: 697-704.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805633

Hood HM, Metten P, Crabbe JC, and Buck KJ (2006).  Fine mapping of a sedative-hypnotic drug withdrawal locus on mouse chromosome 11. Genes Brain Behav 5:1-10.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16436183

Kamens, H. M., Burkhart-Kasch, S., McKinnon, C. S., Li, N., Reed, C., and Phillips, T. J. (2006). Ethanol-related traits in mice selectively bred for differential sensitivity to methamphetamine-induced activation. Behav.Neurosci. 120: 1356-1366. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/17201481

Kliethermes CL, Crabbe JC (2006).  Pharmacological and genetic influences on hole-board behaviors in mice. Pharmacol Biochem Behav 85:57-65.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16949140  

Kliethermes CL, Crabbe JC (2006). Genetic independence of mouse measures of some aspects of novelty seeking. Proc Natl Acad Sci U S A. 103(13):5018-23.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1405908

Lattal, K. M., Radulovic, J. and Lukowiak, K. (2006). Extinction: does it or doesn't it? The requirement of altered gene activity and new protein synthesis. Biological Psychiatry 60, 344-51.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761679

Malmanger, B., Lawler, M., Coulombe, S., Murray, R., Cooper, S., Polyakov, Y., Belknap, J., and Hitzemann, R. (2006). Further studies on using multiple-cross mapping (MCM) to map quantitative trait loci. Mamm.Genome 17: 1193-1204. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/17143586

Mitchell SH, Reeves JM, Li N, Phillips TJ. (2006). Delay discounting predicts behavioral sensitization to ethanol in outbred WSC mice. Alcohol Clin Exp Res. 30(3):429-37.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16499483

Mulligan, Mk, Ponomarev, I, Hitzemann, RJ, Belknap, JK, Tabakoff, B, Harris, RA, Crabbe, JC, Blednov, YA, Grahame, NJ, Phillips, TJ, Finn, DA, Hoffman, PL, Iyer, VR, Koob, GF and Bergeson, SE (2006). Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis, Proc Nat’l Acad Sci USA 103:6368-6373.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458884

Palmer AA, Lessov-Schlaggar CN, Ponder CA, McKinnon CS, Phillips TJ (2006). Sensitivity to the locomotor-stimulant effects of ethanol and allopregnanolone: A quantitative trait locus study of common genetic influence. Genes Brain Behav. 5(7):506-17.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/17010097

Peirce, J. L., Li, H., Wang, J., Manly, K. F., Hitzemann, R. J., Belknap, J. K., et al. (2006). How replicable are mRNA expression QTL? Mamm Genome 17(6), 643-656.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16783644

Rogers, J., R. Garcia, W. Shelledy, J. Kaplan, A. Arya, Z. Johnson, M. Bergstrom, L. Novakowski, P. Nair, A. Vinson, D. Newman, G. Heckman and J. Cameron (2006). An initial genetic linkage map of the rhesus macaque (Macaca mulatta) genome using human microsatellite loci. Genomics87:30-38.  Free open access link: https://www.sciencedirect.com/science/article/pii/S0888754305002958

Rogers, J., J. Kaplan, R. Garcia, W. Shelledy, S. Nair and J.L. Cameron (2006). Mapping of the serotonin transporter locus (SLC6A4) to rhesus chromosome 16 using genetic linkage. Cytogenetic and Genome Research112:341A 1-3.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16484793

Saba, L., Bhave, S. V., Grahame, N., Bice, P., Lapadat, R., Belknap, J., Hoffman, P. L., and Tabakoff, B. (2006). Candidate genes and their regulatory elements: alcohol preference and tolerance. Mamm.Genome 17: 669-688.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16783646

Sikela, JM, MacLaren, EJ, Kim, Y, Karimpour-Fard, A, Cai, W-W, Pollack, J, Hitzemann, R, Belknap, JK, McWeeney, S, Kerns, RT, Downing, C,Johnson, TE, Grant, KJ, Tabakoff, B, Hoffman, P, Wu, CC and Miles, MF (2006). DNA microarray and proteomic strategies for understanding alcohol actions. Alc: Clin Exp Res 30:700-708.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709534

Wahlsten D, Bachmanov A, Finn DA, Crabbe JC (2006). Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades. Proc Natl Acad Sci USA 103:16364–16369.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618164

Weitemier, A.Z., Ryabinin, A.E.  (2006) Urocortin 1 in the dorsal raphe regulates food and fluid consumption, but not ethanol preference in C57BL/6J mice. Neuroscience 137: 1439-1445.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16338088

Wilhelm, CJ, RA Johnson, AJ Eshleman and A Janowsky. (2006) Hydrogen ion concentration differentiates effects of methamphetamine and dopamine on transporter-mediated efflux.  J Neurochemistry 96:1149-59.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16417578


2005 Center Publications

Bechtholt, A. J., & Cunningham, C. L. (2005). Ethanol-induced conditioned place preference is expressed through a ventral tegmental area dependent mechanism. Behavioral Neuroscience 119:213-223.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15727526

Blednov YA, Metten P, Finn DA, Rhodes JS, Bergeson SE, Harris RA, Crabbe JC (2005). Hybrid C57BL/6J x FVB/NJ mice drink more alcohol than do C57BL/6J mice. Alcoholism: Clinical and Experimental Research 29:1949-58.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040102

Crabbe JC, Metten P, Cameron AJ, Wahlsten D (2005). An analysis of the genetics of alcohol intoxication in inbred mice. Neuroscience and Biobehavioral Reviews 28:785-802.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15642621

Cronise, K., Crabbe, J.C. (2005) Murine models of substance and alcohol dependence: unraveling genetic complexities. In G. Peltz (Ed.) Computational Genetics and Genomics: Tools for Understanding Disease, Humana Press, Totowa, N.J., pp 177-198.

Cronise K, Finn DA, Metten P, Crabbe JC (2005). Scheduled access to ethanol results in motor impairment and tolerance in female C57BL/6J mice. Pharmacology, Biochemistry and Behavior. 81:943-53.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16099022

Fehr C, Shirley R, Crabbe JC, Belknap JK, Buck KJ, and Phillips TJ (2005). The syntaxin binding protein gene (Stxbp1) is a candidate for an ethanol preference drinking locus on mouse chromosome 2.  Alcoholism: Clinical and Experimental Research 29: 708-720.  Free open access link: https://www.jneurosci.org/content/22/9/3730.long

Finn DA, Belknap JK, Cronise K, Yoneyama N, Murillo A, Crabbe JC (2005). A procedure to produce high alcohol intake in mice. Psychopharmacology 178:471-80.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15765261

Ford MM, Nickel JD and Finn DA. (2005). Treatment with and withdrawal from finasteride alters ethanol intake patterns in male C57BL/6J mice: potential role of endogenous neurosteroids? Alcohol 37:25-33.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1533880

Ford MM, Nickel JD, Phillips TJ, Finn DA (2005). Neurosteroid modulators of GABA(A) receptors differentially modulate Ethanol intake patterns in male C57BL/6J mice. Alcoholism: Clinical and Experimental Research 29:1630-40.  Free full text link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1540354

Gabriel, K.I., & Cunningham, C. L. (2005). Effects of topiramate on ethanol and saccharin consumption and preferences in C57BL/6J mice. Alcoholism: Clinical and Experimental Research 29:75-80.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15654294

Gorin RE, Crabbe JC, Tanchuck MA, Long SL and Finn DA (2005). Effects of finasteride on chronic and acute ethanol withdrawal severity in the WSP and WSR selected lines. Alcoholism: Clinical and Experimental Research 29:939-48.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15976519

Hickman DL, Burkhart-Kasch S, Phillips TJ (2005). The effect of fostering on the genetic expression of locomotor sensitivity to alcohol. Comparative Medicine 55:498-502.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16422144

Holstein SE, Pastor R, Meyer PJ, Phillips TJ (2005). Naloxone does not attenuate the locomotor effects of ethanol in FAST, SLOW, or two heterogeneous stocks of mice. Psychopharmacology 182:277-89. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15990998

Kamens HM, Burkhart-Kasch S, McKinnon CS, Li N, Reed C, Phillips TJ (2005). Sensitivity to psychostimulants in mice bred for high and low stimulation to methamphetamine. Genes Brain and Behavior 4:110-25.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15720407

Kamens HM, Phillips TJ, Holstein SE, Crabbe JC (2005). Characterization of the parallel rod floor apparatus to test motor incoordination in mice. Genes Brain and Behavior 4:253-66.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15924557

Kliethermes CL, Cronise K, Crabbe JC (2005). Home cage activity and ingestive behaviors in mice following chronic ethanol vapor inhalation. Physiology and Behavior 85:479-88.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16005034

Kozell L, Hitzemann R, Buck KJ (2005). Acute alcohol withdrawal involves c-Fos expression in the basal ganglia and associated circuitry: C57BL/6J and DBA/2J inbred mouse strain analyses. Alcoholism: Clinical and Experimental Research 29:1939-1948.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16340450

Little, H. J., Stephens, D. N., Ripley, T. L., Borlikova, G., Duka, T., Schubert, M., Albrecht, D., Becker, H. C., Lopez, M. F., Weiss, F., Drummond, C., Peoples, M., & Cunningham, C. L. (2005). Alcohol withdrawal and conditioning. Alcoholism: Clinical and Experimental Research 29:453–464. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15770122

Lovinger DM, Crabbe JC (2005). Laboratory models of alcoholism: treatment target identification and insight into mechanisms. Nature Neuroscience 8:1471-80.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16251990

Matthews DB, Bhave SV, Belknap JK, Brittingham C, Chesler EJ, Hitzemann RJ, Hoffmann PL, Lu L, McWeeney S, Miles MF, Tabakoff B, Williams RW (2005). Complex genetics of interactions of alcohol and CNS function and behavior. Alcoholism: Clinical and Experimental Research 29:1706-19.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16205371

Metten P, Crabbe JC (2005). Alcohol withdrawal severity in inbred mouse (Mus musculus) strains. Behavioral Neuroscience 119:911-25.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16187819

Meyer PJ, Palmer AA, McKinnon CS, Phillips TJ (2005).  Behavioral sensitization to ethanol is modulated by environmental conditions, but is not associated with cross-sensitization to allopregnanolone or pentobarbital in DBA/2J mice. Neuroscience 131:263-73.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15708471

Phillips, T. J., Broadbent, J., Burkhart-Kasch, S., Henderson, C., Wenger, C. D., McMullin, C., McKinnon, C. S., & Cunningham, C. L. (2005). Genetic correlational analyses of ethanol reward and aversion phenotypes in short term selected mouse lines bred for ethanol drinking or ethanol-induced conditioned taste aversion. Behavioral Neuroscience 119:892–910.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16187818

Purdy RH, ValenzuelaCF, Janak PH, Finn DA, Biggio G, Bäckström T (2005). Neuroactive steroids and ethanol. Alcoholism: Clinical and Experimental Research 29:1292-1298.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16088987

Rhodes JS, Best K, Belknap JK, Finn DA, Crabbe JC (2005). Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice. Physiology and Behavior 84:53-63.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15642607

Rhodes JS, Crabbe JC (2005). Gene expression induced by drugs of abuse. Current Opinion in Pharmacology 5:26-33.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15661622

Rhodes, J.S., Ryabinin, A.E., Crabbe, J.C. (2005) Patterns of brain activation associated with contextual conditioning to methamphetamine in mice, Behavioral Neuroscience 119:759-771.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15998197

Sharpe AL, Coste SC, Burkhart-Kasch S, Li N, Stenzel-Poore MP, Phillips TJ (2005). Mice deficient in corticotropin-releasing factor receptor type 2 exhibit normal ethanol-associated behaviors. Alcoholism: Clinical and Experimental Research 29:1601-9.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16205360

Sharpe, A.L., Tsivkovskaia, N.O., Ryabinin, A.E. (2005) Ataxia and c-Fos expression in mice drinking ethanol in a limited access session, Alcoholism: Clinical and Experimental Research29:1419-1426.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16131849

Turek, V.F., Ryabinin, A.E. (2005) Ethanol vs. Lipopolysaccharide-induced hypothermia: involvement of urocortin, Neuroscience 133:1021-1028.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15964490

Turek, V.F., Ryabinin, A.E. (2005) Expression of c-Fos in the Edinger-Westphal nucleus following ethanol administration is not secondary to hypothermia or stress, Brain Research 1063:132-139.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16274676

Turek, V.F.,  Tsivkovskaia, N.O., Hyytia, P, Harding, S, Le, A.-D., Ryabinin, A.E.  (2005) Urocortin 1 expression in five pairs of rat lines selectively bred for differences in alcohol drinking. Psychopharmacology181:511-517.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15983799

Wahlsten D, Cooper SF, Crabbe JC (2005). Different rankings of inbred mouse strains on the Morris maze and a refined 4-arm water escape task. Behavioural Brain Research 165:36-51.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16191444

Weitemier, A.Z., Ryabinin, A.E. (2005) Brain region-specific regulation of urocortin 1 innervation and corticotropin-releasing hormone receptor type 2 binding by ethanol exposure. Alcoholism: Clinical and Experimental Research 29:1610-1620.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16205361

Weitemier, A.Z., Ryabinin, A.E. (2005) Lesions of the Edinger-Westphal nucleus alter food and water consumption, Behavioral Neuroscience 119:1235-1243.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/16300431

Weitemier, A.Z., Tsivkovskaia, N.O., Ryabinin, A.E. (2005) Urocortin 1 distribution in mouse brain is strain-dependent, Neuroscience 132:729-740.  PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15837134


2004 Center Publications

Bachtell, R.K., Weitemier, A.Z., Ryabinin, A.E. (2004) Lesions of the Edinger-Westphal nucleus in C57BL/6J mice disrupt ethanol-induced hypothermia and ethanol consumption. European Journal of Neuroscience 20: 1613-1623. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15355328

Bechtholt, A. J., Gremel, C. M., Cunningham, C. L. (2004) Handling blocks expression of conditioned place aversion but not conditioned place preference produced by ethanol in mice. Pharmacology Biochemistry and Behavior 79: 739-744. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15582682

Bechtholt, A. J., Smith, R., Raber, J., Cunningham, C. L. (2004). Enhanced ethanol-, but not cocaine-induced, conditioned place preference in Apoe-/- mice. Pharmacol Biochem.Behav. 77: 783-792. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15099924

Boyce-Rustay, J.M., Cunningham, C.L. (2004) The role of NMDA receptor binding sites in ethanol place conditioning. Behavioral Neuroscience 118: 822-834. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15301608

Buck, K. J., Reilly, M. T., Rogers, L. M., Szeliga, K., Grant, K., and Brodie, M. S. (2004). Serotonin 5-HT2 receptors and alcohol: reward, withdrawal and discrimination. Alcoholism: Clinical and Experimental Research 28: 211-216. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15112928

Churchill, G. A., Airey, D. C., Allayee, H., Angel, J. M., Attie, A. D., Beatty, J., Beavis, W. D., Belknap, J. K., Bennett, B., Berrettini, W., Bleich, A., Bogue, M., Broman, K. W., Buck, K. J., Buckler, E., Burmeister, M., Chesler, E. J., Cheverud, J. M., Clapcote, S., Cook, M. N., Cox, R. D., Crabbe, J. C., Crusio, W. E., Darvasi, A., Deschepper, C. F., Doerge, R. W., Farber, C. R., Forejt, J., Gaile, D., Garlow, S. J., Geiger, H., Gershenfeld, H., Gordon, T., Gu, J., Gu, W., de Haan, G., Hayes, N. L., Heller, C., Himmelbauer, H., Hitzemann, R., Hunter, K., Hsu, H. C., Iraqi, F. A., Ivandic, B., Jacob, H. J., Jansen, R. C., Jepsen, K. J., Johnson, D. K., Johnson, T. E., Kempermann, G., Kendziorski, C., Kotb, M., Kooy, R. F., Llamas, B., Lammert, F., Lassalle, J. M., Lowenstein, P. R., Lu, L., Lusis, A., Manly, K. F., Marcucio, R., Matthews, D., Medrano, J. F., Miller, D. R., Mittleman, G., Mock, B. A., Mogil, J. S., Montagutelli, X., Morahan, G., Morris, D. G., Mott, R., Nadeau, J. H., Nagase, H., Nowakowski, R. S., O'Hara, B. F., Osadchuk, A. V., Page, G. P., Paigen, B., Paigen, K., Palmer, A. A., Pan, H. J., Peltonen-Palotie, L., Peirce, J., Pomp, D., Pravenec, M., Prows, D. R., Qi, Z., Reeves, R. H., Roder, J., Rosen, G. D., Schadt, E. E., Schalkwyk, L. C., Seltzer, Z., Shimomura, K., Shou, S., Sillanpaa, M. J., Siracusa, L. D., Snoeck, H. W., Spearow, J. L., Svenson, K., Tarantino, L. M., Threadgill, D., Toth, L. A., Valdar, W., de Villena, F. P., Warden, C., Whatley, S., Williams, R. W., Wiltshire, T., Yi, N., Zhang, D., Zhang, M., and Zou, F. (2004) The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature Genetics 36: 1133-1137. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15514660

Crabbe, J. C. and Morris, R. G. (2004) Festina lente: late-night thoughts on high-throughput screening of mouse behavior. Nature Neuroscience 7: 1175-1179. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15508013

Crabbe, J. C. and Phillips, T. J. (2004). Pharmacogenetic studies of alcohol self administration and withdrawal. Psychopharmacology 174: 539-560. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/14551670

Fehr, C., Shirley, R. L., Metten, P., Kosobud, A. E., Belknap, J. K., Crabbe, J. C., and Buck, K. J. (2004). Potential pleiotropic effects of Mpdz on vulnerability to seizures. Genes, Brain and Behavior 3: 8-19. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/14960011

Fidler, T. L., Bakner, L., and Cunningham, C. L. (2004). Conditioned place aversion induced by intragastric administration of ethanol in rats. Pharmacol Biochem.Behav. 77: 731-743. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15099918

Finn, D. A., Ford, M. M., Wiren, K. M., Roselli, C. E., and Crabbe, J. C. (2004). The role of pregnane neurosteroids in ethanol withdrawal: behavioral genetic approaches. Pharmacology and Therapeutics 101: 91-112. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/14761701

Finn, D. A., Long, S. L., Tanchuck, M. A., and Crabbe, J. C. (2004). Interaction of chronic ethanol exposure and finasteride: sex and strain differences. Pharmacology Biochemistry and Behavior 78: 435-443. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15251252

Finn, D. A., Sinnott, R. S., Ford, M. M., Long, S. L., Tanchuck, M. A., and Phillips, T. J. (2004). Sex differences in the effect of ethanol injection and consumption on brain allopregnanolone levels in C57BL/6 mice. Neuroscience 123: 813-819. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/14751275

Gabriel, K. I., Cunningham, C. L., and Finn, D. A. (2004) Allopregnanolone does not influence ethanol-induced conditioned place preference in DBA/2J mice. Psychopharmacology: 50-56. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15083256

Hayward, M. D., Hansen, S. T., Pintar, J. E., and Low, M. J. (2004) Operant self-administration of ethanol in C57BL/6 mice lacking beta-endorphin and enkephalin. Pharmacology Biochemistry and Behavior 79: 171-181. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15388297

Hitzemann, R., Reed, C., Malmanger, B., Lawler, M., Hitzemann, B., Cunningham, B., Belknap, J.K., Buck, K.J., Phillips, T.J., and Crabbe, J.C. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. Alcoholism: Clinical and Experimental Research 28: 1437-1448. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15597075

Kale, A., Amende, I., Meyer, G. P., Crabbe, J. C., and Hampton, T. G. (2004) Ethanol's effects on gait dynamics in mice investigated by ventral plane videography. Alcoholism: Clinical and Experimental Research 28: 1839-1848. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15608600

Klein, R. F., Allard, J., Avnur, Z., Nikolcheva, T., Rotstein, D., Carlos, A. S., Shea, M., Waters, R. V., Belknap, J. K., Peltz, G., and Orwoll, E. S. (2004). Regulation of bone mass in mice by the lipoxygenase gene Alox15. Science 303: 229-232. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/14716014

Kliethermes, C. L., Cronise, K., and Crabbe, J. C. (2004). Anxiety-like behavior in mice in two apparatuses during withdrawal from chronic ethanol vapor inhalation. Alcoholism: Clinical and Experimental Research 28: 1012-1019. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15252287

Kliethermes, C. L., Metten, P., Belknap, J. K., Buck, K. J., and Crabbe, J. C. (2004). Selection for pentobarbital withdrawal severity: correlated differences in withdrawal from other sedative drugs. Brain Research 1009: 17-25. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15120579

Metten, P., Best, K. L., Cameron, A. J., Saultz, A. B., Zuraw, J. M., Yu, C. H., Wahlsten, D., and Crabbe, J. C. (2004). Observer-rated ataxia: Rating scales for assessment of genetic differences in ethanol-induced intoxication in mice. Journal of Applied Physiology 97:360-368.  Free open access link: https://jap.physiology.org/content/97/1/360.long

Mueller, J. L., Ellenberger, E. A., Vaughn, L. K., Belknap, J. K., and Quock, R. M. (2004). Detection and mapping of quantitative trait loci that determine responsiveness of mice to nitrous oxide antinociception. Neuroscience 123: 743-749. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/14706786

Palmer, A. A., Sharpe, A. L., Burkhart-Kasch, S., McKinnon, C. S., Coste, S. C., Stenzel-Poore, M. P., and Phillips, T. J. (2004) Corticotropin-releasing factor overexpression decreases ethanol drinking and increases sensitivity to the sedative effects of ethanol. Psychopharmacology 176: 386-397. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15138758

Phillips, T. J., Crabbe, J. C. (2004) Let's not discourage innovative approaches to complex questions. Alcoholism: Clinical and Experimental Research 28: 1607-1608. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15547444

Ponomarev, I. and Crabbe, J. C. (2004). Characterization of acute functional tolerance to the hypnotic effects of ethanol in mice. Alcoholism: Clinical and Experimental Research 28: 991-997. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15252284

Rustay, N. R. and Crabbe, J. C. (2004). Genetic analysis of rapid tolerance to ethanol's incoordinating effects in mice: inbred strains and artificial selection. Behavior Genetics 34: 441-451. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15082941

Rutledge-Gorman, M. and Cynkar, D. (2004). Of brains and safety: neuroscience for five year olds. Primary Science Review 84:17-20.

Samson, H. H., Cunningham, C. L., Czachowski, C. L., Chappell, A., Legg, B., and Shannon, E. (2004). Devaluation of ethanol reinforcement. Alcohol 32: 203-212. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15282114

Shirley, R. L., Walter, N. A., Reilly, M. T., Fehr, C., and Buck, K. J. (2004). Mpdz is a quantitative trait gene for drug withdrawal seizures. Nature Neuroscience 7: 699-700. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15208631

Weitemier, A. Z. and Ryabinin, A. E. (2004). Subregion-specific differences in hippocampal activity between Delay and Trace fear conditioning: an immunohistochemical analysis. Brain Research 995: 55-65. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/14644471

Williams, R. W., Bennett, B., Lu, L., Gu, J., DeFries, J. C., Carosone-Link, P. J., Rikke, B. A., Belknap, J. K., and Johnson, T. E. (2004) Genetic structure of the LXS panel of recombinant inbred mouse strains: a powerful resource for complex trait analysis. Mammalian Genome 15: 637-647. PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/15457343

Zucker, S., Crabbe, J. C., Cooper, G., Finkelman, F., Largman, C., McCarley, R. W., Rice, L., Rubin, J., Richardson, B., Seil, F., Snider, G. L., and Vandenbark, A. A. (2004) Veterans Administration support for medical research: opinions of the endangered species of physician-scientists. FASEB 18: 1481-1486. Free open access link: https://www.fasebj.org/content/18/13/1481.long


2003 Center Publications

Abiola, O., Angel, J. M., Avner, P., Bachmanov, A. A., Belknap, J. K., Bennett, B., Blankenhorn, E. P., Blizard, D. A., Bolivar, V., Brockmann, G. A., Buck, K. J., Bureau, J. F., Casley, W. L., Chesler, E. J., Cheverud, J. M., Churchill, G. A., Cook, M., Crabbe, J. C., et al. (2003). The nature and identification of quantitative trait loci: a community's view. Nature Reviews Genetics 4: 911-916. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063446

Bachtell, R. K., Tsivkovskaia, N. O., and Ryabinin, A. E. (2003). Identification of temperature-sensitive neural circuits in mice using c-Fos expression mapping. Brain Research 960: 157-164. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12505668

Bachtell, R. K., Weitemier, A. Z., Galvan-Rosas, A., Tsivkovskaia, N. O., Risinger, F. O., Phillips, T. J., Grahame, N. J., and Ryabinin, A. E. (2003). The Edinger-Westphal-lateral septum urocortin pathway and its relationship to alcohol consumption. Journal of Neruoscience 23: 2477-2487. Free open access link: http://www.jneurosci.org/content/23/6/2477.long

Belknap, J. K. (2003). Chromosome substitution strains: some quantitative considerations for genome scans and fine mapping. Mammalian Genome 14: 723-732. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/14722722

Bergeson, S. E., Kyle, Warren R., Crabbe, J. C., Metten, P., Gene, Erwin, V, and Belknap, J. K. (2003). Chromosomal loci influencing chronic alcohol withdrawal severity. Mammalian Genome 14: 454-463. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12925894

Bergstrom, H. C., Palmer, A. A., Wood, R. D., Burkhart-Kasch, S., McKinnon, C. S., and Phillips, T. J. (2003). Reverse selection for differential response to the locomotor stimulant effects of ethanol provides evidence for pleiotropic genetic influence on locomotor response to other drugs of abuse. Alcoholism: Clinical and Experimental Research 27: 1535-1547. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/14574223

Boyce-Rustay, J. M. and Risinger, F. O. (2003). Dopamine D3 receptor knockout mice and the motivational effects of ethanol. Pharmacology, Biochemistry and Behavior 75: 373-379. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12873629

Crabbe, J. C. (2003). Current strategies for identifying genes for alcohol sensitivity. In: Maldonado, R. (Eds.), Molecular Biology of Drug Addiction, Humana Press, Totowa, N.J., pp. 249-261.

Crabbe, J. C. (2003). Finding genes for complex behaviors: progress in mouse models of the addictions. In: Plomin, R., DeFries, J. C., Craig, I. W., and McGuffin, P. (Eds.), Behavioral Genetics in the Postgenomic Era, American Psychological Association, WashingtAmerican Psychological Associationon, D.C., pp. 291-308.

Crabbe, J. C., Cotnam, C. J., Cameron, A. J., Schlumbohm, J. P., Rhodes, J. S., Metten, P., and Wahlsten, D. (2003). Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests. Genes Brain, and Behavior 2: 201-213. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12953786

Crabbe, J. C., Metten, P., Yu, C. H., Schlumbohm, J. P., Cameron, A. J., and Wahlsten, D. (2003). Genotypic differences in ethanol sensitivity in two tests of motor incoordination. Journal of Applied Physiology 95: 1338-1351. Free open access link: http://jap.physiology.org/content/95/4/1338.long

Crabbe, J. C. and Phillips, T. J. (2003). Mother nature meets mother nurture. Nature Neuroscience 6: 440-442. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12715008

Crabbe, J. C. and Wahlsten, D. (2003). Of mice and their environments (Letter). Science 299: 1313-1314. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12610278

Crabbe, J. C. and Wiren, K. M. (2003). Molecular and genetic bases of the addictions. In: Rosenberg, R. N., Prusiner, S. B., DiMauro, S., Barchi, R. L., and Nestler, E. J. (Eds.), The Molecular and Genetic Bases of Neurologic and Psychiatric Disease, Butterworth Heinemann, Philadelphia, pp. 779-789.

Cunningham, C. L., Ferree, N. K., and Howard, M. A. (9-2-2003). Apparatus bias and place conditioning with ethanol in mice. Psychopharmacology. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12955296

Cunningham, C. L. and Phillips, T. J. (2003). Genetic basis of ethanol reward. In: Maldonado, R. (Eds.), Molecular Biology of Drug Addiction, Humana Press, Totowa, N.J., pp. 263-294.

Cunningham, C. L., Smith, R., and McMullin, C. (2003). Competition between ethanol-induced reward and aversion in place conditioning. Learning and Behavior 31: 273-280. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/14577550

Dickinson, S. D., Lee, E. L., Rindal, K., and Cunningham, C. L. (2003). Lack of effect of dopamine receptor blockade on expression of ethanol-induced conditioned place preference in mice. Psychopharmacology 165: 238-244. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12451436

Fehr, C., Rademacher, B. L., and Buck, K. J. (2003). Evaluation of the glutamate decarboxylase genes Gad1 and Gad2 as candidate genes for acute ethanol withdrawal severity in mice. Prog.Neuropsychopharmacol.Biol.Psychiatry 27: 467-472. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12691782

Finn DA, Purdy RH and Koob GF. (2003) Animal models of anxiety and stress-induced behavior: Effects of neuroactive steroids. In: Smith, S. (Ed.), Neurosteroid Effects in the Central Nervous System: The Role of the GABAA Receptor, CRC Press, Boca Raton, pp. 317-338.

Finn, D.A., Roberts, A.J., Long, S., Tanchuck, M. and Phillips, T.J. (2003) Neurosteroid consumption has anxiolytic effects in mice. Pharmacology Biochemistry and Behavior 76:451-462. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/14643844

Finn, D. A., Rutledge-Gorman, M. T., and Crabbe, J. C. (2003). Genetic animal models of anxiety. Neurogenetics 4: 109-135. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12687420

Goldsmith, H., Crabbe, J., Dawson, G., Gottesman, I. I., Hewitt, J., McGue, M., Pedersen, N., Plomin, R., Rose, R., and Swanson, J. (2003). Research psychologists' roles in the genetic revolution. AmericanPsychologist 58: 318-319. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12866398

Herson, P. S., Virk, M., Rustay, N. R., Bond, C. T., Crabbe, J. C., Adelman, J. P., and Maylie, J. (2003). A mouse model of episodic ataxia type-1. Nature Neuroscience 6: 378-383. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12612586

Hill, K. G., Alva, H., Blednov, Y. A., and Cunningham, C. L. (2003). Reduced ethanol-induced conditioned taste aversion and conditioned place preference in GIRK2 null mutant mice. Psychopharmacology 169: 108-114. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12721779

Hitzemann, R., Malmanger, B., Reed, C., Lawler, M., Hitzemann, B., Coulombe, S., Buck, K., Rademacher, B., Walter, N., Polyakov, Y., Sikela, J., Gensler, B., Burgers, S., Williams, R. W., Manly, K., Flint, J., and Talbot, C. (2003). A strategy for the integration of QTL, gene expression, and sequence analyses. Mammalian Genome 14: 733-747. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/14722723

Kelly, M. A., Low, M. J., Phillips, T. J., Wakeland, E. K., and Yanagisawa, M. (2003). The mapping of quantitative trait loci underlying strain differences in locomotor activity between 129S6 and C57BL/6J mice. Mammalian Genome 14: 692-702. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/14694905

Kiianmaa, K., Hyytia, P., Samson, H. H., Engel, J. A., Svensson, L., Soderpalm, B., Larsson, A., Colombo, G., Vacca, G., Finn, D. A., Bachtell And RK, and Ryabinin, A. E. (2003). New neuronal networks involved in ethanol reinforcement. Alcoholism: Clinical and Experimental Research 27: 209-219. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12605070

Kliethermes, C. L., Finn, D. A., and Crabbe, J. C. (2003). Validation of a modified mirrored chamber sensitive to anxiolytics and anxiogenics in mice. Psychopharmacology 169: 190-197. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12783153

Lessov, C. N. and Phillips, T. J. (2003). Cross-sensitization between the locomotor stimulant effects of ethanol and those of morphine and cocaine in mice. Alcoholism: Clinical and Experimental Research 27: 616-627. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12711924

Meyer, P. J. and Phillips, T. J. (2003). Bivalent effects of MK-801 on ethanol-induced sensitization do not parallel its effects on ethanol-induced tolerance. Behavioral Neuroscience 117: 641-649. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12802892

Meyer, P. J. and Phillips, T. J. (2003). Sensitivity to ketamine, alone or in combination with ethanol, is altered in mice selectively bred for sensitivity to ethanol's locomotor effects. Alcoholism: Clinical and Experimental Research 27: 1701-1709. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/14634484

Palmer, A. A., Low, M. J., Grandy, D. K., and Phillips, T. J. (2003). Effects of a Drd2 deletion mutation on ethanol-induced locomotor stimulation and sensitization suggest a role for epistasis. Behavior Genetics 33: 311-324. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12837020

Phillips, T. J. (2003). Addiction and genes: animal models. In: Cooper,D. N. (Eds.), Nature Encyclopedia of the Human Genome, Nature Publishing group, New York, pp. 7-15.

Phillips, T. J., Belknap, J. K., Hitzemann, R., Buck, K. J., Cunningham, C. L., and Crabbe, J. C. (2003). Internet resources for genomic, bioinformatics, and medical genetics information. Current Protocols in Neuroscience Online Appendix 5 Databases. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/18428575

Rhodes, J.S. and Crabbe, J.C. (2003) Progress towards finding genes for alcoholism in mice. Clinical Neuroscience Research, 3:315-323.

Risinger, F. O. (2003). Genetic analyses of ethanol-induced hyperglycemia. Alcoholism: Clinical and Experimental Research 27: 756-764. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12766619

Rustay, N. R., Wahlsten, D., and Crabbe, J. C. (2003). Assessment of genetic susceptibility to ethanol intoxication in mice. Proceedings of the National Academy of Sciences USA 100: 2917-2922. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151441

Rustay, N. R., Wahlsten, D., and Crabbe, J. C. (2003). Influence of task parameters on rotarod performance and sensitivity to ethanol in mice. Behavioural Brain Research 141: 237-249. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12742261

Ryabinin, A. E., Galvan-Rosas, A., Bachtell, R. K., and Risinger, F. O. (2003). High alcohol/sucrose consumption during dark circadian phase in C57BL/6J mice: involvement of hippocampus, lateral septum and urocortin-positive cells of the Edinger-Westphal nucleus. Psychopharmacology 165: 296-305. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12442202

Wahlsten, D., Metten, P., and Crabbe, J. C. (2003). A rating scale for wildness and ease of handling laboratory mice: results for 21 inbred strains tested in two laboratories. Genes Brain, and Behavior 2: 71-79. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12884964

Wahlsten, D., Metten, P., and Crabbe, J. C. (2003). Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum. Brain Research 971: 47-54. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12691836

Wahlsten, D., Metten, P., Phillips, T. J., Boehm, S. L., Burkhart-Kasch, S., Dorow, J., Doerksen, S., Downing, C., Fogarty, J., Rodd-Henricks, K., Hen, R., McKinnon, C. S., Merrill, C. M., Nolte, C., Schalomon, M., Schlumbohm, J. P., Sibert, J. R., Wenger, C. D., Dudek, B. C., and Crabbe, J. C. (2003). Different data from different labs: lessons from studies of gene-environment interaction. Journal of Neurobiology 54: 283-311. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12486710

Wahlsten, D., Rustay, N. R., Metten, P., and Crabbe, J. C. (2003). In search of a better mouse test. Trends in Neurosciences 26: 132-136. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12591215

Weitemier, A. Z. and Ryabinin, A. E. (2003). Alcohol-induced memory impairment in trace fear conditioning: a hippocampus-specific effect. Hippocampus 13: 305-315. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12722971


2002 Center Publications

Bachtell, R. K., Tsivkovskaia, N. O., and Ryabinin, A. E. (2002). Alcohol-induced c-Fos expression in the Edinger-Westphal nucleus: pharmacological and signal transduction mechanisms. Journal of Pharmacology and Experimental Therapeutics 302: 516-524. Free open access link: http://jpet.aspetjournals.org/content/302/2/516.long

Bachtell, R. K., Tsivkovskaia, N. O., and Ryabinin, A. E. (2002). Strain differences in urocortin expression in the Edinger-Westphal nucleus and its relation to alcohol-induced hypothermia. Neuroscience 113: 421-434. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12127099

Boehm, S. L., Piercy, M. M., Bergstrom, H. C., and Phillips, T. J. (2002). Ventral tegmental area region governs GABA(B) receptor modulation of ethanol-stimulated activity in mice. Neuroscience 115: 185-200. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12401333

II Boehm, S. L., Reed, C. L., McKinnon, C. S., and Phillips, T. J. (2002). Shared genes influence sensitivity to the effects of ethanol on locomotor and anxiety-like behaviors, and the stress axis. Psychopharmacology 161: 54-63. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11967631

Broadbent, J., Muccino, K. J., and Cunningham, C. L. (2002). Ethanol-induced conditioned taste aversion in 15 inbred mouse strains. Behavioral Neuroscience 116: 138-148. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11895176

Buck, K. J., Rademacher, B. L. S., Metten, P., and Crabbe, J. C. (2002). Mapping murine loci for physical dependence on ethanol. Psychopharmacology 160: 398-407. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11919667

Chester, J. A. and Cunningham, C. L. (2002). GABA(A) receptor modulation of the rewarding and aversive effects of ethanol. Alcohol 26: 131-143. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12057774

Crabbe, J. C. (2002). Alcohol and genetics: New models. American Journal of Medical Genetics (Neuropsychiatric Genetics) 114: 969-974. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12457395

Crabbe, J. C. (2002). Genetic contributions to addiction. Annual Review of Psychology 53: 435-462. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11752492

Crabbe, J. C., Metten, P., Gallaher, E. J., and Belknap, J. K. (2002). Genetic determinants of sensitivity to pentobarbital in inbred mice. Psychopharmacology 161: 408-416. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12073169

Cunningham, C. L., Clemans, J. M., and Fidler, T. L. (2002). Injection timing determines whether intragastric ethanol produces conditioned place preference or aversion in mice. Pharmacology, Biochemistry and Behavior 72: 659-668. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12175463

Cunningham, C. L., Tull, L. E., Rindal, K. E., and Meyer, P. J. (2002). Distal and proximal pre-exposure to ethanol in the place conditioning task: tolerance to aversive effect, sensitization to activating effect, but no change in rewarding effect. Psychopharmacology 160: 414-424. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11919669

Daniels, G. M. and Buck, K. J. (2002). Expression profiling identifies strain-specific changes associated with ethanol withdrawal in mice. Genes, Brain and Behavior 1: 35-45. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12886948

Fehr, C., Shirley, R. L., Belknap, J. K., Crabbe, J. C., and Buck, K. J. (2002). Congenic mapping of alcohol and pentobarbital withdrawal liability Loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene. Journal of Neruoscience 22: 3730-3738. Free open access link: http://www.jneurosci.org/content/22/9/3730.long

Grisel, J. E., Metten, P., Wenger, C. D., Merrill, C. M., and Crabbe, J. C. (2002). Mapping of quantitative trait loci underlying ethanol metabolism in BXD recombinant inbred mouse strains. Alcoholism: Clinical and Experimental Research 26: 610-616. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12045468

Hitzemann, R., Malmanger, B., Cooper, S., Coulombe, S., Reed, C., Demarest, K., Koyner, J., Cipp, L., Flint, J., Talbot, C., Rademacher, B., Buck, K., and McCaughran, J. (2002). Multiple cross mapping (MCM) markedly improves the localization of a QTL for ethanol-induced activation. Genes, Brain and Behavior 1: 214-222. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12882366

Maiya, R., Buck, K. J., Harris, R. A., and Mayfield, R. D. (2002). Ethanol-sensitive sites on the human dopamine transporter. Journal of Biological Chemistry 277: 30724-30729. Free open access link: http://www.jbc.org/content/277/34/30724.long

Mark, G. P. and Finn, D. A. (2002). The relationship between hippocampal acetylcholine release and cholinergic convulsant sensitivity in Withdrawal Seizure-Prone and Withdrawal Seizure-Resistant selected mouse lines. Alcoholism: Clinical and Experimental Research 26: 1141-1152. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12198388

Marshall, K. E., Godden, E. L., Yang, F., Burgers, S., Buck, K. J., and Sikela, J. M. (2002). In silico discovery of gene-coding variants in murine quantitative trait loci using strain-specific genome sequence databases. Genome Biology 3: 1-9. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151180

Palmer, A. A., McKinnon, C. S., Bergstrom, H. C., and Phillips, T. J. (2002). Locomotor activity responses to ethanol, other alcohols, and GABA-A acting compounds in forward- and reverse-selected FAST and SLOW mouse lines. Behavioral Neuroscience 116: 958-967. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12492294

Palmer, A. A., Miller, M. N., McKinnon, C. S., and Phillips, T. J. (2002). Sensitivity to the locomotor stimulant effects of ethanol and allopregnanolone is influenced by common genes. Behavioral Neuroscience 116: 126-137. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11895174

Palmer, A. A., Moyer, M. R., Crabbe, J. C., and Phillips, T. J. (2002). Initial sensitivity, tolerance and cross-tolerance to allopregnanolone- and ethanol-induced hypothermia in selected mouse lines. Psychopharmacology 162: 313-322. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12122490

Palmer, A. A. and Phillips, T. J. (2002). Effect of forward and reverse selection for ethanol-induced locomotor response on other measures of ethanol sensitivity. Alcoholism: Clinical and Experimental Research 26: 1322-1329. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12351925

Palmer, A. A. and Phillips, T. J. (2002). Quantitative trait locus (QTL) mapping in mice. In: Liu, Y. and Lovinger, D. M. (Eds.), Methods in Alcohol-related Neuroscience Research, CRC Press, Boca Raton FL, pp. 1-30.

Phillips, T. J. (2002). Animal models for the genetic study of human alcohol phenotypes. Alcohol Research and Health 26: 202-207. Free full text NIAAA link: http://pubs.niaaa.nih.gov/publications/arh26-3/202-207.htm

Phillips, T. J. and Belknap, J. K. (2002). Complex-trait genetics: emergence of multivariate strategies. Nature Reviews Neuroscience 3: 478-485. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12042883

Phillips, T. J., Belknap, J. K., Hitzemann, R. J., Buck, K. J., Cunningham, C. L., and Crabbe, J. C. (2002). Harnessing the mouse to unravel the genetics of human disease. Genes, Brain and Behavior 1: 14-26. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12886946

Phillips, T. J., Shen, E. H., McKinnon, C. S., Burkhart-Kasch, S., Lessov, C. N., and Palmer, A. A. (2002). Forward, relaxed, and reverse selection for reduced and enhanced sensitivity to ethanol's locomotor stimulant effects in mice. Alcoholism: Clinical and Experimental Research 26: 593-602. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12045466

Ponomarev, I. and Crabbe, J. C. (2002). A novel method to assess initial sensitivity and acute functional tolerance to hypnotic effects of ethanol. Journal of Pharmacology and Experimental Therapeutics 302: 257-263. Free open access link: http://jpet.aspetjournals.org/content/302/1/257.long

Ponomarev, I and Crabbe, J. C. (2002). Ethanol-induced activation and rapid development of tolerance may have some underlying genes in common. Genes, Brain and Behavior 1: 82-87. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12884978

Risinger, F. O. and Boyce, J. M. (2002). Conditioning tastant and the acquisition of conditioned taste avoidance to drugs of abuse in DBA/2J mice. Psychopharmacology 160: 225-232. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11889491

Risinger, F. O., Cunningham, C. L., Bevins, R. A., and Holloway, F. A. (2002). Place conditioning: what does it add to our understanding of ethanol reward? Alcoholism: Clinical and Experimental Research 26: 1444-1452. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12351941

Ryabinin, A. E., Bachtell, R. K., Heinrichs, S. C., Lee, S., Rivier, C., Olive, M. F., Mehmert, K. K., Camarini, R., Kim, J. A., Koenig, H. N., Nannini, M. A., Hodge, C. W., Roberts, A. J., and Koob, G. F. (2002). The corticotropin-releasing factor/urocortin system and alcohol. Alcoholism: Clinical and Experimental Research 26: 714-722. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12045481

Ryabinin, A. E., Miller, M. N., and Durrant, S. (2002). Effects of acute alcohol administration on object recognition learning in C57BL/6J mice. Pharmacology, Biochemistry and Behavior 71: 315-320. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11812537

Sinnott, R. S., Mark, G. P., and Finn, D. A. (2002). Reinforcing effects of the neurosteroid allopregnanolone in rats. Pharmacology, Biochemistry and Behavior 72: 923-929. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12062582

Sinnott, R. S., Phillips, T. J., and Finn, D. A. (2002). Alteration of voluntary ethanol and saccharin consumption by the neurosteroid allopregnanolone in mice. Psychopharmacology 162: 438-447. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12172699


2001 Center Publications

Atkins, A. L., Helms, M. L., O'Toole, L. A., and Belknap, J. K. (2001). Stereotypic behaviors in mice selectively bred for high and low methamphetamine-induced stereotypic chewing. Psychopharmacology 157: 96-104. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11512049

Bachtell, R. K. and Ryabinin, A. E. (2001). Interactive effects of nicotine and alcohol co-administration on expression of inducible transcription factors in mouse brain. Neuroscience 103: 941-954. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11301203

Belknap, J. K. and Atkins, A. L. (2001). The replicability of QTLs for murine alcohol preference drinking behavior across eight independent studies. Mammalian Genome 12: 893-899. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11707775

Belknap, J. K., Hitzemann, R., Crabbe, J. C., Phillips, T. J., Buck, K. J., and Williams, R. W. (2001). QTL analysis and genomewide mutagenesis in mice: Complementary genetic approaches to the dissection of complex traits. Behavior Genetics 31: 5-15. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11529275

Bergeson, S. E., Helms, M. L., O'Toole, L. A., Jarvis, M. W., Hain, H. S., Mogil, J. S., and Belknap, J. K. (2001). Quantitative trait loci influencing morphine antinociception in four mapping populations. Mammalian Genome 12: 546-553. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11420618

Buck, K. J. and Finn, D. A. (2001). Genetic factors in addiction: QTL mapping and candidate gene studies implicate GABAergic genes in alcohol and barbiturate withdrawal in mice. Addiction 96: 139-149. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11177525

Coste, S. C., Murray, S. E., and Stenzel-Poore, M. P. (2001). Animal models of CRH excess and CRH receptor deficiency display altered adaptations to stress. Peptides 22: 733-741. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11337086

Crabbe, J. C. (2001). Use of genetic analyses to refine phenotypes related to alcohol tolerance and dependence. Alcoholism: Clinical and Experimental Research 25: 288-292. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11236845

Crawshaw, L. I. and Wallace, H. L. (2001). Thermoregulation. In: Auerbach, P. S. (Eds.), Wilderness Medicine, Mosby, St. Louis.

Crawshaw, L. I., Wallace, H. L., Christensen, R., and Crabbe, J. C. (2001). Influence of ethanol on thermoregulation: mapping quantitative trait loci. Physiological Genomics 7: 159-169. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11773602

Finn, D. A. (2001). Dissecting GABAergic and serotonergic involvement in anxiety. Behav Pharmacol 12: 467-470. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11742140

Grupe, A., Germer, S., Usuka, J., Aud, D., Belknap, J. K., Klein, R. F., Ahluwalia, M. K., Higuchi, R., and Peltz, G. (2001). In silico mapping of complex disease-related traits in mice. Science 292: 1915-1918. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11397946

Hoffman, P. L., Yagi, T., Tabakoff, B., Phillips, T. J., Kono, H., Messing, R. O., and Choi, D. S. (2001). Transgenic and gene "knockout" models in alcohol research. Alcoholism: Clinical and Experimental Research 25: 60S-66S. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11391051

Hood, H. M., Belknap, J. K., Crabbe, J. C., and Buck, K. J. (2001). Genomewide search for epistasis in a complex trait: Pentobarbital withdrawal convulsions in mice. Behavior Genetics 31: 93-100. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11529278

Janowsky, A., Mah, C., Johnson, R. A., Cunningham, C. L., Phillips, T. J., Crabbe, J. C., Eshleman, A. J., and Belknap, J. K. (2001). Mapping genes that regulate density of dopamine transporters and correlated behaviors in recombinant inbred mice. Journal of Pharmacology and Experimental Therapeutics 298: 634-643. Free open access link: http://jpet.aspetjournals.org/content/298/2/634.long

Klein, R. F., Shea, M., Gunness, M. E., Pelz, G. B., Belknap, J. K., and Orwoll, E. S. (2001). Phenotypic characterization of mice bred for high and low peak bone mass. Journal of Bone and Mineral Research 16: 63-71. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11149491

Le, A. D., Kiianmaa, K., Cunningham, C. L., Engel, J. A., Ericson, M., Soderpalm, B., Koob, G. F., Roberts, A. J., Weiss, F., Hyytia, P., Janhunen, S., Mikkola, J., Backstrom, P., Ponomarev, I., and Crabbe, J. C. (2001). Neurobiological processes in alcohol addiction. Alcoholism: Clinical and Experimental Research 25: 144S-151S. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11391064

Lessov, C. N., Palmer, A. A., Quick, E. A., and Phillips, T. J. (2001). Voluntary ethanol drinking in C57BL/6J and DBA/2J mice before and after sensitization to the locomotor stimulant effects of ethanol. Psychopharmacology 155: 91-99. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11374341

Lessov, C. N., Risinger, F. O., and Phillips, T. J. (2001). Attenuation of ethanol-induced conditioned taste aversion in mice sensitized to the locomotor stimulant effects of ethanol. Behavioral Neuroscience 115: 146-153. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11256438

Mason, J. N., Eshleman, A. J., Belknap, J. K., Crabbe, J. C., Loftis, J. M., Macey, T. A., and Janowsky, A. (2001). NMDA receptor subunit mRNA and protein expression in ethanol-Withdrawal Seizure-Prone and -Resistant Mice. Alcoholism: Clinical and Experimental Research 25: 651-660. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11371713

Murray, S. E., Coste, S. C., Lindberg, I., and Stenzel-Poore, M. P. (2001). Genetic mutants with dysregulation of corticotropin pathways. Transgenic Models in Endocrinology, Kluwer Academic, Dordrecht, the Netherlands, pp. 143-173.

Murray, S. E., Lallman, H. R., Heard, A. D., Rittenberg, M. B., and Stenzel-Poore, M. P. (2001). A genetic model of stress displays decreased lymphocytes and impaired antibody responses without altered susceptibility to Streptococcus pneumoniae. Journal of Immunology 167: 691-698. Free open access link: http://www.jimmunol.org/content/167/2/691.long

Reilly, M. T., Fehr, C., and Buck, K. J. (2001). Alcohol and gene expression in the central nervous system. In: Moussa-Moustaid, N. and Berdanier, C. D. (Eds.), Nutrient-Gene Interactions in Health and Disease, CRC Press, Boca Raton FL, pp. 131-162.

Risinger, F. O., Freeman, P. A., Greengard, P., and Fienberg, A. A. (2001). Motivational effects of ethanol in DARPP-32 knock-out mice. Journal of Neuroscience 21: 340-348. Free open access link: http://www.jneurosci.org/content/21/1/340.long

Rustay, N. R., Boehm, S. L., Schafer, G. L., Browman, K. E., Erwin, V. G., and Crabbe, J. C. (2001). Sensitivity and tolerance to ethanol-induced incoordination and hypothermia in HAFT and LAFT mice. Pharmacology, Biochemistry and Behavior 70: 167-174. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11566154

Ryabinin, A. E., Bachtell, R. K., Freeman, P., and Risinger, F. O. (2001). ITF expression in mouse brain during acquisition of alcohol self- administration. Brain Research 890: 192-195. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11164784

Schafer, G. L., Crabbe, J. C., and Wiren, K. M. (2001). Ethanol-regulated gene expression of neuroendocrine specific protein in mice: brain region and genotype specificity. Brain Research 897: 139-149. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11282367

Suwaki, H., Kalant, H., Higuchi, S., Crabbe, J. C., Ohkuma, S., Katsura, M., Yoshimura, M., Stewart, R. C., Li, T. K., and Weiss, F. (2001). Recent research on alcohol tolerance and dependence. Alcoholism: Clinical and Experimental Research 25: 189S-196S. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11391070

Ueno, S., Harris, R. A., Messing, R. O., Sanchez-Perez, A. M., Hodge, C. W., McMahon, T., Wang, D., Mehmert, K. K., Kelley, S. P., Haywood, A., Olive, M. F., Buck, K. J., Hood, H. M., Blednov, Y., Findlay, G., and Mascia, M. P. (2001). Alcohol actions on GABA(A) receptors: from protein structure to mouse behavior. Alcoholism: Clinical and Experimental Research 25: 76S-81S. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11391054

Wahlsten, D., Crabbe, J. C., and Dudek, B. C. (2001). Behavioural testing of standard inbred and 5HT(1B) knockout mice: implications of absent corpus callosum. Behavioural Brain Research 125: 23-32. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11682089

Weitemier, A. Z., Woerner, A., Backstrom, P., Hyytia, And P., and Ryabinin, A. E. (2001). Expression of c-Fos in Alko Alcohol Rats Responding for Ethanol in an Operant Paradigm. Alcoholism: Clinical and Experimental Research 25: 704-710. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11371719


2000 Center Publications

Atkins, A. L., Rustay, N. R., and Crabbe, J. C. (2000). Anxiety and sensitivity to ethanol and pentobarbital in alcohol withdrawal seizure-prone and withdrawal seizure-resistant mice. Alcoholism: Clinical and Experimental Research 24: 1743-1749. PubMed Link:  http://www.ncbi.nlm.nih.gov/pubmed/11141031

Beadles-Bohling, A. S., Crabbe, J. C., and Wiren, K. M. (2000). Elevated prodynorphin expression associated with ethanol withdrawal convulsions. Neurochemistry International 37: 463-472. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10871698

Boehm, S. L., Crabbe, J. C., and Phillips, T. J. (2000). Sensitivity to ethanol-induced motor incoordination in FAST and SLOW selectively bred mice. Pharmacology, Biochemistry and Behavior 66: 241-247. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10880675

Boehm, S. L., Schafer, G. L., Phillips, T. J., Browman, K. E., and Crabbe, J. C. (2000). Sensitivity to ethanol-induced motor incoordination in 5-HT(1B) receptor null mutant mice is task-dependent: implications for behavioral assessment of genetically altered mice. Behavioral Neuroscience 114: 401-409.  PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10832800

Boyce, J. M. and Risinger, F. O. (2000). Enhancement of ethanol reward by dopamine D3 receptor blockade. Brain Research 880: 202-206. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11033008

Browman, K. E. and Crabbe, J. C. (2000). Quantitative trait loci affecting ethanol sensitivity in BXD recombinant inbred mice. Alcoholism: Clinical and Experimental Research 24: 17-23.  PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10656187

Browman, K. E., Crabbe, J. C., and Li, T.-K. (2000). Genetic strategies in preclinical substance abuse research. In: Bloom, F. E. and Kupfer, D. J. (Eds.), Psychopharmacology: A Fourth Generation of Progress, Lippincott, Williams, & Wilkins, New York.

Browman, K. E., Rustay, N. R., Nikolaidis, N., Crawshaw, L., and Crabbe, J. C. (2000). Sensitivity and tolerance to ethanol in mouse lines selected for ethanol-induced hypothermia. Pharmacology, Biochemistry and Behavior 67: 821-829. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11166073

Buck, K. J., Crabbe, J. C., and Belknap, J. K. (2000). Alcohol and other abused drugs. In: Pfaff, D. W., Berrettini, W. H., Joh, T. H., and Maxson, S. C. (Eds.), Genetic Influences on Neural and Behavioral Functions, CRC Press, Boca Raton FL, pp. 159-183.

Buck, K., Lischka, T., Dorow, J., and Crabbe, J. (2000). Mapping quantitative trait loci that regulate sensitivity and tolerance to quinpirole, a dopamine mimetic selective for D(2)/D(3) receptors. American Journal of Medical Genetics 96: 696-705. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11054779

Coste, S. C., Kesterson, R. A., Heldwein, K. A., Stevens, S. L., Heard, A. D., Hollis, J. H., Murray, S. E., Hill, J. K., Pantely, G. A., Hohimer, A. R., Hatton, D. C., Phillips, T. J., Finn, D. A., Low, M. J., Rittenberg, M. B., Stenzel, P., and Stenzel-Poore, M. P. (2000). Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2. Nature Genetics 24: 403-409.  PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10742107

Crabbe, J. C. (2000). And a mouse is miracle enough to stagger sextillions of infidels. (Review of "What's Wrong with My Mouse?"). Trends in Genetics 16: 365-366.

Crabbe, J. C. (2000). Genetic modification as a tool for the study of behavioral consequences of signaling processes. NIAAA Research Monograph 35: 137-144.  NIAAA ordering information: http://pubs.niaaa.nih.gov/publications/monograp.htm

Crabbe, J. C. (2000). Review of alcohol and alcoholism: Effects on brain development. Journal of Studies on Alcohol 61: 484-485.

Cunningham, C. L. and Dworkin, S. I. (2000). Alcoholism and drug addiction: What determines vulnerability? Molecular Medicine Today 6: 101-103.

Cunningham, C. L., Fidler, T. L., and Hill, K. G. (2000). Animal models of alcohol's motivational effects. Alcohol Research and Health 24: 85-92. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11199282

Cunningham, C. L. and Henderson, C. M. (2000). Ethanol-induced conditioned place aversion in mice. Behavioural Pharmacology 11: 591-602. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11198130

Cunningham, C. L., Howard, M. A., Gill, S. J., Rubinstein, M., Low, M. J., and Grandy, D. K. (2000). Ethanol-conditioned place preference is reduced in dopamine D2 receptor- deficient mice. Pharmacology, Biochemistry and Behavior 67: 693-699. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11166059

Finn, D. A., Gallaher, E. J., and Crabbe, J. C. (2000). Differential change in neuroactive steroid sensitivity during ethanol withdrawal. Journal of Pharmacology and Experimental Therapeutics 292: 394-405.  Free open access link: http://jpet.aspetjournals.org/content/292/1/394.long

Hain, H. S., Crabbe, J. C., Bergeson, S. E., and Belknap, J. K. (2000). Cocaine-induced seizure thresholds: quantitative trait loci detection and mapping in two populations derived from the C57BL/6 and DBA/2 mouse strains. Journal of Pharmacology and Experimental Therapeutics 293: 180-187. Free open access link: http://jpet.aspetjournals.org/content/293/1/180.long

Hatton, D. C., Qi, Y., and Belknap, J. K. (2000). Heritability of the blood pressure response to acute ethanol exposure in five inbred strains of mice. Alcoholism: Clinical and Experimental Research 24: 1483-1487. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11045854

Hoffman, P. L., Morrow, A. L., Phillips, T. J., and Siggins, G. R. (2000). Neuroadaptation to ethanol at the molecular and cellular levels. NIAAA Research Monograph 34: 85-188.  NIAAA ordering information: http://pubs.niaaa.nih.gov/publications/monograp.htm

Hood, H. M. and Buck, K. J. (2000). Allelic variation in the GABA A receptor gamma2 subunit is associated with genetic susceptibility to ethanol-induced motor incoordination and hypothermia, conditioned taste aversion, and withdrawal in BXD/Ty recombinant inbred mice. Alcoholism: Clinical and Experimental Research 24: 1327-1334. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11003197

McMahon, T., Andersen, R., Metten, P., Crabbe, J.C., and Messing, R. O. (2000). Protein kinase C epsilon mediates up-regulation of N-type calcium channels by ethanol. Molecular Pharmacology 57: 53-58.  Free open access link: http://molpharm.aspetjournals.org/content/57/1/53.long

Mogil, J. S., Grisel, J. E., Hayward, M. D., Bales, J. R., Rubinstein, M., Belknap, J. K., and Low, M. J. (2000). Disparate spinal and supraspinal opioid antinociceptive responses in beta-endorphin-deficient mutant mice. Neuroscience 101: 709-717. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11113319

Morikawa, H., Manzoni, O. J., Crabbe, J. C., and Williams, J. T. (2000). Regulation of central synaptic transmission by 5-HT(1B) auto- and heteroreceptors. Molecular Pharmacology 58: 1271-1278. Free open access link: http://molpharm.aspetjournals.org/content/58/6/1271.long

Plomin, R. and Crabbe, J. (2000). DNA. Psychological Bulletin 126: 806-828. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11107877

Rausch, R. N., Crawshaw, L. I., and Wallace, H. L. (2000). Effects of hypoxia, anoxia, and endogenous ethanol on thermoregulation in goldfish, Carassius auratus. American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology 278: R545-R555.  Free open access link: http://ajpregu.physiology.org/content/278/3/R545.long

Reilly, M. T. and Buck, K. J. (2000). GABA(A) receptor beta(2) subunit mRNA content is differentially regulated in ethanol-dependent DBA/2J and C57BL/6J mice. Neurochemistry International 37: 443-452. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10871696

Reilly, M. T., Crabbe, J. C., Rustay, N. R., and Finn, D. A. (2000). Acute neuroactive steroid withdrawal in withdrawal seizure-prone and withdrawal seizure-resistant mice. Pharmacology, Biochemistry and Behavior 67: 709-717. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11166061

Risinger, F. O. and Cunningham, C. L. (2000). DBA/2J mice develop stronger lithium chloride-induced conditioned taste and place aversions than C57BL/6J mice. Pharmacology, Biochemistry and Behavior 67: 17-24. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11113479

Risinger, F. O., Freeman, P. A., Rubinstein, M., Low, M. J., and Grandy, D. K. (2000). Lack of operant ethanol self-administration in dopamine D2 receptor knockout mice. Psychopharmacology 152: 343-350. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11105945

Risinger, F. O., Quick, E., and Belknap, J. K. (2000). Quantitative trait loci for acute behavioral sensitivity to paraoxon. Neurotoxicology and Teratology 22: 667-674. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11106859

Ron, D., Vagts, A. J., Dohrman, D. P., Yaka, R., Jiang, Z., Yao, L., Crabbe, J., Grisel, J. E., and Diamond, I. (2000). Uncoupling of bIIPKC from its targeting protein RACK1 in response to ethanol in cultured cells and mouse brain. FASEB Journal 14: 2303-2314. Free open access link: http://www.fasebj.org/content/14/14/2303.long

Ryabinin, A. E. (2000). ITF mapping after drugs of abuse: Pharmacological versus perceptional effects. Acta Neurobiologiae Experimentalis 60: 547-555. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11200183

Ryabinin, A. E., Wang, Y., Bachtell, R. K., Kinney, A. E., Grubb, M. C., and Mark, G. P. (2000). Cocaine- and alcohol-mediated expression of inducible transcription factors is blocked by pentobarbital anesthesia. Brain Research 877: 251-261. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10986339


1999 Center Publications

Bachtell, R. K., Wang, Y. M., Freeman, P., Risinger, F. O., and Ryabinin, A. E. (1999). Alcohol drinking produces brain region-selective changes in expression of inducible transcription factors. Brain Research 847: 157-165. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10575084

Broadbent, J. and Harless, W. E. (1999). Differential effects of GABA(A) and GABA(B) agonists on sensitization to the locomotor stimulant effects of ethanol in DBA/2 J mice. Psychopharmacology 141: 197-205. PubMed Link:  http://www.ncbi.nlm.nih.gov/pubmed/9952045

Broadbent, J. and Weitemier, A. Z. (1999). Dizocilpine (MK-801) prevents the development of sensitization to ethanol in DBA/2J mice. Alcohol and Alcoholism 34: 283-288. Free open access link: http://alcalc.oxfordjournals.org/content/34/3/283.long

Browman, K. E. and Crabbe, J. C. (1999). Alcohol and genetics: New animal models. Molecular Medicine Today 5: 310-318. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10377523

Buck, K., Metten, P., Belknap, J., and Crabbe, J. (1999). Quantitative trait loci affecting risk for pentobarbital withdrawal map near alcohol withdrawal loci on mouse chromosomes 1, 4, and 11. Mammalian Genome 10: 431-437. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10337613

Buckman, J. F. and Meshul, C. K. (1999). Glial differences between naive Withdrawal Seizure-Prone and -Resistant mice. Alcoholism: Clinical and Experimental Research 23: 1905-1913. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10630609

Buckman, J. F., Meshul, C. K., Finn, D. A., and Janowsky, A. (1999). Glutamate uptake in mice bred for ethanol withdrawal severity. Psychopharmacology 143: 174-182. PubMed Link:  http://www.ncbi.nlm.nih.gov/pubmed/10326780

Burrows, K. B. and Meshul, C. K. (1999). High-dose methamphetamine treatment alters presynaptic GABA and glutamate immunoreactivity. Neuroscience 90: 833-850. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10218784

Chester, J. A. and Cunningham, C. L. (1999). Baclofen alters ethanol-stimulated activity but not conditioned place preference or taste aversion in mice. Pharmacology, Biochemistry and Behavior 63: 325-331. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10371663

Chester, J. A. and Cunningham, C. L. (1999). GABA(A) receptors modulate ethanol-induced conditioned place preference and taste aversion in mice. Psychopharmacology 144: 363-372. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10435409

Crabbe, J. C. (1999). Animal models in neurobehavioral genetics: Methods for estimating genetic correlation. In: Mormede, P. and Jones, B. C. (Eds.), Neurobehavioral Genetics: Methods and Applications, CRC Press, Boca Raton FL, pp. 121-138.

Crabbe, J. C. (1999). Molecular genetics of addiction. In: Charney, D. S., Nestler, E. J., and Bunney, B. S. (Eds.), Neurobiology of Mental Illness, Oxford Univ. Press, New York, pp. 591-600.

Crabbe, J. C. (1999). Psychopharmacogenetics of alcohol. In: Mormede, P. and Jones, B. C. (Eds.), Neurobehavioral Genetics: Methods and Applications, CRC Press, Boca Raton FL, pp. 329-339.

Crabbe, J. C. and Cunningham, C. L. (1999). Drug and alcohol dependence-related behaviors. In: Crusio, W. E. and Gerlai, R. T. (Eds.), Handbook of Molecular-Genetic Techniques for Brain and Behavior Research, Elsevier, Amsterdam, pp. 652-666.

Crabbe, J. C., Phillips, T. J., Buck, K. J., Cunningham, C. L., and Belknap, J. K. (1999). Identifying genes for alcohol and drug sensitivity: recent progress and future directions. Trends in Neurosciences 22: 173-179. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10203855

Crabbe, J. C., Wahlsten, D., and Dudek, B. C. (1999). Genetics of mouse behavior: Interactions with laboratory environment. Science 284: 1670-1672. PubMed Link:  http://www.ncbi.nlm.nih.gov/pubmed/10356397

Cunningham, C. L., Dickinson, S. D., Grahame, N. J., Okorn, D. M., and McMullin, C. S. (1999). Genetic differences in cocaine-induced conditioned place preference in mice depend on conditioning trial duration. Psychopharmacology 146: 73-80. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10485967

Demarest, K., McCaughran, J., Mahjubi, E., Cipp, L., and Hitzemann, R. (1999). Identification of an acute ethanol response quantitative trait locus on mouse chromosome 2. Journal of Neuroscience 19: 549-561. Free open access link: http://www.jneurosci.org/content/19/2/549.long

Finn, D. A. and Crabbe, J. C. (1999). Chronic ethanol differentially alters susceptibility to chemically induced convulsions in withdrawal seizure-prone and -resistant mice. Journal of Pharmacology and Experimental Therapeutics 288: 782-790. Free open access link: http://jpet.aspetjournals.org/content/288/2/782.long

Grisel, J. E., Mogil, J. S., Grahame, N. J., Rubinstein, M., Belknap, J. K., Crabbe, J. C., and Low, M. J. (1999). Ethanol oral self-administration is increased in mutant mice with decreased beta-endorphin expression. Brain Research 835: 62-67.  PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10448196

Hain, H. S., Belknap, J. K., and Mogil, J. S. (1999). Pharmacogenetic evidence for the involvement of 5-hydroxytryptamine (Serotonin)-1B receptors in the mediation of morphine antinociceptive sensitivity. Journal of Pharmacology and Experimental Therapeutics 291: 444-449. Free open access link: http://jpet.aspetjournals.org/content/291/2/444.long

Kest, B., Jenab, S., Brodsky, M., Sadowski, B., Belknap, J. K., Mogil, J. S., and Inturrisi, C. E. (1999). Mu and delta opioid receptor analgesia, binding density, and mRNA levels in mice selectively bred for high and low analgesia. Brain Research 816: 381-389. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9878841

Mark, G. P., Hajnal, A., Kinney, A. E., and Keys, A. S. (1999). Self-administration of cocaine increases the release of acetylcholine to a greater extent than response-independent cocaine in the nucleus accumbens of rats. Psychopharmacology 143: 47-53. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10227079

Mark, G. P., Kinney, A. E., Grubb, M. C., and Keys, A. S. (1999). Involvement of acetylcholine in the nucleus accumbens in cocaine reinforcement. Annals of the New York Academy of Sciences 877: 792-795. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10415706

Metten, P. and Crabbe, J. C. (1999). Genetic determinants of severity of acute withdrawal from diazepam in mice: Commonality with ethanol and pentobarbital. Pharmacology, Biochemistry and Behavior 63: 473-479. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10418790

Mogil, J. S., Wilson, S. G., Bon, K., Lee, S. E., Chung, K., Raber, P., Pieper, J. O., Hain, H. S., Belknap, J. K., Hubert, L., Elmer, G. I., Chung, J. M., and Devor, M. (1999). Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception. Pain 80: 67-82. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10204719

Mogil, J. S., Wilson, S. G., Bon, K., Lee, S. E., Chung, K., Raber, P., Pieper, J. O., Hain, H. S., Belknap, J. K., Hubert, L., Elmer, G. I., Chung, J. M., and Devor, M. (1999). Heritability of nociception II. 'Types' of nociception revealed by genetic correlation analysis. Pain 80: 83-93. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10204720

Phillips, T. J., Hen, R., and Crabbe, J. C. (1999). Complications associated with genetic background effects in research using knockout mice. Psychopharmacology 147: 5-7. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10591855

Ponomarev, I. and Crabbe, J. C. (1999). Genetic association between chronic ethanol withdrawal severity and acoustic startle parameters WSP and WSR mice. Alcoholism: Clinical and Experimental Research 23: 1730-1735. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10591588

Risinger, F. O., Brown, M. M., Oakes, R. A., and Love, J. A. (1999). Effects of haloperidol or SCH-23390 on ethanol-induced conditioned taste aversion. Alcohol 18: 139-145. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10456564

Risinger, F. O., Doan, A. M., and Vickrey, A. C. (1999). Oral operant ethanol self-administration in 5-HT1b knockout mice. Behavioural Brain Research 102: 211-215. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10403028

Ryabinin, A. E., Wang, Y. M., and Finn, D. A. (1999). Different levels of Fos immunoreactivity after repeated handling and injection stress in two inbred strains of mice. Pharmacology, Biochemistry and Behavior 63: 143-151. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10340535

Ryabinin, A. E., Wang, Y. M., Freeman, P., and Risinger, F. O. (1999). Selective effects of alcohol drinking on restraint-induced expression of immediate early genes in mouse brain. Alcoholism: Clinical and Experimental Research 23: 1272-1280. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10443996

Thrasher, M. J., Freeman, P. A., and Risinger, F. O. (1999). Clozapine's effects on ethanol's motivational properties. Alcoholism: Clinical and Experimental Research 23: 1377-1385. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10470981

Wood, R. D., Shen, E. H., Chester, J. A., and Phillips, T. J. (1999). Ontogeny of ethanol-induced locomotor activity and hypothermia differences in selectively bred FAST and SLOW mice. Pharmacology, Biochemistry and Behavior 62: 339-347. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9972702


1998 Center Publications

Belknap, J. K. (1998). Effect of within-strain sample size on QTL detection and mapping using recombinant inbred mouse strains. Behavior Genetics 28: 29-38. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9573644

Belknap, J. K., Riggan, J., Cross, S., Young, E. R., Gallaher, E. J., and Crabbe, J. C. (1998). Genetic determinants of morphine activity and thermal responses in 15 inbred mouse strains. Pharmacology, Biochemistry and Behavior 59: 353-360. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9476981

Buck, K. J. (1998). Recent progress toward the identification of genes related to risk for alcoholism. Mammalian Genome 9: 927-928. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9880654

Buck, K. J. and Amara, S. G. (1998). In vivo generation of chimeras. Methods in Enzymology 296: 466-475. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9779468

Buck, K. J. and Hood, H. M. (1998). Genetic association of a GABA(A) receptor gamma2 subunit variant with severity of acute physiological dependence on alcohol. Mammalian Genome 9: 975-978. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9880662

Chester, J. A. and Cunningham, C. L. (1998). Modulation of corticosterone does not affect the acquisition or expression of ethanol-induced conditioned place preference in DBA/2J mice. Pharmacology, Biochemistry and Behavior 59: 67-75. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9443538

Chester, J. A., Risinger, F. O., and Cunningham, C. L. (1998). Ethanol reward and aversion in mice bred for sensitivity to ethanol withdrawal. Alcoholism: Clinical and Experimental Research 22: 468-473. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9581655

Crabbe, J. C. (1998). Provisional mapping of quantitative trait loci for chronic ethanol withdrawal severity in BXD recombinant inbred mice. Journal of Pharmacology and Experimental Therapeutics 286: 263-271. Free open access link: http://jpet.aspetjournals.org/content/286/1/263.long

Crabbe, J. C. and Belknap, J. K. (1998). Ethical consequences of mapping QTLs for complex human traits. In: Paterson, A. H. (Eds.), Molecular Dissection of Complex Traits, CRC Press, Boca Raton FL, pp. 279-285.

Crabbe, J. C., Belknap, J. K., Metten, P., Grisel, J. E., and Buck, K. J. (1998). Quantitative trait loci: Mapping drug and alcohol-related genes. Advances in Pharmacology 42: 1033-1037. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9328074

Crabbe, J. C., Gallaher, E. J., Cross, S. J., and Belknap, J. K. (1998). Genetic determinants of sensitivity to diazepam in inbred mice. Behavioral Neuroscience 112: 668-677. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9676982

Crabbe, J. C. and Phillips, T. J. (1998). Genetics of alcohol and other abused drugs. Drug and Alcohol Dependence 51: 61-71. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9716930

Crawshaw, L. I., Wallace, H., and Crabbe, J. (1998). Ethanol, body temperature and thermoregulation. Clinical and Experimental Pharmacology and Physiology 25: 150-154. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9493506

Cunningham, C. L. (1998). Drug conditioning and drug-seking behavior. In: O'Donohue, W. (Eds.), Learning and Behavior Therapy, Allyn & Bacon, Boston, pp. 518-544.

Dickinson, S. D. and Cunningham, C. L. (1998). Altered ambient temperature and ethanol-induced conditioned place preference in mice. Alcohol 16: 13-18. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9650631

Grahame, N. J., Low, M. J., and Cunningham, C. L. (1998). Intravenous self-administration of ethanol in beta-endorphin-deficient mice. Alcoholism: Clinical and Experimental Research 22: 1093-1098. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9726280

Hajnal, A., Mark, G. P., Keys, A. S., and Lenard, L. (1998). Involvement of dopamine and acetylcholine in the interaction between amygdala and nucleus accumbens: chronic microdialysis in rats. Neurobiology 6: 363-367. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9778654

Kelly, M. A., Rubinstein, M., Phillips, T. J., Lessov, C. N., Burkhart-Kasch, S., Zhang, G., Bunzow, J. R., Fang, Y., Gerhardt, G. A., Grandy, D. K., and Low, M. J. (1998). Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations. Journal of Neruoscience 18: 3470-3479. Free open access link: http://www.jneurosci.org/content/18/9/3470.long

Keys, A. S. and Mark, G. P. (1998). D1 and D2 dopamine receptor mediation of amphetamine-induced acetylcholine release in nucleus accumbens. Neuroscience 86: 521-531. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9881866

Keys, A. S., Mark, G. P., Emre, N., and Meshul, C. K. (1998). Reduced glutamate immunolabeling in the nucleus accumbens following extended withdrawal from self-administered cocaine. Synapse 30: 393-401. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9881866

Klein, R. F., Mitchell, S. R., Phillips, T. J., Belknap, J. K., and Orwoll, E. S. (1998). Quantitative trait loci affecting peak bone mineral density in mice. Journal of Bone and Mineral Research 13: 1648-1656. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9797472

Lessov, C. N. and Phillips, T. J. (1998). Duration of sensitization to the locomotor stimulant effects of ethanol in mice. Psychopharmacology 135: 374-382. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9539262

Metten, P., Belknap, J. K., and Crabbe, J. C. (1998). Drug withdrawal convulsions and susceptibility to convulsants after short-term selective breeding for acute ethanol withdrawal. Behavioural Brain Research 95: 113-122. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9754883

Metten, P., Phillips, T. J., Crabbe, J. C., Tarantino, L. M., McClearn, G. E., Plomin, R., Erwin, V. G., and Belknap, J. K. (1998). High genetic susceptibility to ethanol withdrawal predicts low ethanol consumption. Mammalian Genome 9: 983-990. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9880664

Phillips, T. J. (1998). Alcohol-related genetics in animals: Knockouts and antisense technology. Report of a Subcommittee of the National Advisory Council on Alcohol Abuse and Alcoholism on the Review of the Extramural Research Portfolio for Genetics, DHHS, PHS, NIH pp. 38-40.

Phillips, T. J., Belknap, J. K., Buck, K. J., and Cunningham, C. L. (1998). Genes on mouse chromosomes 2 and 9 determine variation in ethanol consumption. Mammalian Genome 9: 936-941. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9880656

Phillips, T. J., Brown, K. J., Burkhart-Kasch, S., Wenger, C. D., Kelly, M. A., Rubinstein, M., Grandy, D. K., and Low, M. J. (1998). Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors. Nature Neuroscience 1: 610-615. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/10196569

Phillips, T. J., Huson, M. G., and McKinnon, C. S. (1998). Localization of genes mediating acute and sensitized locomotor responses to cocaine in BXD/Ty recombinant inbred mice. Journal of Neruoscience 18: 3023-3034. Free open access link: http://www.jneurosci.org/content/18/8/3023.long

Risinger, F. O., Brown, M. M., Doan, A. M., and Oakes, R. A. (1998). Mouse strain differences in oral operant ethanol reinforcement under continuous access conditions. Alcoholism: Clinical and Experimental Research 22: 677-684. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9622450

Risinger, F. O. and Cunningham, C. L. (1998). Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice. Alcoholism: Clinical and Experimental Research 22: 1234-1244. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9756038

Rocha, B. A., Scearce-Levie, K., Lucas, J. J., Hiroi, N., Castanon, N., Crabbe, J. C., Nestler, E. J., and Hen, R. (1998). Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor. Nature 393: 175-178. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9603521

Ryabinin, A. E. (1998). Role of hippocampus in alcohol-induced memory impairment: Implications from behavioral and immediate early gene studies. Psychopharmacology 139: 34-43. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9768540

Ryabinin, A. E. and Wang, Y-M. (1998). Repeated alcohol administration differentially affects c-Fos and FosB protein immunoreactivity in DBA/2J mice. Alcoholism: Clinical and Experimental Research 22: 1646-1654. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9835277

Schafer, G. L., Crabbe, J. C., and Wiren, K. M. (1998). Identification of neuroendocrine-specific protein as an ethanol-regulated gene with mRNA differential display. Mammalian Genome 9: 979-982. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9880663

Shen, E. H., Dorow, J., Harland, R., Burkhart-Kasch, S., and Phillips, T. J. (1998). Seizure sensitivity and GABAergic modulation of ethanol sensitivity in selectively bred FAST and SLOW mouse lines. Journal of Pharmacology and Experimental Therapeutics 287: 606-615. Free open access link: http://jpet.aspetjournals.org/content/287/2/606.long

Shen, E. H. and Phillips, T. J. (1998). MK-801 potentiates ethanol's effects on locomotor activity in mice. Pharmacology, Biochemistry and Behavior 59: 135-143. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9443548


1997 Center Publications

Belknap, J. K., Dubay, C., Crabbe, J. C., and Buck, K. J. (1997). Mapping quantitative trait loci for behavioral traits in the mouse. In: Blum, K. and Noble, E. P. (Eds.), Handbook of Psychiatric Genetics, CRC Press, Boca Raton FL, pp. 435-453.

Belknap, J. K., Richards, S. P., O'Toole, L. A., Helms, M. L., and Phillips, T. J. (1997). Short-term selective breeding as a tool for QTL mapping: ethanol preference drinking in mice. Behavior Genetics 27: 55-66. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9145544

Boehm, S. L., II, Lundahl, K. R., Caldwell, J., and Gilliam, D. M. (1997). Ethanol teratogenesis in the C57BL/6J, DBA/2J and A/J inbred mouse strains. Alcohol 14: 389-395. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9209555

Buck, K. J., Metten, P., Belknap, J. K., and Crabbe, J. C. (1997). Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. Journal of Neuroscience 17: 3946-3955. Free open access link: http://www.jneurosci.org/content/17/10/3946.long

Buckman, J. F. and Meshul, C. K. (1997). Immunocytochemical analysis of glutamate and GABA in selectively bred mice. Brain Research 760: 193-203. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9237535

Burrows, K. B. and Meshul, C. K. (1997). Methamphetamine alters presynaptic glutamate immunoreactivity in the caudate nucleus and motor cortex. Synapse 27: 133-144. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9266774

Crabbe, J. C. (1997). Where does alcohol act in the brain? Molecular Psychiatry 2: 17-20. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9154213

Crawley, J. N., Belknap, J. K., Collins, A., Crabbe, J. C., Frankel, W., Henderson, N., Hitzemann, R. J., Maxson, S. C., Miner, L. L., Silva, A. J., Wehner, J. M., Wynshaw-Boris, A., and Paylor, R. (1997). Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology 132: 107-124. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9266608

Crawshaw, L. I., Wallace, H. L., Crabbe, J. C., Ramos, C., Duerr, J., and O'Connor, C. S. (1997). Ethanol disrupts and decreases the regulated body temperature differentially in C57BL/6J and DBA/2J mice. American Journal of Physiology 273: R696-R702. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9277557

Cunningham, C. L., Okorn, D. M., and Howard, C. E. (1997). Interstimulus interval determines whether ethanol produces conditioned place preference or aversion in mice. Animal Learning and Behavior 25: 31-42.

Finn, D. A. and Crabbe, J. C. (1997). Exploring alcohol withdrawal syndrome. Alcohol Health and Research World 21: 149-156. NIAAA free full text link: http://pubs.niaaa.nih.gov/publications/arh21-2/149.pdf

Finn, D. A., Phillips, T. J., Okorn, D. M., Chester, J. A., and Cunningham, C. L. (1997). Rewarding effect of the neuroactive steroid 3 alpha-hydroxy-5 alpha-pregnan-20-one in mice. Pharmacology, Biochemistry and Behavior 56: 261-264. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9050083

Finn, D. A., Roberts, A. J., Lotrich, F., and Gallaher, E. J. (1997). Genetic differences in behavioral sensitivity to a neuroactive steroid. Journal of Pharmacology and Experimental Therapeutics 280: 820-828. Free open access link: http://jpet.aspetjournals.org/content/280/2/820.long

Grahame, N. J. and Cunningham, C. L. (1997). Intravenous ethanol self-administration in C57BL/6J and DBA/2J mice. Alcoholism: Clinical and Experimental Research 21: 56-62. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9046373

Grisel, J. E., Belknap, J. K., O'Toole, L. A., Helms, M. L., Wenger, C. D., and Crabbe, J. C. (1997). Quantitative trait loci affecting methamphetamine responses in BXD recombinant inbred mouse strains. Journal of Neuroscience 17: 745-754. Free open access link: http://www.jneurosci.org/content/17/2/745.long

Hajnal, A., Mark, G. P., Rada, P. V., Lenard, L., and Hoebel, B. G. (1997). Norepinephrine microinjections in the hypothalamic paraventricular nucleus increase extracellular dopamine and decrease acetylcholine in the nucleus accumbens: Relevance to feeding reinforcement. Journal of Neurochemistry 68: 667-674. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9003054

Keys, A. S. (1997). Structural CNS changes following cocaine: Implications for feedback regulation of mesolimbic circuitry. In: Nahas, G. G. and Burks, T. F. (Eds.), Drug Abuse in the Decade of the Brain, IOS Press, Amsterdam, pp. 223-232.

Phillips, T. J. (1997). Behavior genetics of drug sensitization. Critical Reviews in Neurobiology 11: 21-33.  PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9093812

Phillips, T. J. (1997). Genetic studies with animal models. Contribution to Alcohol and Health, Ninth Special Report to the U.S.Congress from Secretary of Health and Human Services, DHHS, PHS, NIH, NIAAA pp. 40-43.  NIAAA ordering information: http://www.niaaa.nih.gov/news-events/news-releases/ninth-special-report-alcohol-and-health-marks-research-gains

Phillips, T. J., Roberts, A. J., and Lessov, C. N. (1997). Behavioral sensitization to ethanol: Genetics and the effects of stress. Pharmacology, Biochemistry and Behavior 57: 487-493. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9218273

Phillips, T. J., Wenger, C. D., and Dorow, J. D. (1997). Naltrexone effects on ethanol drinking acquisition and on established ethanol consumption in C57BL/6J mice. Alcoholism: Clinical and Experimental Research 21: 691-702. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9194926

Risinger, F. O. (1997). Fluoxetine's effects on ethanol's rewarding, aversive and stimulus properties. Life Sciences 61: PL235-PL242. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/9353173

Rubinstein, M., Phillips, T. J., Bunzow, J. R., Falzone, T. L., Dziewczapolski, G., Zhang, G., Fang, Y., Larson, J. L., McDougall, J. A., Chester, J. A., Saez, C., Pugsley, T. A., Gershanik, O., Low, M. J., and Grandy, D. K. (1997). Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell 90: 991-1001. Free open access link: http://www.sciencedirect.com/science/article/pii/S0092867400803657


1996 Center Publications

Belknap, J. K., Mitchell, S. R., O'Toole, L. A., Helms, M. L., and Crabbe, J. C. (1996). Type I and type II error rates for quantitative trait loci (QTL) mapping studies using recombinant inbred mouse strains. Behavior Genetics 26: 149-160. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/8639150

Broadbent, J., Linder, H. V., and Cunningham, C. L. (1996). Genetic differences in naloxone enhancement of ethanol-induced conditioned taste aversion. Psychopharmacology 126: 147-155. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/8856834

Gallaher, E. J., Jones, G. E., Belknap, J. K., and Crabbe, J. C. (1996). Identification of genetic markers for initial sensitivity and rapid tolerance to ethanol-induced ataxia using quantitative trait locus analysis in BXD recombinant inbred mice. Journal of Pharmacology and Experimental Therapeutics 277: 604-612. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/8627537

Phillips, T. J., Lessov, C. N., Harland, R. D., and Mitchell, S. R. (1996). Evaluation of potential genetic associations between ethanol tolerance and sensitization in BXD/Ty recombinant inbred mice. Journal of Pharmacology and Experimental Therapeutics 277: 613-623. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/8627538

Crabbe, J. C., Phillips, T. J., Gallaher, E. J., Crawshaw, L. I., and Mitchell, S. R. (1996). Common genetic determinants of the ataxic and hypothermic effects of ethanol in BXD/Ty recombinant inbred mice: genetic correlations and quantitative trait loci. Journal of Pharmacology and Experimental Therapeutics 277: 624-632. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/8627539

Crabbe, J. C. (1996). A genetic animal model of alcohol withdrawal. Alcoholism: Clinical and Experimental Research 20: 96A-100A. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/8947243

Buck, K. J. (1996). New insight into the mechanisms of ethanol effects on GABAA receptor function and expression, and their relevance to behavior. Alcoholism: Clinical and Experimental Research 20: 198A-202A. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/8947265

Risinger, F. O. and Oakes, R. A. (1996). Mianserin enhancement of ethanol-induced conditioned place preference. Behavioral Pharmacology 7: 294-298. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/11224421

Shen, E. H., Dorow, J. D., Huson, M., and Phillips, T. J. (1996). Correlated responses to selection in FAST and SLOW mice: Effects of ethanol on ataxia, temperature, sedation, and withdrawal. Alcoholism: Clinical and Experimental Research 20: 688-696. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/8800386

Lotrich, F. E. and Gallaher, E. J. (1996). Micropharmacokinetics: A system dynamics model of drug diffusion and uptake following localized injection into the brain. In: Anderson, J. G. and Katzper, M. (Eds.), Simulation in the Medical Sciences: Proceedings of the 1996 Western Multiconference, Society for Computer Simulation, San Diego CA, pp. 165-170.

Buck, K. J. (1996). Molecular genetic analysis of the role of GABAergic systems in the behavioral and cellular actions of alcohol. Behavior Genetics 26: 313-323. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/8754254

Risinger, F. O., Bormann, N. M., and Oakes, R. A. (1996). Reduced sensitivity to ethanol reward, but not ethanol aversion, in mice lacking 5-HT1B receptors. Alcoholism: Clinical and Experimental Research 20: 1401-1405. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/8947316

Phillips, T. J. and Shen, E. H. (1996). Neurochemical bases of locomotion and ethanol stimulant effects. International Review of Neurobiology 39: 243-282. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/8894850

Devaud, L. L., Purdy, R. H., Finn, D. A., and Morrow, A. L. (1996). Sensitization of g-aminobutyric acidA receptors to neuroactive steroids in rats during ethanol withdrawal. Journal of Pharmacology and Experimental Therapeutics 278: 510-517. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/8768698

Crabbe, J. C. (1996). Quantitative Trait Locus gene mapping: A new method for locating alcohol response genes. Addiction Biology 1: 229-235. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/12893462

Buck, K. J., Lorang, D., and Amara, S. G. (1996). Discrete structural domains and cell-specific expression determine functional selectivity of the dopamine and norepinephrine transporters. NIDA Research Monograph 161: 154-175. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/8784850

Crabbe, J. C., Buck, K. J., Metten, P., and Belknap, J. K. (1996). Strategies for identifying genes underlying drug abuse susceptibility. NIDA Research Monograph 161: 201-219. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/8784852

Crabbe, J. C., Phillips, T. J., Feller, D. J., Hen, R., Wenger, C. D., Lessov, C. N., and Schafer, G. L. (1996). Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptors. Nature Genetics 14: 98-101. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/8782828

Meshul, C. K., Bunker, G. L., Mason, J. N., Allen, C., and Janowsky, A. (1996). Effects of subchronic clozapine and haloperidol on striatal glutamatergic synapses. Journal of Neurochemistry 67: 1965-1973. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/8863502

Risinger, F. O. and Brown, M. M. (1996). Genetic differences in nicotine-induced conditioned taste aversion. Life Sciences 58: PL223-PL229. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/8786704

Schafer, G. L. and Crabbe, J. C. (1996). Sensitivity to ethanol-induced ataxia in HOT and COLD selected lines of mice. Alcoholism: Clinical and Experimental Research 20: 1604-1612. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/8986211

Watts, V. J. and Neve, K. A. (1996). Sensitization of endogenous and recombinant adenylate cyclase by activation of D2 dopamine receptors. Molecular Pharmacology 50: 966-976. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/8863843

Metten, P. and Crabbe, J. C. (1996). Dependence and withdrawal. In: Deitrich, R. A. and Erwin, V. G. (Eds.), Pharmacological Effects of Ethanol on the Nervous System, CRC Press, Boca Raton FL, pp. 269-290.

Risinger, F. O. and Oakes, R. A. (1996). Dose- and conditioning trial-dependent ethanol-induced conditioned place preference in Swiss-Webster mice. Pharmacology, Biochemistry and Behavior 55: 117-123. PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed/8870046